These Ly-49A transgenic mice express the mouse Klra1 (killer cell lectin-like receptor, subfamily A, member 1) gene under the control of a modified mouse CD4 antigen (Cd4) promoter (this promoter lacks the silencer element sequence suppressing expression in CD8 T cells). Transgene expression is detected during early T cell development and throughout CD4 and CD8 T cell differentiation and migration. On the B10.HTG background, which lacks H2dd, cell surface transgene expression is increased when compared to transgenic mice on backgrounds carrying H2dd. The presence of H2dd ligand during T cell development impairs negative selection in the thymus and can result in increased apoptosis of thymocytes, fewer CD4 single positive cells, and autoreactive T cells with the development of a graft-versus-host-disease-like syndrome. This mutant mouse strain may be useful in studies of autoimmune and inflammatory diseases.

These Ly-49A transgenic mice express the mouse Klra1 (killer cell lectin-like receptor, subfamily A, member 1) gene under the control of a modified mouse CD4 antigen (Cd4) promoter (this promoter lacks the silencer element sequence suppressing expression in CD8 T cells). Transgene expression is detected during early T cell development and throughout CD4 and CD8 T cell differentiation and migration. This mutant mouse strain may be useful in studies of autoimmune and inflammatory diseases.

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