JAX Mouse Strain Datasheet

B6.Cg-Nos2^tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/Mmjax

MMRRC Stock No:: 34849-JAX |; iNOS-; Tg-SwDI

Cryo Recovery

Overview

Also Known As: iNOS-; Tg-SwDI, APPSwDI/NOS2 bigenic mice, APPSwDI/NOS2-/-

These APPSwDI/NOS2 bigenic mice harbor the APPSwDI transgene and a targeted "null" mutation of the nitric oxide synthase 2 (Nos2) locus. Homozygous bigenic mice (APPSwDI/NOS2^-/-) progress from Aβ production and amyloid deposition to hyperphosphorylated normal mouse tau at Alzheimer's disease-associated epitopes, aggregation and redistribution of tau to somatodendritic regions of neurons, significant neuronal loss (including loss of interneurons), moderate-severe cerebral amyloid angiopathy, and severe learning and memory deficits. This Alzheimer's disease-like pathology is also accompanied by robust behavioral changes. These APPSwDI/NOS2 bigenic mice may be useful in studying Alzheimer's disease progression and the role of nitric oxide in altering chronic neurological disease processes.

Donating Investigator

IMR Colony, The Jackson Laboratory

Genetic overview

Genetic Background	Generation

Nos2^tm1Lau

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Nos2	nitric oxide synthase 2, inducible

Tg(Thy1-APPSwDutIowa)BWevn

Allele Type
Transgenic (Humanized sequence, Inserted expressed sequence)

View Genetics

Research Applications

Internal/Organ Research
Metabolism Research
Neurobiology Research
Research Tools
Immunology, Inflammation and Autoimmunity Research

View All Research Applications

Details

Detailed Description

These APPSwDI/NOS2 bigenic mice harbor the APPSwDI transgene and a targeted "null" mutation of the nitric oxide synthase 2 (Nos2) locus. Expression of the APPSwDI transgene (a neuronally derived human amyloid beta-precursor protein [APP or AβPP] 770 isoform containing three Alzheimer's disease-associated mutations [Swedish K670N/M671L, Dutch E693Q and Iowa D694N] all under the control of the mouse thymus cell antigen 1, theta [Thy1] promoter) produces amyloid-beta (Aβ) peptides that cannot be transported out of the brain across the cerebrovascular interface and results in Aβ peptide accumulation at the blood vessels (see C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax). The Nos2 mutation results in loss of inducible NOS (iNOS) expression which alters physiological functions related to disease and injury (see B6.129P2-Nos2^tm1Lau/J). Homozygous bigenic mice (APPSwDI/NOS2^-/-) progress from Abeta; production and amyloid deposition to hyperphosphorylated normal mouse tau at Alzheimer's disease-associated epitopes, aggregation and redistribution of tau to somatodendritic regions of neurons, significant neuronal loss (including loss of interneurons), moderate-severe cerebral amyloid angiopathy, and severe learning and memory deficits. This Alzheimer's disease-like pathology is also accompanied by robust behavioral changes. Compared to mice only harboring the APPSwDI transgene, these APPSwDI/NOS2 bigenic mice exhibit more severe human Alzheimer's disease pathology and additional human Alzheimer's disease features, and may be useful in studying Alzheimer's disease progression and the role of nitric oxide in altering chronic neurological disease processes.

Development

To generate this double mutant colony, homozygous Tg(Thy1-APPSwDutIowa)BWevn females (from C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax) were bred with heterozygous or homozygous Nos2^tm1Lau males (from B6.129P2-Nos2^tm1Lau/J). The resulting double mutant animals were bred together to produce this strain.

A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at the MMRRC at The Jackson Laboratory. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 4 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to the MMRRC at The Jackson Laboratory were on a mixed C57BL/6J ; C57BL/6N genetic background.

Expression Data

Expressed Gene	APP, amyloid beta precursor protein, human
Site of Expression

Selected References

Colton CA; Wilcock DM; Wink DA; Davis J; Van Nostrand WE; Vitek MP. 2008. The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP. J Alzheimers Dis 15(4):571-87. PubMed: 19096157 MGI: J:143551

View All References

Genetics

Nos2^tm1Lau

Allele Symbol: Nos2^tm1Lau

Allele Name	targeted mutation 1, Victor E Laubach
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	NOS2-; NOS2^tm/Lau; Nos2tm1Lau; iNOS KO; iNOS-; iNOS^-
Gene Symbol and Name	Nos2, nitric oxide synthase 2, inducible
Gene Synonym(s)	HEP-NOS; INOS; NOS; NOS-II; NOS2A; Nos-2; Nos-2; Nos2a; iNOS; iNos; nitric oxide synthase-2 (brain)
Strain of Origin	129P2/OlaHsd
Chromosome	11
Molecular Note	A neomycin cassette replaced exons 12 and 13 of the gene, which encode the calmodulin-binding domain. Northern and Western blots of IFNg/LPS-stimulated peritoneal macrophages showed no detectable Nos2 mRNA or protein, respectively.
Mutations Made By	Dr. Victor Laubach, University of Virginia Health Sci. Ctr.

Tg(Thy1-APPSwDutIowa)BWevn

Allele Symbol: Tg(Thy1-APPSwDutIowa)BWevn

Allele Name	transgene insertion B, William E Van Nostrand
Allele Type	Transgenic (Humanized sequence, Inserted expressed sequence)
Allele Synonym(s)	APPSwDI; Tg-SwDI; Tg-SwDI/B
Gene Symbol and Name	Tg(Thy1-APPSwDutIowa)BWevn, transgene insertion B, William E Van Nostrand
Gene Synonym(s)	APPSwDI; Tg-SwDI; Tg-SwDI/B
Promoter	Thy1, thymus cell antigen 1, theta, mouse, laboratory
Expressed Gene	APP, amyloid beta precursor protein, human
Strain of Origin	C57BL/6
Chromosome	UN
Molecular Note	A transgenic construct containing 2.1kb of the human amyloid beta-precursor protein, APP gene, 770 isoform, with the Swedish K670N/M671L, Dutch E693Q and Iowa D694N mutations, under the control of the mouse thymus cell antigen 1, theta, Thy1, promoter was injected into fertilized C57BL/6 mouse eggs. Founder line B was subsequently established and homozygotes generated. Human amyloid beta precursor protein expression is detected in the brains of transgenic mice. Two other lines, A anc C were also generated, with line A having similar levels of transgene expression and amyloid beta accumulation to line B while line C has 2-fold higher expression of human Amyloid beta-precursor protein and shows 4-fold higher accumulations of soluble and insoluble AB peptides in the brain.
Mutations Made By	William Van Nostrand, Stony Brook University

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Internal/Organ Research
- Wound Healing
  - delayed/impaired
Metabolism Research
- Free Radical Research
Neurobiology Research
- Alzheimer's Disease
  - strains expressing mutant APP
- Behavioral and Learning Defects
- Neurodegeneration
Research Tools
- Immunology, Inflammation and Autoimmunity Research
  - genes regulating susceptibility to infectious disease and endotoxin
- Neurobiology Research
- Toxicology Research
  - free radical research

Genotype: APP related

Neurobiology Research
- Alzheimer's Disease
- Neurodegeneration

Genotype: Nos2^tm1Lau related

Immunology, Inflammation and Autoimmunity Research
- Inflammation
  - Inflammatory bowel disease
Neurobiology Research
- Alzheimer's Disease

Mammalian Phenotype Terms by Genotype

Genotype: Nos2^tm1Lau/Nos2^tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/?
involves: C57BL/6

nervous system phenotype

abnormal brain interneuron morphology
- 65% loss of NPY interneurons in the hippocampus

abnormal hippocampus CA3 region morphology
- neuronal loss
- thinning of the CA3 and subiculum, with a 40% loss of neurons in the CA3 region

abnormal subiculum morphology
- 35% loss of neurons in the subiculum
- neuronal loss

amyloid beta deposits
- amyloid beta deposits in the hippocampus, in the subiculum and thalamus
- deposits are observed by 52 weeks of age

decreased neuron number
- neuronal loss is observed in hippocampus, subiculum and CA3

hippocampal neuron degeneration
- 30% loss of neurons in the hippocampus
- 50% reduction in neuropeptide Y-immunopositive neurons overall throughout the hippocampus, a 65% reduction in the CA3 region, and 50% reduction in the subiculum

increased neuron apoptosis

neurodegeneration
- 30% loss of NeuN-immunopositive neurons in the hippocampus, 35% loss in the subiculum, and 40% loss in the CA3 region of the hippocampus
- loss of neuropeptide Y-immunopositive neurons particularly in the CA3 region and in the subiculum

tau protein deposits
- hyperphosphorylated tau is seen in the brain and in neuronal processes associated with blood vessels
- mice show intraneuronal aggregrates of tau

homeostasis/metabolism phenotype

amyloid beta deposits
- amyloid beta deposits in the hippocampus, in the subiculum and thalamus
- deposits are observed by 52 weeks of age

behavior/neurological phenotype

abnormal spatial reference memory
- mice make more errors in the radial-arm water maze than single Tg(Thy1-APPSwDutIowa)BWevn transgenics, especially on subsequent days, indicating slowed learning and/or retrieval of the task
- mice show increased impaired performance on the Barnes maze compared to single Tg(Thy1-APPSwDutIowa)BWevn transgenics

cellular phenotype

increased neuron apoptosis

References

Colton CA; Wilcock DM; Wink DA; Davis J; Van Nostrand WE; Vitek MP. 2008. The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP. J Alzheimers Dis 15(4):571-87. PubMed: 19096157 MGI: J:143551

