JAX
Mouse Strain Datasheet - 008875
B6.129P2-Lgr5tm1(cre/ERT2)Cle/J
Also Known As: Lgr5-EGFP-IRES-creERT2
Heterozygous mice harbor an Lgr5-EGFP-IRES-creERT2 "knock-in" allele that both abolishes Lgr5 gene function and expresses EGFP and CreERT2 fusion protein. When these mice mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in the Lgr5-expressing cells of the offspring. These mice may be useful for lineage-tracing or marking Lgr5-expressing stem cells of the small intestine.
Donating Investigator
Hans Clevers, Hubrecht Institute
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N11+N3F5
|
Lgr5tm1(cre/ERT2)Cle
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Inducible, Recombinase-expressing, Reporter) | Lgr5 | leucine rich repeat containing G protein coupled receptor 5 |
Research Applications
- Cancer Research
- Internal/Organ Research
- Research Tools
Base Price
Starting at:
| $255.00 Domestic price for female |
| $329.00 Domestic price for breeder pair |
Important Note
The donating investigator reports variegated expression of the Lgr5-EGFP-IRES-CreERT2 transgene in the small intestine and colon (something which may happen often with genes that are expressed early during intestinal development). This variegated expression is advantageous for performing clonal lineage tracing and sorting intestinal stem cells, but may have limitations for more quantitative studies such as Lgr5-Cre driven knockout strategies.
Detailed Description
While homozygous mice are not viable, heterozygous Lgr5-EGFP-IRES-CreERT2 mice are viable and fertile; harboring a Lgr5-EGFP-IRES-creERT2 "knock-in" allele that both abolishes Lgr5 (Gpr49) gene function and expresses EGFP and CreERT2 fusion protein from the Lgr5 promoter/enhancer elements. EGFP fluorescence is observed in crypt base columnar cells in small intestine (aka stem cells of the small intestine) and colon. Cre-ERT2 fusion gene activity is inducible; observed in the same cells only following tamoxifen administration. EGFP or inducible CreERT2 expression may also be observed in other Lgr5-expressing cell types (including pre-malignant mouse adenomas, colon cancer cells, epithelial stem cells of the stomach gland, basal epithelial layer stem cells of the mammary glands, and hair follicle stem cells).
The donating investigator reports variegated expression of the Lgr5-EGFP-IRES-CreERT2 transgene in the small intestine and colon (something which may happen often with genes that are expressed early during intestinal development). This variegated expression is advantageous for performing clonal lineage tracing and sorting intestinal stem cells, but may have limitations for more quantitative studies such as Lgr5-Cre driven knockout strategies.
The Cre-ERT2 fusion protein consists of Cre recombinase fused to a triple mutant form of the human estrogen receptor; which does not bind its natural ligand (17β-estradiol) at physiological concentrations but will bind the synthetic estrogen receptor ligands 4-hydroxytamoxifen (OHT or tamoxifen) and, with lesser sensitivity, ICI 182780. Restricted to the cytoplasm, Cre-ERT2 can only gain access to the nuclear compartment after exposure to tamoxifen. To counteract the mixed estrogen agonist effects of tamoxifen injections, which can result in late fetal abortions in pregnant mice, progesterone may be coadministered. As such, when Lgr5-EGFP-IRES-creERT2 mice are bred with mice containing loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in the Lgr5-expressing cells of the offspring.
View cre expression characterization.
Development
The EGFP-IRES-creERT2 targeting construct was designed to insert an enhanced green fluorescent protein sequence (EGFP), an internal ribosome entry site (IRES), a CreERT2 fusion gene (Cre-ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain), a polyA signal, and a loxP-flanked neo cassette into the first ATG codon of the targeted gene. This construct was inserted into the targeted gene via electroporation into male 129P2/OlaHsd-derived IB10/E14IB10 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts and chimeric males were bred with C57BL/6 females. Mutant mice were then crossed to EIIa-cre mice (C57BL/6 genetic background; see Stock No. 003724) to remove the neo selection cassette. The donating investigator reported that the resulting Lgr5-EGFP-IRES-creERT2 mice (floxed-neo removed) were then backcrossed to C57BL/6J (see SNP note below) for at least 4 generations. Next, Lgr5-EGFP-IRES-creERT2 mice were bred with Rosa26-lacZ mice (C57BL/6 genetic background; see Stock No. 003474). Mice with both mutations were further backcrossed for more than 6 generations. Upon arrival at The Jackson Laboratory, the mice were bred with C57BL/6J inbred mice (Stock No. 000664) for at least one generation to establish the colony. Mice were then selectively bred to remove the Rosa26-lacZ allele.
A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 2 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.
Expression Data
| Expressed Gene | GFP, Green Fluorescent Protein, |
|---|---|
| Expressed Gene | cre/ERT2, Cre recombinase and estrogen receptor 1 (human) fusion gene, |
| Site of Expression | Variegated EGFP fluorescence is observed in crypt base columnar cells in small intestine (stem cells of the small intestine) and colon. |
Control Suggestions
- Wild-type from the colony
- 000664 C57BL/6J
Additional Information
Selected References
- Barker N; van Es JH; Kuipers J; Kujala P; van den Born M; Cozijnsen M; Haegebarth A; Korving J; Begthel H; Peters PJ; Clevers H. 2007. Identification of stem cells in small intestine and colon by marker gene Lgr5.. In: . . MGI: J:127123
Lgr5tm1(cre/ERT2)Cle
Allele Symbol: Lgr5tm1(cre/ERT2)Cle
| Allele Name | targeted mutation 1, Hans Clevers |
|---|---|
| Allele Type | Targeted (Inducible, Recombinase-expressing, Reporter) |
| Allele Synonym(s) | Lgr5 EGFP-IRES-creERT2; Lgr5-EGFP; Lgr5-EGFP-IRES-creERT2; Lgr5-cre; Lgr5-creERT; Lgr5tm1(cre/ESR1)Cle |
| Gene Symbol and Name | Lgr5, leucine rich repeat containing G protein coupled receptor 5 |
| Gene Synonym(s) | FEX; G protein-coupled receptor 49; GPR49; GPR67; GRP49; Gpr49; Gpr49; HG38 |
| Expressed Gene | GFP, Green Fluorescent Protein, |
| Expressed Gene | cre/ERT2, Cre recombinase and estrogen receptor 1 (human) fusion gene, |
