Mice hemizygous for the TgNL1 transgene are viable and fertile. The TgNL1 transgene encodes a hemagglutinin-tagged mouse neuroligin 1 (<i>Nlgn1</i> or NL1) gene driven by the murine Thy1.2 expression cassette.  HA-NL1 transcript and protein is expressed in brain and to a lesser extend in spinal cord, with highest levels of expression in the cortex and hippocampus, intermediate in the striatum and lowest in the cerebellum and olfactory bulb. TgNL1.6 mice have moderate to high levels of HA-NL1 expression (approximately two-fold greater than wildtype NL1). This overexpression results in significant deficits in memory acquisition, impairments in the induction of long-term potentiation, altered spine morphology, and enhanced excitatory synaptic transmission that lead to learning deficits. These TgNL1.6 mice may be useful in neurobiological studies of neuroligin adhesion molecules in excitatory/inhibitory synapse maturation and function, memory formation and synaptic plasticity.


These TgNL1.6 mice harbor have expression of a hemagglutinin-tagged mouse neuroligin 1 (<i>Nlgn1</i> or NL1) gene driven by the murine Thy1.2 expression cassette. TgNL1.6 mice manifest significant deficits in memory acquisition, impairments in the induction of long-term potentiation, altered spine morphology, and enhanced excitatory synaptic transmission that lead to learning deficits. These transgenic mice may be useful in neurobiological studies of neuroligin adhesion molecules in excitatory/inhibitory synapse maturation and function, memory formation and synaptic plasticity.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

<a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> for more information.