Homozyous targeted mutation mice are more prone to ventricular rupture in the first 10 days after a myocardial infarction, but surviving mice show less fibrosis and better ventricular performance. They also show less fibrosis and hypertrophy following long-term pressure overload. The developing feet and hearts of 1-day-old mice show no expression of protein. No significant protein is found in the extracellular matrix of the heart after postnatal development, although the valves show persistent expression within fibroblasts. Homozygotes are slightly smaller than wild-type and heterozygous animals. This strain may be useful in studies of cardiac remodeling and hypertrophy. 

Removal of this mouse colony is imminent. If live mice are needed for your studies, it is advised that they be ordered immediately. After removal, the mice will be available from a cryorecovery. Homozyous Postn (periostin, osteoblast specific factor) targeted mutation mice are more prone to ventricular rupture in the first 10 days after a myocardial infarction, but surviving mice show less fibrosis and better ventricular performance. They also show less fibrosis and hypertrophy following long-term pressure overload. This strain may be useful in studies of cardiac remodeling and hypertrophy.