Additional - Nos2^tm1Lau related

Abu-Ghanem Y; Cohen H; Buskila Y; Grauer E; Amitai Y. 2008. Enhanced stress reactivity in nitric oxide synthase type 2 mutant mice: findings in support of astrocytic nitrosative modulation of behavior. Neuroscience 156(2):257-65. PubMed: 18723080 MGI: J:141014
Adams LB; Job CK; Krahenbuhl JL. 2000. Role of inducible nitric oxide synthase in resistance to Mycobacterium leprae in mice. Infect Immun 68(9):5462-5. PubMed: 10948185 MGI: J:64036
Aheng C; Ly N; Kelly M; Ibrahim S; Ricquier D; Alves-Guerra MC; Miroux B. 2011. Deletion of UCP2 in iNOS deficient mice reduces the severity of the disease during experimental autoimmune encephalomyelitis. PLoS One 6(8):e22841. PubMed: 21857957 MGI: J:176503
Ahn B; Ohshima H. 2001. Suppression of intestinal polyposis in Apc(Min/+) mice by inhibiting nitric oxide production. Cancer Res 61(23):8357-60. PubMed: 11731407 MGI: J:73152
Akita Y; Otani H; Matsuhisa S; Kyoi S; Enoki C; Hattori R; Imamura H; Kamihata H; Kimura Y; Iwasaka T. 2007. Exercise-induced activation of cardiac sympathetic nerve triggers cardioprotection via redox-sensitive activation of eNOS and upregulation of iNOS. Am J Physiol Heart Circ Physiol 292(5):H2051-9. PubMed: 17259438 MGI: J:125942
Al Gadban MM; German J; Truman JP; Soodavar F; Riemer EC; Twal WO; Smith KJ; Heller D; Hofbauer AF; Oates JC; Hammad SM. 2012. Lack of nitric oxide synthases increases lipoprotein immune complex deposition in the aorta and elevates plasma sphingolipid levels in lupus. Cell Immunol 276(1-2):42-51. PubMed: 22560558 MGI: J:188295
Anand RJ; Dai S; Rippel C; Leaphart C; Qureshi F; Gribar SC; Kohler JW; Li J; Stolz DB; Sodhi C; Hackam DJ. 2008. Activated macrophages inhibit enterocyte gap junctions via the release of nitric oxide. Am J Physiol Gastrointest Liver Physiol 294(1):G109-19. PubMed: 17975131 MGI: J:130509
Anavi S; Eisenberg-Bord M; Hahn-Obercyger M; Genin O; Pines M; Tirosh O. 2015. The role of iNOS in cholesterol-induced liver fibrosis. Lab Invest 95(8):914-24. PubMed: 26097999 MGI: J:225739
Ando A; Yang A; Mori K; Yamada H; Yamada E; Takahashi K; Saikia J; Kim M; Melia M; Fishman M; Huang P; Campochiaro PA. 2002. Nitric oxide is proangiogenic in the retina and choroid. J Cell Physiol 191(1):116-24. PubMed: 11920687 MGI: J:106207
Andrade RM; Portillo JA; Wessendarp M; Subauste CS. 2005. CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates. Infect Immun 73(5):3115-23. PubMed: 15845519 MGI: J:97614
Arantes RM; Marche HH; Bahia MT; Cunha FQ; Rossi MA; Silva JS. 2004. Interferon-gamma-induced nitric oxide causes intrinsic intestinal denervation in Trypanosoma cruzi-infected mice. Am J Pathol 164(4):1361-8. PubMed: 15039223 MGI: J:89108
Arnett HA; Hellendall RP; Matsushima GK; Suzuki K; Laubach VE; Sherman P; Ting JP. 2002. The protective role of nitric oxide in a neurotoxicant-induced demyelinating model. J Immunol 168(1):427-33. PubMed: 11751989 MGI: J:125459
Au L; Meisch JP; Das LM; Binko AM; Boxer RS; Wen AM; Steinmetz NF; Lu KQ. 2015. Suppression of Hyperactive Immune Responses Protects against Nitrogen Mustard Injury. J Invest Dermatol 135(12):2971-81. PubMed: 26288355 MGI: J:227726
Bandeira M; Santos CS; de Azevedo EC; Soares LM; Macedo JO; Marchi S; da Silva CL; Chagas-Junior AD; McBride AJ; McBride FW; Reis MG; Athanazio DA. 2011. Attenuated Nephritis in Inducible Nitric Oxide Synthase Knockout C57BL/6 Mice and Pulmonary Hemorrhage in CB17 SCID and Recombination Activating Gene 1 Knockout C57BL/6 Mice Infected with Leptospira interrogans. Infect Immun 79(7):2936-40. PubMed: 21576342 MGI: J:173478
Barrios B; Baez NS; Reynolds D; Iribarren P; Cejas H; Young HA; Rodriguez-Galan MC. 2014. Abrogation of TNFalpha production during cancer immunotherapy is crucial for suppressing side effects due to the systemic expression of IL-12. PLoS One 9(2):e90116. PubMed: 24587231 MGI: J:214472
Bartholdy C; Nansen A; Christensen JE; Marker O; Thomsen AR. 1999. Inducible nitric-oxide synthase plays a minimal role in lymphocytic choriomeningitis virus-induced, T cell-mediated protective immunity and immunopathology. J Gen Virol 80(Pt 11):2997-3005. PubMed: 10580062 MGI: J:103345
Bast A; Erttmann SF; Walther R; Steinmetz I. 2010. Influence of iNOS and COX on peroxiredoxin gene expression in primary macrophages. Free Radic Biol Med 49(12):1881-91. PubMed: 20869433 MGI: J:167094
Becerril S; Rodriguez A; Catalan V; Sainz N; Ramirez B; Collantes M; Penuelas I; Gomez-Ambrosi J; Fruhbeck G. 2010. Deletion of inducible nitric-oxide synthase in leptin-deficient mice improves brown adipose tissue function. PLoS One 5(6):e10962. PubMed: 20532036 MGI: J:161815
Beck PL; Li Y; Wong J; Chen CW; Keenan CM; Sharkey KA; McCafferty DM. 2007. Inducible nitric oxide synthase from bone marrow-derived cells plays a critical role in regulating colonic inflammation. Gastroenterology 132(5):1778-90. PubMed: 17449036 MGI: J:128325
Beck PL; Xavier R; Wong J; Ezedi I; Mashimo H; Mizoguchi A; Mizoguchi E; Bhan AK; Podolsky DK. 2004. Paradoxical roles of different nitric oxide synthase isoforms in colonic injury. Am J Physiol Gastrointest Liver Physiol 286(1):G137-47. PubMed: 14665440 MGI: J:87601
Beisiegel M; Mollenkopf HJ; Hahnke K; Koch M; Dietrich I; Reece ST; Kaufmann SH. 2009. Combination of host susceptibility and Mycobacterium tuberculosis virulence define gene expression profile in the host. Eur J Immunol 39(12):3369-84. PubMed: 19795415 MGI: J:155483
Bhandari V; Choo-Wing R; Harijith A; Sun H; Syed MA; Homer RJ; Elias JA. 2012. Increased hyperoxia-induced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2. Am J Respir Cell Mol Biol 46(5):668-76. PubMed: 22227562 MGI: J:196034
Bhopale VM; Yang M; Yu K; Thom SR. 2015. Factors Associated with Nitric Oxide-mediated beta2 Integrin Inhibition of Neutrophils. J Biol Chem 290(28):17474-84. PubMed: 26032418 MGI: J:223389
Blanchard TG; Yu F; Hsieh CL; Redline RW. 2003. Severe inflammation and reduced bacteria load in murine helicobacter infection caused by lack of phagocyte oxidase activity. J Infect Dis 187(10):1609-15. PubMed: 12721941 MGI: J:120653
Blyszczuk P; Berthonneche C; Behnke S; Glonkler M; Moch H; Pedrazzini T; Luscher TF; Eriksson U; Kania G. 2013. Nitric oxide synthase 2 is required for conversion of pro-fibrogenic inflammatory CD133(+) progenitors into F4/80(+) macrophages in experimental autoimmune myocarditis. Cardiovasc Res 97(2):219-29. PubMed: 23090609 MGI: J:210288
Bokhari SM; Kim KJ; Pinson DM; Slusser J; Yeh HW; Parmely MJ. 2008. NK cells and gamma interferon coordinate the formation and function of hepatic granulomas in mice infected with the Francisella tularensis live vaccine strain. Infect Immun 76(4):1379-89. PubMed: 18227174 MGI: J:133531
Boyer L; Plantier L; Dagouassat M; Lanone S; Goven D; Caramelle P; Berrehar F; Kerbrat S; Dinh-Xuan AT; Crestani B; Le Gouvello S; Boczkowski J. 2011. Role of nitric oxide synthases in elastase-induced emphysema. Lab Invest 91(3):353-62. PubMed: 20956973 MGI: J:169267
Brahmachari S; Pahan K. 2010. Myelin basic protein priming reduces the expression of Foxp3 in T cells via nitric oxide. J Immunol 184(4):1799-809. PubMed: 20083653 MGI: J:159486
Brahmachari S; Pahan K. 2009. Suppression of regulatory T cells by IL-12p40 homodimer via nitric oxide. J Immunol 183(3):2045-58. PubMed: 19587012 MGI: J:151706
Bratt JM; Franzi LM; Linderholm AL; Last MS; Kenyon NJ; Last JA. 2009. Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin. Toxicol Appl Pharmacol 234(3):273-80. PubMed: 19027033 MGI: J:145875
Breitbach K; Klocke S; Tschernig T; van Rooijen N; Baumann U; Steinmetz I. 2006. Role of Inducible Nitric Oxide Synthase and NADPH Oxidase in Early Control of Burkholderia pseudomallei Infection in Mice. Infect Immun 74(11):6300-6309. PubMed: 17000727 MGI: J:113561
Brumshagen C; Maus R; Bischof A; Ueberberg B; Bohling J; Osterholzer JJ; Ogunniyi AD; Paton JC; Welte T; Maus UA. 2012. FMS-like tyrosine kinase 3 ligand treatment of mice aggravates acute lung injury in response to Streptococcus pneumoniae: role of pneumolysin. Infect Immun 80(12):4281-90. PubMed: 23006850 MGI: J:190619
Buhtoiarov IN; Lum HD; Berke G; Sondel PM; Rakhmilevich AL. 2006. Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects. J Immunol 176(1):309-18. PubMed: 16365423 MGI: J:126263
Burrer R; Buchmeier MJ; Wolfe T; Ting JP; Feuer R; Iglesias A; von Herrath MG. 2007. Exacerbated pathology of viral encephalitis in mice with central nervous system-specific autoantibodies. Am J Pathol 170(2):557-66. PubMed: 17255324 MGI: J:117906
Buskila Y; Abu-Ghanem Y; Levi Y; Moran A; Grauer E; Amitai Y. 2007. Enhanced astrocytic nitric oxide production and neuronal modifications in the neocortex of a NOS2 mutant mouse. PLoS One 2(9):e843. PubMed: 17786214 MGI: J:129384
Buxbaum LU; Uzonna JE; Goldschmidt MH; Scott P. 2002. Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependent. Eur J Immunol 32(11):3206-15. PubMed: 12555666 MGI: J:115538
Cambien B; Bergmeier W; Saffaripour S; Mitchell HA; Wagner DD. 2003. Antithrombotic activity of TNF-alpha. J Clin Invest 112(10):1589-96. PubMed: 14617760 MGI: J:117987
Cardini B; Watschinger K; Hermann M; Obrist P; Oberhuber R; Brandacher G; Chuaiphichai S; Channon KM; Pratschke J; Maglione M; Werner ER. 2014. Crucial role for neuronal nitric oxide synthase in early microcirculatory derangement and recipient survival following murine pancreas transplantation. PLoS One 9(11):e112570. PubMed: 25389974 MGI: J:225156
Carnio EC; Stabile AM; Batalhao ME; Silva JS; Antunes-Rodrigues J; Branco LG; Magder S. 2005. Vasopressin release during endotoxaemic shock in mice lacking inducible nitric oxide synthase. Pflugers Arch 450(6):390-4. PubMed: 15971084 MGI: J:106197
Cauwels A; Janssen B; Buys E; Sips P; Brouckaert P. 2006. Anaphylactic shock depends on PI3K and eNOS-derived NO. J Clin Invest 116(8):2244-51. PubMed: 16886062 MGI: J:113106
Cauwels A; Van Molle W; Janssen B; Everaerdt B; Huang P; Fiers W; Brouckaert P. 2000. Protection against TNF-induced lethal shock by soluble guanylate cyclase inhibition requires functional inducible nitric oxide synthase. Immunity 13(2):223-31. PubMed: 10981965 MGI: J:64176
Cha HN; Kim YW; Kim JY; Kim YD; Song IH; Min KN; Park SY. 2010. Lack of inducible nitric oxide synthase does not prevent aging-associated insulin resistance. Exp Gerontol 45(9):711-8. PubMed: 20493940 MGI: J:164264
Chan JY; Cooney GJ; Biden TJ; Laybutt DR. 2011. Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells. Diabetologia 54(7):1766-76. PubMed: 21472432 MGI: J:172611
Charbonneau A; Marette A. 2010. Inducible nitric oxide synthase induction underlies lipid-induced hepatic insulin resistance in mice: potential role of tyrosine nitration of insulin signaling proteins. Diabetes 59(4):861-71. PubMed: 20103705 MGI: J:164330
Chatterjee S; Lardinois O; Bonini MG; Bhattacharjee S; Stadler K; Corbett J; Deterding LJ; Tomer KB; Kadiiska M; Mason RP. 2009. Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis. J Immunol 183(6):4055-66. PubMed: 19717511 MGI: J:152293
Chauhan SD; Seggara G; Vo PA; Macallister RJ; Hobbs AJ; Ahluwalia A. 2003. Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice. FASEB J 17(6):773-5. PubMed: 12586741 MGI: J:118016
Chen L; Majde JA; Krueger JM. 2003. Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes. Brain Res 973(2):214-22. PubMed: 12738065 MGI: J:83571
Chen L; Taishi P; Duricka D; Krueger JM. 2004. Brainstem prolactin mRNA is enhanced in mice with suppressed neuronal nitric oxide synthase activity. Brain Res Mol Brain Res 129(1-2):179-84. PubMed: 15469894 MGI: J:115454
Chen L; Taishi P; Majde JA; Peterfi Z; Obal F Jr; Krueger JM. 2004. The role of nitric oxide synthases in the sleep responses to tumor necrosis factor-alpha. Brain Behav Immun 18(4):390-8. PubMed: 15157956 MGI: J:105452
Chiang E; Dang O; Anderson K; Matsuzawa A; Ichijo H; David M. 2006. Cutting edge: apoptosis-regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide. J Immunol 176(10):5720-4. PubMed: 16670275 MGI: J:131688
Choi KS; Song EK; Yim CY. 2008. Cytokines secreted by IL-2-activated lymphocytes induce endogenous nitric oxide synthesis and apoptosis in macrophages. J Leukoc Biol 83(6):1440-50. PubMed: 18339892 MGI: J:136847
Chyu KY; Dimayuga P; Zhu J; Nilsson J; Kaul S; Shah PK; Cercek B. 1999. Decreased neointimal thickening after arterial wall injury in inducible nitric oxide synthase knockout mice. Circ Res 85(12):1192-8. PubMed: 10590247 MGI: J:59834
Coburn LA; Gong X; Singh K; Asim M; Scull BP; Allaman MM; Williams CS; Rosen MJ; Washington MK; Barry DP; Piazuelo MB; Casero RA Jr; Chaturvedi R; Zhao Z; Wilson KT. 2012. L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis. PLoS One 7(3):e33546. PubMed: 22428068 MGI: J:224210
Cohen O; Ish-Shalom E; Kfir-Erenfeld S; Herr I; Yefenof E. 2012. Nitric oxide and glucocorticoids synergize in inducing apoptosis of CD4(+)8(+) thymocytes: implications for 'Death by Neglect' and T-cell function. Int Immunol 24(12):783-91. PubMed: 22949567 MGI: J:190546
Cole C; Thomas S; Filak H; Henson PM; Lenz LL. 2012. Nitric oxide increases susceptibility of Toll-like receptor-activated macrophages to spreading Listeria monocytogenes. Immunity 36(5):807-20. PubMed: 22542147 MGI: J:187324
Cole MP; Chaiswing L; Oberley TD; Edelmann SE; Piascik MT; Lin SM; Kiningham KK; St Clair DK. 2006. The protective roles of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity. Cardiovasc Res 69(1):186-97. PubMed: 16157314 MGI: J:133742
Cole MP; Tangpong J; Oberley TD; Chaiswing L; Kiningham KK; St Clair DK. 2014. Nuclear interaction between ADR-induced p65 and p53 mediates cardiac injury in iNOS (-/-) mice. PLoS One 9(2):e89251. PubMed: 24586632 MGI: J:213759
Collazo CM; Meierovics AI; De Pascalis R; Wu TH; Lyons CR; Elkins KL. 2009. T cells from lungs and livers of Francisella tularensis-immune mice control the growth of intracellular bacteria. Infect Immun 77(5):2010-21. PubMed: 19237526 MGI: J:148524
Colton CA; Vitek MP; Wink DA; Xu Q; Cantillana V; Previti ML; Van Nostrand WE; Weinberg B; Dawson H. 2006. NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 103(34):12867-72. PubMed: 16908860 MGI: J:112919
Comtois AS; El-Dwairi Q; Laubach VE; Hussain SN. 1999. Lipopolysaccharide-induced diaphragmatic contractile dysfunction in mice lacking the inducible nitric oxide synthase. Am J Respir Crit Care Med 159(6):1975-80. PubMed: 10351947 MGI: J:57227
Cowley SC; Hamilton E; Frelinger JA; Su J; Forman J; Elkins KL. 2005. CD4-CD8- T cells control intracellular bacterial infections both in vitro and in vivo. J Exp Med 202(2):309-19. PubMed: 16027239 MGI: J:100513
Cuenca J; Martin-Sanz P; Alvarez-Barrientos AM; Bosca L; Goren N. 2006. Infiltration of Inflammatory Cells Plays an Important Role in Matrix Metalloproteinase Expression and Activation in the Heart during Sepsis. Am J Pathol 169(5):1567-76. PubMed: 17071581 MGI: J:114564
Cusumano ZT; Watson ME Jr; Caparon MG. 2014. Streptococcus pyogenes arginine and citrulline catabolism promotes infection and modulates innate immunity. Infect Immun 82(1):233-42. PubMed: 24144727 MGI: J:206198
D'Alessio FR; Tsushima K; Aggarwal NR; Mock JR; Eto Y; Garibaldi BT; Files DC; Avalos CR; Rodriguez JV; Waickman AT; Reddy SP; Pearse DB; Sidhaye VK; Hassoun PM; Crow MT; King LS. 2012. Resolution of experimental lung injury by monocyte-derived inducible nitric oxide synthase. J Immunol 189(5):2234-45. PubMed: 22844117 MGI: J:189863
D'Aveni M; Rossignol J; Coman T; Sivakumaran S; Henderson S; Manzo T; Santos e Sousa P; Bruneau J; Fouquet G; Zavala F; Alegria-Prevot O; Garfa-Traore M; Suarez F; Trebeden-Negre H; Mohty M; Bennett CL; Chakraverty R; Hermine O; Rubio MT. 2015. G-CSF mobilizes CD34+ regulatory monocytes that inhibit graft-versus-host disease. Sci Transl Med 7(281):281ra42. PubMed: 25834108 MGI: J:234081