| Site of Expression | Variegated EGFP fluorescence is observed in crypt base columnar cells in small intestine (stem cells of the small intestine) and colon. |
| Strain of Origin | 129P2/OlaHsd |
| Chromosome | 10 |
| Molecular Note | An EGFP-IRES-creERT2 cassette was inserted into exon 1 of the gene along with a loxP-flanked neomycin cassette. The neomycin gene was then excised in vivo by crossing with cre-deleter strain. GFP expression is driven by the endogenous promoter. Cre expression is induced in Lgr5 expressing cells by tamoxifen treatment. |
| Mutations Made By | Nick Barker, Hubrecht Institute |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Cancer Research
- Other
- tumor metastasis
- Other
- Internal/Organ Research
- Gastrointestinal Defects
- Research Tools
- Cancer Research
- Cre-lox System
- Cre Recombinase Expression
- Cre Recombinase Expression: Inducible
- Developmental Biology Research
- Cre-lox System
- transplantation marker for embryonic and adult tissue
- Fluorescent Proteins
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
- Tissue/Cell Markers
- Tissue/Cell Markers: Cre-lox System
- Tissue/Cell Markers: multiple
- Tissue/Cell Markers: transplantation marker for embryonic and adult tissue
- Toxicology Research
- xenograft/transplant host
Genotype: GFP related
- Research Tools
- Fluorescent Proteins
References
- Barker N; van Es JH; Kuipers J; Kujala P; van den Born M; Cozijnsen M; Haegebarth A; Korving J; Begthel H; Peters PJ; Clevers H. 2007. Identification of stem cells in small intestine and colon by marker gene Lgr5.. In: . . MGI: J:127123
Additional - Lgr5tm1(cre/ERT2)Cle related
- Afrazi A; Branca MF; Sodhi CP; Good M; Yamaguchi Y; Egan CE; Lu P; Jia H; Shaffiey S; Lin J; Ma C; Vincent G; Prindle T Jr; Weyandt S; Neal MD; Ozolek JA; Wiersch J; Tschurtschenthaler M; Shiota C; Gittes GK; Billiar TR; Mollen K; Kaser A; Blumberg R; Hackam DJ. 2014. Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis.. In: . . MGI: J:212438
- Arnold K; Sarkar A; Yram MA; Polo JM; Bronson R; Sengupta S; Seandel M; Geijsen N; Hochedlinger K. 2011. Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice.. In: . . MGI: J:177655
- Asfaha S; Hayakawa Y; Muley A; Stokes S; Graham TA; Ericksen RE; Westphalen CB; von Burstin J; Mastracci TL; Worthley DL; Guha C; Quante M; Rustgi AK; Wang TC. 2015. Krt19(+)/Lgr5(-) Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine.. In: . . MGI: J:224765
- Barker N; Huch M; Kujala P; van de Wetering M; Snippert HJ; van Es JH; Sato T; Stange DE; Begthel H; van den Born M; Danenberg E; van den Brink S; Korving J; Abo A; Peters PJ; Wright N; Poulsom R; Clevers H. 2010. Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.. In: . . MGI: J:157075
- Barker N; Ridgway RA; van Es JH; van de Wetering M; Begthel H; van den Born M; Danenberg E; Clarke AR; Sansom OJ; Clevers H. 2009. Crypt stem cells as the cells-of-origin of intestinal cancer.. In: . . MGI: J:144216
- Barry ER; Morikawa T; Butler BL; Shrestha K; de la Rosa R; Yan KS; Fuchs CS; Magness ST; Smits R; Ogino S; Kuo CJ; Camargo FD. 2013. Restriction of intestinal stem cell expansion and the regenerative response by YAP.. In: . . MGI: J:194212
- Basak O; van de Born M; Korving J; Beumer J; van der Elst S; van Es JH; Clevers H. 2014. Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele.. In: . . MGI: J:216072
- Beyaz S; Mana MD; Roper J; Kedrin D; Saadatpour A; Hong SJ; Bauer-Rowe KE; Xifaras ME; Akkad A; Arias E; Pinello L; Katz Y; Shinagare S; Abu-Remaileh M; Mihaylova MM; Lamming DW; Dogum R; Guo G; Bell GW; Selig M; Nielsen GP; Gupta N; Ferrone CR; Deshpande V; Yuan GC; Orkin SH; Sabatini DM; Yilmaz OH. 2016. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.. In: . . MGI: J:229664
- Blanco S; Bandiera R; Popis M; Hussain S; Lombard P; Aleksic J; Sajini A; Tanna H; Cortes-Garrido R; Gkatza N; Dietmann S; Frye M. 2016. Stem cell function and stress response are controlled by protein synthesis.. In: . . MGI: J:235735
- Boumahdi S; Driessens G; Lapouge G; Rorive S; Nassar D; Le Mercier M; Delatte B; Caauwe A; Lenglez S; Nkusi E; Brohee S; Salmon I; Dubois C; del Marmol V; Fuks F; Beck B; Blanpain C. 2014. SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma.. In: . . MGI: J:213264
- Buczacki SJ; Zecchini HI; Nicholson AM; Russell R; Vermeulen L; Kemp R; Winton DJ. 2013. Intestinal label-retaining cells are secretory precursors expressing Lgr5.. In: . . MGI: J:194841
- Cai J; Maitra A; Anders RA; Taketo MM; Pan D. 2015. beta-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis.. In: . . MGI: J:226066
- Callejas-Valera JL; Iglesias-Bartolome R; Amornphimoltham P; Palacios-Garcia J; Martin D; Califano JA; Molinolo AA; Gutkind JS. 2016. mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model.. In: . . MGI: J:235431
- Cammareri P; Rose AM; Vincent DF; Wang J; Nagano A; Libertini S; Ridgway RA; Athineos D; Coates PJ; McHugh A; Pourreyron C; Dayal JH; Larsson J; Weidlich S; Spender LC; Sapkota GP; Purdie KJ; Proby CM; Harwood CA; Leigh IM; Clevers H; Barker N; Karlsson S; Pritchard C; Marais R; Chelala C; South AP; Sansom OJ; Inman GJ. 2016. Inactivation of TGFbeta receptors in stem cells drives cutaneous squamous cell carcinoma.. In: . . MGI: J:241617
- Carulli AJ; Keeley TM; Demitrack ES; Chung J; Maillard I; Samuelson LC. 2015. Notch receptor regulation of intestinal stem cell homeostasis and crypt regeneration.. In: . . MGI: J:222415
- Chai R; Kuo B; Wang T; Liaw EJ; Xia A; Jan TA; Liu Z; Taketo MM; Oghalai JS; Nusse R; Zuo J; Cheng AG. 2012. Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea.. In: . . MGI: J:184776
- Chai R; Xia A; Wang T; Jan TA; Hayashi T; Bermingham-McDonogh O; Cheng AG. 2011. Dynamic expression of lgr5, a wnt target gene, in the developing and mature mouse cochlea.. In: . . MGI: J:173579
- Cheasley D; Pereira L; Lightowler S; Vincan E; Malaterre J; Ramsay RG. 2011. Myb controls intestinal stem cell genes and self-renewal.. In: . . MGI: J:190196
- Chen M; Tian S; Glasgow NG; Gibson G; Yang X; Shiber CE; Funderburgh J; Watkins S; Johnson JW; Schuman JS; Liu H. 2015. Lgr5(+) amacrine cells possess regenerative potential in the retina of adult mice.. In: . . MGI: J:224785
