Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This amino acid substitution in the <i>Cdkn1b</i> (p27) phosphorylation site results in an increased association of p27 with cyclin and cyclin dependent kinase complexes. In addition, mice exhibit a reduced susceptibility to urethane-induced lung tumors as compared to wild-type and p27 null mice, suggesting a function for phosphorylation of p27 in the regulation of tumor suppression.


This targeted mutation of the cyclin-dependent kinase inhibitor 1B (<i>Cdkn1b</i>) gene develops fewer urethane-induced lung tumors and may be useful in studies of cell cycle regulation and tumor suppression.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

Typically mice are recovered in 12-16 weeks. <a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> to place an order or for more information.