Dai M; Yang Y; Omelchenko I; Nuttall AL; Kachelmeier A; Xiu R; Shi X. 2010. Bone marrow cell recruitment mediated by inducible nitric oxide synthase/stromal cell-derived factor-1alpha signaling repairs the acoustically damaged cochlear blood-labyrinth barrier. Am J Pathol 177(6):3089-99. PubMed: 21057001 MGI: J:167627
Dal Secco D; Paron JA; de Oliveira SH; Ferreira SH; Silva JS; Cunha Fde Q. 2003. Neutrophil migration in inflammation: nitric oxide inhibits rolling, adhesion and induces apoptosis. Nitric Oxide 9(3):153-64. PubMed: 14732339 MGI: J:118999
Dallaire P; Bellmann K; Laplante M; Gelinas S; Centeno-Baez C; Penfornis P; Peyot ML; Latour MG; Lamontagne J; Trujillo ME; Scherer PE; Prentki M; Deshaies Y; Marette A. 2008. Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism. Diabetes 57(8):1999-2011. PubMed: 18458147 MGI: J:141699
Davie SA; Maglione JE; Manner CK; Young D; Cardiff RD; MacLeod CL; Ellies LG. 2007. Effects of FVB/NJ and C57Bl/6J strain backgrounds on mammary tumor phenotype in inducible nitric oxide synthase deficient mice. Transgenic Res 16(2):193-201. PubMed: 17206489 MGI: J:121391
Dayal S; Blokhin IO; Erger RA; Jensen M; Arning E; Stevens JW; Bottiglieri T; Faraci FM; Lentz SR. 2014. Protective vascular and cardiac effects of inducible nitric oxide synthase in mice with hyperhomocysteinemia. PLoS One 9(9):e107734. PubMed: 25226386 MGI: J:223414
De Luca G; Di Giorgio RM; Macaione S; Calpona PR; Di Paola ED; Costa N; Cuzzocrea S; Citraro R; Russo E; De Sarro G. 2006. Amino acid levels in some brain areas of inducible nitric oxide synthase knock out mouse (iNOS-/-) before and after pentylenetetrazole kindling. Pharmacol Biochem Behav 85(4):804-12. PubMed: 17223186 MGI: J:124504
Demchenko IT; Atochin DN; Gutsaeva DR; Godfrey RR; Huang PL; Piantadosi CA; Allen BW. 2008. Contributions of nitric oxide synthase isoforms to pulmonary oxygen toxicity, local vs. mediated effects. Am J Physiol Lung Cell Mol Physiol 294(5):L984-90. PubMed: 18326824 MGI: J:136632
Denda A; Kitayama W; Kishida H; Murata N; Tamura K; Kusuoka O; Tsutsumi M; Nishikawa F; Kita E; Nakae D; Konishi Y; Kuniyasu H. 2007. Expression of inducible nitric oxide (NO) synthase but not prevention by its gene ablation of hepatocarcinogenesis with fibrosis caused by a choline-deficient, L-amino acid-defined diet in rats and mice. Nitric Oxide 16(1):164-76. PubMed: 16931074 MGI: J:118071
Deppong CM; Bricker TL; Rannals BD; Van Rooijen N; Hsieh CS; Green JM. 2013. CTLA4Ig inhibits effector T cells through regulatory T cells and TGF-beta. J Immunol 191(6):3082-9. PubMed: 23956428 MGI: J:205876
Dhar N; McKinney JD. 2010. Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice. Proc Natl Acad Sci U S A 107(27):12275-80. PubMed: 20566858 MGI: J:162073
Di Marco S; Mazroui R; Dallaire P; Chittur S; Tenenbaum SA; Radzioch D; Marette A; Gallouzi IE. 2005. NF-(kappa)B-mediated MyoD decay during muscle wasting requires nitric oxide synthase mRNA stabilization, HuR protein, and nitric oxide release. Mol Cell Biol 25(15):6533-45. PubMed: 16024790 MGI: J:100108
DiMagno MJ; Hao Y; Tsunoda Y; Williams JA; Owyang C. 2004. Secretagogue-stimulated pancreatic secretion is differentially regulated by constitutive NOS isoforms in mice. Am J Physiol Gastrointest Liver Physiol 286(3):G428-36. PubMed: 14551061 MGI: J:95674
Dias MB; Almeida MC; Carnio EC; Branco LG. 2005. Role of nitric oxide in tolerance to lipopolysaccharide in mice. J Appl Physiol 98(4):1322-7. PubMed: 15579566 MGI: J:110018
Diesen DL; Hess DT; Stamler JS. 2008. Hypoxic vasodilation by red blood cells: evidence for an s-nitrosothiol-based signal. Circ Res 103(5):545-53. PubMed: 18658051 MGI: J:152645
Duque-Correa MA; Kuhl AA; Rodriguez PC; Zedler U; Schommer-Leitner S; Rao M; Weiner J 3rd; Hurwitz R; Qualls JE; Kosmiadi GA; Murray PJ; Kaufmann SH; Reece ST. 2014. Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas. Proc Natl Acad Sci U S A 111(38):E4024-32. PubMed: 25201986 MGI: J:216485
Edelson BT; Unanue ER. 2002. MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity. J Immunol 169(7):3869-75. PubMed: 12244184 MGI: J:120406
Eigenbrod T; Bode KA; Dalpke AH. 2013. Early inhibition of IL-1beta expression by IFN-gamma is mediated by impaired binding of NF-kappaB to the IL-1beta promoter but is independent of nitric oxide. J Immunol 190(12):6533-41. PubMed: 23667107 MGI: J:204860
Ellies LG. 2003. PyV-mT-induced parotid gland hyperplasia as detected by altered lectin reactivity is not modulated by inducible nitric oxide deficiency. Arch Oral Biol 48(6):415-22. PubMed: 12749913 MGI: J:84218
Ellies LG; Fishman M; Hardison J; Kleeman J; Maglione JE; Manner CK; Cardiff RD; MacLeod CL. 2003. Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase. Int J Cancer 106(1):1-7. PubMed: 12794750 MGI: J:84004
Everts B; Amiel E; Huang SC; Smith AM; Chang CH; Lam WY; Redmann V; Freitas TC; Blagih J; van der Windt GJ; Artyomov MN; Jones RG; Pearce EL; Pearce EJ. 2014. TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKvarepsilon supports the anabolic demands of dendritic cell activation. Nat Immunol 15(4):323-32. PubMed: 24562310 MGI: J:209894
Everts B; Amiel E; van der Windt GJ; Freitas TC; Chott R; Yarasheski KE; Pearce EL; Pearce EJ. 2012. Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells. Blood 120(7):1422-31. PubMed: 22786879 MGI: J:189164
Fabis MJ; Scott GS; Kean RB; Koprowski H; Hooper DC. 2007. Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models. Proc Natl Acad Sci U S A 104(13):5656-61. PubMed: 17372191 MGI: J:120115
Falcone S; Perrotta C; De Palma C; Pisconti A; Sciorati C; Capobianco A; Rovere-Querini P; Manfredi AA; Clementi E. 2004. Activation of acid sphingomyelinase and its inhibition by the nitric oxide/cyclic guanosine 3',5'-monophosphate pathway: key events in Escherichia coli-elicited apoptosis of dendritic cells. J Immunol 173(7):4452-63. PubMed: 15383576 MGI: J:93735
Felmy B; Songhet P; Slack EM; Muller AJ; Kremer M; Van Maele L; Cayet D; Heikenwalder M; Sirard JC; Hardt WD. 2013. NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium. PLoS One 8(10):e77204. PubMed: 24143212 MGI: J:209119
Feng HM; Walker DH. 2004. Mechanisms of immunity to Ehrlichia muris: a model of monocytotropic ehrlichiosis. Infect Immun 72(2):966-71. PubMed: 14742542 MGI: J:87862
Fernandes KS; Neto EH; Brito MM; Silva JS; Cunha FQ; Barja-Fidalgo C. 2008. Detrimental role of endogenous nitric oxide in host defence against Sporothrix schenckii. Immunology 123(4):469-79. PubMed: 18194265 MGI: J:136580
Fraszczak J; Trad M; Janikashvili N; Cathelin D; Lakomy D; Granci V; Morizot A; Audia S; Micheau O; Lagrost L; Katsanis E; Solary E; Larmonier N; Bonnotte B. 2010. Peroxynitrite-dependent killing of cancer cells and presentation of released tumor antigens by activated dendritic cells. J Immunol 184(4):1876-84. PubMed: 20089706 MGI: J:159469
Fukumura D; Gohongi T; Kadambi A; Izumi Y; Ang J; Yun CO; Buerk DG; Huang PL; Jain RK. 2001. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc Natl Acad Sci U S A 98(5):2604-9. PubMed: 11226286 MGI: J:67870
Ganley L; Babu S; Rajan TV. 2001. Course of Brugia malayi infection in C57BL/6J NOS2 +/+ and -/- mice. Exp Parasitol 98(1):35-43. PubMed: 11426950 MGI: J:102684
Gaur U; Roberts SC; Dalvi RP; Corraliza I; Ullman B; Wilson ME. 2007. An effect of parasite-encoded arginase on the outcome of murine cutaneous leishmaniasis. J Immunol 179(12):8446-53. PubMed: 18056391 MGI: J:155195
Gericke A; Goloborodko E; Sniatecki JJ; Steege A; Wojnowski L; Pfeiffer N. 2013. Contribution of nitric oxide synthase isoforms to cholinergic vasodilation in murine retinal arterioles. Exp Eye Res 109:60-6. PubMed: 23434456 MGI: J:210420
Ghosn EE; Russo M; Almeida SR. 2006. Nitric oxide-dependent killing of Cryptococcus neoformans by B-1-derived mononuclear phagocyte. J Leukoc Biol 80(1):36-44. PubMed: 16670124 MGI: J:110472
Gillman BM; Batchelder J; Flaherty P; Weidanz WP. 2004. Suppression of Plasmodium chabaudi parasitemia is independent of the action of reactive oxygen intermediates and/or nitric oxide. Infect Immun 72(11):6359-66. PubMed: 15501765 MGI: J:93252
Giordano D; Li C; Suthar MS; Draves KE; Ma DY; Gale M Jr; Clark EA. 2011. Nitric oxide controls an inflammatory-like Ly6C(hi)PDCA1+ DC subset that regulates Th1 immune responses. J Leukoc Biol 89(3):443-55. PubMed: 21178115 MGI: J:170375
Gobert AP; Cheng Y; Akhtar M; Mersey BD; Blumberg DR; Cross RK; Chaturvedi R; Drachenberg CB; Boucher JL; Hacker A; Casero RA Jr; Wilson KT. 2004. Protective role of arginase in a mouse model of colitis. J Immunol 173(3):2109-17. PubMed: 15265947 MGI: J:92035
Goldmann O; von Kockritz-Blickwede M; Holtje C; Chhatwal GS; Geffers R; Medina E. 2007. Transcriptome analysis of murine macrophages in response to infection with Streptococcus pyogenes reveals an unusual activation program. Infect Immun 75(8):4148-57. PubMed: 17526748 MGI: J:123374
Gomes SA; Rangel EB; Premer C; Dulce RA; Cao Y; Florea V; Balkan W; Rodrigues CO; Schally AV; Hare JM. 2013. S-nitrosoglutathione reductase (GSNOR) enhances vasculogenesis by mesenchymal stem cells. Proc Natl Acad Sci U S A 110(8):2834-9. PubMed: 23288904 MGI: J:193262
Gomez-Ambrosi J; Becerril S; Oroz P; Zabalza S; Rodriguez A; Muruzabal FJ; Archanco M; Gil MJ; Burrell MA; Fruhbeck G. 2004. Reduced adipose tissue mass and hypoleptinemia in iNOS deficient mice: effect of LPS on plasma leptin and adiponectin concentrations. FEBS Lett 577(3):351-6. PubMed: 15556608 MGI: J:94571
Gonzalez C; Cuvellier S; Hue-Beauvais C; Levi-Strauss M. 2003. Genetic control of non obese diabetic mice susceptibility to high-dose streptozotocin-induced diabetes. Diabetologia 46(9):1291-5. PubMed: 12879252 MGI: J:95957
Gorbunov NV; Kiang JG. 2009. Up-regulation of autophagy in small intestine Paneth cells in response to total-body gamma-irradiation. J Pathol 219(2):242-52. PubMed: 19681094 MGI: J:152797
Gramaglia I; Sobolewski P; Meays D; Contreras R; Nolan JP; Frangos JA; Intaglietta M; van der Heyde HC. 2006. Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria. Nat Med 12(12):1417-22. PubMed: 17099710 MGI: J:129543
Greenberg SS; Ouyang J; Zhao X; Parrish C; Nelson S; Giles TD. 1999. Effects of ethanol on neutrophil recruitment and lung host defense in nitric oxide synthase I and nitric oxide synthase II knockout mice. Alcohol Clin Exp Res 23(9):1435-45. PubMed: 10512307 MGI: J:59745
Grifka-Walk HM; Giles DA; Segal BM. 2015. IL-12-polarized Th1 cells produce GM-CSF and induce EAE independent of IL-23. Eur J Immunol 45(10):2780-6. PubMed: 26220255 MGI: J:233105
Guhring H; Gorig M; Ates M; Coste O; Zeilhofer HU; Pahl A; Rehse K; Brune K. 2000. Suppressed injury-induced rise in spinal prostaglandin E2 production and reduced early thermal hyperalgesia in iNOS-deficient mice. J Neurosci 20(17):6714-20. PubMed: 10964977 MGI: J:64215
Guo Y; Jones WK; Xuan YT; Tang XL; Bao W; Wu WJ; Han H; Laubach VE; Ping P; Yang Z; Qiu Y; Bolli R. 1999. The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene [see comments] Proc Natl Acad Sci U S A 96(20):11507-12. PubMed: 10500207 MGI: J:57975
Guthrie SM; Curtis LM; Mames RN; Simon GG; Grant MB; Scott EW. 2005. The nitric oxide pathway modulates hemangioblast activity of adult hematopoietic stem cells. Blood 105(5):1916-22. PubMed: 15546953 MGI: J:98135
Haag D; Zipper P; Westrich V; Karra D; Pfleger K; Toedt G; Blond F; Delhomme N; Hahn M; Reifenberger J; Reifenberger G; Lichter P. 2012. Nos2 inactivation promotes the development of medulloblastoma in Ptch1(+/-) mice by deregulation of Gap43-dependent granule cell precursor migration. PLoS Genet 8(3):e1002572. PubMed: 22438824 MGI: J:183478
Hamada T; Duarte S; Tsuchihashi S; Busuttil RW; Coito AJ. 2009. Inducible nitric oxide synthase deficiency impairs matrix metalloproteinase-9 activity and disrupts leukocyte migration in hepatic ischemia/reperfusion injury. Am J Pathol 174(6):2265-77. PubMed: 19443702 MGI: J:148923
Hampton TG; Amende I; Fong J; Laubach VE; Li J; Metais C; Simons M. 2000. Basic FGF reduces stunning via a NOS2-dependent pathway in coronary-perfused mouse hearts. Am J Physiol Heart Circ Physiol 279(1):H260-8. PubMed: 10899065 MGI: J:107850
Hardiman KM; Lindsey JR; Matalon S. 2001. Lack of amiloride-sensitive transport across alveolar and respiratory epithelium of iNOS(-/-) mice in vivo. Am J Physiol Lung Cell Mol Physiol 281(3):L722-31. PubMed: 11504701 MGI: J:71505
Hegazi RA; Rao KN; Mayle A; Sepulveda AR; Otterbein LE; Plevy SE. 2005. Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway. J Exp Med 202(12):1703-13. PubMed: 16365149 MGI: J:118826
Hernandez-Cuellar E; Tsuchiya K; Hara H; Fang R; Sakai S; Kawamura I; Akira S; Mitsuyama M. 2012. Cutting edge: nitric oxide inhibits the NLRP3 inflammasome. J Immunol 189(11):5113-7. PubMed: 23100513 MGI: J:190677
Hertz CJ; Mansfield JM. 1999. IFN-gamma-dependent nitric oxide production is not linked to resistance in experimental African trypanosomiasis. Cell Immunol 192(1):24-32. PubMed: 10066343 MGI: J:114251
Hervera A; Leanez S; Negrete R; Motterlini R; Pol O. 2012. Carbon monoxide reduces neuropathic pain and spinal microglial activation by inhibiting nitric oxide synthesis in mice. PLoS One 7(8):e43693. PubMed: 22928017 MGI: J:191571
Hickman-Davis JM; Wang Z; Fierro-Perez GA; Chess PR; Page GP; Matalon S; Notter RH. 2007. Surfactant dysfunction in SP-A-/- and iNOS-/- mice with mycoplasma infection. Am J Respir Cell Mol Biol 36(1):103-13. PubMed: 16917077 MGI: J:130520
Hoang T; Choi DK; Nagai M; Wu DC; Nagata T; Prou D; Wilson GL; Vila M; Jackson-Lewis V; Dawson VL; Dawson TM; Chesselet MF; Przedborski S. 2009. Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease. Free Radic Biol Med 47(7):1049-56. PubMed: 19616617 MGI: J:152538
Hokari R; Kato S; Matsuzaki K; Kuroki M; Iwai A; Kawaguchi A; Nagao S; Miyahara T; Itoh K; Sekizuka E; Nagata H; Ishii H; Miura S. 2001. Reduced sensitivity of inducible nitric oxide synthase-deficient mice to chronic colitis. Free Radic Biol Med 31(2):153-63. PubMed: 11440827 MGI: J:70811
Hollenberg SM; Broussard M; Osman J; Parrillo JE. 2000. Increased microvascular reactivity and improved mortality in septic mice lacking inducible nitric oxide synthase. Circ Res 86(7):774-8. PubMed: 10764411 MGI: J:110288
Houpt ER; Glembocki DJ; Obrig TG; Moskaluk CA; Lockhart LA; Wright RL; Seaner RM; Keepers TR; Wilkins TD; Petri WA Jr. 2002. The mouse model of amebic colitis reveals mouse strain susceptibility to infection and exacerbation of disease by CD4+ T cells. J Immunol 169(8):4496-503. PubMed: 12370386 MGI: J:120012
Hromatka BS; Noble SM; Johnson AD. 2005. Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulence. Mol Biol Cell 16(10):4814-26. PubMed: 16030247 MGI: J:106530
Hsieh SH; Lin JS; Huang JH; Wu SY; Chu CL; Kung JT; Wu-Hsieh BA. 2011. Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis. Infect Immun 79(11):4493-502. PubMed: 21911464 MGI: J:177771
Huang B; Pan PY; Li Q; Sato AI; Levy DE; Bromberg J; Divino CM; Chen SH. 2006. Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Res 66(2):1123-31. PubMed: 16424049 MGI: J:106544
Hussain MB; Hobbs AJ; MacAllister RJ. 1999. Autoregulation of nitric oxide-soluble guanylate cyclase-cyclic GMP signalling in mouse thoracic aorta. Br J Pharmacol 128(5):1082-8. PubMed: 10556946 MGI: J:59681
Hussain SP; He P; Subleski J; Hofseth LJ; Trivers GE; Mechanic L; Hofseth AB; Bernard M; Schwank J; Nguyen G; Mathe E; Djurickovic D; Haines D; Weiss J; Back T; Gruys E; Laubach VE; Wiltrout RH; Harris CC. 2008. Nitric oxide is a key component in inflammation-accelerated tumorigenesis. Cancer Res 68(17):7130-6. PubMed: 18757428 MGI: J:138926
Hussain SP; Trivers GE; Hofseth LJ; He P; Shaikh I; Mechanic LE; Doja S; Jiang W; Subleski J; Shorts L; Haines D; Laubach VE; Wiltrout RH; Djurickovic D; Harris CC. 2004. Nitric oxide, a mediator of inflammation, suppresses tumorigenesis. Cancer Res 64(19):6849-53. PubMed: 15466171 MGI: J:93662