- Chen M; Tian S; Yang X; Lane AP; Reed RR; Liu H. 2014. Wnt-responsive Lgr5(+) globose basal cells function as multipotent olfactory epithelium progenitor cells.. In: . . MGI: J:211703
- Cheung EC; Athineos D; Lee P; Ridgway RA; Lambie W; Nixon C; Strathdee D; Blyth K; Sansom OJ; Vousden KH. 2013. TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis.. In: . . MGI: J:198650
- Chiacchiera F; Rossi A; Jammula S; Zanotti M; Pasini D. 2016. PRC2 preserves intestinal progenitors and restricts secretory lineage commitment.. In: . . MGI: J:237929
- Chivukula RR; Shi G; Acharya A; Mills EW; Zeitels LR; Anandam JL; Abdelnaby AA; Balch GC; Mansour JC; Yopp AC; Maitra A; Mendell JT. 2014. An essential mesenchymal function for miR-143/145 in intestinal epithelial regeneration.. In: . . MGI: J:214382
- Choi E; Petersen CP; Lapierre LA; Williams JA; Weis VG; Goldenring JR; Nam KT. 2015. Dynamic expansion of gastric mucosal doublecortin-like kinase 1-expressing cells in response to parietal cell loss is regulated by gastrin.. In: . . MGI: J:225645
- Cordero JB; Ridgway RA; Valeri N; Nixon C; Frame MC; Muller WJ; Vidal M; Sansom OJ. 2014. c-Src drives intestinal regeneration and transformation.. In: . . MGI: J:211668
- Cox BC; Chai R; Lenoir A; Liu Z; Zhang L; Nguyen DH; Chalasani K; Steigelman KA; Fang J; Rubel EW; Cheng AG; Zuo J. 2014. Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo.. In: . . MGI: J:208434
- Das S; Yu S; Sakamori R; Vedula P; Feng Q; Flores J; Hoffman A; Fu J; Stypulkowski E; Rodriguez A; Dobrowolski R; Harada A; Hsu W; Bonder EM; Verzi MP; Gao N. 2015. Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche.. In: . . MGI: J:239365
- Davidson LA; Callaway ES; Kim E; Weeks BR; Fan YY; Allred CD; Chapkin RS. 2015. Targeted Deletion of p53 in Lgr5-Expressing Intestinal Stem Cells Promotes Colon Tumorigenesis in a Preclinical Model of Colitis-Associated Cancer.. In: . . MGI: J:227330
- DeClercq V; McMurray DN; Chapkin RS. 2015. Obesity promotes colonic stem cell expansion during cancer initiation.. In: . . MGI: J:226621
- Dehmer JJ; Garrison AP; Speck KE; Dekaney CM; Landeghem LV; Sun X; Henning SJ; Helmrath MA. 2011. Expansion of intestinal epithelial stem cells during murine development.. In: . . MGI: J:180965
- Demidov ON; Zhu Y; Kek C; Goloudina AR; Motoyama N; Bulavin DV. 2012. Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis.. In: . . MGI: J:204789
- Demitrack ES; Gifford GB; Keeley TM; Carulli AJ; VanDussen KL; Thomas D; Giordano TJ; Liu Z; Kopan R; Samuelson LC. 2015. Notch signaling regulates gastric antral LGR5 stem cell function.. In: . . MGI: J:226632
- Fan YY; Davidson LA; Callaway ES; Goldsby JS; Chapkin RS. 2014. Differential effects of 2- and 3-series E-prostaglandins on in vitro expansion of Lgr5+ colonic stem cells.. In: . . MGI: J:208174
- Fan YY; Davidson LA; Callaway ES; Wright GA; Safe S; Chapkin RS. 2015. A bioassay to measure energy metabolism in mouse colonic crypts, organoids, and sorted stem cells.. In: . . MGI: J:224793
- Farin HF; Jordens I; Mosa MH; Basak O; Korving J; Tauriello DV; de Punder K; Angers S; Peters PJ; Maurice MM; Clevers H. 2016. Visualization of a short-range Wnt gradient in the intestinal stem-cell niche.. In: . . MGI: J:229237
- Feng Y; Sakamoto N; Wu R; Liu JY; Wiese A; Green ME; Green M; Akyol A; Roy BC; Zhai Y; Cho KR; Fearon ER. 2015. Tissue-Specific Effects of Reduced beta-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium.. In: . . MGI: J:231703
- Feng Y; Sentani K; Wiese A; Sands E; Green M; Bommer GT; Cho KR; Fearon ER. 2013. Sox9 induction, ectopic paneth cells, and mitotic spindle axis defects in mouse colon adenomatous epithelium arising from conditional biallelic apc inactivation.. In: . . MGI: J:199069
- Finnberg NK; Gokare P; Navaraj A; Lang Kuhs KA; Cerniglia G; Yagita H; Takeda K; Motoyama N; El-Deiry WS. 2016. Agonists of the TRAIL Death Receptor DR5 Sensitize Intestinal Stem Cells to Chemotherapy-Induced Cell Death and Trigger Gastrointestinal Toxicity.. In: . . MGI: J:237555
- Fischer JM; Schepers AG; Clevers H; Shibata D; Liskay RM. 2014. Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention.. In: . . MGI: J:204534
- Flesken-Nikitin A; Hwang CI; Cheng CY; Michurina TV; Enikolopov G; Nikitin AY. 2013. Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche.. In: . . MGI: J:194916
- Fordham RP; Yui S; Hannan NR; Soendergaard C; Madgwick A; Schweiger PJ; Nielsen OH; Vallier L; Pedersen RA; Nakamura T; Watanabe M; Jensen KB. 2013. Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury.. In: . . MGI: J:204682
- Genetic Resource Science at The Jackson Laboratory. 2012. Expression/Specificity Patterns of Cre Alleles, 2012. In: . . MGI: J:184579
- Genetic Resource Science at The Jackson Laboratory. 2008. Expression/Specificity Patterns of Cre Alleles. In: . . MGI: J:137887
- Gerbe F; van Es JH; Makrini L; Brulin B; Mellitzer G; Robine S; Romagnolo B; Shroyer NF; Bourgaux JF; Pignodel C; Clevers H; Jay P. 2011. Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium.. In: . . MGI: J:170320
- Ghanem LR; Chatterji P; Liebhaber SA. 2014. Specific enrichment of the RNA-binding proteins PCBP1 and PCBP2 in chief cells of the murine gastric mucosa.. In: . . MGI: J:207478
- Goto N; Ueo T; Fukuda A; Kawada K; Sakai Y; Miyoshi H; Taketo MM; Chiba T; Seno H. 2017. Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine.. In: . . MGI: J:243196
- Grachtchouk M; Pero J; Yang SH; Ermilov AN; Michael LE; Wang A; Wilbert D; Patel RM; Ferris J; Diener J; Allen M; Lim S; Syu LJ; Verhaegen M; Dlugosz AA. 2011. Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations.. In: . . MGI: J:173930
- Gregorieff A; Liu Y; Inanlou MR; Khomchuk Y; Wrana JL. 2015. Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer.. In: . . MGI: J:226759
- Grun D; Muraro MJ; Boisset JC; Wiebrands K; Lyubimova A; Dharmadhikari G; van den Born M; van Es J; Jansen E; Clevers H; de Koning EJ; van Oudenaarden A. 2016. De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data.. In: . . MGI: J:238358
- Gustin SE; Hogg K; Stringer JM; Rastetter RH; Pelosi E; Miles DC; Sinclair AH; Wilhelm D; Western PS. 2016. WNT/beta-catenin and p27/FOXL2 differentially regulate supporting cell proliferation in the developing ovary.. In: . . MGI: J:231673
