JAX Mouse Strain Datasheet - 009086

B6.129S4-Gt(ROSA)26Sor^tm1(FLP1)Dym/RainJ

Stock No:: 009086 |; ROSA26::FLPe knock in

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Overview

Also Known As: ROSA26::FLPe knock in

This FLP deleter strain may be useful for generating frt-FLP conditional mutations and serves as a source of FLP1-expressing primary cell lines.

Donating Investigator

Elaine W Raines and Carole L Wilson, Univ. Washington School of Medicine

Genetic overview

Genetic Background	Generation
	N10+N1F11 (18-AUG-17)

Gt(ROSA)26Sor^tm1(FLP1)Dym

Allele Type	Gene Symbol	Gene Name
Targeted (Recombinase-expressing)	Gt(ROSA)26Sor	gene trap ROSA 26, Philippe Soriano

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Research Applications

Research Tools

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Base Price

Starting at:

$246.50 Domestic price for female

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Details

Detailed Description

Homozygous FLPeR mice are viable and fertile, with widespread expression of the FLPe variant of the Saccharomyces cerevisiae FLP1 recombinase gene driven by the Gt(ROSA)26Sor promoter. The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being four-fold and ten-fold that of wild type FLP at 37C and 40C, respectively. The Gt(ROSA)26Sor promoter drives expression from preimplantation onward and extensive target gene recombination can be achieved in most tissue types, including cells of the developing germ line. The knock-in construct also includes a neomycin resistance gene driven by the mouse phosphoglycerate kinase promoter (PGK neo) and polyadenylation signal sequence. When bred with mice containing a frt-flanked sequence of interest, FLP-mediated recombination will result in deletion of the frt-flanked sequence(s) in the offspring. This FLP deleter strain may be useful for generating frt-FLP conditional mutations and serves as a source of FLP1-expressing primary cell lines.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Development

Homozygous males from The Jackson Laboratory strain 129S4/SvJaeSor-Gt(ROSA)26Sor^tm1(FLP1)Dym/J (Stock No. 003946) were purchased by Elaine W. Raines and Carole L. Wilson (University of Washington School of Medicine).
The R26^Fki knock-in construct was designed by Dr. Susan M. Dymecki (Harvard Medical School) by first inserting a FLPe cassette into a ROSA26 knock-in vector. This construct also includes a neomycin resistance gene driven by the mouse phosphoglycerate kinase promoter (PGK neo) and polyadenylation signal sequence. The R26^Fki knock-in construct was electroporated into 129S4/S4JaeSor-derived AK7 embryonic stem (ES) cells, thereby disrupting the Gt(ROSA)26Sor locus. Correctly targeted ES cells were utilized to generate chimeras.
Mutant males were backcrossed to C57BL/6J inbred females (see Stock No. 000664) for ten generations and then made homozygous prior to arrival at The Jackson Laboratory (as Stock No. 009086). The Y chromosome may not have been fixed to the genetic background during the backcross.

Expression Data

Expressed Gene	FLP, FLP recombinase, Saccharomyces cerevisiae
Site of Expression	constitutive expression of FLP1 recombinase from preimplantation onward and in most tissue types (including cells of the developing germ line)

Control Suggestions

000664 C57BL/6J

Additional Information

Considerations for Choosing Controls

Selected References

Farley FW; Soriano P; Steffen LS; Dymecki SM. 2000. Widespread recombinase expression using FLPeR (Flipper) mice Genesis 28(3-4):106-10. PubMed: 11105051 MGI: J:66893

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Genetics

Gt(ROSA)26Sor^tm1(FLP1)Dym

Allele Symbol: Gt(ROSA)26Sor^tm1(FLP1)Dym

Allele Name	targeted mutation 1, Susan Dymecki
Allele Type	Targeted (Recombinase-expressing)
Allele Synonym(s)	CAGGS-Flpe; FLP; FLP deleter; FLPe; FLPeR; R26^Fki; ROSA26::FLPe knock in; ROSA26^Fki; flipper
Gene Symbol and Name	Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano
Gene Synonym(s)	AV258896; Gtrgeo26; Gtrgeo26; Gtrosa26; Gtrosa26; R26; ROSA26; SETD5-AS1; Thumpd3as1; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26
Expressed Gene	FLP, FLP recombinase, Saccharomyces cerevisiae
Site of Expression	constitutive expression of FLP1 recombinase from preimplantation onward and in most tissue types (including cells of the developing germ line)
Strain of Origin	129S4/SvJaeSor
Chromosome	6
Molecular Note	An enhanced flp cassette containing a splice acceptor site was ligated to a downstream PGK-neo cassette and inserted at the endogenous locus. Efficient frt-specific recombination in transgenic mice carrying a reporter gene was reported to reflect constituitive expression of the Gt(ROSA)26Sor from preimplantation onward.
Mutations Made By	Susan Dymecki, Harvard Medical School

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Research Tools
- FLP-FRT System
  - FLP Recombinase Expression
  - FLP Recombinase Expression: Germline/Embryonic Expression
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: FLP recombinase

Genotype: FLP related

Research Tools
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: FLP recombinase

References

Farley FW; Soriano P; Steffen LS; Dymecki SM. 2000. Widespread recombinase expression using FLPeR (Flipper) mice Genesis 28(3-4):106-10. PubMed: 11105051 MGI: J:66893

Additional - Gt(ROSA)26Sor^tm1(FLP1)Dym related

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Awatramani R; Soriano P; Mai JJ; Dymecki S. 2001. An Flp indicator mouse expressing alkaline phosphatase from the ROSA26 locus. Nat Genet 29(3):257-9. PubMed: 11687793 MGI: J:72406
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Also Known As: ROSA26::FLPe knock in

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