Mice hemizygous for the human leucine-rich repeat kinase 2 transgene, (LRRK2), are viable and fertile. Expression of LRRK2 is regulated by a tetracycline operator (tetO); also called tetracycline-responsive element (TRE, TetRE) or tet-operator). When mated to a mutant strain expressing tetracycline-controlled transactivator protein (tTA), expression of LRRK2 protein may be regulated with tetracycline or its analog doxycycline (dox) in the double mutant offspring. LRRK2 protein, also known as Dardarin, contains multiple functional domains and may function as both an active GTPase and kinase. LRRK2 may regulate alpha-synuclein-mediated neuropathology through modulating the intracellular trafficking and accumulation of SNCA protein. These mice may be useful for studying Parkinson's disease pathogenesis and neurodegeneration.

These hemizygous transgenic mice carry a human leucine-rich repeat kinase 2 gene, LRRK2, regulated by a tetracycline operator (tetO). When mated to a mutant strain expressing tetracycline-controlled transactivator protein (tTA), expression of LRRK2 protein may be regulated with the tetracycline analog doxycycline (dox) in the double mutant offspring. These mice may be useful for studying the Parkinson's disease pathogenesis and neurodegeneration.

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STOCK Tg(teto-LRRK2)C7874Cai/J Frozen Embryo