- Hashimoto K; Yamada Y; Semi K; Yagi M; Tanaka A; Itakura F; Aoki H; Kunisada T; Woltjen K; Haga H; Sakai Y; Yamamoto T; Yamada Y. 2017. Cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior.. In: . . MGI: J:239530
- Hayakawa Y; Sakitani K; Konishi M; Asfaha S; Niikura R; Tomita H; Renz BW; Tailor Y; Macchini M; Middelhoff M; Jiang Z; Tanaka T; Dubeykovskaya ZA; Kim W; Chen X; Urbanska AM; Nagar K; Westphalen CB; Quante M; Lin CS; Gershon MD; Hara A; Zhao CM; Chen D; Worthley DL; Koike K; Wang TC. 2017. Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling.. In: . . MGI: J:238420
- Heuberger J; Kosel F; Qi J; Grossmann KS; Rajewsky K; Birchmeier W. 2014. Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine.. In: . . MGI: J:207407
- Hirata A; Utikal J; Yamashita S; Aoki H; Watanabe A; Yamamoto T; Okano H; Bardeesy N; Kunisada T; Ushijima T; Hara A; Jaenisch R; Hochedlinger K; Yamada Y. 2013. Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium.. In: . . MGI: J:191050
- Hirsch D; Barker N; McNeil N; Hu Y; Camps J; McKinnon K; Clevers H; Ried T; Gaiser T. 2014. LGR5 positivity defines stem-like cells in colorectal cancer.. In: . . MGI: J:208184
- Ho LL; Sinha A; Verzi M; Bernt KM; Armstrong SA; Shivdasani RA. 2013. DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions.. In: . . MGI: J:203756
- Horvay K; Jarde T; Casagranda F; Perreau VM; Haigh K; Nefzger CM; Akhtar R; Gridley T; Berx G; Haigh JJ; Barker N; Polo JM; Hime GR; Abud HE. 2015. Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium.. In: . . MGI: J:221041
- Huels DJ; Ridgway RA; Radulescu S; Leushacke M; Campbell AD; Biswas S; Leedham S; Serra S; Chetty R; Moreaux G; Parry L; Matthews J; Song F; Hedley A; Kalna G; Ceteci F; Reed KR; Meniel VS; Maguire A; Doyle B; Soderberg O; Barker N; Watson A; Larue L; Clarke AR; Sansom OJ. 2015. E-cadherin can limit the transforming properties of activating beta-catenin mutations.. In: . . MGI: J:226570
- Igarashi M; Guarente L. 2016. mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction.. In: . . MGI: J:234645
- Itzkovitz S; Blat IC; Jacks T; Clevers H; van Oudenaarden A. 2012. Optimality in the development of intestinal crypts.. In: . . MGI: J:181333
- Itzkovitz S; Lyubimova A; Blat IC; Maynard M; van Es J; Lees J; Jacks T; Clevers H; van Oudenaarden A. 2011. Single-molecule transcript counting of stem-cell markers in the mouse intestine.. In: . . MGI: J:178925
- Jaks V; Barker N; Kasper M; van Es JH; Snippert HJ; Clevers H; Toftgard R. 2008. Lgr5 marks cycling, yet long-lived, hair follicle stem cells.. In: . . MGI: J:143598
- Kabiri Z; Greicius G; Madan B; Biechele S; Zhong Z; Zaribafzadeh H; Edison; Aliyev J; Wu Y; Bunte R; Williams BO; Rossant J; Virshup DM. 2014. Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts.. In: . . MGI: J:213583
- Kasper M; Jaks V; Are A; Bergstrom A; Schwager A; Barker N; Toftgard R. 2011. Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes.. In: . . MGI: J:170330
- Kechele DO; Blue RE; Zwarycz B; Espenschied ST; Mah AT; Siegel MB; Perou CM; Ding S; Magness ST; Lund PK; Caron KM. 2017. Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation.. In: . . MGI: J:239820
- Kim E; Davidson LA; Zoh RS; Hensel ME; Patil BS; Jayaprakasha GK; Callaway ES; Allred CD; Turner ND; Weeks BR; Chapkin RS. 2016. Homeostatic responses of colonic LGR5+ stem cells following acute in vivo exposure to a genotoxic carcinogen.. In: . . MGI: J:230516
- Kim R; Sheaffer KL; Choi I; Won KJ; Kaestner KH. 2016. Epigenetic regulation of intestinal stem cells by Tet1-mediated DNA hydroxymethylation.. In: . . MGI: J:237203
- Kim TH; Escudero S; Shivdasani RA. 2012. Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells.. In: . . MGI: J:182139
- Kim TH; Li F; Ferreiro-Neira I; Ho LL; Luyten A; Nalapareddy K; Long H; Verzi M; Shivdasani RA. 2014. Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity.. In: . . MGI: J:207494
- Kim TH; Shivdasani RA. 2011. Notch signaling in stomach epithelial stem cell homeostasis.. In: . . MGI: J:176833
- Koo BK; Spit M; Jordens I; Low TY; Stange DE; van de Wetering M; van Es JH; Mohammed S; Heck AJ; Maurice MM; Clevers H. 2012. Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.. In: . . MGI: J:186765
- Kozar S; Morrissey E; Nicholson AM; van der Heijden M; Zecchini HI; Kemp R; Tavare S; Vermeulen L; Winton DJ. 2013. Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas.. In: . . MGI: J:202689
- Kundu P; Genander M; Straat K; Classon J; Ridgway RA; Tan EH; Bjork J; Martling A; van Es J; Sansom OJ; Clevers H; Pettersson S; Frisen J. 2015. An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth.. In: . . MGI: J:234079
- Kuo BR; Baldwin EM; Layman WS; Taketo MM; Zuo J. 2015. In Vivo Cochlear Hair Cell Generation and Survival by Coactivation of beta-Catenin and Atoh1.. In: . . MGI: J:225888
- Kuzmichev AN; Kim SK; D'Alessio AC; Chenoweth JG; Wittko IM; Campanati L; McKay RD. 2012. Sox2 acts through Sox21 to regulate transcription in pluripotent and differentiated cells.. In: . . MGI: J:199754
- Ladang A; Rapino F; Heukamp LC; Tharun L; Shostak K; Hermand D; Delaunay S; Klevernic I; Jiang Z; Jacques N; Jamart D; Migeot V; Florin A; Goktuna S; Malgrange B; Sansom OJ; Nguyen L; Buttner R; Close P; Chariot A. 2015. Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.. In: . . MGI: J:227334
- Lapouge G; Beck B; Nassar D; Dubois C; Dekoninck S; Blanpain C. 2012. Skin squamous cell carcinoma propagating cells increase with tumour progression and invasiveness.. In: . . MGI: J:193125
- Lehoczky JA; Tabin CJ. 2015. Lgr6 marks nail stem cells and is required for digit tip regeneration.. In: . . MGI: J:227186
- Lei NY; Jabaji Z; Wang J; Joshi VS; Brinkley GJ; Khalil H; Wang F; Jaroszewicz A; Pellegrini M; Li L; Lewis M; Stelzner M; Dunn JC; Martin MG. 2014. Intestinal subepithelial myofibroblasts support the growth of intestinal epithelial stem cells.. In: . . MGI: J:212573
- Leushacke M; Ng A; Galle J; Loeffler M; Barker N. 2013. Lgr5(+) gastric stem cells divide symmetrically to effect epithelial homeostasis in the pylorus.. In: . . MGI: J:205131
- Li N; Yousefi M; Nakauka-Ddamba A; Tobias JW; Jensen ST; Morrisey EE; Lengner CJ. 2016. Heterogeneity in readouts of canonical wnt pathway activity within intestinal crypts.. In: . . MGI: J:233822
- Li W; Wu J; Yang J; Sun S; Chai R; Chen ZY; Li H. 2015. Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway.. In: . . MGI: J:218237
