Homozygotes can be recognized by two weeks of age by smaller body size, tremor, and leaning side-to-side gait. While some homozygotes die by three weeks of age, most live to adulthood. Poor marrow, thymic atrophy, and disorganization of the neurons of the brain were found in homozygotes.
The scrambler 4 Jackson mutation arose spontaneously in the CBA/J inbred strain at The Jackson Laboratory in 2006 and has been maintained on this background ever since.
|Allele Name||scrambler 4 Jackson|
|Gene Symbol and Name||Dab1, disabled 1|
|Strain of Origin||CBA/J|
|Molecular Note||Non-complementation with the scrambler 2 Jackson mutation proved that this is an allele of the Dab1 gene.|