| Allele Name | transgene insertion 1, Sally A Camper |
| Allele Type | Transgenic (Recombinase-expressing) |
| Allele Synonym(s) | Tg(Gh-cre)SAC1 |
| Gene Symbol and Name | Tg(GH1-cre)1Sac, transgene insertion 1, Sally A Camper |
| Gene Synonym(s) | |
| Promoter | Gh1, growth hormone 1, rat |
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| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
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| Site of Expression | When crossed with cre-reporter strains, cre expression is observed in the pituitary somatotropes, with limited expression in lactotropes, and no detectable expression in other pituitary cell types. Cre expression is also detected in the skin of embryonic forelimbs and trunk, and in adult testis, ovary, and kidney. |
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| Strain of Origin | (C57BL/6J x SJL/J)F2 |
| Chromosome | UN |
| Molecular Note | The human growth hormone locus control region (-16.2 to -14.6 kb relative to the GH1 promoter) was fused to 1.77 kb of rat Gh1 promoter to drive expression of a cre recombinase cassette in the pituitary gland. About 30-50 copies of the transgene construct inserted into the genome after injection into zygotes. When crossed with cre-reporter strains, cre expression was observed in the pituitary somatotropes, with limited expression in lactotropes, and no detectable expression in other pituitary cell types. Cre expression was also detected in the skin of embryonic forelimbs and trunk, and in adult testis, ovary, and kidney. |
| Mutations Made By | Dr. Sally Camper, University of Michigan Medical School |