Hutchinson D; Ho V; Dodd M; Dawson HN; Zumwalt AC; Schmitt D; Colton CA. 2007. Quantitative measurement of postural sway in mouse models of human neurodegenerative disease. Neuroscience 148(4):825-32. PubMed: 17764851 MGI: J:128390
Ii M; Nishimura H; Iwakura A; Wecker A; Eaton E; Asahara T; Losordo DW. 2005. Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via 'imported' nitric oxide synthase activity. Circulation 111(9):1114-20. PubMed: 15723985 MGI: J:108997
Into T; Inomata M; Nakashima M; Shibata K; Hacker H; Matsushita K. 2008. Regulation of MyD88-dependent signaling events by S nitrosylation retards toll-like receptor signal transduction and initiation of acute-phase immune responses. Mol Cell Biol 28(4):1338-47. PubMed: 18086890 MGI: J:132654
Isaksson J; Farooque M; Olsson Y. 2005. Improved functional outcome after spinal cord injury in iNOS-deficient mice. Spinal Cord 43(3):167-70. PubMed: 15520837 MGI: J:110081
Itzhak Y; Martin JL; Ali SF. 1999. Methamphetamine- and 1-methyl-4-phenyl- 1,2,3, 6-tetrahydropyridine-induced dopaminergic neurotoxicity in inducible nitric oxide synthase-deficient mice. Synapse 34(4):305-12. PubMed: 10529724 MGI: J:59707
Iwakiri Y; Cadelina G; Sessa WC; Groszmann RJ. 2002. Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension. Am J Physiol Gastrointest Liver Physiol 283(5):G1074-81. PubMed: 12381520 MGI: J:108056
Jantsch J; Schatz V; Friedrich D; Schroder A; Kopp C; Siegert I; Maronna A; Wendelborn D; Linz P; Binger KJ; Gebhardt M; Heinig M; Neubert P; Fischer F; Teufel S; David JP; Neufert C; Cavallaro A; Rakova N; Kuper C; Beck FX; Neuhofer W; Muller DN; Schuler G; Uder M; Bogdan C; Luft FC; Titze J. 2015. Cutaneous Na+ storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense. Cell Metab 21(3):493-501. PubMed: 25738463 MGI: J:220700
Jayaraman P; Parikh F; Lopez-Rivera E; Hailemichael Y; Clark A; Ma G; Cannan D; Ramacher M; Kato M; Overwijk WW; Chen SH; Umansky VY; Sikora AG. 2012. Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release. J Immunol 188(11):5365-76. PubMed: 22529296 MGI: J:188746
Jones SP; Greer JJ; Ware PD; Yang J; Walsh K; Lefer DJ. 2005. Deficiency of iNOS does not attenuate severe congestive heart failure in mice. Am J Physiol Heart Circ Physiol 288(1):H365-70. PubMed: 15319210 MGI: J:95577
Jones SP; Trocha SD; Lefer DJ. 2001. Cardioprotective actions of endogenous IL-10 are independent of iNOS. Am J Physiol Heart Circ Physiol 281(1):H48-52. PubMed: 11406467 MGI: J:70292
Joo JD; Kim M; Horst P; Kim J; D'Agati VD; Emala CW Sr; Lee HT. 2007. Acute and delayed renal protection against renal ischemia and reperfusion injury with A1 adenosine receptors. Am J Physiol Renal Physiol 293(6):F1847-57. PubMed: 17928414 MGI: J:127544
Kahl KG; Schmidt HH; Jung S; Sherman P; Toyka KV; Zielasek J. 2004. Experimental autoimmune encephalomyelitis in mice with a targeted deletion of the inducible nitric oxide synthase gene: increased T-helper 1 response. Neurosci Lett 358(1):58-62. PubMed: 15016434 MGI: J:88809
Kalns J; Scruggs J; Millenbaugh N; Vivekananda J; Shealy D; Eggers J; Kiel J. 2002. TNF Receptor 1, IL-1 Receptor, and iNOS Genetic Knockout Mice Are Not Protected from Anthrax Infection. Biochem Biophys Res Commun 292(1):41-4. PubMed: 11890668 MGI: J:75694
Kan MJ; Lee JE; Wilson JG; Everhart AL; Brown CM; Hoofnagle AN; Jansen M; Vitek MP; Gunn MD; Colton CA. 2015. Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. J Neurosci 35(15):5969-82. PubMed: 25878270 MGI: J:221677
Kania G; Siegert S; Behnke S; Prados-Rosales R; Casadevall A; Luscher TF; Luther SA; Kopf M; Eriksson U; Blyszczuk P. 2013. Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis. Circulation 127(23):2285-94. PubMed: 23671208 MGI: J:211390
Kenyon NJ; van der Vliet A; Schock BC; Okamoto T; McGrew GM; Last JA. 2002. Susceptibility to ozone-induced acute lung injury in iNOS-deficient mice. Am J Physiol Lung Cell Mol Physiol 282(3):L540-5. PubMed: 11839550 MGI: J:75613
Kim HA; Kim SH; Ko HM; Choi JH; Kim KJ; Oh SH; Cho KO; Choi IW; Im SY. 2008. Nitric oxide plays a key role in the platelet-activating factor-induced enhancement of resistance against systemic candidiasis. Immunology 124(3):428-35. PubMed: 18397269 MGI: J:138455
Kim JS; Cha SH; Kim WS; Han SJ; Cha SB; Kim HM; Kwon KW; Kim SJ; Choi HH; Lee J; Cho SN; Koh WJ; Park YM; Shin SJ. 2016. A Novel Therapeutic Approach Using Mesenchymal Stem Cells to Protect Against Mycobacterium abscessus. Stem Cells 34(7):1957-70. PubMed: 26946350 MGI: J:238117
Kirksey MA; Tischler AD; Simeone R; Hisert KB; Uplekar S; Guilhot C; McKinney JD. 2011. Spontaneous Phthiocerol Dimycocerosate-Deficient Variants of Mycobacterium tuberculosis Are Susceptible to Gamma Interferon-Mediated Immunity. Infect Immun 79(7):2829-38. PubMed: 21576344 MGI: J:173476
Kisley LR; Barrett BS; Bauer AK; Dwyer-Nield LD; Barthel B; Meyer AM; Thompson DC; Malkinson AM. 2002. Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis. Cancer Res 62(23):6850-6. PubMed: 12460898 MGI: J:80325
Kitayama J; Faraci FM; Gunnett CA; Heistad DD. 2006. Impairment of dilator responses of cerebral arterioles during diabetes mellitus: role of inducible NO synthase. Stroke 37(8):2129-33. PubMed: 16809563 MGI: J:135707
Kleeberger SR; Reddy SP; Zhang LY; Cho HY; Jedlicka AE. 2001. Toll-like receptor 4 mediates ozone-induced murine lung hyperpermeability via inducible nitric oxide synthase. Am J Physiol Lung Cell Mol Physiol 280(2):L326-33. PubMed: 11159012 MGI: J:108671
Klingstrom J; Akerstrom S; Hardestam J; Stoltz M; Simon M; Falk KI; Mirazimi A; Rottenberg M; Lundkvist A. 2006. Nitric oxide and peroxynitrite have different antiviral effects against hantavirus replication and free mature virions. Eur J Immunol 36(10):2649-57. PubMed: 16955520 MGI: J:118085
Knotek M; Rogachev B; Wang W; Ecder T; Melnikov V; Gengaro PE; Esson M; Edelstein CL; Dinarello CA; Schrier RW. 2001. Endotoxemic renal failure in mice: Role of tumor necrosis factor independent of inducible nitric oxide synthase. Kidney Int 59(6):2243-9. PubMed: 11380827 MGI: J:104003
Knudsen L; Atochina-Vasserman EN; Guo CJ; Scott PA; Haenni B; Beers MF; Ochs M; Gow AJ. 2014. NOS2 is critical to the development of emphysema in Sftpd deficient mice but does not affect surfactant homeostasis. PLoS One 9(1):e85722. PubMed: 24465666 MGI: J:212338
Knudsen L; Atochina-Vasserman EN; Massa CB; Birkelbach B; Guo CJ; Scott P; Haenni B; Beers MF; Ochs M; Gow AJ. 2015. The role of inducible nitric oxide synthase for interstitial remodeling of alveolar septa in surfactant protein D-deficient mice. Am J Physiol Lung Cell Mol Physiol 309(9):L959-69. PubMed: 26320150 MGI: J:232878
Ko J; Gendron-Fitzpatrick A; Splitter GA. 2002. Susceptibility of IFN regulatory factor-1 and IFN consensus sequence binding protein-deficient mice to brucellosis. J Immunol 168(5):2433-40. PubMed: 11859135 MGI: J:74725
Kotamraju S; Matalon S; Matsunaga T; Shang T; Hickman-Davis JM; Kalyanaraman B. 2006. Upregulation of immunoproteasomes by nitric oxide: Potential antioxidative mechanism in endothelial cells. Free Radic Biol Med 40(6):1034-44. PubMed: 16540399 MGI: J:107075
Kozak W; Kozak A. 2003. Genetic Models in Applied Physiology. Differential role of nitric oxide synthase isoforms in fever of different etiologies: studies using Nos gene-deficient mice. J Appl Physiol 94(6):2534-44. PubMed: 12562678 MGI: J:103018
Krieglstein CF; Anthoni C; Cerwinka WH; Stokes KY; Russell J; Grisham MB; Granger DN. 2007. Role of blood- and tissue-associated inducible nitric-oxide synthase in colonic inflammation. Am J Pathol 170(2):490-6. PubMed: 17255317 MGI: J:117890
Krieglstein CF; Cerwinka WH; Laroux FS; Salter JW; Russell JM; Schuermann G; Grisham MB; Ross CR; Granger DN. 2001. Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide. J Exp Med 194(9):1207-18. PubMed: 11696587 MGI: J:134388
Kuhlencordt PJ; Chen J; Han F; Astern J; Huang PL. 2001. Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice. Circulation 103(25):3099-104. PubMed: 11425775 MGI: J:103350
Kummer MP; Hermes M; Delekarte A; Hammerschmidt T; Kumar S; Terwel D; Walter J; Pape HC; Konig S; Roeber S; Jessen F; Klockgether T; Korte M; Heneka MT. 2011. Nitration of tyrosine 10 critically enhances amyloid beta aggregation and plaque formation. Neuron 71(5):833-44. PubMed: 21903077 MGI: J:176667
Kurtz S; McKinnon KP; Runge MS; Ting JP; Braunstein M. 2006. The SecA2 secretion factor of Mycobacterium tuberculosis promotes growth in macrophages and inhibits the host immune response. Infect Immun 74(12):6855-64. PubMed: 17030572 MGI: J:116072
LaCasse CJ; Janikashvili N; Larmonier CB; Alizadeh D; Hanke N; Kartchner J; Situ E; Centuori S; Har-Noy M; Bonnotte B; Katsanis E; Larmonier N. 2011. Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-gamma-dependent mechanism. J Immunol 187(12):6310-7. PubMed: 22075702 MGI: J:180408
Lai JF; Zindl CL; Duffy LB; Atkinson TP; Jung YW; van Rooijen N; Waites KB; Krause DC; Chaplin DD. 2010. Critical role of macrophages and their activation via MyD88-NFkappaB signaling in lung innate immunity to Mycoplasma pneumoniae. PLoS One 5(12):e14417. PubMed: 21203444 MGI: J:168336
Lamon BD; Upmacis RK; Deeb RS; Koyuncu H; Hajjar DP. 2010. Inducible nitric oxide synthase gene deletion exaggerates MAPK-mediated cyclooxygenase-2 induction by inflammatory stimuli. Am J Physiol Heart Circ Physiol 299(3):H613-23. PubMed: 20543082 MGI: J:164511
Landgraf RG; Russo M; Jancar S. 2005. Acute inhibition of inducible nitric oxide synthase but not its absence suppresses asthma-like responses. Eur J Pharmacol 518(2-3):212-20. PubMed: 16023634 MGI: J:106361
Laspas P; Goloborodko E; Sniatecki JJ; Kordasz ML; Manicam C; Wojnowski L; Li H; Patzak A; Pfeiffer N; Gericke A. 2014. Role of nitric oxide synthase isoforms for ophthalmic artery reactivity in mice. Exp Eye Res 127:1-8. PubMed: 25017185 MGI: J:230132
Laubach VE; Foley PL; Shockey KS; Tribble CG; Kron IL. 1998. Protective roles of nitric oxide and testosterone in endotoxemia: evidence from NOS-2-deficient mice. Am J Physiol 275(6 Pt 2):H2211-8. PubMed: 9843821 MGI: J:51564
Laubach VE; Shesely EG; Smithies O; Sherman PA. 1995. Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc Natl Acad Sci U S A 92(23):10688-92. PubMed: 7479866 MGI: J:29677
Leal EC; Manivannan A; Hosoya K; Terasaki T; Cunha-Vaz J; Ambrosio AF; Forrester JV. 2007. Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. Invest Ophthalmol Vis Sci 48(11):5257-65. PubMed: 17962481 MGI: J:127155
Lee MR; Seo GY; Kim YM; Kim PH. 2011. iNOS potentiates mouse Ig isotype switching through AID expression. Biochem Biophys Res Commun 410(3):602-7. PubMed: 21684254 MGI: J:174949
Lee WB; Kang JS; Choi WY; Zhang Q; Kim CH; Choi UY; Kim-Ha J; Kim YJ. 2016. Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution. Nat Commun 7:11322. PubMed: 27089465 MGI: J:236887
Lee YS; Li N; Shin S; Jun HS. 2009. Role of nitric oxide in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice. J Virol 83(16):8004-11. PubMed: 19535454 MGI: J:151516
Lefer DJ; Jones SP; Girod WG; Baines A; Grisham MB; Cockrell AS; Huang PL; Scalia R. 1999. Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice. Am J Physiol 276(6 Pt 2):H1943-50. PubMed: 10362674 MGI: J:55936
Lewis CJ; Cobb BA. 2010. Carbohydrate oxidation acidifies endosomes, regulating antigen processing and TLR9 signaling. J Immunol 184(7):3789-800. PubMed: 20200279 MGI: J:160075
Li D; Laubach VE; Johns RA. 2001. Upregulation of lung soluble guanylate cyclase during chronic hypoxia is prevented by deletion of eNOS. Am J Physiol Lung Cell Mol Physiol 281(2):L369-76. PubMed: 11435211 MGI: J:108269
Li D; Shin JH; Duan D. 2011. iNOS Ablation Does Not Improve Specific Force of the Extensor Digitorum Longus Muscle in Dystrophin-Deficient mdx4cv Mice. PLoS One 6(6):e21618. PubMed: 21738735 MGI: J:174763
Li E; Zhou P; Singer SM. 2006. Neuronal nitric oxide synthase is necessary for elimination of Giardia lamblia infections in mice. J Immunol 176(1):516-21. PubMed: 16365445 MGI: J:126256
Li G; Veenstra AA; Talahalli RR; Wang X; Gubitosi-Klug RA; Sheibani N; Kern TS. 2012. Marrow-derived cells regulate the development of early diabetic retinopathy and tactile allodynia in mice. Diabetes 61(12):3294-303. PubMed: 22923475 MGI: J:208497
Li J; Baud O; Vartanian T; Volpe JJ; Rosenberg PA. 2005. Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes. Proc Natl Acad Sci U S A 102(28):9936-41. PubMed: 15998743 MGI: J:99857
Li W; Ren G; Huang Y; Su J; Han Y; Li J; Chen X; Cao K; Chen Q; Shou P; Zhang L; Yuan ZR; Roberts AI; Shi S; Le AD; Shi Y. 2012. Mesenchymal stem cells: a double-edged sword in regulating immune responses. Cell Death Differ 19(9):1505-13. PubMed: 22421969 MGI: J:204801
Li X; McKinstry KK; Swain SL; Dalton DK. 2007. IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals. J Immunol 179(2):939-49. PubMed: 17617585 MGI: J:149401
Liao S; Cheng G; Conner DA; Huang Y; Kucherlapati RS; Munn LL; Ruddle NH; Jain RK; Fukumura D; Padera TP. 2011. Impaired lymphatic contraction associated with immunosuppression. Proc Natl Acad Sci U S A 108(46):18784-9. PubMed: 22065738 MGI: J:180179
Libby RT; Howell GR; Pang IH; Savinova OV; Mehalow AK; Barter JW; Smith RS; Clark AF; John SW. 2007. Inducible nitric oxide synthase, Nos2, does not mediate optic neuropathy and retinopathy in the DBA/2J glaucoma model. BMC Neurosci 8:108. PubMed: 18093296 MGI: J:130816
Liberatore GT; Jackson-Lewis V; Vukosavic S; Mandir AS; Vila M; McAuliffe WG; Dawson VL; Dawson TM; Przedborski S. 1999. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease [see comments] Nat Med 5(12):1403-9. PubMed: 10581083 MGI: J:58724
Lichten LA; Liuzzi JP; Cousins RJ. 2009. Interleukin-1beta contributes via nitric oxide to the upregulation and functional activity of the zinc transporter Zip14 (Slc39a14) in murine hepatocytes. Am J Physiol Gastrointest Liver Physiol 296(4):G860-7. PubMed: 19179618 MGI: J:149697
Lidington D; Li F; Tyml K. 2007. Deletion of neuronal NOS prevents impaired vasodilation in septic mouse skeletal muscle. Cardiovasc Res 74(1):151-8. PubMed: 17258180 MGI: J:119500
Lindgren H; Stenmark S; Chen W; Tarnvik A; Sjostedt A. 2004. Distinct roles of reactive nitrogen and oxygen species to control infection with the facultative intracellular bacterium Francisella tularensis. Infect Immun 72(12):7172-82. PubMed: 15557642 MGI: J:94215
Ling W; Zhang J; Yuan Z; Ren G; Zhang L; Chen X; Rabson AB; Roberts AI; Wang Y; Shi Y. 2014. Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment. Cancer Res 74(5):1576-87. PubMed: 24452999 MGI: J:208149
Ling YM; Shaw MH; Ayala C; Coppens I; Taylor GA; Ferguson DJ; Yap GS. 2006. Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages. J Exp Med 203(9):2063-71. PubMed: 16940170 MGI: J:124556
Liu YH; Carretero OA; Cingolani OH; Liao TD; Sun Y; Xu J; Li LY; Pagano PJ; Yang JJ; Yang XP. 2005. Role of inducible nitric oxide synthase in cardiac function and remodeling in mice with heart failure due to myocardial infarction. Am J Physiol Heart Circ Physiol 289(6):H2616-23. PubMed: 16055518 MGI: J:104749
Lizarbe TR; Tarin C; Gomez M; Lavin B; Aracil E; Orte LM; Zaragoza C. 2009. Nitric Oxide Induces the Progression of Abdominal Aortic Aneurysms through the Matrix Metalloproteinase Inducer EMMPRIN. Am J Pathol :. PubMed: 19779140 MGI: J:152751
Lu G; Zhang R; Geng S; Peng L; Jayaraman P; Chen C; Xu F; Yang J; Li Q; Zheng H; Shen K; Wang J; Liu X; Wang W; Zheng Z; Qi CF; Si C; He JC; Liu K; Lira SA; Sikora AG; Li L; Xiong H. 2015. Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization. Nat Commun 6:6676. PubMed: 25813085 MGI: J:221863
Lue Y; Sinha Hikim AP; Wang C; Leung A; Swerdloff RS. 2003. Functional role of inducible nitric oxide synthase in the induction of male germ cell apoptosis, regulation of sperm number, and determination of testes size: evidence from null mutant mice. Endocrinology 144(7):3092-100. PubMed: 12810565 MGI: J:84347
