Mice that are homozygous for the targeted mutation are viable, but show an increased incidence of sarcomas and lymphomas.  Sperm, tail and tumor cells from homozygous mice exhibit microsatellite instability.  Male mice on the mixed C57BL/6 and 129S2 background are infertile with reduced numbers of spermatozoa.  Spermatozoa exhibit misshapen heads, truncated, irregular flagella. This strain may be useful in the studies of spermatogenesis, cancer and DNA mismatch repair.

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This targeted mutation of the postmeiotic segregation increased 2 gene (<i>Pms2</i>) exhibits male infertility, microsatellite DNA instability and increased tumor incidence. This strain may useful in the studies of spermatogenesis, cancer and DNA mismatch repair.

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