JAX
Mouse Strain Datasheet - 009659
B6.D2(BKS)-Dock7m/J
This spontaneous mutation of the dedicator of cytokinesis 7 (Dock7m) gene or misty displays a dilute coat color, variable spotting and some abnormalities in platelets and adipose tissue.
Read More +Genetic overview
| Genetic Background | Generation |
|---|---|
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Dock7m
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Spontaneous | Dock7 | dedicator of cytokinesis 7 |
Detailed Description
The recessive misty mutation causes a mild dilution of coat color and on certain backgrounds a white tail tip often accompanied by a belly spot. Melanocytes from m/m mice have a highly dendritic shape, show deficient proliferation in culture and have much more melanin content. Fewer melanoblasts are found in primary cultures from m/m mice than from wildtype controls. Between two and five weeks of age, m/m mice are smaller than controls. At 35 days of age they are shorter, weigh 15% less on average, and have less inguinal adipose mass than controls. Misty homozygotes completely lack brown fat. Although platelet count, seratonin content and ATP content are normal, there is increased bleed time and reduced platelet AD levels in m/m homozygotes. (Woolley, 1941 and 1945; Truett et al., 1998; Sviderskaya et al., 1998.)
Development
The coat color mutation, misty (m), arose spontaneously in a DBA/J colony at The Jackson Laboratory in 1941. The single male was identified by a light color, white tail tip and white belly spot. Misty was introgressed into C57BLKS-Leprdb to create the repulsion stock, BKS.Cg-Dock7m +/+ Leprdb/J. The two alleles were used to identify genotypes in the diabetes colony prior to the use of PCR genotyping. Both mutations then were backcrossed to the C57BL/6 background. In 2008, misty was bred out of the B6.Cg-Dock7m +/+ Leprdb/J colony.
Control Suggestions
Selected References
- Woolley GW. 1941. "Misty," a new coat color dilution in the mouse, Mus musculus. Am Naturalist 75:507-508. MGI: J:12159
Dock7m
Allele Symbol: Dock7m
| Allele Name | misty |
|---|---|
| Allele Type | Spontaneous |
| Allele Synonym(s) | m |
| Gene Symbol and Name | Dock7, dedicator of cytokinesis 7 |
| Gene Synonym(s) | 3110056M06Rik; 3110056M06Rik; EIEE23; Gm430; LOC242555; RIKEN cDNA 3110056M06 gene; ZIR2; gene model 430, (NCBI); m; m; mKIAA1771; misty |
| Strain of Origin | DBA/J |
| Chromosome | 4 |
| Molecular Note | Crosses between mice homozygous for misty and for moonlight, which mapped to overlapping critical regions on Chr 4, demonstrated failure of the two mutations to complement one another. Once moonlight had been identified as a mutation of Dock7 (Dock7mnlt), sequence analysis of this gene from misty mice revealed a retrotransposon LTR insertion following nucleotide 2045 (numbering from the A of the transcription initiation codon) that interrupts exon 18 and shifts the reading frame after codon 682 so that ten incorrect amino acids are incorporated into the protein before its premature termination. |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Dermatology Research
- Color and White Spotting Defects
Genotype: Dock7m related
- Dermatology Research
- Color and White Spotting Defects
Mammalian Phenotype Terms by Genotype
Genotype: Dock7m/Dock7m
B6.D(Cg)-Dock7m
adipose tissue phenotype
- abnormal brown adipose tissue mass
- appears to be completely absent in neonatal mice (MGI Ref ID J:45425)
- decreased white adipose tissue amount
- mice have 21% less inguinal adipose mass (MGI Ref ID J:48831)
growth/size/body region phenotype
- decreased body length
- mutants are 8% shorter (MGI Ref ID J:48831)
- decreased body weight
- mutants weigh 15% less (MGI Ref ID J:48831)
hematopoietic system phenotype
- decreased platelet ADP level
homeostasis/metabolism phenotype
- increased bleeding time
- (MGI Ref ID J:45425)
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Dock7m/Dock7m
BKS.Cg-Dock7m +/+ Leprdb/BomTac
behavior/neurological phenotype
- behavior/neurological phenotype
- homozygous mutant and wild type control (C57BL/6J) mice exhibit similar locomotor activity; response in the tail-suspension test for depressive behavior; learning as measured by habituation of object exploration; working memory as measured using the Y maze; anxiety-like behavior in a light-dark transfer test; and preference for social familiarity/noveltye; anxiety-like behavior in a light-dark transfer test; and preference for social familiarity/novelty (MGI Ref ID J:146458)
Genotype: Dock7m/Dock7m
DBA/J
References
- Woolley GW. 1941. "Misty," a new coat color dilution in the mouse, Mus musculus. Am Naturalist 75:507-508. MGI: J:12159
Additional - Dock7m related
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