Mice homozygous for the totterer mutation exhibit mild tremors at approximately 2 weeks of age with worsening muscle weakness such that by 6 to 8 weeks of age they display a shaking, limb grasping, hunched, sprawled, tottering walk and develop late-onset clinical paralysis. Premature death results. Homozygotes are poor breeders, reproducing at most once or twice, and females are poor mothers.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Mpz | myelin protein zero |
Mice homozygous for the totterer mutation exhibit mild tremors at approximately 2 weeks of age with worsening muscle weakness such that by 6 to 8 weeks of age they display a shaking, limb grasping, hunched, sprawled, tottering walk and develop late-onset clinical paralysis. Premature death results. Homozygotes are poor breeders, reproducing at most once or twice, and females are poor mothers.
The totterer mutation arose spontaneously in the strain B6.129P2-Nos3tm1Unc/J at The Jackson Laboratory in 2003 when that parental strain was at generation N12F7. This mutant subline has been maintained by sibling inbreeding, and the targeted mutation was bred out.
Allele Name | totterer |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Mpz, myelin protein zero |
Gene Synonym(s) | |
Strain of Origin | B6.129P2-Nos3tm1Unc/J |
Chromosome | 1 |
Molecular Note | Exon 8 contains a deletion of 4 nucleotides and a duplication of 12 nucleotides, which is predicted to result in multiple amino acid changes at the protein amino terminus. |
When using the B6.Cg-Mpzttrr/GrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #010494 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Mpz<ttrr> |
Frozen Mouse Embryo | B6.Cg-Mpz<ttrr>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | B6.Cg-Mpz<ttrr>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | B6.Cg-Mpz<ttrr>/GrsrJ | $3373.50 |
Frozen Mouse Embryo | B6.Cg-Mpz<ttrr>/GrsrJ | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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