Pale lethal homozygotes are smaller than normal littermates, have a pale light grey skin color, evident at birth, and most die by one week of age, although some have survived to 3 or 4 weeks of age. Some prenatal lethality is implied by the fact that heterozygous crosses yield fewer than 25% homozygotes.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Ank1 | ankyrin 1, erythroid |
Pale lethal homozygotes are smaller than normal littermates, have a pale light grey skin color, evident at birth, and most die by one week of age, although some have survived to 3 or 4 weeks of age. Some prenatal lethality is implied by the fact that heterozygous crosses yield fewer than 25% homozygotes.
pale lethal arose spontaneously on the C57BL/6J inbred background at The Jackson Laboratory in 2005 and was been maintained on this background. In 2012 sperm was cryopreserved from heterozygous males at generation F16.
Allele Name | pale lethal |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Ank1, ankyrin 1, erythroid |
Gene Synonym(s) | |
Strain of Origin | C57BL/6J |
Chromosome | 8 |
Molecular Note | This spontaneous mutation was identified at The Jackson Laboratory. Sequence analysis of mutant genomic DNA compared with wild type C57BL/6J genomic DNA identified a single nucleotide transition from G to A at nucleotide 24224235 (build NCBI37 or m9). This mutation disrupts the consensus AG dinucleotide of the CAG splice acceptor of the adjacent exon (exon 26 of ENSMUST00000118733). |
When using the C57BL/6J-Ank1pale/GrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #009157 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or wildtype for Ank1<pale> |
Frozen Mouse Embryo | C57BL/6J-Ank1<pale>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | C57BL/6J-Ank1<pale>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | C57BL/6J-Ank1<pale>/GrsrJ | $3373.50 |
Frozen Mouse Embryo | C57BL/6J-Ank1<pale>/GrsrJ | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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