Luiking YC; Hallemeesch MM; Lamers WH; Deutz NE. 2005. NOS3 is involved in the increased protein and arginine metabolic response in muscle during early endotoxemia in mice. Am J Physiol Endocrinol Metab 288(6):E1258-64. PubMed: 15644457 MGI: J:98378
Luiking YC; Hallemeesch MM; Lamers WH; Deutz NE. 2005. The role of NOS2 and NOS3 in renal protein and arginine metabolism during early endotoxemia in mice. Am J Physiol Renal Physiol 288(4):F816-22. PubMed: 15547116 MGI: J:97198
Lush CW; Cepinskas G; Sibbald WJ; Kvietys PR. 2001. Endothelial E- and P-selectin expression in iNOS- deficient mice exposed to polymicrobial sepsis. Am J Physiol Gastrointest Liver Physiol 280(2):G291-7. PubMed: 11208553 MGI: J:68060
Maa MC; Chang MY; Li J; Li YY; Hsieh MY; Yang CJ; Chen YJ; Li Y; Chen HC; Cheng WE; Hsieh CY; Cheng CW; Leu TH. 2011. The iNOS/Src/FAK axis is critical in Toll-like receptor-mediated cell motility in macrophages. Biochim Biophys Acta 1813(1):136-47. PubMed: 20849883 MGI: J:170208
Mahnke A; Meier RJ; Schatz V; Hofmann J; Castiglione K; Schleicher U; Wolfbeis OS; Bogdan C; Jantsch J. 2014. Hypoxia in Leishmania major Skin Lesions Impairs the NO-Dependent Leishmanicidal Activity of Macrophages. J Invest Dermatol 134(9):2339-46. PubMed: 24583949 MGI: J:212841
Malan D; Ji GJ; Schmidt A; Addicks K; Hescheler J; Levi RC; Bloch W; Fleischmann BK. 2004. Nitric oxide, a key signaling molecule in the murine early embryonic heart. FASEB J 18(10):1108-10. PubMed: 15132985 MGI: J:118469
Malaviya R; Gow AJ; Francis M; Abramova EV; Laskin JD; Laskin DL. 2015. Radiation-induced lung injury and inflammation in mice: role of inducible nitric oxide synthase and surfactant protein D. Toxicol Sci 144(1):27-38. PubMed: 25552309 MGI: J:227785
Malik M; Jividen K; Padmakumar VC; Cataisson C; Li L; Lee J; Howard OM; Yuspa SH. 2012. Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation. Proc Natl Acad Sci U S A 109(16):6130-5. PubMed: 22474389 MGI: J:183611
Marigo I; Bosio E; Solito S; Mesa C; Fernandez A; Dolcetti L; Ugel S; Sonda N; Bicciato S; Falisi E; Calabrese F; Basso G; Zanovello P; Cozzi E; Mandruzzato S; Bronte V. 2010. Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. Immunity 32(6):790-802. PubMed: 20605485 MGI: J:162002
Marigo I; Zilio S; Desantis G; Mlecnik B; Agnellini AH; Ugel S; Sasso MS; Qualls JE; Kratochvill F; Zanovello P; Molon B; Ries CH; Runza V; Hoves S; Bilocq AM; Bindea G; Mazza EM; Bicciato S; Galon J; Murray PJ; Bronte V. 2016. T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells. Cancer Cell 30(3):377-90. PubMed: 27622331 MGI: J:234978
Marjanovic JA; Stojanovic A; Brovkovych VM; Skidgel RA; Du X. 2008. Signaling-mediated functional activation of inducible nitric-oxide synthase and its role in stimulating platelet activation. J Biol Chem 283(43):28827-34. PubMed: 18753139 MGI: J:142549
Marriott HM; Hellewell PG; Cross SS; Ince PG; Whyte MK; Dockrell DH. 2006. Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia. J Immunol 177(9):6480-8. PubMed: 17056580 MGI: J:140505
Martin LJ; Chen K; Liu Z. 2005. Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation. J Neurosci 25(27):6449-59. PubMed: 16000635 MGI: J:99428
Mascia F; Lam G; Keith C; Garber C; Steinberg SM; Kohn E; Yuspa SH. 2013. Genetic ablation of epidermal EGFR reveals the dynamic origin of adverse effects of anti-EGFR therapy. Sci Transl Med 5(199):199ra110. PubMed: 23966299 MGI: J:213463
Mastroeni P; Vazquez-Torres A; Fang FC; Xu Y; Khan S; Hormaeche CE; Dougan G. 2000. Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. II. Effects on microbial proliferation and host survival in vivo. J Exp Med 192(2):237-48. PubMed: 10899910 MGI: J:63489
Mathe E; Nguyen GH; Funamizu N; He P; Moake M; Croce CM; Hussain SP. 2012. Inflammation regulates microRNA expression in cooperation with p53 and nitric oxide. Int J Cancer 131(3):760-5. PubMed: 22042537 MGI: J:186121
Mayr U; Zou Y; Zhang Z; Dietrich H; Hu Y; Xu Q. 2006. Accelerated arteriosclerosis of vein grafts in inducible NO synthase(-/-) mice is related to decreased endothelial progenitor cell repair. Circ Res 98(3):412-20. PubMed: 16385078 MGI: J:118879
McKenna KC; Beatty KM; Scherder RC; Li F; Liu H; Chen AF; Ghosh A; Stuehr DJ. 2013. Ascorbate in aqueous humor augments nitric oxide production by macrophages. J Immunol 190(2):556-64. PubMed: 23241881 MGI: J:191191
McKim SE; Gabele E; Isayama F; Lambert JC; Tucker LM; Wheeler MD; Connor HD; Mason RP; Doll MA; Hein DW; Arteel GE. 2003. Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice. Gastroenterology 125(6):1834-44. PubMed: 14724835 MGI: J:86852
McKinnon RL; Lidington D; Bolon M; Ouellette Y; Kidder GM; Tyml K. 2006. Reduced arteriolar conducted vasoconstriction in septic mouse cremaster muscle is mediated by nNOS-derived NO. Cardiovasc Res 69(1):236-44. PubMed: 16226732 MGI: J:112791
Meesters DM; Neubert S; Wijnands KA; Heyer FL; Zeiter S; Ito K; Brink PR; Poeze M. 2016. Deficiency of inducible and endothelial nitric oxide synthase results in diminished bone formation and delayed union and nonunion development. Bone 83:111-8. PubMed: 26555548 MGI: J:228744
Merkel MJ; Liu L; Cao Z; Packwood W; Hurn PD; Van Winkle DM. 2008. Estradiol abolishes reduction in cell death by the opioid agonist Met5-enkephalin after oxygen glucose deprivation in isolated cardiomyocytes from both sexes. Am J Physiol Heart Circ Physiol 295(1):H409-15. PubMed: 18502904 MGI: J:138205
Mestriner FL; Spiller F; Laure HJ; Souto FO; Tavares-Murta BM; Rosa JC; Basile-Filho A; Ferreira SH; Greene LJ; Cunha FQ. 2007. Acute-phase protein alpha-1-acid glycoprotein mediates neutrophil migration failure in sepsis by a nitric oxide-dependent mechanism. Proc Natl Acad Sci U S A 104(49):19595-600. PubMed: 18048324 MGI: J:128489
Mgbemena V; Segovia JA; Chang TH; Tsai SY; Cole GT; Hung CY; Bose S. 2012. Transactivation of inducible nitric oxide synthase gene by Kruppel-like factor 6 regulates apoptosis during influenza A virus infection. J Immunol 189(2):606-15. PubMed: 22711891 MGI: J:189798
Michael SL; Mayeux PR; Bucci TJ; Warbritton AR; Irwin LK; Pumford NR; Hinson JA. 2001. Acetaminophen-induced hepatotoxicity in mice lacking inducible nitric oxide synthase activity. Nitric Oxide 5(5):432-41. PubMed: 11587558 MGI: J:72352
Miguel RD; Cherpes TL; Watson LJ; McKenna KC. 2010. CTL Induction of Tumoricidal Nitric Oxide Production by Intratumoral Macrophages Is Critical for Tumor Elimination. J Immunol 185(11):6706-18. PubMed: 21041723 MGI: J:166136
Mishra BB; Rathinam VA; Martens GW; Martinot AJ; Kornfeld H; Fitzgerald KA; Sassetti CM. 2013. Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1beta. Nat Immunol 14(1):52-60. PubMed: 23160153 MGI: J:191074
Mittal R; Gonzalez-Gomez I; Goth KA; Prasadarao NV. 2010. Inhibition of inducible nitric oxide controls pathogen load and brain damage by enhancing phagocytosis of Escherichia coli K1 in neonatal meningitis. Am J Pathol 176(3):1292-305. PubMed: 20093483 MGI: J:158359
Miyazawa M; Suzuki H; Masaoka T; Kai A; Suematsu M; Nagata H; Miura S; Ishii H. 2003. Suppressed apoptosis in the inflamed gastric mucosa of Helicobacter pylori-colonized iNOS-knockout mice. Free Radic Biol Med 34(12):1621-30. PubMed: 12788482 MGI: J:119415
Moayeri M; Crown D; Newman ZL; Okugawa S; Eckhaus M; Cataisson C; Liu S; Sastalla I; Leppla SH. 2010. Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment. PLoS Pathog 6(12):e1001222. PubMed: 21170303 MGI: J:168096
Moayeri M; Martinez NW; Wiggins J; Young HA; Leppla SH. 2004. Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity. Infect Immun 72(8):4439-47. PubMed: 15271901 MGI: J:91775
Moens AL; Leyton-Mange JS; Niu X; Yang R; Cingolani O; Arkenbout EK; Champion HC; Bedja D; Gabrielson KL; Chen J; Xia Y; Hale AB; Channon KM; Halushka MK; Barker N; Wuyts FL; Kaminski PM; Wolin MS; Kass DA; Barouch LA. 2009. Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor. J Mol Cell Cardiol 47(5):576-85. PubMed: 19766235 MGI: J:155006
Montezuma K; Biojone C; Lisboa SF; Cunha FQ; Guimaraes FS; Joca SR. 2012. Inhibition of iNOS induces antidepressant-like effects in mice: pharmacological and genetic evidence. Neuropharmacology 62(1):485-91. PubMed: 21939674 MGI: J:183566
Moore ZW; Hui DY. 2005. Apolipoprotein E inhibition of vascular hyperplasia and neointima formation requires inducible nitric oxide synthase. J Lipid Res 46(10):2083-90. PubMed: 16061951 MGI: J:104724
Moraes JC; Amaral ME; Picardi PK; Calegari VC; Romanatto T; Bermudez-Echeverry M; Chiavegatto S; Saad MJ; Velloso LA. 2006. Inducible-NOS but not neuronal-NOS participate in the acute effect of TNF-alpha on hypothalamic insulin-dependent inhibition of food intake. FEBS Lett 580(19):4625-31. PubMed: 16876161 MGI: J:112153
Morton J; Coles B; Wright K; Gallimore A; Morrow JD; Terry ES; Anning PB; Morgan BP; Dioszeghy V; Kuhn H; Chaitidis P; Hobbs AJ; Jones SA; O'Donnell VB. 2008. Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFNgamma-dependent iNOS expression in the vasculature of healthy mice. Blood 111(10):5187-94. PubMed: 18281503 MGI: J:135580
Mota BE; Gallardo-Romero N; Trindade G; Keckler MS; Karem K; Carroll D; Campos MA; Vieira LQ; da Fonseca FG; Ferreira PC; Bonjardim CA; Damon IK; Kroon EG. 2011. Adverse Events Post Smallpox-Vaccination: Insights from Tail Scarification Infection in Mice with Vaccinia virus. PLoS One 6(4):e18924. PubMed: 21526210 MGI: J:172270
Myers L; Croft M; Kwon BS; Mittler RS; Vella AT. 2005. Peptide-specific CD8 T regulatory cells use IFN-gamma to elaborate TGF-beta-based suppression. J Immunol 174(12):7625-32. PubMed: 15944263 MGI: J:100786
Naghashpour M; Dahl G. 2000. Relaxation of myometrium by calcitonin gene-related peptide is independent of nitric oxide synthase activity in mouse uterus. Biol Reprod 63(5):1421-7. PubMed: 11058547 MGI: J:108667
Nam KT; Oh SY; Ahn B; Kim YB; Jang DD; Yang KH; Hahm KB; Kim DY. 2004. Decreased Helicobacter pylori associated gastric carcinogenesis in mice lacking inducible nitric oxide synthase. Gut 53(9):1250-5. PubMed: 15306579 MGI: J:92904
Naura AS; Zerfaoui M; Kim H; Abd Elmageed ZY; Rodriguez PC; Hans CP; Ju J; Errami Y; Park J; Ochoa AC; Boulares AH. 2010. Requirement for inducible nitric oxide synthase in chronic allergen exposure-induced pulmonary fibrosis but not inflammation. J Immunol 185(5):3076-85. PubMed: 20668217 MGI: J:163265
Nemeth K; Leelahavanichkul A; Yuen PS; Mayer B; Parmelee A; Doi K; Robey PG; Leelahavanichkul K; Koller BH; Brown JM; Hu X; Jelinek I; Star RA; Mezey E. 2009. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 15(1):42-9. PubMed: 19098906 MGI: J:146566
Niedbala W; Alves-Filho JC; Fukada SY; Vieira SM; Mitani A; Sonego F; Mirchandani A; Nascimento DC; Cunha FQ; Liew FY. 2011. Regulation of type 17 helper T-cell function by nitric oxide during inflammation. Proc Natl Acad Sci U S A 108(22):9220-5. PubMed: 21576463 MGI: J:173232
Nishida M; Ogushi M; Suda R; Toyotaka M; Saiki S; Kitajima N; Nakaya M; Kim KM; Ide T; Sato Y; Inoue K; Kurose H. 2011. Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-{kappa}B. Proc Natl Acad Sci U S A 108(16):6662-7. PubMed: 21464294 MGI: J:171373
Nishikawa M; Chang B; Inoue M. 2004. Inducible NO synthase inhibits the growth of free tumor cells, but enhances the growth of solid tumors. Carcinogenesis 25(11):2101-5. PubMed: 15205363 MGI: J:93780
Njoku C; Self SE; Ruiz P; Hofbauer AF; Gilkeson GS; Oates JC. 2008. Inducible nitric oxide synthase inhibitor SD-3651 reduces proteinuria in MRL/lpr mice deficient in the NOS2 gene. J Investig Med 56(7):911-9. PubMed: 18797415 MGI: J:205256
Noh HS; Kim DW; Cho GJ; Choi WS; Kang SS. 2006. Increased nitric oxide caused by the ketogenic diet reduces the onset time of kainic acid-induced seizures in ICR mice. Brain Res 1075(1):193-200. PubMed: 16460714 MGI: J:107300
Norman MU; Zbytnuik L; Kubes P. 2008. Interferon-gamma limits Th1 lymphocyte adhesion to inflamed endothelium: A nitric oxide regulatory feedback mechanism. Eur J Immunol 38(5):1368-80. PubMed: 18412158 MGI: J:134151
Noronha BT; Li JM; Wheatcroft SB; Shah AM; Kearney MT. 2005. Inducible nitric oxide synthase has divergent effects on vascular and metabolic function in obesity. Diabetes 54(4):1082-9. PubMed: 15793247 MGI: J:105205
O'Connor RA; Wittmer S; Dalton DK. 2005. Infection-induced apoptosis deletes bystander CD4(+) T cells: a mechanism for suppression of autoimmunity during BCG infection. J Autoimmun 24(2):93-100. PubMed: 15829401 MGI: J:97542
Okayama H; Saito M; Oue N; Weiss JM; Stauffer J; Takenoshita S; Wiltrout RH; Hussain SP; Harris CC. 2013. NOS2 enhances KRAS-induced lung carcinogenesis, inflammation and microRNA-21 expression. Int J Cancer 132(1):9-18. PubMed: 22618808 MGI: J:191775
Olson N; Greul AK; Hristova M; Bove PF; Kasahara DI; van der Vliet A. 2009. Nitric oxide and airway epithelial barrier function: regulation of tight junction proteins and epithelial permeability. Arch Biochem Biophys 484(2):205-13. PubMed: 19100237 MGI: J:150975
Olson N; Kasahara DI; Hristova M; Bernstein R; Janssen-Heininger Y; van der Vliet A. 2011. Modulation of NF-kappaB and hypoxia-inducible factor--1 by S-nitrosoglutathione does not alter allergic airway inflammation in mice. Am J Respir Cell Mol Biol 44(6):813-23. PubMed: 20693401 MGI: J:185029
Ono K; Suzuki H; Sawada M. 2010. Delayed neural damage is induced by iNOS-expressing microglia in a brain injury model. Neurosci Lett 473(2):146-50. PubMed: 20178828 MGI: J:159909
Parathath SR; Gravanis I; Tsirka SE. 2007. Nitric oxide synthase isoforms undertake unique roles during excitotoxicity. Stroke 38(6):1938-45. PubMed: 17446423 MGI: J:150557
Parekh VV; Wu L; Olivares-Villagomez D; Wilson KT; Van Kaer L. 2013. Activated invariant NKT cells control central nervous system autoimmunity in a mechanism that involves myeloid-derived suppressor cells. J Immunol 190(5):1948-60. PubMed: 23345328 MGI: J:193488
Parent MA; Wilhelm LB; Kummer LW; Szaba FM; Mullarky IK; Smiley ST. 2006. Gamma interferon, tumor necrosis factor alpha, and nitric oxide synthase 2, key elements of cellular immunity, perform critical protective functions during humoral defense against lethal pulmonary Yersinia pestis infection. Infect Immun 74(6):3381-6. PubMed: 16714568 MGI: J:109236
Park KM; Byun JY; Kramers C; Kim JI; Huang PL; Bonventre JV. 2003. Inducible nitric-oxide synthase is an important contributor to prolonged protective effects of ischemic preconditioning in the mouse kidney. J Biol Chem 278(29):27256-66. PubMed: 12682064 MGI: J:120673
Park KM; Kim JI; Ahn Y; Bonventre AJ; Bonventre JV. 2004. Testosterone is responsible for enhanced susceptibility of males to ischemic renal injury. J Biol Chem 279(50):52282-92. PubMed: 15358759 MGI: J:95182
Park YH; Shin HJ; Kim SU; Kim JM; Kim JH; Bang DH; Chang KT; Kim BY; Yu DY. 2013. iNOS promotes HBx-induced hepatocellular carcinoma via upregulation of JNK activation. Biochem Biophys Res Commun 435(2):244-9. PubMed: 23643810 MGI: J:201929
Pascual O; Ben Achour S; Rostaing P; Triller A; Bessis A. 2012. Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission. Proc Natl Acad Sci U S A 109(4):E197-205. PubMed: 22167804 MGI: J:180137
Pearl JE; Torrado E; Tighe M; Fountain JJ; Solache A; Strutt T; Swain S; Appelberg R; Cooper AM. 2012. Nitric oxide inhibits the accumulation of CD4(+) CD44(hi) Tbet(+) CD69(lo) T cells in mycobacterial infection. Eur J Immunol 42(12):3267-79. PubMed: 22890814 MGI: J:190236
Peng X; Abdulnour RE; Sammani S; Ma SF; Han EJ; Hasan EJ; Tuder R; Garcia JG; Hassoun PM. 2005. Inducible nitric oxide synthase contributes to ventilator-induced lung injury. Am J Respir Crit Care Med 172(4):470-9. PubMed: 15937288 MGI: J:114335
Perreault M; Marette A. 2001. Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med 7(10):1138-43. PubMed: 11590438 MGI: J:72215