- Lin J; Zhang X; Wu F; Lin W. 2015. Hair cell damage recruited Lgr5-expressing cells are hair cell progenitors in neonatal mouse utricle.. In: . . MGI: J:242678
- Lindemans CA; Calafiore M; Mertelsmann AM; O'Connor MH; Dudakov JA; Jenq RR; Velardi E; Young LF; Smith OM; Lawrence G; Ivanov JA; Fu YY; Takashima S; Hua G; Martin ML; O'Rourke KP; Lo YH; Mokry M; Romera-Hernandez M; Cupedo T; Dow LE; Nieuwenhuis EE; Shroyer NF; Liu C; Kolesnick R; van den Brink MR; Hanash AM. 2015. Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration.. In: . . MGI: J:228301
- Lindley LE; Curtis KM; Sanchez-Mejias A; Rieger ME; Robbins DJ; Briegel KJ. 2015. The WNT-controlled transcriptional regulator LBH is required for mammary stem cell expansion and maintenance of the basal lineage.. In: . . MGI: J:220326
- Liu CY; Dube PE; Girish N; Reddy AT; Polk DB. 2015. Optical reconstruction of murine colorectal mucosa at cellular resolution.. In: . . MGI: J:224167
- Liu S; Qian Y; Li L; Wei G; Guan Y; Pan H; Guan X; Zhang L; Lu X; Zhao Y; Liu M; Li D. 2013. Lgr4 gene deficiency increases susceptibility and severity of dextran sodium sulfate-induced inflammatory bowel disease in mice.. In: . . MGI: J:197850
- Llado V; Nakanishi Y; Duran A; Reina-Campos M; Shelton PM; Linares JF; Yajima T; Campos A; Aza-Blanc P; Leitges M; Diaz-Meco MT; Moscat J. 2015. Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of beta-Catenin and Yap by PKCzeta. In: . . MGI: J:222050
- Lo Sasso G; Ryu D; Mouchiroud L; Fernando SC; Anderson CL; Katsyuba E; Piersigilli A; Hottiger MO; Schoonjans K; Auwerx J. 2014. Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer.. In: . . MGI: J:219037
- Lowry WE; Flores A; White AC. 2016. Exploiting Mouse Models to Study Ras-Induced Cutaneous Squamous Cell Carcinoma.. In: . . MGI: J:235005
- Mahapatro M; Foersch S; Hefele M; He GW; Giner-Ventura E; Mchedlidze T; Kindermann M; Vetrano S; Danese S; Gunther C; Neurath MF; Wirtz S; Becker C. 2016. Programming of Intestinal Epithelial Differentiation by IL-33 Derived from Pericryptal Fibroblasts in Response to Systemic Infection.. In: . . MGI: J:235754
- Mesa KR; Rompolas P; Zito G; Myung P; Sun TY; Brown S; Gonzalez DG; Blagoev KB; Haberman AM; Greco V. 2015. Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool.. In: . . MGI: J:226377
- Miller TE; Wang J; Sukhdeo K; Horbinski C; Tesar PJ; Wechsler-Reya RJ; Rich JN. 2014. Lgr5 Marks Post-Mitotic, Lineage Restricted Cerebellar Granule Neurons during Postnatal Development.. In: . . MGI: J:225124
- Miyoshi H; Ajima R; Luo CT; Yamaguchi TP; Stappenbeck TS. 2012. Wnt5a potentiates TGF-beta signaling to promote colonic crypt regeneration after tissue injury.. In: . . MGI: J:187747
- Miyoshi H; VanDussen KL; Malvin NP; Ryu SH; Wang Y; Sonnek NM; Lai CW; Stappenbeck TS. 2017. Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium.. In: . . MGI: J:238856
- Montgomery RK; Carlone DL; Richmond CA; Farilla L; Kranendonk ME; Henderson DE; Baffour-Awuah NY; Ambruzs DM; Fogli LK; Algra S; Breault DT. 2011. Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells.. In: . . MGI: J:169012
- Morgner J; Ghatak S; Jakobi T; Dieterich C; Aumailley M; Wickstrom SA. 2015. Integrin-linked kinase regulates the niche of quiescent epidermal stem cells.. In: . . MGI: J:227018
- Munoz J; Stange DE; Schepers AG; van de Wetering M; Koo BK; Itzkovitz S; Volckmann R; Kung KS; Koster J; Radulescu S; Myant K; Versteeg R; Sansom OJ; van Es JH; Barker N; van Oudenaarden A; Mohammed S; Heck AJ; Clevers H. 2012. The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers.. In: . . MGI: J:186432
- Mustata RC; Vasile G; Fernandez-Vallone V; Strollo S; Lefort A; Libert F; Monteyne D; Perez-Morga D; Vassart G; Garcia MI. 2013. Identification of Lgr5-independent spheroid-generating progenitors of the mouse fetal intestinal epithelium.. In: . . MGI: J:203768
- Myant KB; Cammareri P; McGhee EJ; Ridgway RA; Huels DJ; Cordero JB; Schwitalla S; Kalna G; Ogg EL; Athineos D; Timpson P; Vidal M; Murray GI; Greten FR; Anderson KI; Sansom OJ. 2013. ROS Production and NF-kappaB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation.. In: . . MGI: J:198485
- Nagel JM; Geiger BM; Karagiannis AK; Gras-Miralles B; Horst D; Najarian RM; Ziogas DC; Chen X; Kokkotou E. 2012. Reduced intestinal tumorigenesis in APCmin mice lacking melanin-concentrating hormone.. In: . . MGI: J:189691
- Nakanishi Y; Seno H; Fukuoka A; Ueo T; Yamaga Y; Maruno T; Nakanishi N; Kanda K; Komekado H; Kawada M; Isomura A; Kawada K; Sakai Y; Yanagita M; Kageyama R; Kawaguchi Y; Taketo MM; Yonehara S; Chiba T. 2013. Dclk1 distinguishes between tumor and normal stem cells in the intestine.. In: . . MGI: J:193873
- Nakata T; Shimizu H; Nagata S; Ito G; Fujii S; Suzuki K; Kawamoto A; Ishibashi F; Kuno R; Anzai S; Murano T; Mizutani T; Oshima S; Tsuchiya K; Nakamura T; Hozumi K; Watanabe M; Okamoto R. 2017. Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors.. In: . . MGI: J:241719
- Nakaya T; Ogawa S; Manabe I; Tanaka M; Sanada M; Sato T; Taketo MM; Nakao K; Clevers H; Fukayama M; Kuroda M; Nagai R. 2014. KLF5 regulates the integrity and oncogenicity of intestinal stem cells.. In: . . MGI: J:211557
- Nassar D; Latil M; Boeckx B; Lambrechts D; Blanpain C. 2015. Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma.. In: . . MGI: J:228762
- Neal MD; Sodhi CP; Jia H; Dyer M; Egan CE; Yazji I; Good M; Afrazi A; Marino R; Slagle D; Ma C; Branca MF; Prindle T Jr; Grant Z; Ozolek J; Hackam DJ. 2012. Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis.. In: . . MGI: J:192131
- Niessen MT; Scott J; Zielinski JG; Vorhagen S; Sotiropoulou PA; Blanpain C; Leitges M; Niessen CM. 2013. aPKClambda controls epidermal homeostasis and stem cell fate through regulation of division orientation.. In: . . MGI: J:201737
- Nigmatullina L; Norkin M; Dzama MM; Messner B; Sayols S; Soshnikova N. 2017. Id2 controls specification of Lgr5+ intestinal stem cell progenitors during gut development.. In: . . MGI: J:240625
- Ohashi W; Kimura S; Iwanaga T; Furusawa Y; Irie T; Izumi H; Watanabe T; Hijikata A; Hara T; Ohara O; Koseki H; Sato T; Robine S; Mori H; Hattori Y; Watarai H; Mishima K; Ohno H; Hase K; Fukada T. 2016. Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress.. In: . . MGI: J:236234
