Prdm1-Cre (Blimp1-Cre) transgenic mice express Cre recombinase under the control of the mouse Prdm1 (PR domain containing 1, with ZNF domain; Blimp1) promoter. Cre-mediated recombination is detected in 55-76% of primordial germ cells when this strain is crossed with Gt(ROSA)26-GFP reporter mice. Expression is also seen in plasma cells. These mice may be useful for generating tissue-specific targeted mutants for studies of development and germ cell fate. Heterozygotes are slow to produce litters. The litters are small and it is not uncommon to lose pups before weaning. Heterozygote x wildtype (or C57BL/6J, Stock No. <a href="https://www.jax.org/strain/000664">000664</a>) crosses are recommended to maintain this strain. Given the breeding/viability challenges, homozygotes will not be produced in the JAX colony. (February, 2020). Hair loss, likely attributable to the C57BL/6 genetic background, is also observed.

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Prdm1-Cre (Blimp1-Cre) transgenic mice express Cre recombinase under the control of the mouse Prdm1 promoter. These mice may be useful for generating tissue-specific targeted mutants for studies of development and germ cell fate.Heterozygotes are slow to produce litters. The litters are small and it is not uncommon to lose pups before weaning. Heterozygote x wildtype (or C57BL/6J, Stock No. <a href="https://www.jax.org/strain/000664">000664</a>) crosses are recommended to maintain this strain. Given the breeding/viability challenges, homozygotes will not be produced in the JAX colony. (February, 2020). Hair loss, likely attributable to the C57BL/6 genetic background, is also observed.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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