Peshes-Yaloz N; Rosen D; Sondel PM; Krammer PH; Berke G. 2007. Up-regulation of Fas (CD95) expression in tumour cells in vivo. Immunology 120(4):502-11. PubMed: 17343612 MGI: J:122702
Pol O; Sasaki M; Jimenez N; Dawson VL; Dawson TM; Puig MM. 2005. The involvement of nitric oxide in the enhanced expression of mu-opioid receptors during intestinal inflammation in mice. Br J Pharmacol 145(6):758-66. PubMed: 15852037 MGI: J:114344
Poljakovic M; Persson K. 2003. Urinary tract infection in iNOS-deficient mice with focus on bacterial sensitivity to nitric oxide. Am J Physiol Renal Physiol 284(1):F22-31. PubMed: 12494944 MGI: J:127929
Ponnuswamy P; Ostermeier E; Schrottle A; Chen J; Huang PL; Ertl G; Nieswandt B; Kuhlencordt PJ. 2009. Oxidative stress and compartment of gene expression determine proatherosclerotic effects of inducible nitric oxide synthase. Am J Pathol 174(6):2400-10. PubMed: 19465644 MGI: J:148912
Ponnuswamy P; Schrottle A; Ostermeier E; Gruner S; Huang PL; Ertl G; Hoffmann U; Nieswandt B; Kuhlencordt PJ. 2012. eNOS protects from atherosclerosis despite relevant superoxide production by the enzyme in apoE mice. PLoS One 7(1):e30193. PubMed: 22291917 MGI: J:224062
Portillo JA; Feliciano LM; Okenka G; Heinzel F; Subauste MC; Subauste CS. 2012. CD40 and tumour necrosis factor-alpha co-operate to up-regulate inducuble nitric oxide synthase expression in macrophages. Immunology 135(2):140-50. PubMed: 22044243 MGI: J:181390
Prajeeth CK; Haeberlein S; Sebald H; Schleicher U; Bogdan C. 2011. Leishmania-infected macrophages are targets of NK cell-derived cytokines but not of NK cell cytotoxicity. Infect Immun 79(7):2699-708. PubMed: 21518784 MGI: J:173486
Predescu D; Predescu S; Shimizu J; Miyawaki-Shimizu K; Malik AB. 2005. Constitutive eNOS-derived nitric oxide is a determinant of endothelial junctional integrity. Am J Physiol Lung Cell Mol Physiol 289(3):L371-81. PubMed: 16093363 MGI: J:115733
Pullamsetti SS; Savai R; Dumitrascu R; Dahal BK; Wilhelm J; Konigshoff M; Zakrzewicz D; Ghofrani HA; Weissmann N; Eickelberg O; Guenther A; Leiper J; Seeger W; Grimminger F; Schermuly RT. 2011. The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis. Sci Transl Med 3(87):87ra53. PubMed: 21677199 MGI: J:173535
Qiu H; Kuolee R; Harris G; Chen W. 2009. Role of NADPH phagocyte oxidase in host defense against acute respiratory Acinetobacter baumannii infection in mice. Infect Immun 77(3):1015-21. PubMed: 19103777 MGI: J:145717
Raghuvanshi S; Sharma P; Singh S; Van Kaer L; Das G. 2010. Mycobacterium tuberculosis evades host immunity by recruiting mesenchymal stem cells. Proc Natl Acad Sci U S A :. PubMed: 21135221 MGI: J:167304
Reece ST; Loddenkemper C; Askew DJ; Zedler U; Schommer-Leitner S; Stein M; Mir FA; Dorhoi A; Mollenkopf HJ; Silverman GA; Kaufmann SH. 2010. Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice. J Clin Invest 120(9):3365-76. PubMed: 20679732 MGI: J:165286
Reho JJ; Zheng X; Asico LD; Fisher SA. 2015. Redox signaling and splicing dependent change in myosin phosphatase underlie early versus late changes in NO vasodilator reserve in a mouse LPS model of sepsis. Am J Physiol Heart Circ Physiol 308(9):H1039-50. PubMed: 25724497 MGI: J:222122
Ren G; Su J; Zhao X; Zhang L; Zhang J; Roberts AI; Zhang H; Das G; Shi Y. 2008. Apoptotic cells induce immunosuppression through dendritic cells: critical roles of IFN-gamma and nitric oxide. J Immunol 181(5):3277-84. PubMed: 18713999 MGI: J:138951
Reynolds CM; Suliman HB; Hollingsworth JW; Welty-Wolf KE; Carraway MS; Piantadosi CA. 2009. Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia. Free Radic Biol Med 46(5):564-72. PubMed: 19073249 MGI: J:145176
Ridnour LA; Dhanapal S; Hoos M; Wilson J; Lee J; Cheng RY; Brueggemann EE; Hines HB; Wilcock DM; Vitek MP; Wink DA; Colton CA. 2012. Nitric oxide-mediated regulation of beta-amyloid clearance via alterations of MMP-9/TIMP-1. J Neurochem 123(5):736-49. PubMed: 23016931 MGI: J:190735
Rigamonti E; Touvier T; Clementi E; Manfredi AA; Brunelli S; Rovere-Querini P. 2013. Requirement of inducible nitric oxide synthase for skeletal muscle regeneration after acute damage. J Immunol 190(4):1767-77. PubMed: 23335752 MGI: J:193495
Rivera J; Mukherjee J; Weiss LM; Casadevall A. 2002. Antibody Efficacy in Murine Pulmonary Cryptococcus neoformans Infection: A Role for Nitric Oxide. J Immunol 168(7):3419-27. PubMed: 11907100 MGI: J:75578
Rocha FJ; Schleicher U; Mattner J; Alber G; Bogdan C. 2007. Cytokines, signaling pathways, and effector molecules required for the control of Leishmania (Viannia) braziliensis in mice. Infect Immun 75(8):3823-32. PubMed: 17517868 MGI: J:123377
Ropelle ER; Pauli JR; Cintra DE; da Silva AS; De Souza CT; Guadagnini D; Carvalho BM; Caricilli AM; Katashima CK; Carvalho-Filho MA; Hirabara S; Curi R; Velloso LA; Saad MJ; Carvalheira JB. 2013. Targeted disruption of inducible nitric oxide synthase protects against aging, S-nitrosation, and insulin resistance in muscle of male mice. Diabetes 62(2):466-70. PubMed: 22991447 MGI: J:208474
Rosypal AC; Lindsay DS; Duncan R Jr; Ahmed SA; Zajac AM; Dubey JP. 2002. Mice lacking the gene for inducible or endothelial nitric oxide are resistant to sporocyst induced Sarcocystis neurona infections. Vet Parasitol 103(4):315-21. PubMed: 11777610 MGI: J:106322
Rothfuchs AG; Gigliotti D; Palmblad K; Andersson U; Wigzell H; Rottenberg ME. 2001. IFN-alphabeta-dependent, IFN-gamma secretion by bone marrow-derived macrophages controls an intracellular bacterial infection. J Immunol 167(11):6453-61. PubMed: 11714812 MGI: J:72825
Rottenberg ME; Gigliotti Rothfuchs AC; Gigliotti D; Svanholm C; Bandholtz L; Wigzell H. 1999. Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice. J Immunol 162(5):2829-36. PubMed: 10072530 MGI: J:124536
Rudkowski JC; Barreiro E; Harfouche R; Goldberg P; Kishta O; D'Orleans-Juste P; Labonte J; Lesur O; Hussain SN. 2004. Roles of iNOS and nNOS in sepsis-induced pulmonary apoptosis. Am J Physiol Lung Cell Mol Physiol 286(4):L793-800. PubMed: 14660484 MGI: J:108149
Russell MS; Dudani R; Krishnan L; Sad S. 2009. IFN-gamma expressed by T cells regulates the persistence of antigen presentation by limiting the survival of dendritic cells. J Immunol 183(12):7710-8. PubMed: 19923462 MGI: J:157498
Saini AS; Shenoy GN; Rath S; Bal V; George A. 2014. Inducible nitric oxide synthase is a major intermediate in signaling pathways for the survival of plasma cells. Nat Immunol 15(3):275-82. PubMed: 24441790 MGI: J:209367
Sam F; Sawyer DB; Xie Z; Chang DL; Ngoy S; Brenner DA; Siwik DA; Singh K; Apstein CS; Colucci WS. 2001. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. Circ Res 89(4):351-6. PubMed: 11509452 MGI: J:115413
Saraswathy S; Nguyen AM; Rao NA. 2010. The role of TLR4 in photoreceptor {alpha}a crystallin upregulation during early experimental autoimmune uveitis. Invest Ophthalmol Vis Sci 51(7):3680-6. PubMed: 20207969 MGI: J:164096
Sato K; Ozaki K; Oh I; Meguro A; Hatanaka K; Nagai T; Muroi K; Ozawa K. 2007. Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood 109(1):228-34. PubMed: 16985180 MGI: J:142176
Scallan JP; Davis MJ. 2013. Genetic removal of basal nitric oxide enhances contractile activity in isolated murine collecting lymphatic vessels. J Physiol 591(Pt 8):2139-56. PubMed: 23420659 MGI: J:208101
Scanga CA; Mohan VP; Tanaka K; Alland D; Flynn JL; Chan J. 2001. The Inducible Nitric Oxide Synthase Locus Confers Protection against Aerogenic Challenge of Both Clinical and Laboratory Strains of Mycobacterium tuberculosis in Mice. Infect Immun 69(12):7711-7. PubMed: 11705952 MGI: J:73135
Schleicher U; Paduch K; Debus A; Obermeyer S; Konig T; Kling JC; Ribechini E; Dudziak D; Mougiakakos D; Murray PJ; Ostuni R; Korner H; Bogdan C. 2016. TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection. Cell Rep 15(5):1062-75. PubMed: 27117406 MGI: J:235391
Scott DJ; Hull MA; Cartwright EJ; Lam WK; Tisbury A; Poulsom R; Markham AF; Bonifer C; Coletta PL. 2001. Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the apc(min/+) mouse. Gastroenterology 121(4):889-99. PubMed: 11606502 MGI: J:72030
Seimetz M; Parajuli N; Pichl A; Veit F; Kwapiszewska G; Weisel FC; Milger K; Egemnazarov B; Turowska A; Fuchs B; Nikam S; Roth M; Sydykov A; Medebach T; Klepetko W; Jaksch P; Dumitrascu R; Garn H; Voswinckel R; Kostin S; Seeger W; Schermuly RT; Grimminger F; Ghofrani HA; Weissmann N. 2011. Inducible NOS Inhibition Reverses Tobacco-Smoke-Induced Emphysema and Pulmonary Hypertension in Mice. Cell 147(2):293-305. PubMed: 22000010 MGI: J:177505
Sercan O; Hammerling GJ; Arnold B; Schuler T. 2006. Innate immune cells contribute to the IFN-gamma-dependent regulation of antigen-specific CD8+ T cell homeostasis. J Immunol 176(2):735-9. PubMed: 16393956 MGI: J:126599
Seril DN; Liao J; Yang GY. 2007. Colorectal carcinoma development in inducible nitric oxide synthase-deficient mice with dextran sulfate sodium-induced ulcerative colitis. Mol Carcinog 46(5):341-53. PubMed: 17219424 MGI: J:121634
Shesely EG; Gilbert C; Granderson G; Carretero CD; Carretero OA; Beierwaltes WH. 2001. Nitric oxide synthase gene knockout mice do not become hypertensive during pregnancy. Am J Obstet Gynecol 185(5):1198-203. PubMed: 11717657 MGI: J:117212
Shesely EG; Maeda N; Kim HS; Desai KM; Krege JH; Laubach VE; Sherman PA; Sessa WC; Smithies O. 1996. Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci U S A 93(23):13176-81. PubMed: 8917564 MGI: J:36559
Shie FS; Montine KS; Breyer RM; Montine TJ. 2005. Microglial EP2 is critical to neurotoxicity from activated cerebral innate immunity. Glia 52(1):70-7. PubMed: 15920732 MGI: J:156154
Shimazu T; Otani H; Yoshioka K; Fujita M; Okazaki T; Iwasaka T. 2011. Sepiapterin enhances angiogenesis and functional recovery in mice after myocardial infarction. Am J Physiol Heart Circ Physiol 301(5):H2061-72. PubMed: 21890687 MGI: J:178332
Shin HJ; Park YH; Kim SU; Moon HB; Park do S; Han YH; Lee CH; Lee DS; Song IS; Lee DH; Kim M; Kim NS; Kim DG; Kim JM; Kim SK; Kim YN; Kim SS; Choi CS; Kim YB; Yu DY. 2011. Hepatitis B virus X protein regulates hepatic glucose homeostasis via activation of inducible nitric oxide synthase. J Biol Chem 286(34):29872-81. PubMed: 21690090 MGI: J:176632
Simmons CP; Goncalves NS; Ghaem-Maghami M; Bajaj-Elliott M; Clare S; Neves B; Frankel G; Dougan G; MacDonald TT. 2002. Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma. J Immunol 168(4):1804-12. PubMed: 11823513 MGI: J:74480
Somers JR; Beck PL; Lees-Miller JP; Roach D; Li Y; Guo J; Loken S; Zhan S; Semeniuk L; Duff HJ. 2008. iNOS in cardiac myocytes plays a critical role in death in a murine model of hypertrophy induced by calcineurin. Am J Physiol Heart Circ Physiol 295(3):H1122-H1131. PubMed: 18621856 MGI: J:141285
Speyer CL; Neff TA; Warner RL; Guo RF; Sarma JV; Riedemann NC; Murphy ME; Murphy HS; Ward PA. 2003. Regulatory effects of iNOS on acute lung inflammatory responses in mice. Am J Pathol 163(6):2319-28. PubMed: 14633605 MGI: J:86598
Spohr F; Cornelissen AJ; Busch C; Gebhard MM; Motsch J; Martin EO; Weimann J. 2005. Role of endogenous nitric oxide in endotoxin-induced alteration of hypoxic pulmonary vasoconstriction in mice. Am J Physiol Heart Circ Physiol 289(2):H823-31. PubMed: 15778287 MGI: J:100323
Stadler K; Bonini MG; Dallas S; Duma D; Mason RP; Kadiiska MB. 2008. Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis. Am J Physiol Endocrinol Metab 295(2):E456-62. PubMed: 18559982 MGI: J:139996
Steed MM; Tyagi N; Sen U; Schuschke DA; Joshua IG; Tyagi SC. 2010. Functional consequences of the collagen/elastin switch in vascular remodeling in hyperhomocysteinemic wild-type, eNOS-/-, and iNOS-/- mice. Am J Physiol Lung Cell Mol Physiol 299(3):L301-11. PubMed: 20581102 MGI: J:164613
Streifel KM; Moreno JA; Hanneman WH; Legare ME; Tjalkens RB. 2012. Gene deletion of nos2 protects against manganese-induced neurological dysfunction in juvenile mice. Toxicol Sci 126(1):183-92. PubMed: 22174044 MGI: J:183641
Strobl B; Bubic I; Bruns U; Steinborn R; Lajko R; Kolbe T; Karaghiosoff M; Kalinke U; Jonjic S; Muller M. 2005. Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus. J Immunol 175(6):4000-8. PubMed: 16148148 MGI: J:116703
Sugimura Y; Murase T; Oyama K; Uchida A; Sato N; Hayasaka S; Kano Y; Takagishi Y; Hayashi Y; Oiso Y; Murata Y. 2009. Prevention of neural tube defects by loss of function of inducible nitric oxide synthase in fetuses of a mouse model of streptozotocin-induced diabetes. Diabetologia 52(5):962-71. PubMed: 19283362 MGI: J:148113
Sugita H; Fujimoto M; Yasukawa T; Shimizu N; Sugita M; Yasuhara S; Martyn JA; Kaneki M. 2005. Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells. J Biol Chem 280(14):14203-11. PubMed: 15805118 MGI: J:98746
Suliman HB; Babiker A; Withers CM; Sweeney TE; Carraway MS; Tatro LG; Bartz RR; Welty-Wolf KE; Piantadosi CA. 2010. Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice. Free Radic Biol Med 48(5):736-46. PubMed: 20043987 MGI: J:157083
Sun K; Gan Y; Metzger DW. 2011. Analysis of murine genetic predisposition to pneumococcal infection reveals a critical role of alveolar macrophages in maintaining the sterility of the lower respiratory tract. Infect Immun 79(5):1842-7. PubMed: 21321074 MGI: J:171962
Sunil VR; Shen J; Patel-Vayas K; Gow AJ; Laskin JD; Laskin DL. 2012. Role of reactive nitrogen species generated via inducible nitric oxide synthase in vesicant-induced lung injury, inflammation and altered lung functioning. Toxicol Appl Pharmacol 261(1):22-30. PubMed: 22446026 MGI: J:186088
Suvorava T; Stegbauer J; Thieme M; Pick S; Friedrich S; Rump LC; Hohlfeld T; Kojda G. 2015. Sustained hypertension despite endothelial-specific eNOS rescue in eNOS-deficient mice. Biochem Biophys Res Commun 458(3):576-83. PubMed: 25680465 MGI: J:220487
Tangpong J; Sompol P; Vore M; St Clair W; Butterfield DA; St Clair DK. 2008. Tumor necrosis factor alpha-mediated nitric oxide production enhances manganese superoxide dismutase nitration and mitochondrial dysfunction in primary neurons: an insight into the role of glial cells. Neuroscience 151(2):622-9. PubMed: 18160224 MGI: J:130957
Tanioka T; Tamura Y; Fukaya M; Shinozaki S; Mao J; Kim M; Shimizu N; Kitamura T; Kaneki M. 2011. Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta. J Biol Chem 286(33):29388-96. PubMed: 21700708 MGI: J:175918
Tao F; Tao YX; Mao P; Zhao C; Li D; Liaw WJ; Raja SN; Johns RA. 2003. Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase. Neuroscience 120(3):847-54. PubMed: 12895524 MGI: J:126175
Tarin C; Lavin B; Gomez M; Saura M; Diez-Juan A; Zaragoza C. 2011. The extracellular matrix metalloproteinase inducer EMMPRIN is a target of nitric oxide in myocardial ischemia/reperfusion. Free Radic Biol Med 51(2):387-95. PubMed: 21570464 MGI: J:174100
Tatemichi M; Ogura T; Sakurazawa N; Nagata H; Sugita M; Esumi H. 2003. Roles of inducible nitric oxide synthase in the development and healing of experimentally induced gastric ulcers. Int J Exp Pathol 84(5):213-20. PubMed: 14690480 MGI: J:87317
Tavener SA; Kubes P. 2006. Cellular and molecular mechanisms underlying LPS-associated myocyte impairment. Am J Physiol Heart Circ Physiol 290(2):H800-6. PubMed: 16172157 MGI: J:106721
TeKippe M; Harrison DE; Chen J. 2003. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. Exp Hematol 31(6):521-7. PubMed: 12829028 MGI: J:115677
Theodorakis NG; Wang YN; Skill NJ; Metz MA; Cahill PA; Redmond EM; Sitzmann JV. 2003. The role of nitric oxide synthase isoforms in extrahepatic portal hypertension: studies in gene-knockout mice. Gastroenterology 124(5):1500-8. PubMed: 12730888 MGI: J:107756
Thoeni G; Stoitzner P; Brandacher G; Romani N; Heufler C; Werner-Felmayer G; Werner ER. 2005. Tetrahydro-4-aminobiopterin attenuates dendritic cell-induced T cell priming independently from inducible nitric oxide synthase. J Immunol 174(12):7584-91. PubMed: 15944258 MGI: J:100788
