Mice homozygous for this f(&alpha;3) conditional allele are viable and fertile, with loxP sites flanking exons 11-18 of the Itga3 (integrin alpha 3 (or alpha3-integrin (&alpha;3-integrin)) gene. When bred to mice that express Cre recombinase, the resulting offspring will have the floxed region deleted in the cre-expressing tissue(s): such deletion leads to a non-sense mutation from direct splicing of exon 10 to exon 19 and results in a truncated peptide that is predicted to be missing more than half of the wild-type sequence, including those that encode the transmembrane and the cytoplasmic domains. These f(&alpha;3) mutant mice may be useful in generating conditional mutations for studying the role of Itga3 transmembrane cell adhesion receptors in neuronal functions in the developing and adult central nervous system, including synaptic plasticity and memory formation.

 When bred to a strain expressing Cre recombinase in the hippocampal CA1 pyramidal cells (see Stock No. <a href="https://www.jax.org/strain/005359">005359</a> for example), this mutant mouse strain may be useful in studies of long term potentiation and memory.

These f(&alpha;3) mutant mice harbor loxP sites flanking exons 11-18 of the Itga3 (integrin alpha 3 (or alpha3-integrin (&alpha;3-integrin)) gene and may be useful in generating conditional mutations for studying the role of Itga3 transmembrane cell adhesion receptors in neuronal functions in the developing and adult central nervous system, including synaptic plasticity and memory formation.

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