This Wlds spontaneous mutant mouse strain may be useful in studies of peripheral nerve regeneration and neurodegenerative disorders.
Umrao R Monani, Columbia University Medical Center
The Wallerian degeneration slow spontaneous mutation, Wlds arose on the C57BL/Ola background. On the congenic FVB/N background, mice that are homozygous for this mutation exhibit delayed Wallerian degeneration compared to wildtype controls. Wallerian degeneration is the process of degeneration, after transection, of axons distal to the sever site of a peripheral nerve, and includes infiltration of macrophages, demyelination and initiation of Schwann cell mitosis.
The Wlds mutation is widely expressed and is detected in neural tissue.
The Wallerian degeneration slow spontaneous mutation, Wlds arose on the C57BL/Ola background. The Donating Investigator backcrossed the mice to FVB/N for 9 generations and notes that there are incidental mutant loci. Upon arrival at The Jackson Laboratory the mice were crossed with FVB/NJ at least once to establish the colony and the resulting offspring carrying only the Wlds allele were selectively bred to establish this strain.
|Allele Name||Wallerian degeneration slow|
|Gene Symbol and Name||Wld, wallerian degeneration|
|Strain of Origin||C57BL/6Ola|
|Molecular Note||The underlying mutation is an 85-kb tandem triplication on chromosome 4. This triplication results in the expression of an abnormal transcript that encodes a fusion of the N-terminal fragment of ubiquitination factor E4B (Ube4b) fused to nicotinamide mononucleotide adenylyltransferase 1 (Nmnat1).|
|Mutations Made By|| |
Umrao Monani, Columbia University Medical Center
When maintaining a live colony, these mice can be bred as homozygotes.
When using the FVB.B-WldS/UmonJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #008820 in your Materials and Methods section.