| Allele Name | transgene insertion 102, Douglas Monks |
| Allele Type | Transgenic (Recombinase-expressing, Inducible, Transactivator) |
| Allele Synonym(s) | HSA-rtTA/TRE-Cre; TRE-Cre |
| Gene Symbol and Name | Tg(ACTA1-rtTA,tetO-cre)102Monk, transgene insertion 102, Douglas Monks |
| Gene Synonym(s) | |
| Promoter | ACTA1, actin, alpha 1, skeletal muscle, human |
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| Promoter | tetO, tet operator, |
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| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
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| Expressed Gene | rtTA, reverse tetracycline-controlled transactivator, E. coli |
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| Site of Expression | tetracycline (doxycycline) inducible Cre-mediated recombination system that is specific for skeletal muscle myocytes. |
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| Strain of Origin | (C57BL/6 x C3H)F2 |
| Chromosome | UN |
| Molecular Note | A transgenic construct containing cre recombinase under the control of the tetracycline-responsive regulatory element (tetO) and a second transgenic construct containing rtTA, under the control of the human ACTA1, actin, alpha 1, skeletal muscle promoter were coinjected into fertilized (C57BL/6 X C3H)F2 mouse eggs. Founder line 102 was subsequently established. Female founder animals were bred to wildtype C57BL/6J mice. |
