Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This amino acid substitution in the <i>Cdkn1b</i> (p27) phosphorylation site results in an increased association of p27 with cyclin and cyclin dependent kinase complexes. In addition, mice exhibit a reduced susceptibility to urethane-induced lung tumors as compared to wild-type and p27 null mice, suggesting a function for phosphorylation of p27 in the regulation of tumor suppression.


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This targeted mutation of the cyclin-dependent kinase inhibitor 1B (<i>Cdkn1b</i>) gene develops fewer urethane-induced lung tumors and may be useful in studies of cell cycle regulation and tumor suppression.

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