BXD29/Ty

Stock number: 010981
Research areas: Dermatology Research, Mouse/Human Gene Homologs, Neurobiology Research, Research Tools

Description

The BXD set of RI strains is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes. The strain distribution pattern (SDP) for BXD RI strains is available through the Mouse Genome Informatics Recombinant Inbred Strain Distribution Patterns. The BXD strains are derived from the C57BL/6J (Stock No. 000664) and DBA/2J (Stock No. 000671) progenitor strains.

Detailed description

The BXD RI strains are used to study the genetics of behavioral phenotypes including alcohol and drug addiction, stress, and locomotor activity. The BXD set of RI strains also are used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in organ weight and bone mineral density.

The strain distribution pattern (SDP) for the BXD RI strains is available through the Mouse Genome Informatics

Contributed Data Sets and Gene Network.

Additional tools and information are presented through the Mouse Phenome Database

Specialized Strain Panel Query Form, and

Gene Network .

This strain has the wild-type allele of Tlr4. For the subline homozygous for the mutation defective lipopolysaccharide response 2 Jackson, please see stock number 000029.

Development

The BXD set of RI strains was developed in the laboratory of Benjamin Taylor and was transferred to The Jackson Laboratory from Dr. Taylor's research colony upon his retirement. Of 42 BXD RI strains originally derived from the C57BL/6J (Stock No. 000664) and DBA/2J (Stock No. 000671), a number have become extinct over the years. The other BXD RI strains now being distributed are listed under "Related Recombinant Inbred Strains." In 1979 the BXD29/Ty strain was cryopreserved, then at generation F39, and was also kept breeding on the shelf as Stock No. 000029. In 2006 Cook et al., reported that a mutation had spontaneously arisin in the Tlr4 sequence, allele Tlr4^lps-2J, in the line that had been maintained on the shelf all those years (Stock No. 000029). The cryopreserved bankstock from 1979 was recovered and found to have no mutation in Tlr4. This Tlr4 wild-type strain (Stock No. 010981) is descended from that 2006 thaw of the 1979 bankstock.

Allele

Symbol: Myo5a^d
Name: dilute
MGI accession ID: MGI:1856004
Generation method: Spontaneous
Marker symbol: Myo5a
Marker name: myosin VA
Chromosome: 9
Strain of origin: old mutant of the mouse fancy
Molecular note: This mutation is the result of the integration of ecotropic murine leukemia virus Emv-3 into a noncoding region of the Myo5a^d gene. Reversions of Myo5a^d to wild-type are caused by excision of the virus leaving exactly one long terminal repeat in place.