FVB.B-Wld^S/UmonJ

Stock number: 008820
Research areas: Neurobiology Research

Description

This Wld^s spontaneous mutant mouse strain may be useful in studies of peripheral nerve regeneration and neurodegenerative disorders.

Detailed description

The Wallerian degeneration slow spontaneous mutation, Wld^s arose on the C57BL/Ola background. On the congenic FVB/N background, mice that are homozygous for this mutation exhibit delayed Wallerian degeneration compared to wildtype controls. Wallerian degeneration is the process of degeneration, after transection, of axons distal to the sever site of a peripheral nerve, and includes infiltration of macrophages, demyelination and initiation of Schwann cell mitosis. The Wld^s mutation is widely expressed and is detected in neural tissue.

Development

The Wallerian degeneration slow spontaneous mutation, Wld^s arose on the C57BL/Ola background. The Donating Investigator backcrossed the mice to FVB/N for 9 generations and notes that there are incidental mutant loci. Upon arrival at The Jackson Laboratory the mice were crossed with FVB/NJ at least once to establish the colony and the resulting offspring carrying only the Wld^s allele were selectively bred to establish this strain.

Allele

Symbol: Wld^s
Name: Wallerian degeneration slow
MGI accession ID: MGI:1857538
Generation method: Spontaneous
Marker symbol: Wld
Marker name: wallerian degeneration
Chromosome: 4
Strain of origin: C57BL/6Ola
Molecular note: The underlying mutation is an 85-kb tandem triplication on chromosome 4. This triplication results in the expression of an abnormal transcript that encodes a fusion of the N-terminal fragment of ubiquitination factor E4B (Ube4b) fused to nicotinamide mononucleotide adenylyltransferase 1 (Nmnat1).