A human placental alkaline phosphatase (ALPP) gene was used to disrupt the mouse advillin(<i>Avil</i>) locus.  Approximately 50% of mice that are homozygous for the targeted mutation die before E10.5, however, the remaining homozygotes are viable, fertile, and normal in size and do not display any gross physical or behavioral abnormalities.  Alkaline phosphatase staining of heterozygote sections allows visualization of peripheral sensory neurons. Trigeminal sensory neurons cultured from homozygotes display a reduction in regenerative axon growth.  Following whisker cauterization in homozygotes, trigeminal central projections exhibit a reduced plasticity.  This mutant mouse strain may be useful in the visualization of sensory neurons and axon projections as well as in the study of axon remodeling and regrowth.






This targeted mutation of the <i>Avil</i> gene displays reduced regenerative axon growth and may be useful in the visualization (via ALPP) of sensory neurons and axon projections.

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