- Ohe S; Tanaka T; Yanai H; Komai Y; Omachi T; Kanno S; Tanaka K; Ishigaki K; Saiga K; Nakamura N; Ohsugi H; Tokuyama Y; Atsumi N; Hisha H; Yoshida N; Kumano K; Yamazaki F; Okamoto H; Ueno H. 2015. Maintenance of sweat glands by stem cells located in the acral epithelium.. In: . . MGI: J:232868
- Ohnishi K; Semi K; Yamamoto T; Shimizu M; Tanaka A; Mitsunaga K; Okita K; Osafune K; Arioka Y; Maeda T; Soejima H; Moriwaki H; Yamanaka S; Woltjen K; Yamada Y. 2014. Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation.. In: . . MGI: J:212039
- Ordonez-Moran P; Dafflon C; Imajo M; Nishida E; Huelsken J. 2015. HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer.. In: . . MGI: J:227407
- Oudhoff MJ; Braam MJ; Freeman SA; Wong D; Rattray DG; Wang J; Antignano F; Snyder K; Refaeli I; Hughes MR; McNagny KM; Gold MR; Arrowsmith CH; Sato T; Rossi FM; Tatlock JH; Owen DR; Brown PJ; Zaph C. 2016. SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/beta-Catenin and Hippo/YAP Signaling.. In: . . MGI: J:240229
- Page ME; Lombard P; Ng F; Gottgens B; Jensen KB. 2013. The epidermis comprises autonomous compartments maintained by distinct stem cell populations.. In: . . MGI: J:202041
- Peregrina K; Houston M; Daroqui C; Dhima E; Sellers RS; Augenlicht LH. 2015. Vitamin D is a determinant of mouse intestinal Lgr5 stem cell functions.. In: . . MGI: J:218278
- Perekatt AO; Valdez MJ; Davila M; Hoffman A; Bonder EM; Gao N; Verzi MP. 2014. YY1 is indispensable for Lgr5+ intestinal stem cell renewal.. In: . . MGI: J:211033
- Peuker K; Muff S; Wang J; Kunzel S; Bosse E; Zeissig Y; Luzzi G; Basic M; Strigli A; Ulbricht A; Kaser A; Arlt A; Chavakis T; van den Brink GR; Schafmayer C; Egberts JH; Becker T; Bianchi ME; Bleich A; Rocken C; Hampe J; Schreiber S; Baines JF; Blumberg RS; Zeissig S. 2016. Epithelial calcineurin controls microbiota-dependent intestinal tumor development.. In: . . MGI: J:234956
- Pitzonka L; Wang X; Ullas S; Wolff DW; Wang Y; Goodrich DW. 2013. The THO ribonucleoprotein complex is required for stem cell homeostasis in the adult mouse small intestine.. In: . . MGI: J:204752
- Plaks V; Brenot A; Lawson DA; Linnemann JR; Van Kappel EC; Wong KC; de Sauvage F; Klein OD; Werb Z. 2013. Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis.. In: . . MGI: J:196320
- Powell AE; Wang Y; Li Y; Poulin EJ; Means AL; Washington MK; Higginbotham JN; Juchheim A; Prasad N; Levy SE; Guo Y; Shyr Y; Aronow BJ; Haigis KM; Franklin JL; Coffey RJ. 2012. The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor.. In: . . MGI: J:186084
- Qiu W; Wang X; Leibowitz B; Liu H; Barker N; Okada H; Oue N; Yasui W; Clevers H; Schoen RE; Yu J; Zhang L. 2010. Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis.. In: . . MGI: J:166608
- Quante M; Bhagat G; Abrams JA; Marache F; Good P; Lee MD; Lee Y; Friedman R; Asfaha S; Dubeykovskaya Z; Mahmood U; Figueiredo JL; Kitajewski J; Shawber C; Lightdale CJ; Rustgi AK; Wang TC. 2012. Bile Acid and inflammation activate gastric cardia stem cells in a mouse model of barrett-like metaplasia.. In: . . MGI: J:180282
- Rad R; Cadinanos J; Rad L; Varela I; Strong A; Kriegl L; Constantino-Casas F; Eser S; Hieber M; Seidler B; Price S; Fraga MF; Calvanese V; Hoffman G; Ponstingl H; Schneider G; Yusa K; Grove C; Schmid RM; Wang W; Vassiliou G; Kirchner T; McDermott U; Liu P; Saur D; Bradley A. 2013. A Genetic Progression Model of Braf(V600E)-Induced Intestinal Tumorigenesis Reveals Targets for Therapeutic Intervention.. In: . . MGI: J:199307
- Radulescu S; Brookes MJ; Salgueiro P; Ridgway RA; McGhee E; Anderson K; Ford SJ; Stones DH; Iqbal TH; Tselepis C; Sansom OJ. 2012. Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo.. In: . . MGI: J:196014
- Radulescu S; Ridgway RA; Cordero J; Athineos D; Salgueiro P; Poulsom R; Neumann J; Jung A; Patel S; Woodgett J; Barker N; Pritchard DM; Oien K; Sansom OJ. 2013. Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation.. In: . . MGI: J:197230
- Rastetter RH; Bernard P; Palmer JS; Chassot AA; Chen H; Western PS; Ramsay RG; Chaboissier MC; Wilhelm D. 2014. Marker genes identify three somatic cell types in the fetal mouse ovary.. In: . . MGI: J:216158
- Reddy VK; Short SP; Barrett CW; Mittal MK; Keating CE; Thompson JJ; Harris EI; Revetta F; Bader DM; Brand T; Washington MK; Williams CS. 2016. BVES Regulates Intestinal Stem Cell Programs and Intestinal Crypt Viability after Radiation.. In: . . MGI: J:234301
- Ren W; Lewandowski BC; Watson J; Aihara E; Iwatsuki K; Bachmanov AA; Margolskee RF; Jiang P. 2014. Single Lgr5- or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo.. In: . . MGI: J:216756
- Riemer P; Sreekumar A; Reinke S; Rad R; Schafer R; Sers C; Blaker H; Herrmann BG; Morkel M. 2015. Transgenic expression of oncogenic BRAF induces loss of stem cells in the mouse intestine, which is antagonized by beta-catenin activity.. In: . . MGI: J:222531
- Ritsma L; Ellenbroek SI; Zomer A; Snippert HJ; de Sauvage FJ; Simons BD; Clevers H; van Rheenen J. 2014. Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging.. In: . . MGI: J:208759
- Saha S; Aranda E; Hayakawa Y; Bhanja P; Atay S; Brodin NP; Li J; Asfaha S; Liu L; Tailor Y; Zhang J; Godwin AK; Tome WA; Wang TC; Guha C; Pollard JW. 2016. Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury.. In: . . MGI: J:242600
- Sakamaki A; Katsuragi Y; Otsuka K; Tomita M; Obata M; Iwasaki T; Abe M; Sato T; Ochiai M; Sakuraba Y; Aoyagi Y; Gondo Y; Sakimura K; Nakagama H; Mishima Y; Kominami R. 2015. Bcl11b SWI/SNF-complex subunit modulates intestinal adenoma and regeneration after gamma-irradiation through Wnt/beta-catenin pathway.. In: . . MGI: J:221957
- Sakamori R; Das S; Yu S; Feng S; Stypulkowski E; Guan Y; Douard V; Tang W; Ferraris RP; Harada A; Brakebusch C; Guo W; Gao N. 2012. Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice.. In: . . MGI: J:184563
- Sakamori R; Yu S; Zhang X; Hoffman A; Sun J; Das S; Vedula P; Li G; Fu J; Walker F; Yang CS; Yi Z; Hsu W; Yu DH; Shen L; Rodriguez AJ; Taketo MM; Bonder EM; Verzi MP; Gao N. 2014. CDC42 inhibition suppresses progression of incipient intestinal tumors.. In: . . MGI: J:216187
- Sampson LL; Davis AK; Grogg MW; Zheng Y. 2016. mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice.. In: . . MGI: J:230899
