Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.  No functional gene product (protein) is detected by receptor autoradiography analysis of the brain.  Experimentally induced cerebral infarction volume and resulting neurological function impairment are reduced in homozygotes.  Treatment with receptor agonist, CGS 21680, does not elicit decreased locomotor activity in homozygotes, as compared to wildtype.  Homozygotes have reduced spontaneous activity and increased resistance to the addictive substances amphetamine and cocaine.  This mutant mouse strain may be useful in studies of behavior, ischemic brain injury, stroke, responses to addictive substances and T cell response to inflammation.

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Mice that are homozygous for this knockout of the <em>Adora2a</em> gene, are resistant to experimentally induced ischemic brain injury and exhibit increased resistance to the addictive substances amphetamine and cocaine.

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