Mice that are homozygous for the mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Screening of third generation mice (G3) on standard chow identified a 20 week old male (born 11/21/2002) with an increased albumin-creatinine ratio of 22 mg/g. Retesting one week later confirmed this observation with a reading of 91 mg/g. This mutant mouse strain may be useful in studies of albuminuria.
Following multidose ethylnitrosourea (ENU) treatments to induce mutations in male founder C57BL/6J mice (Stock No. 000664), a forward genetic screen was utilized to identify phenotypic deviants in complex heart, lung, blood, and sleep disorders, at the Mouse Heart, Lung, Blood, and Sleep Disorders (HLBS) Center at The Jackson Laboratory. Mapping identified the location of the mutation to Chromosome 2.
|Allele Name||renal 5|
|Allele Type||Chemically induced (ENU)|
|Gene Symbol and Name||Stk39, serine/threonine kinase 39|
|Strain of Origin||C57BL/6J|
|Molecular Note||This mutant was identified in an ENU mutagenesis screen. It has been mapped to position 68155248 of chromosome 2 in intron 8 of Stk39.|