- Sasaki N; Sachs N; Wiebrands K; Ellenbroek SI; Fumagalli A; Lyubimova A; Begthel H; van den Born M; van Es JH; Karthaus WR; Li VS; Lopez-Iglesias C; Peters PJ; van Rheenen J; van Oudenaarden A; Clevers H. 2016. Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon.. In: . . MGI: J:235576
- Sato T; Vries RG; Snippert HJ; van de Wetering M; Barker N; Stange DE; van Es JH; Abo A; Kujala P; Peters PJ; Clevers H. 2009. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.. In: . . MGI: J:224358
- Sato T; van Es JH; Snippert HJ; Stange DE; Vries RG; van den Born M; Barker N; Shroyer NF; van de Wetering M; Clevers H. 2011. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.. In: . . MGI: J:168728
- Schepers AG; Snippert HJ; Stange DE; van den Born M; van Es JH; van de Wetering M; Clevers H. 2012. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas.. In: . . MGI: J:186630
- Schuijers J; Junker JP; Mokry M; Hatzis P; Koo BK; Sasselli V; van der Flier LG; Cuppen E; van Oudenaarden A; Clevers H. 2015. Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.. In: . . MGI: J:224020
- Schwitalla S; Fingerle AA; Cammareri P; Nebelsiek T; Goktuna SI; Ziegler PK; Canli O; Heijmans J; Huels DJ; Moreaux G; Rupec RA; Gerhard M; Schmid R; Barker N; Clevers H; Lang R; Neumann J; Kirchner T; Taketo MM; van den Brink GR; Sansom OJ; Arkan MC; Greten FR. 2013. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties.. In: . . MGI: J:197481
- Sei Y; Lu X; Liou A; Zhao X; Wank SA. 2011. A stem cell marker-expressing subset of enteroendocrine cells resides at the crypt base in the small intestine.. In: . . MGI: J:168494
- Sheaffer KL; Kim R; Aoki R; Elliott EN; Schug J; Burger L; Schubeler D; Kaestner KH. 2014. DNA methylation is required for the control of stem cell differentiation in the small intestine.. In: . . MGI: J:209593
- Shi F; Hu L; Edge AS. 2013. Generation of hair cells in neonatal mice by beta-catenin overexpression in Lgr5-positive cochlear progenitors.. In: . . MGI: J:200672
- Shirokova V; Biggs LC; Jussila M; Ohyama T; Groves AK; Mikkola ML. 2016. Foxi3 Deficiency Compromises Hair Follicle Stem Cell Specification and Activation.. In: . . MGI: J:238111
- Snippert HJ; Haegebarth A; Kasper M; Jaks V; van Es JH; Barker N; van de Wetering M; van den Born M; Begthel H; Vries RG; Stange DE; Toftgard R; Clevers H. 2010. Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.. In: . . MGI: J:157895
- Snippert HJ; Schepers AG; van Es JH; Simons BD; Clevers H. 2014. Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion.. In: . . MGI: J:211965
- Snippert HJ; van der Flier LG; Sato T; van Es JH; van den Born M; Kroon-Veenboer C; Barker N; Klein AM; van Rheenen J; Simons BD; Clevers H. 2010. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells.. In: . . MGI: J:164644
- Stringer EJ; Duluc I; Saandi T; Davidson I; Bialecka M; Sato T; Barker N; Clevers H; Pritchard CA; Winton DJ; Wright NA; Freund JN; Deschamps J; Beck F. 2012. Cdx2 determines the fate of postnatal intestinal endoderm.. In: . . MGI: J:179732
- Stzepourginski I; Nigro G; Jacob JM; Dulauroy S; Sansonetti PJ; Eberl G; Peduto L. 2017. CD34+ mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury.. In: . . MGI: J:239521
- Sukhdeo K; Koch CE; Miller TE; Zhou H; Rivera M; Yan K; Cepko CL; Lathia JD; Rich JN. 2014. The Lgr5 transgene is expressed specifically in glycinergic amacrine cells in the mouse retina.. In: . . MGI: J:210379
- Takada Y; Fukuda A; Chiba T; Seno H. 2016. Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling.. In: . . MGI: J:236406
- Takahashi T; Ohnishi H; Sugiura Y; Honda K; Suematsu M; Kawasaki T; Deguchi T; Fujii T; Orihashi K; Hippo Y; Watanabe T; Yamagaki T; Yuba S. 2014. Non-neuronal acetylcholine as an endogenous regulator of proliferation and differentiation of Lgr5-positive stem cells in mice.. In: . . MGI: J:229219
- Takeda N; Jain R; Leboeuf MR; Padmanabhan A; Wang Q; Li L; Lu MM; Millar SE; Epstein JA. 2013. Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells.. In: . . MGI: J:195123
- Takeda N; Jain R; Leboeuf MR; Wang Q; Lu MM; Epstein JA. 2011. Interconversion Between Intestinal Stem Cell Populations in Distinct Niches.. In: . . MGI: J:178296
- Tanaka T; Komai Y; Tokuyama Y; Yanai H; Ohe S; Okazaki K; Ueno H. 2013. Identification of stem cells that maintain and regenerate lingual keratinized epithelial cells.. In: . . MGI: J:197688
- Taniguchi CM; Miao YR; Diep AN; Wu C; Rankin EB; Atwood TF; Xing L; Giaccia AJ. 2014. PHD inhibition mitigates and protects against radiation-induced gastrointestinal toxicity via HIF2.. In: . . MGI: J:215343
- Tao S; Tang D; Morita Y; Sperka T; Omrani O; Lechel A; Sakk V; Kraus J; Kestler HA; Kuhl M; Rudolph KL. 2015. Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage.. In: . . MGI: J:219566
- Tian H; Biehs B; Chiu C; Siebel CW; Wu Y; Costa M; de Sauvage FJ; Klein OD. 2015. Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis.. In: . . MGI: J:228167
- Tinkum KL; Stemler KM; White LS; Loza AJ; Jeter-Jones S; Michalski BM; Kuzmicki C; Pless R; Stappenbeck TS; Piwnica-Worms D; Piwnica-Worms H. 2015. Fasting protects mice from lethal DNA damage by promoting small intestinal epithelial stem cell survival.. In: . . MGI: J:228306
- Valenta T; Degirmenci B; Moor AE; Herr P; Zimmerli D; Moor MB; Hausmann G; Cantu C; Aguet M; Basler K. 2016. Wnt Ligands Secreted by Subepithelial Mesenchymal Cells Are Essential for the Survival of Intestinal Stem Cells and Gut Homeostasis.. In: . . MGI: J:235388
- Van Keymeulen A; Rocha AS; Ousset M; Beck B; Bouvencourt G; Rock J; Sharma N; Dekoninck S; Blanpain C. 2011. Distinct stem cells contribute to mammary gland development and maintenance.. In: . . MGI: J:180048
- Vandussen KL; Carulli AJ; Keeley TM; Patel SR; Puthoff BJ; Magness ST; Tran IT; Maillard I; Siebel C; Kolterud A; Grosse AS; Gumucio DL; Ernst SA; Tsai YH; Dempsey PJ; Samuelson LC. 2012. Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells.. In: . . MGI: J:179656
- Veniaminova NA; Hayes MM; Varney JM; Merchant JL. 2012. Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia.. In: . . MGI: J:226232
- Vermeulen L; Morrissey E; van der Heijden M; Nicholson AM; Sottoriva A; Buczacki S; Kemp R; Tavare S; Winton DJ. 2013. Defining stem cell dynamics in models of intestinal tumor initiation.. In: . . MGI: J:205193
