The ILSXISS#/Tej recombinant inbred (RI) strains originate from crosses between ILS/IbgTejJ (009324) and ISS/IbgTejJ (009325) They may be used to study the genetics of neurogenetic, neuropharmacological and behavioral phenotypes involved in alcohol-related traits and complex or potentially complex physiologic phenotypes (including differences in longevity under ad libitum and dietary restriction conditions, aging, body temperature and body weight).
Thomas Johnson, University of Colorado at Boulder
The ILSXISS recombinant inbred (RI) strains are used to study the genetics of
neurogenetic, neuropharmacological and behavioral phenotypes involved in alcohol-related traits including ethanol-induced loss of righting, psychomotor activation, hypothermia, blood ethanol concentration at wakening and numerous morphometric CNS traits as well as complex or potentially complex physiologic phenotypes including differences in longevity under ad libitum and dietary restriction conditions, aging, body temperature and body weight.
The strain distribution pattern (SDP) for the ILSXISS RI strains is available through
Gene Network.
Additional tools and information are presented through the Mouse Phenome Database
Specialized Strain Panel Query Form, and
Gene Network.
The ILSXISS#/Tej (formerly LXS) recombinant inbred lines were generated from crosses between ILS/Ibg (Inbred Long Sleep)(009324) and ISS/Ibg(Inbred Short Sleep) (009325). These two progenitor strains were developed
from the LS and SS selected lines derived from a heterogenous stock
derived from an 8 way cross (A, AKR, BALB/c,
C3H/2, C57BL, DBA/2, IS/Bi and RIII) created at the Cancer Research
Genetics Laboratory at the University of California, Berkley. ILS and ISS are the product of inbreeding LS and SS, lines selected for long or short duration of loss-of-righting response following high dose intraperitoneal administration of ethanol.
The ILSXISS set was initiated in the laboratory of John DeFries and colleagues at the Institute of Behavioral Genetics, Boulder CO in 1996. Crosses at the F2 generation ensured that the Y chromosome and mitochondrial genes were randomly segregating. Three hundred-thirty MIT markers were used for screening. Seventy-seven RI strains reached the 22nd generation of inbreeding, however, since that time, a number have become extinct. Approximately 65 lines and the progenitors were donated to The Jackson Laboratory Repository in 2009 by Dr. Thomas E. Johnson and Dr. Jerry Stitzel at the University of Colorado, Boulder.
Currently there are no related genes or alleles for this strain.
When using the ILSXISS73/TejJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #009277 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Inbred, 1 pair minimum will be supplied |
Frozen Mouse Embryo | ILSXISS73/TejJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | ILSXISS73/TejJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | ILSXISS73/TejJ Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | ILSXISS73/TejJ Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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