This Wlds spontaneous mutant mouse strain may be useful in studies of peripheral nerve regeneration and neurodegenerative disorders.
Umrao R Monani, Columbia University Medical Center
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Wld | wallerian degeneration |
The Wallerian degeneration slow spontaneous mutation, Wlds arose on the C57BL/Ola background. On the congenic FVB/N background, mice that are homozygous for this mutation exhibit delayed Wallerian degeneration compared to wildtype controls. Wallerian degeneration is the process of degeneration, after transection, of axons distal to the sever site of a peripheral nerve, and includes infiltration of macrophages, demyelination and initiation of Schwann cell mitosis.
The Wlds mutation is widely expressed and is detected in neural tissue.
The Wallerian degeneration slow spontaneous mutation, Wlds arose on the C57BL/Ola background. The Donating Investigator backcrossed the mice to FVB/N for 9 generations and notes that there are incidental mutant loci. Upon arrival at The Jackson Laboratory the mice were crossed with FVB/NJ at least once to establish the colony and the resulting offspring carrying only the Wlds allele were selectively bred to establish this strain.
Allele Name | Wallerian degeneration slow |
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Allele Type | Spontaneous |
Allele Synonym(s) | Wlds |
Gene Symbol and Name | Wld, wallerian degeneration |
Gene Synonym(s) | |
Strain of Origin | C57BL/6Ola |
Chromosome | 4 |
Molecular Note | The underlying mutation is an 85-kb tandem triplication on chromosome 4. This triplication results in the expression of an abnormal transcript that encodes a fusion of the N-terminal fragment of ubiquitination factor E4B (Ube4b) fused to nicotinamide mononucleotide adenylyltransferase 1 (Nmnat1). |
Mutations Made By | Umrao Monani, Columbia University Medical Center |
When maintaining a live colony, these mice can be bred as homozygotes.
When using the FVB.B-WldS/UmonJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #008820 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or wildtype for Wld<S> |
Frozen Mouse Embryo | FVB.B-Wld<S>/UmonJ | $2595.00 |
Frozen Mouse Embryo | FVB.B-Wld<S>/UmonJ | $2595.00 |
Frozen Mouse Embryo | FVB.B-Wld<S>/UmonJ | $3373.50 |
Frozen Mouse Embryo | FVB.B-Wld<S>/UmonJ | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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