Mice carrying this recessive re-mutation in the Dab1 gene are characterized by small size and abnormal gait.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Dab1 | disabled 1 |
Homozygotes can be recognized by two weeks of age by smaller body size, tremor, and leaning side-to-side gait. While some homozygotes die by three weeks of age, most live to adulthood. Poor marrow, thymic atrophy, and disorganization of the neurons of the brain were found in homozygotes.
The scrambler 4 Jackson mutation arose spontaneously in the CBA/J inbred strain at The Jackson Laboratory in 2006 and has been maintained on this background ever since.
Allele Name | scrambler 4 Jackson |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Dab1, disabled 1 |
Gene Synonym(s) | |
Strain of Origin | CBA/J |
Chromosome | 4 |
Molecular Note | Non-complementation with the scrambler 2 Jackson mutation proved that this is an allele of the Dab1 gene. |
When using the scrambler 4 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #010970 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Progeny testing required but not provided. No genotyping assay is available for these recessive cryo-recovered animals of undefined genotype |
Frozen Mouse Embryo | CBA/J-Dab1<scm-4J>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | CBA/J-Dab1<scm-4J>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | CBA/J-Dab1<scm-4J>/GrsrJ | $3373.50 |
Frozen Mouse Embryo | CBA/J-Dab1<scm-4J>/GrsrJ | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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