- Vetter E; Kronast M; Tolge M; Zimmermann W. 2015. Lgr5-expressing stem cells are not the cells of origin of pyloric neuroendocrine carcinomas in mice.. In: . . MGI: J:227722
- Wang D; Cai C; Dong X; Yu QC; Zhang XO; Yang L; Zeng YA. 2015. Identification of multipotent mammary stem cells by protein C receptor expression.. In: . . MGI: J:217483
- Wang S; Li N; Yousefi M; Nakauka-Ddamba A; Li F; Parada K; Rao S; Minuesa G; Katz Y; Gregory BD; Kharas MG; Yu Z; Lengner CJ. 2015. Transformation of the intestinal epithelium by the MSI2 RNA-binding protein.. In: . . MGI: J:221881
- Wang T; Chai R; Kim GS; Pham N; Jansson L; Nguyen DH; Kuo B; May LA; Zuo J; Cunningham LL; Cheng AG. 2015. Lgr5+ cells regenerate hair cells via proliferation and direct transdifferentiation in damaged neonatal mouse utricle.. In: . . MGI: J:222739
- Watson EC; Koenig MN; Grant ZL; Whitehead L; Trounson E; Dewson G; Coultas L. 2016. Apoptosis regulates endothelial cell number and capillary vessel diameter but not vessel regression during retinal angiogenesis.. In: . . MGI: J:236410
- Wei L; Leibowitz BJ; Wang X; Epperly M; Greenberger J; Zhang L; Yu J. 2016. Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice.. In: . . MGI: J:239622
- Whissell G; Montagni E; Martinelli P; Hernando-Momblona X; Sevillano M; Jung P; Cortina C; Calon A; Abuli A; Castells A; Castellvi-Bel S; Nacht AS; Sancho E; Stephan-Otto Attolini C; Vicent GP; Real FX; Batlle E. 2014. The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression.. In: . . MGI: J:219389
- White AC; Khuu JK; Dang CY; Hu J; Tran KV; Liu A; Gomez S; Zhang Z; Yi R; Scumpia P; Grigorian M; Lowry WE. 2014. Stem cell quiescence acts as a tumour suppressor in squamous tumours.. In: . . MGI: J:208368
- Wiener Z; Band AM; Kallio P; Hogstrom J; Hyvonen V; Kaijalainen S; Ritvos O; Haglund C; Kruuna O; Robine S; Louvard D; Ben-Neriah Y; Alitalo K. 2014. Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-beta.. In: . . MGI: J:211270
- Wilson CH; Crombie C; van der Weyden L; Poulogiannis G; Rust AG; Pardo M; Gracia T; Yu L; Choudhary J; Poulin GB; McIntyre RE; Winton DJ; March HN; Arends MJ; Fraser AG; Adams DJ. 2012. Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.. In: . . MGI: J:184685
- Witkowski MT; Cimmino L; Hu Y; Trimarchi T; Tagoh H; McKenzie MD; Best SA; Tuohey L; Willson TA; Nutt SL; Busslinger M; Aifantis I; Smyth GK; Dickins RA. 2015. Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia.. In: . . MGI: J:221970
- Wong VW; Stange DE; Page ME; Buczacki S; Wabik A; Itami S; van de Wetering M; Poulsom R; Wright NA; Trotter MW; Watt FM; Winton DJ; Clevers H; Jensen KB. 2012. Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling.. In: . . MGI: J:196030
- Wuidart A; Ousset M; Rulands S; Simons BD; Van Keymeulen A; Blanpain C. 2016. Quantitative lineage tracing strategies to resolve multipotency in tissue-specific stem cells.. In: . . MGI: J:233310
- Yan KS; Chia LA; Li X; Ootani A; Su J; Lee JY; Su N; Luo Y; Heilshorn SC; Amieva MR; Sangiorgi E; Capecchi MR; Kuo CJ. 2012. The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations.. In: . . MGI: J:179994
- Yang H; Adam RC; Ge Y; Hua ZL; Fuchs E. 2017. Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices.. In: . . MGI: J:241508
- Yang Z; Balic A; Michon F; Juuri E; Thesleff I. 2015. Mesenchymal Wnt/beta-Catenin Signaling Controls Epithelial Stem Cell Homeostasis in Teeth by Inhibiting the Antiapoptotic Effect of Fgf10.. In: . . MGI: J:224182
- Yee KK; Li Y; Redding KM; Iwatsuki K; Margolskee RF; Jiang P. 2013. Lgr5-EGFP Marks Taste Bud Stem/Progenitor Cells in Posterior Tongue.. In: . . MGI: J:196314
- Yu S; Nie Y; Knowles B; Sakamori R; Stypulkowski E; Patel C; Das S; Douard V; Ferraris RP; Bonder EM; Goldenring JR; Ip YT; Gao N. 2014. TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis.. In: . . MGI: J:215917
- Yum MK; Kang JS; Lee AE; Jo YW; Seo JY; Kim HA; Kim YY; Seong J; Lee EB; Kim JH; Han JM; Kim S; Kong YY. 2016. AIMP2 Controls Intestinal Stem Cell Compartments and Tumorigenesis by Modulating Wnt/beta-Catenin Signaling.. In: . . MGI: J:234840
- Zhang YQ; Li P; Zhang FQ; Sun SJ; Cao YG. 2016. Lgr5 regulates the regeneration of lesioned nasal respiratory epithelium.. In: . . MGI: J:240815
- Zhao B; Qi Z; Li Y; Wang C; Fu W; Chen YG. 2015. The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells.. In: . . MGI: J:224876
- Zhou WJ; Geng ZH; Spence JR; Geng JG. 2013. Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection.. In: . . MGI: J:204377
- Zhu Y; Huang YF; Kek C; Bulavin DV. 2013. Apoptosis differently affects lineage tracing of Lgr5 and Bmi1 intestinal stem cell populations.. In: . . MGI: J:195138
- da Silva-Diz V; Sole-Sanchez S; Valdes-Gutierrez A; Urpi M; Riba-Artes D; Penin RM; Pascual G; Gonzalez-Suarez E; Casanovas O; Vinals F; Paramio JM; Batlle E; Munoz P. 2013. Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis.. In: . . MGI: J:199981
- de Lau W; Barker N; Low TY; Koo BK; Li VS; Teunissen H; Kujala P; Haegebarth A; Peters PJ; van de Wetering M; Stange DE; van Es JE; Guardavaccaro D; Schasfoort RB; Mohri Y; Nishimori K; Mohammed S; Heck AJ; Clevers H. 2011. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.. In: . . MGI: J:174842
- de Lau W; Kujala P; Schneeberger K; Middendorp S; Li VS; Barker N; Martens A; Hofhuis F; DeKoter RP; Peters PJ; Nieuwenhuis E; Clevers H. 2012. Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts".. In: . . MGI: J:188796
- de Visser KE; Ciampricotti M; Michalak EM; Tan DW; Speksnijder EN; Hau CS; Clevers H; Barker N; Jonkers J. 2012. Developmental stage-specific contribution of LGR5(+) cells to basal and luminal epithelial lineages in the postnatal mammary gland.. In: . . MGI: J:190035
- van Es JH; Sato T; van de Wetering M; Lyubimova A; Nee AN; Gregorieff A; Sasaki N; Zeinstra L; van den Born M; Korving J; Martens AC; Barker N; van Oudenaarden A; Clevers H. 2012. Dll1+ secretory progenitor cells revert to stem cells upon crypt damage.. In: . . MGI: J:193937
- van der Flier LG; van Gijn ME; Hatzis P; Kujala P; Haegebarth A; Stange DE; Begthel H; van den Born M; Guryev V; Oving I; van Es JH; Barker N; Peters PJ; van de Wetering M; Clevers H. 2009. Transcription factor achaete scute-like 2 controls intestinal stem cell fate.. In: . . MGI: J:148715