The New Zealand ginger (NZG) mouse is characterized by rapid growth and a large body size as a result of excessive lean body mass. Mice are susceptible to high fat diet-induced obesity, but not diabetes. This inbred strain may be useful for studies of pigmentation, metabolism, fat deposition, and resistance to type 2 diabetes.Read More +
The New Zealand Ginger (NZG) mouse is characterized by rapid growth and a large body size as a result of excessive lean body mass. This inbred strain is not obese, diabetic or insulin resistant. Both sexes exhibit a rapid growth rate which plateaus at 60 days, however, males are heavier than females. ELISA assay indicates that mice have higher levels of circulating insulin-like growth factor I (IGF1) than C57BL/6 mice, but comparable levels of insulin and growth hormone.
Mice have an unusual pattern of fat distribution compared to C57BL/6 mice with higher percentages of retroperitoneal, gonadal and inguinal fat rather than visceral fat. NZG mice have less total body fat (6%) than C57BL/6 mice (13.8%). These mice are susceptible to high fat (45%) diet-induced obesity, but not diet-induced diabetes.
Genetic analysis indicates that the yellow (ginger) coat is not the result of alleles at either agouti or the melanocortin 1 receptor (Mc1r) genes. The fur is described as ginger-tipped with a light grey base. This inbred strain may be useful for studies of pigmentation, metabolism and fat deposition, and resistance to type 2 diabetes.
This inbred strain is the result of a 4-way cross between white bellied agouti (Aw) mice, C57, CBA and an albino strain called Ruakura White. Mice produced from the cross were selected for body weight. The colony was sibling mated until F37 and then randomly mated until F77. Over time, caretakers selectively choose large pink-eyed, (yellow) ginger mice for matings and a separate line was established. The inbred strain New Zealand Ginger (NZG) was developed from this line. The strain has been maintained in the laboratory of Dr. Kathleen Mountjoy at the University of Auckland since 1990; it was donated to the Repository in 2009.
Currently there are no related genes or alleles for this strain.