Homozygous <i>Bmf</i> (BCL2 modifying factor) targeted mutant mice lack expression of its protein which bears only the pro-apoptotic BH3 domain. Expression in brain, spleen, thymus and lymph node tissues is eliminated. Female homozygotes exhibit an imperforate vagina and hydrometrocolpos (22% penetrance).  Male and female mice exhibit increased numbers of B cells. 

Homozygous <i>Bmf</i> (BCL2 modifying factor) targeted mutant mice lack expression of its protein which bears only the pro-apoptotic BH3 domain.This strain may be useful in studies of apoptosis or female reproductive tract defects.



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