Homozygous targeted mice are runted and demonstrate a failure to thrive. Most die before or around weaning age. Mice surviving after postnatal day 25 (P25) usually recover and apparently have normal life spans. All of the mice develop rhinitis and sinusitis and are unable to clear Pseudomonas aeruginosa bacteria from the nasal cavity. There is a complete absence of mucociliary transport caused by a marked lack of motile cilia in the nasal epithelium. Anemia and ductal dilation in the pancreas and kidneys is also observed. Homozygous males have compromised fertility. This strain may be useful as a model of primary ciliary dyskinesia.

Most Cby1 (chibby homolog 1 (Drosophila)) targeted mutant homozygotes die before or around weaning age. The mice develop rhinitis and sinusitis and are unable to clear Pseudomonas aeruginosa bacteria from the nasal cavity. There is a complete absence of mucociliary transport caused by a marked lack of motile cilia in the nasal epithelium. This strain may be a useful model of primary ciliary dyskinesia.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

Typically mice are recovered in 12-16 weeks. <a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> to place an order or for more information.