Tranguch S; Huet-Hudson Y. 2003. Decreased viability of nitric oxide synthase double knockout mice. Mol Reprod Dev 65(2):175-9. PubMed: 12704728 MGI: J:83112
Tsui AK; Marsden PA; Mazer CD; Adamson SL; Henkelman RM; Ho JJ; Wilson DF; Heximer SP; Connelly KA; Bolz SS; Lidington D; El-Beheiry MH; Dattani ND; Chen KM; Hare GM. 2011. Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia. Proc Natl Acad Sci U S A 108(42):17544-9. PubMed: 21976486 MGI: J:177441
Uemura T; Stringer DE; Blohm-Mangone KA; Gerner EW. 2010. Polyamine transport is mediated by both endocytic and solute carrier transport mechanisms in the gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol 299(2):G517-22. PubMed: 20522643 MGI: J:163345
Ullrich R; Bloch KD; Ichinose F; Steudel W; Zapol WM. 1999. Hypoxic pulmonary blood flow redistribution and arterial oxygenation in endotoxin-challenged NOS2-deficient mice. J Clin Invest 104(10):1421-9. PubMed: 10562304 MGI: J:58501
Uppington H; Menager N; Boross P; Wood J; Sheppard M; Verbeek S; Mastroeni P. 2006. Effect of immune serum and role of individual Fcgamma receptors on the intracellular distribution and survival of Salmonella enterica serovar Typhimurium in murine macrophages. Immunology 119(2):147-58. PubMed: 16836651 MGI: J:118526
Van den Bossche J; Baardman J; Otto NA; van der Velden S; Neele AE; van den Berg SM; Luque-Martin R; Chen HJ; Boshuizen MC; Ahmed M; Hoeksema MA; de Vos AF; de Winther MP. 2016. Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages. Cell Rep 17(3):684-696. PubMed: 27732846 MGI: J:240771
Vareniuk I; Pavlov IA; Obrosova IG. 2008. Inducible nitric oxide synthase gene deficiency counteracts multiple manifestations of peripheral neuropathy in a streptozotocin-induced mouse model of diabetes. Diabetologia 51(11):2126-33. PubMed: 18802679 MGI: J:142727
Velez CD; Lewis CJ; Kasper DL; Cobb BA. 2009. Type I Streptococcus pneumoniae carbohydrate utilizes a nitric oxide and MHC II-dependent pathway for antigen presentation. Immunology 127(1):73-82. PubMed: 18778282 MGI: J:155663
Vig M; Srivastava S; Kandpal U; Sade H; Lewis V; Sarin A; George A; Bal V; Durdik JM; Rath S. 2004. Inducible nitric oxide synthase in T cells regulates T cell death and immune memory. J Clin Invest 113(12):1734-42. PubMed: 15199408 MGI: J:90903
Villalta SA; Nguyen HX; Deng B; Gotoh T; Tidball JG. 2009. Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy. Hum Mol Genet 18(3):482-96. PubMed: 18996917 MGI: J:143545
Vishwakarma V; Pati NB; Chandel HS; Sahoo SS; Saha B; Suar M. 2012. Evaluation of Salmonella enterica serovar Typhimurium TTSS-2 deficient fur mutant as safe live-attenuated vaccine candidate for immunocompromised mice. PLoS One 7(12):e52043. PubMed: 23284865 MGI: J:195626
Vissers YL; Hallemeesch MM; Soeters PB; Lamers WH; Deutz NE. 2004. NOS2 deficiency increases intestinal metabolism both in nonstimulated and endotoxemic mice. Am J Physiol Gastrointest Liver Physiol 286(5):G747-51. PubMed: 14656712 MGI: J:95679
Wang L; Mehta S; Gillis C; Law C; Taneja R. 2010. Modulation of neutrophil apoptosis by murine pulmonary microvascular endothelial cell inducible nitric oxide synthase. Biochem Biophys Res Commun 401(2):207-12. PubMed: 20833133 MGI: J:165852
Wang LF; Mehta S; Weicker S; Scott JA; Joseph M; Razavi HM; McCormack DG. 2001. Relative contribution of hemopoietic and pulmonary parenchymal cells to lung inducible nitric oxide synthase (inos) activity in murine endotoxemia. Biochem Biophys Res Commun 283(3):694-9. PubMed: 11341781 MGI: J:114281
Wang T. 2002. Role of iNOS and eNOS in modulating proximal tubule transport and acid-base balance. Am J Physiol Renal Physiol 283(4):F658-62. PubMed: 12217856 MGI: J:113614
Wang T; Inglis FM; Kalb RG. 2000. Defective fluid and HCO(3)(-) absorption in proximal tubule of neuronal nitric oxide synthase-knockout mice. Am J Physiol Renal Physiol 279(3):F518-24. PubMed: 10966931 MGI: J:64896
Watanuki M; Sakai A; Sakata T; Tsurukami H; Miwa M; Uchida Y; Watanabe K; Ikeda K; Nakamura T. 2002. Role of inducible nitric oxide synthase in skeletal adaptation to acute increases in mechanical loading. J Bone Miner Res 17(6):1015-25. PubMed: 12054156 MGI: J:112399
Weberpals M; Hermes M; Hermann S; Kummer MP; Terwel D; Semmler A; Berger M; Schafers M; Heneka MT. 2009. NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits. J Neurosci 29(45):14177-84. PubMed: 19906966 MGI: J:154742
Wei W; Li B; Hanes MA; Kakar S; Chen X; Liu L. 2010. S-nitrosylation from GSNOR deficiency impairs DNA repair and promotes hepatocarcinogenesis. Sci Transl Med 2(19):19ra13. PubMed: 20371487 MGI: J:167883
Wei W; Yang Z; Tang CH; Liu L. 2011. Targeted deletion of GSNOR in hepatocytes of mice causes nitrosative inactivation of O6-alkylguanine-DNA alkyltransferase and increased sensitivity to genotoxic diethylnitrosamine. Carcinogenesis 32(7):973-7. PubMed: 21385828 MGI: J:173666
White JK; Mastroeni P; Popoff JF; Evans CA; Blackwell JM. 2005. Slc11a1-mediated resistance to Salmonella enterica serovar Typhimurium and Leishmania donovani infections does not require functional inducible nitric oxide synthase or phagocyte oxidase activity. J Leukoc Biol 77(3):311-20. PubMed: 15601666 MGI: J:97453
Whiteus C; Freitas C; Grutzendler J. 2014. Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period. Nature 505(7483):407-11. PubMed: 24305053 MGI: J:207919
Wiese M; Gerlach RG; Popp I; Matuszak J; Mahapatro M; Castiglione K; Chakravortty D; Willam C; Hensel M; Bogdan C; Jantsch J. 2012. Hypoxia-mediated impairment of the mitochondrial respiratory chain inhibits the bactericidal activity of macrophages. Infect Immun 80(4):1455-66. PubMed: 22252868 MGI: J:182549
Wilcock DM; Gharkholonarehe N; Van Nostrand WE; Davis J; Vitek MP; Colton CA. 2009. Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. J Neurosci 29(25):7957-65. PubMed: 19553436 MGI: J:150418
Wilcock DM; Lewis MR; Van Nostrand WE; Davis J; Previti ML; Gharkholonarehe N; Vitek MP; Colton CA. 2008. Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. J Neurosci 28(7):1537-45. PubMed: 18272675 MGI: J:132221
Wilcock DM; Vitek MP; Colton CA. 2009. Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease. Neuroscience 159(3):1055-69. PubMed: 19356689 MGI: J:148938
Winter SE; Winter MG; Xavier MN; Thiennimitr P; Poon V; Keestra AM; Laughlin RC; Gomez G; Wu J; Lawhon SD; Popova IE; Parikh SJ; Adams LG; Tsolis RM; Stewart VJ; Baumler AJ. 2013. Host-derived nitrate boosts growth of E. coli in the inflamed gut. Science 339(6120):708-11. PubMed: 23393266 MGI: J:193601
Wipke BT; Allen PM. 2001. Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis. J Immunol 167(3):1601-8. PubMed: 11466382 MGI: J:120467
Wood KC; Hebbel RP; Lefer DJ; Granger DN. 2006. Critical role of endothelial cell-derived nitric oxide synthase in sickle cell disease-induced microvascular dysfunction. Free Radic Biol Med 40(8):1443-53. PubMed: 16631534 MGI: J:108238
Wu D; Xu C; Cederbaum A. 2009. Role of nitric oxide and nuclear factor-kappaB in the CYP2E1 potentiation of tumor necrosis factor alpha hepatotoxicity in mice. Free Radic Biol Med 46(4):480-91. PubMed: 19063961 MGI: J:145179
Wuthrich M; Filutowicz HI; Warner T; Klein BS. 2002. Requisite elements in vaccine immunity to Blastomyces dermatitidis: plasticity uncovers vaccine potential in immune-deficient hosts. J Immunol 169(12):6969-76. PubMed: 12471131 MGI: J:118419
Xi L; Jarrett NC; Hess ML; Kukreja RC. 1999. Myocardial ischemia/reperfusion injury in the inducible nitric oxide synthase knockout mice. Life Sci 65(9):935-45. PubMed: 10465353 MGI: J:57432
Xi L; Jarrett NC; Hess ML; Kukreja RC. 1999. Essential role of inducible nitric oxide synthase in monophosphoryl lipid A-induced late cardioprotection: evidence from pharmacological inhibition and gene knockout mice. Circulation 99(16):2157-63. PubMed: 10217657 MGI: J:54841
Xu G; Zhang Y; Zhang L; Ren G; Shi Y. 2008. Bone marrow stromal cells induce apoptosis of lymphoma cells in the presence of IFNgamma and TNF by producing nitric oxide. Biochem Biophys Res Commun 375(4):666-70. PubMed: 18755151 MGI: J:140996
Xu W; Xin L; Soong L; Zhang K. 2011. Sphingolipid degradation by Leishmania major is required for its resistance to acidic pH in the mammalian host. Infect Immun 79(8):3377-87. PubMed: 21576322 MGI: J:175272
Yan BS; Pichugin AV; Jobe O; Helming L; Eruslanov EB; Gutierrez-Pabello JA; Rojas M; Shebzukhov YV; Kobzik L; Kramnik I. 2007. Progression of pulmonary tuberculosis and efficiency of bacillus Calmette-Guerin vaccination are genetically controlled via a common sst1-mediated mechanism of innate immunity. J Immunol 179(10):6919-32. PubMed: 17982083 MGI: J:154010
Yang JZ; Ajonuma LC; Rowlands DK; Tsang LL; Ho LS; Lam SY; Chen WY; Zhou CX; Chung YW; Cho CY; Tse JY; James AE; Chan HC. 2005. The role of inducible nitric oxide synthase in gamete interaction and fertilization: a comparative study on knockout mice of three NOS isoforms. Cell Biol Int 29(9):785-91. PubMed: 16087361 MGI: J:112824
Yang L; Calay ES; Fan J; Arduini A; Kunz RC; Gygi SP; Yalcin A; Fu S; Hotamisligil GS. 2015. METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction. Science 349(6247):500-6. PubMed: 26228140 MGI: J:226327
Yang S; Porter VA; Cornfield DN; Milla C; Panoskaltsis-Mortari A; Blazar BR; Haddad IY. 2001. Effects of oxidant stress on inflammation and survival of iNOS knockout mice after marrow transplantation. Am J Physiol Lung Cell Mol Physiol 281(4):L922-30. PubMed: 11557596 MGI: J:72096
Yang Z; Huang YC; Koziel H; de Crom R; Ruetten H; Wohlfart P; Thomsen RW; Kahlert JA; Sorensen HT; Jozefowski S; Colby A; Kobzik L. 2014. Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target. Elife 3:. PubMed: 25317947 MGI: J:218028
Yang Z; Wang ZE; Doulias PT; Wei W; Ischiropoulos H; Locksley RM; Liu L. 2010. Lymphocyte Development Requires S-nitrosoglutathione Reductase. J Immunol 185(11):6664-9. PubMed: 20980633 MGI: J:166150
Yerushalmi HF; Besselsen DG; Ignatenko NA; Blohm-Mangone KA; Padilla-Torres JL; Stringer DE; Cui H; Holubec H; Payne CM; Gerner EW. 2006. The role of NO synthases in arginine-dependent small intestinal and colonic carcinogenesis. Mol Carcinog 45(2):93-105. PubMed: 16329147 MGI: J:107079
Yook YH; Kang KH; Maeng O; Kim TR; Lee JO; Kang KI; Kim YS; Paik SG; Lee H. 2004. Nitric oxide induces BNIP3 expression that causes cell death in macrophages. Biochem Biophys Res Commun 321(2):298-305. PubMed: 15358175 MGI: J:91305
Zaki MH; Fujii S; Okamoto T; Islam S; Khan S; Ahmed KA; Sawa T; Akaike T. 2009. Cytoprotective function of heme oxygenase 1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis. J Immunol 182(6):3746-56. PubMed: 19265153 MGI: J:145919
Zaragoza C; Lopez-Rivera E; Garcia-Rama C; Saura M; Martinez-Ruiz A; Lizarbe TR; Martin-de-Lara F; Lamas S. 2006. Cbfa-1 mediates nitric oxide regulation of MMP-13 in osteoblasts. J Cell Sci 119(Pt 9):1896-902. PubMed: 16636074 MGI: J:108930
Zaragoza C; Ocampo CJ; Saura M; Bao C; Leppo M; Lafond-Walker A; Thiemann DR; Hruban R; Lowenstein CJ. 1999. Inducible nitric oxide synthase protection against coxsackievirus pancreatitis. J Immunol 163(10):5497-504. PubMed: 10553076 MGI: J:58451
Zeidler PC; Millecchia LM; Castranova V. 2004. Role of inducible nitric oxide synthase-derived nitric oxide in lipopolysaccharide plus interferon-gamma-induced pulmonary inflammation. Toxicol Appl Pharmacol 195(1):45-54. PubMed: 14962504 MGI: J:87978
Zelickson BR; Benavides GA; Johnson MS; Chacko BK; Venkatraman A; Landar A; Betancourt AM; Bailey SM; Darley-Usmar VM. 2011. Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes. Biochim Biophys Acta 1807(12):1573-82. PubMed: 21971515 MGI: J:180333
Zell JA; Ignatenko NA; Yerushalmi HF; Ziogas A; Besselsen DG; Gerner EW; Anton-Culver H. 2007. Risk and risk reduction involving arginine intake and meat consumption in colorectal tumorigenesis and survival. Int J Cancer 120(3):459-68. PubMed: 17096347 MGI: J:117825
Zhang P; Xu X; Hu X; van Deel ED; Zhu G; Chen Y. 2007. Inducible nitric oxide synthase deficiency protects the heart from systolic overload-induced ventricular hypertrophy and congestive heart failure. Circ Res 100(7):1089-98. PubMed: 17363700 MGI: J:133913
Zhao T; Xi L; Chelliah J; Levasseur JE; Kukreja RC. 2000. Inducible nitric oxide synthase mediates delayed myocardial protection induced by activation of adenosine A(1) receptors: evidence from gene-knockout mice. Circulation 102(8):902-7. PubMed: 10952960 MGI: J:103302
Zhao TC; Zhang L; Liu JT; Guo TL. 2012. Disruption of Nox2 and TNFRp55/p75 eliminates cardioprotection induced by anisomycin. Am J Physiol Heart Circ Physiol 303(10):H1263-72. PubMed: 22982779 MGI: J:191277
Zhao Y; Ferguson DJ; Wilson DC; Howard JC; Sibley LD; Yap GS. 2009. Virulent Toxoplasma gondii evade immunity-related GTPase-mediated parasite vacuole disruption within primed macrophages. J Immunol 182(6):3775-81. PubMed: 19265156 MGI: J:145916
Zhou J; Dehne N; Brune B. 2009. Nitric oxide causes macrophage migration via the HIF-1-stimulated small GTPases Cdc42 and Rac1. Free Radic Biol Med 47(6):741-9. PubMed: 19523512 MGI: J:152571
Zhou J; Tang PC; Qin L; Gayed PM; Li W; Skokos EA; Kyriakides TR; Pober JS; Tellides G. 2010. CXCR3-dependent accumulation and activation of perivascular macrophages is necessary for homeostatic arterial remodeling to hemodynamic stresses. J Exp Med 207(9):1951-66. PubMed: 20733031 MGI: J:165720
Zhu B; Bando Y; Xiao S; Yang K; Anderson AC; Kuchroo VK; Khoury SJ. 2007. CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis. J Immunol 179(8):5228-37. PubMed: 17911608 MGI: J:153031
Zhu B; Kennedy JK; Wang Y; Sandoval-Garcia C; Cao L; Xiao S; Wu C; Elyaman W; Khoury SJ. 2011. Plasticity of Ly-6C(hi) myeloid cells in T cell regulation. J Immunol 187(5):2418-32. PubMed: 21824867 MGI: J:179261
Zhu DY; Liu SH; Sun HS; Lu YM. 2003. Expression of inducible nitric oxide synthase after focal cerebral ischemia stimulates neurogenesis in the adult rodent dentate gyrus. J Neurosci 23(1):223-9. PubMed: 12514219 MGI: J:124823
Zhu X; Zhao H; Graveline AR; Buys ES; Schmidt U; Bloch KD; Rosenzweig A; Chao W. 2006. MyD88 and NOS2 are essential for toll-like receptor 4-mediated survival effect in cardiomyocytes. Am J Physiol Heart Circ Physiol 291(4):H1900-9. PubMed: 16648192 MGI: J:116319
Zingarelli B; Szabo C; Salzman AL. 1999. Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase. Gut 45(2):199-209. PubMed: 10403731 MGI: J:56980
Zoller EE; Lykens JE; Terrell CE; Aliberti J; Filipovich AH; Henson PM; Jordan MB. 2011. Hemophagocytosis causes a consumptive anemia of inflammation. J Exp Med 208(6):1203-14. PubMed: 21624938 MGI: J:176823
de Jonge WJ; Hallemeesch MM; Kwikkers KL; Ruijter JM; de Gier-de Vries C; van Roon MA; Meijer AJ; Marescau B; de Deyn PP; Deutz NE; Lamers WH. 2002. Overexpression of arginase I in enterocytes of transgenic mice elicits a selective arginine deficiency and affects skin, muscle, and lymphoid development. Am J Clin Nutr 76(1):128-40. PubMed: 12081826 MGI: J:80556
de Jonge WJ; Kwikkers KL; te Velde AA; van Deventer SJ; Nolte MA; Mebius RE; Ruijter JM; Lamers MC; Lamers WH. 2002. Arginine deficiency affects early B cell maturation and lymphoid organ development in transgenic mice. J Clin Invest 110(10):1539-48. PubMed: 12438451 MGI: J:80204
van Der Heyde HC; Gu Y; Zhang Q; Sun G; Grisham MB. 2000. Nitric oxide is neither necessary nor sufficient for resolution of plasmodium chabaudi malaria in mice J Immunol 165(6):3317-23. PubMed: 10975849 MGI: J:64564
van Rossum AM; Lysenko ES; Weiser JN. 2005. Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. Infect Immun 73(11):7718-26. PubMed: 16239576 MGI: J:104292
van der Heijden J; Bosman ES; Reynolds LA; Finlay BB. 2015. Direct measurement of oxidative and nitrosative stress dynamics in Salmonella inside macrophages. Proc Natl Acad Sci U S A 112(2):560-5. PubMed: 25548165 MGI: J:218822

