Overview

This strain is extinct. Please search the JAX^® Mice Database for strains carrying the Hps6^ru allele.

Genetic overview

Genetic Background	Generation

Hps6^ru-8J

Allele Type	Gene Symbol	Gene Name
Spontaneous	Hps6	HPS6, biogenesis of lysosomal organelles complex 2 subunit 3

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Research Applications

Dermatology Research

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Details

Control Suggestions

+/? from the colony
000664 C57BL/6J

Additional Information

Considerations for Choosing Controls

Selected References

Karst SY; Ward-Bailey PF; Samples R; Berstrom D; Donahue LR; Davisson MT. 2009. Ruby-eye 8 Jackson; a remutation in the Hps6 gene MGI Direct Data SubmissionMGI: J:147268

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Genetics

Hps6^ru-8J

Allele Symbol: Hps6^ru-8J

Allele Name	ruby-eye 8 Jackson
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	Hps6, HPS6, biogenesis of lysosomal organelles complex 2 subunit 3
Gene Synonym(s)
Strain of Origin	B6.Cg-Prkdc^scid/SzJ
Chromosome	19
Molecular Note	This mutation was shown to be an allelic by noncomplementation with the original ruby-eye mutation and the ruby-eye 7 Jackson mutation.

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Hps6^ru-8J related

Dermatology Research
- Color and White Spotting Defects

Mammalian Phenotype Terms by Genotype

The following phenotype relates to a compound genotype created using this strain

Genotype: Hps6^ru-8J/Hps6^ru-8J
B6(Cg)-Hps6/J

integument phenotype

diluted coat color
- gray coat color

pigmentation phenotype

diluted coat color
- gray coat color

decreased eye pigmentation
- ruby colored eyes

vision/eye phenotype

decreased eye pigmentation
- ruby colored eyes

References

Karst SY; Ward-Bailey PF; Samples R; Berstrom D; Donahue LR; Davisson MT. 2009. Ruby-eye 8 Jackson; a remutation in the Hps6 gene MGI Direct Data SubmissionMGI: J:147268

Additional - Hps6^ru-8J related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Mating System
- Backcross-Intercross
- homozygote x C57BL/6J, then obligate heterozygous intercros

Terms Of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

Genetic overview

Research Applications

Control Suggestions

Additional Information

Selected References

Hps6ru-8J

Allele Symbol: Hps6ru-8J

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Hps6ru-8J related

Mammalian Phenotype Terms by Genotype

Genotype: Hps6ru-8J/Hps6ru-8JB6(Cg)-Hps6/J

integument phenotype

pigmentation phenotype

vision/eye phenotype

References

Additional - Hps6ru-8J related

Genotyping Protocols

Mating System

Terms Of Use

Licensing Information

Hps6^ru-8J

Allele Symbol: Hps6^ru-8J

Genotype: Hps6^ru-8J related

Genotype: Hps6^ru-8J/Hps6^ru-8J
B6(Cg)-Hps6/J

Additional - Hps6^ru-8J related