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Homozyous Postn (periostin, osteoblast specific factor) targeted mutation mice are more prone to ventricular rupture in the first 10 days after a myocardial infarction, but surviving mice show less fibrosis and better ventricular performance. They also show less fibrosis and hypertrophy following long-term pressure overload. This strain may be useful in studies of cardiac remodeling and hypertrophy.
Jeffery D. Molkentin, Cincinnati Children's Hospital
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Targeted (Null/Knockout) | Postn | periostin, osteoblast specific factor |
Homozyous targeted mutation mice are more prone to ventricular rupture in the first 10 days after a myocardial infarction, but surviving mice show less fibrosis and better ventricular performance. They also show less fibrosis and hypertrophy following long-term pressure overload. The developing feet and hearts of 1-day-old mice show no expression of protein. No significant protein is found in the extracellular matrix of the heart after postnatal development, although the valves show persistent expression within fibroblasts. Homozygotes are slightly smaller than wild-type and heterozygous animals. This strain may be useful in studies of cardiac remodeling and hypertrophy.
Exons 4-10 were replaced with a neomycin resistance cassette placed in the reverse transcriptional orientation. A 129-derived embryonic stem (ES) cell line was used to create the mutation. Chimeric mice were crossed to C57BL/6. This line was maintained on a mixed C57BL/6 and 129 genetic background by the donating laboratory.
Allele Name | targeted mutation 1, Jeffery D Molkentin |
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Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | Pn- |
Gene Symbol and Name | Postn, periostin, osteoblast specific factor |
Gene Synonym(s) | |
Strain of Origin | 129/Sv |
Chromosome | 3 |
Molecular Note | Exons 4 through 10 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on P1 developing foot and heart extracts. |
Mutations Made By | Jeffery Molkentin, Cincinnati Children's Hospital |
The donating investigator reports that homozygous females do not breed.
When using the B6;129-Postntm1Jmol/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #009067 in your Materials and Methods section.
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