Overview

Also Known As:skimpy

This strain has been discontinued, please refer to Stock No. 022008

Skimpy homozygotes are smaller than their littermates, walk on their toes, have poor balance, and die by four weeks of age.

Genetic overview

Genetic Background	Generation

skp

Allele Type	Gene Symbol	Gene Name
Spontaneous	skp	skimpy

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Research Applications

Developmental Biology Research
Neurobiology Research
Reproductive Biology Research
Sensorineural Research

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Details

Detailed Description

Skimpy homozygotes are smaller than their littermates, walk on their toes, have poor balance, and die by four weeks of age.

Development

The skimpy mutation arose spontaneously in the strain CXB5/ByJ at The Jackson Laboratory in 2001 when that recombinant inbred strain was at generation F107. This mutant subline has been maintained by sibling inbreeding progeny tested heterozygotes ever since.

Control Suggestions

Wild-type from the colony
000355 CXB5/ByJ

Additional Information

Considerations for Choosing Controls

Selected References

Harris BS; Ward-Bailey PF; Johnson KR; Bronson RT. 2009. Skimpy: A new mutation on Chromosome 7 causing impaired balance and reduced lifespan MGI Direct Data SubmissionMGI: J:153578

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Genetics

skp

Allele Symbol: skp

Allele Name	skimpy
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	skp, skimpy
Gene Synonym(s)
Strain of Origin	Not Specified
Chromosome	7
Molecular Note	This spontaneous mutation was identified at The Jackson Laboratory.

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: skp related

Developmental Biology Research
- Growth Defects
- Postnatal Lethality
  - Homozygous
Neurobiology Research
- Myelination Defects
- Ataxia (Movement) Defects
Reproductive Biology Research
- Developmental Defects Affecting Gonads
  - germ cell deficient
Sensorineural Research
- Eye Defects

Mammalian Phenotype Terms by Genotype

The following phenotype relates to a compound genotype created using this strain

Genotype: skp/skp
CXB5/ByJ-skp/GrsrJ

behavior/neurological phenotype

abnormal gait
- mutants walk on their toes

impaired balance

endocrine/exocrine gland phenotype

thymus atrophy

growth/size/body region phenotype

decreased body size

hematopoietic system phenotype

thymus atrophy

immune system phenotype

thymus atrophy

mortality/aging

postnatal lethality, incomplete penetrance
- usually die by 4 weeks of age

nervous system phenotype

abnormal myelin sheath morphology
- underdeveloped myelin

reproductive system phenotype

abnormal spermiogenesis

References

Harris BS; Ward-Bailey PF; Johnson KR; Bronson RT. 2009. Skimpy: A new mutation on Chromosome 7 causing impaired balance and reduced lifespan MGI Direct Data SubmissionMGI: J:153578

Additional - skp related

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