Additional - Tg(Thy1-APPSwDutIowa)BWevn related

Burgess BL; McIsaac SA; Naus KE; Chan JY; Tansley GH; Yang J; Miao F; Ross CJ; van Eck M; Hayden MR; van Nostrand W; St George-Hyslop P; Westaway D; Wellington CL. 2006. Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma. Neurobiol Dis 24(1):114-27. PubMed: 16899370 MGI: J:113199
Carrasco J; Adlard P; Cotman C; Quintana A; Penkowa M; Xu F; Van Nostrand WE; Hidalgo J. 2006. Metallothionein-I and -III expression in animal models of Alzheimer disease. Neuroscience 143(4):911-22. PubMed: 17027170 MGI: J:117948
Chow N; Bell RD; Deane R; Streb JW; Chen J; Brooks A; Van Nostrand W; Miano JM; Zlokovic BV. 2007. Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype. Proc Natl Acad Sci U S A 104(3):823-8. PubMed: 17215356 MGI: J:119251
Davis J; Xu F; Deane R; Romanov G; Previti ML; Zeigler K; Zlokovic BV; Van Nostrand WE. 2004. Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. J Biol Chem 279(19):20296-306. PubMed: 14985348 MGI: J:89848
Davis J; Xu F; Miao J; Previti ML; Romanov G; Ziegler K; Van Nostrand WE. 2006. Deficient cerebral clearance of vasculotropic mutant Dutch/Iowa Double Ass in human AssPP transgenic mice. Neurobiol Aging 27(7):946-54. PubMed: 16105708 MGI: J:108851
Dhurandhar EJ; Allison DB; van Groen T; Kadish I. 2013. Hunger in the absence of caloric restriction improves cognition and attenuates Alzheimer's disease pathology in a mouse model. PLoS One 8(4):e60437. PubMed: 23565247 MGI: J:200150
Fan R; Defilippis K; Van Nostrand WE. 2007. Induction of complement proteins in a mouse model of cerebral microvascular Abeta deposition. J Neuroinflammation 4(1):22. PubMed: 17877807 MGI: J:124911
Frake RA; Ricketts T; Menzies FM; Rubinsztein DC. 2015. Autophagy and neurodegeneration. J Clin Invest 125(1):65-74. PubMed: 25654552 MGI: J:219892
Frost JL; Le KX; Cynis H; Ekpo E; Kleinschmidt M; Palmour RM; Ervin FR; Snigdha S; Cotman CW; Saido TC; Vassar RJ; George-Hyslop PS; Ikezu T; Schilling S; Demuth HU; Lemere CA. 2013. Pyroglutamate-3 Amyloid-beta Deposition in the Brains of Humans, Non-Human Primates, Canines, and Alzheimer Disease-Like Transgenic Mouse Models. Am J Pathol 183(2):369-81. PubMed: 23747948 MGI: J:199082
Hirsch-Reinshagen V; Maia LF; Burgess BL; Blain JF; Naus KE; McIsaac SA; Parkinson PF; Chan JY; Tansley GH; Hayden MR; Poirier J; Van Nostrand W; Wellington CL. 2005. The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease. J Biol Chem 280(52):43243-56. PubMed: 16207707 MGI: J:105900
Hohsfield LA; Daschil N; Oradd G; Stromberg I; Humpel C. 2014. Vascular pathology of 20-month-old hypercholesterolemia mice in comparison to triple-transgenic and APPSwDI Alzheimer's disease mouse models. Mol Cell Neurosci 63:83-95. PubMed: 25447943 MGI: J:231418
Hohsfield LA; Humpel C. 2015. Intravenous infusion of monocytes isolated from 2-week-old mice enhances clearance of Beta-amyloid plaques in an Alzheimer mouse model. PLoS One 10(4):e0121930. PubMed: 25830951 MGI: J:233423
Hutchinson D; Ho V; Dodd M; Dawson HN; Zumwalt AC; Schmitt D; Colton CA. 2007. Quantitative measurement of postural sway in mouse models of human neurodegenerative disease. Neuroscience 148(4):825-32. PubMed: 17764851 MGI: J:128390
Kan MJ; Lee JE; Wilson JG; Everhart AL; Brown CM; Hoofnagle AN; Jansen M; Vitek MP; Gunn MD; Colton CA. 2015. Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. J Neurosci 35(15):5969-82. PubMed: 25878270 MGI: J:221677
Liao MC; Van Nostrand WE. 2010. Degradation of soluble and fibrillar amyloid beta-protein by matrix metalloproteinase (MT1-MMP) in vitro. Biochemistry 49(6):1127-36. PubMed: 20050683 MGI: J:159886
Lonskaya I; Hebron ML; Desforges NM; Schachter JB; Moussa CE. 2014. Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance. J Mol Med (Berl) 92(4):373-86. PubMed: 24337465 MGI: J:221697
Lonskaya I; Hebron ML; Selby ST; Turner RS; Moussa CE. 2015. Nilotinib and bosutinib modulate pre-plaque alterations of blood immune markers and neuro-inflammation in Alzheimer's disease models. Neuroscience 304:316-27. PubMed: 26235435 MGI: J:226267
Medeiros R; Kitazawa M; Caccamo A; Baglietto-Vargas D; Estrada-Hernandez T; Cribbs DH; Fisher A; Laferla FM. 2011. Loss of muscarinic m(1) receptor exacerbates Alzheimer's disease-like pathology and cognitive decline. Am J Pathol 179(2):980-91. PubMed: 21704011 MGI: J:174403
Miao J; Vitek MP; Xu F; Previti ML; Davis J; Van Nostrand WE. 2005. Reducing cerebral microvascular amyloid-beta protein deposition diminishes regional neuroinflammation in vasculotropic mutant amyloid precursor protein transgenic mice. J Neurosci 25(27):6271-7. PubMed: 16000616 MGI: J:99430
Miao J; Xu F; Davis J; Otte-Holler I; Verbeek MM; Van Nostrand WE. 2005. Cerebral Microvascular Amyloid {beta} Protein Deposition Induces Vascular Degeneration and Neuroinflammation in Transgenic Mice Expressing Human Vasculotropic Mutant Amyloid {beta} Precursor Protein. Am J Pathol 167(2):505-15. PubMed: 16049335 MGI: J:99946
Passos GF; Medeiros R; Cheng D; Vasilevko V; Laferla FM; Cribbs DH. 2013. The Bradykinin B1 Receptor Regulates Abeta Deposition and Neuroinflammation in Tg-SwDI Mice. Am J Pathol 182(5):1740-9. PubMed: 23470163 MGI: J:195541
Ridnour LA; Dhanapal S; Hoos M; Wilson J; Lee J; Cheng RY; Brueggemann EE; Hines HB; Wilcock DM; Vitek MP; Wink DA; Colton CA. 2012. Nitric oxide-mediated regulation of beta-amyloid clearance via alterations of MMP-9/TIMP-1. J Neurochem 123(5):736-49. PubMed: 23016931 MGI: J:190735
Sagare AP; Bell RD; Zhao Z; Ma Q; Winkler EA; Ramanathan A; Zlokovic BV. 2013. Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat Commun 4:2932. PubMed: 24336108 MGI: J:221300
Searcy JL; Le Bihan T; Salvadores N; McCulloch J; Horsburgh K. 2014. Impact of age on the cerebrovascular proteomes of wild-type and Tg-SwDI mice. PLoS One 9(2):e89970. PubMed: 24587158 MGI: J:214476
Van Vickle GD; Esh CL; Daugs ID; Kokjohn TA; Kalback WM; Patton RL; Luehrs DC; Walker DG; Lue LF; Beach TG; Davis J; Van Nostrand WE; Castano EM; Roher AE. 2008. Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy. Am J Pathol 173(2):483-93. PubMed: 18599612 MGI: J:137886
Wilcock DM; Gharkholonarehe N; Van Nostrand WE; Davis J; Vitek MP; Colton CA. 2009. Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. J Neurosci 29(25):7957-65. PubMed: 19553436 MGI: J:150418
Wilcock DM; Lewis MR; Van Nostrand WE; Davis J; Previti ML; Gharkholonarehe N; Vitek MP; Colton CA. 2008. Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. J Neurosci 28(7):1537-45. PubMed: 18272675 MGI: J:132221
Wilcock DM; Vitek MP; Colton CA. 2009. Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease. Neuroscience 159(3):1055-69. PubMed: 19356689 MGI: J:148938
Xu F; Grande AM; Robinson JK; Previti ML; Vasek M; Davis J; Van Nostrand WE. 2007. Early-onset subicular microvascular amyloid and neuroinflammation correlate with behavioral deficits in vasculotropic mutant amyloid beta-protein precursor transgenic mice. Neuroscience 146(1):98-107. PubMed: 17331655 MGI: J:122063
Xu F; Vitek MP; Colton CA; Previti ML; Gharkholonarehe N; Davis J; Van Nostrand WE. 2008. Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice. J Neurosci 28(20):5312-20. PubMed: 18480287 MGI: J:136318
Zeng Y; Callaghan D; Xiong H; Yang Z; Huang P; Zhang W. 2012. Abcg2 deficiency augments oxidative stress and cognitive deficits in Tg-SwDI transgenic mice. J Neurochem :. PubMed: 22578166 MGI: J:186567
Zhang L; Dasuri K; Fernandez-Kim SO; Bruce-Keller AJ; Freeman LR; Pepping JK; Beckett TL; Murphy MP; Keller JN. 2013. Prolonged diet induced obesity has minimal effects towards brain pathology in mouse model of cerebral amyloid angiopathy: implications for studying obesity-brain interactions in mice. Biochim Biophys Acta 1832(9):1456-62. PubMed: 23313575 MGI: J:202444

Also Known As: iNOS-; Tg-SwDI, APPSwDI/NOS2 bigenic mice, APPSwDI/NOS2-/-

Donating Investigator

Genetic overview

Research Applications

Detailed Description

Development

Expression Data

Selected References

Nos2tm1Lau

Allele Symbol: Nos2tm1Lau

Tg(Thy1-APPSwDutIowa)BWevn

Allele Symbol: Tg(Thy1-APPSwDutIowa)BWevn

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: APP related

Genotype: Nos2tm1Lau related

Mammalian Phenotype Terms by Genotype

Genotype: Nos2tm1Lau/Nos2tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/?involves: C57BL/6

nervous system phenotype

homeostasis/metabolism phenotype

behavior/neurological phenotype

cellular phenotype

References

Additional - Nos2tm1Lau related

Additional - Tg(Thy1-APPSwDutIowa)BWevn related

Genotyping Protocols

Breeding Considerations

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Terms of Use

Additional Use Restrictions Apply

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Nos2^tm1Lau

Allele Symbol: Nos2^tm1Lau

Genotype: Nos2^tm1Lau related

Genotype: Nos2^tm1Lau/Nos2^tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/?
involves: C57BL/6

Additional - Nos2^tm1Lau related