Mice carrying this X-linked spontaneous mutation in the Bruton agammaglobulinemia tyrosine kinase gene (Btk) are a model of human X-linked immunodeficiency. Mice exhibit reduced numbers of B cells, and defects in B cell maturation.
Read More +Genetic Background | Generation |
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000664 C57BL/6J |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Btk | Bruton agammaglobulinemia tyrosine kinase |
Mice carrying this X-linked spontaneous mutation in the Bruton agammaglobulinemia tyrosine kinase gene (Btk) are a model of human X-linked immunodeficiency. They have a B-lymphocyte-specific defect that results in an inability to launch an antibody response to thymus-independent type II antigens, although they do produce normal amounts of antibody in response to some protein antigens. They have low serum IgM and IgG3 and a reduced number of B-cells. Moreover, the B-cells that are present have a reduced surface IgM to IgD ratio, which suggests a disorder in B-cell maturation.
The X-linked immunodeficiency spontaneous mutation was first observed in the CBA/HN colony at the NIH in the the early 1970s. The mutation was backcrossed to C57BL/6 and held for many years at the NIH. The C57BL/6 congenic was transferred to Dr. Robert Lindsley at the University of Massachusetts in the late 1990s and then to Dr. David Allman at the University of Pennsylvania, both of whom maintained it by sibling matings. Dr. Allman donated the strain to the Repository in 2009.
Allele Name | X linked immune deficiency |
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Allele Type | Spontaneous |
Allele Synonym(s) | xid |
Gene Symbol and Name | Btk, Bruton agammaglobulinemia tyrosine kinase |
Gene Synonym(s) | |
Strain of Origin | C57BL/6 |
Chromosome | X |
Molecular Note | The C to T substitution at coding nucleotidr 82 changes codon 28 from an arginine to a cysteine (p.R28C). |
When using the B6.CBA-Btkxid/AllmJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #009361 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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X linked - Heterozygous females and Wild type males for Btk<xid> |
Frozen Mouse Embryo | B6.CBA-Btk<xid>/AllmJ Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6.CBA-Btk<xid>/AllmJ Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6.CBA-Btk<xid>/AllmJ Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | B6.CBA-Btk<xid>/AllmJ Frozen Embryo | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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