immune system phenotype

• decreased B-1 B cell number
  • the peritoneal B1 cell population is reduced in young and old mutants
  (MGI Ref ID J:94911)

• decreased B-2 B cell number
  • the peritoneal B2 cell population is reduced only in older mutants
  (MGI Ref ID J:94911)

• decreased plasma cell number
  • the number of antibody-secreting cells is reduced in the bone marrow and increased in the spleen 9 days after immunization, however long-term antibody production is not impaired
  (MGI Ref ID J:94911)
  • a greater than 20-fold reduction in the number of T cell independent antigen-specific plasma cells in the bone marrow is seen after immunization with Ficoll
  (MGI Ref ID J:94911)

• decreased immunoglobulin level
  • basal levels of serum IG of all isotypes are reduced
  (MGI Ref ID J:94911)

• abnormal B cell differentiation
  • a large number of the B cell precursors die before they can complete the differentiation process
  (MGI Ref ID J:94911)
  • B cell precursors are found in the blood
  (MGI Ref ID J:94911)

• decreased mature B cell number
  • the total number of mature B cells in the spleen is reduced to about 65% of wild-type
  (MGI Ref ID J:94911)

• abnormal Peyer's patch follicle morphology
  • B cell follicles are more dispersed, frequently occur deep in the lamina propria, and some have enlarged T cell zones
  (MGI Ref ID J:94911)

hematopoietic system phenotype

• abnormal B cell differentiation
  • B cell precursors are found in the blood
  (MGI Ref ID J:94911)
  • a large number of the B cell precursors die before they can complete the differentiation process
  (MGI Ref ID J:94911)

• decreased mature B cell number
  • the total number of mature B cells in the spleen is reduced to about 65% of wild-type
  (MGI Ref ID J:94911)

• decreased plasma cell number
  • the number of antibody-secreting cells is reduced in the bone marrow and increased in the spleen 9 days after immunization, however long-term antibody production is not impaired
  (MGI Ref ID J:94911)
  • a greater than 20-fold reduction in the number of T cell independent antigen-specific plasma cells in the bone marrow is seen after immunization with Ficoll
  (MGI Ref ID J:94911)

• decreased B-2 B cell number
  • the peritoneal B2 cell population is reduced only in older mutants
  (MGI Ref ID J:94911)

• decreased immunoglobulin level
  • basal levels of serum IG of all isotypes are reduced
  (MGI Ref ID J:94911)

• decreased B-1 B cell number
  • the peritoneal B1 cell population is reduced in young and old mutants
  (MGI Ref ID J:94911)

growth/size/body region phenotype

• increased susceptibility to diet-induced obesity
  • in mice fed a high-fat diet despite normal food intake
  (MGI Ref ID J:217569)
  • Normal - however, mice fed standard chow exhibit normal weight
  (MGI Ref ID J:217569)

hematopoietic system phenotype

• abnormal macrophage cell number
  • 2.3-fold decreased F4/80+CD11b+CD206+CD11c- M2 adipose tissue macrophages in the white adipose tissue of mice fed a high-fat diet
  (MGI Ref ID J:217569)
  • increased F4/80+CD11b+CD206-CD11c+ M1 adipose tissue macrophages in the white adipose tissue of mice fed a high-fat diet
  (MGI Ref ID J:217569)

• decreased CD4-positive, alpha beta T cell number
  • 2.4-fold decrease in the white adipose tissue of mice fed a high-fat diet
  (MGI Ref ID J:217569)

• increased CD8-positive, alpha-beta T cell number
  • 2.6-fold increase in the white adipose tissue of mice fed a high-fat diet
  (MGI Ref ID J:217569)

• decreased B cell number
  • in the white adipose tissue of mice fed a high-fat diet
  (MGI Ref ID J:217569)

homeostasis/metabolism phenotype

• impaired adaptive thermogenesis
  • Normal - however, body temperature when housed at 25 degrees Celsius is normal
  (MGI Ref ID J:217569)
  • cold-exposed mice fed a high-fat diet exhibit lower body temperatures compared with wild-type mice
  (MGI Ref ID J:217569)

• increased susceptibility to diet-induced obesity
  • Normal - however, mice fed standard chow exhibit normal weight
  (MGI Ref ID J:217569)
  • in mice fed a high-fat diet despite normal food intake
  (MGI Ref ID J:217569)

• decreased oxygen consumption
  • Normal - however, oxygen consumption normalized to lean body mass is normal
  (MGI Ref ID J:217569)
  • in mice fed a high-fat diet during the light and dark phase
  (MGI Ref ID J:217569)

immune system phenotype

• abnormal macrophage cell number
  • increased F4/80+CD11b+CD206-CD11c+ M1 adipose tissue macrophages in the white adipose tissue of mice fed a high-fat diet
  (MGI Ref ID J:217569)
  • 2.3-fold decreased F4/80+CD11b+CD206+CD11c- M2 adipose tissue macrophages in the white adipose tissue of mice fed a high-fat diet
  (MGI Ref ID J:217569)

• decreased B cell number
  • in the white adipose tissue of mice fed a high-fat diet
  (MGI Ref ID J:217569)

• increased CD8-positive, alpha-beta T cell number
  • 2.6-fold increase in the white adipose tissue of mice fed a high-fat diet
  (MGI Ref ID J:217569)

• decreased CD4-positive, alpha beta T cell number
  • 2.4-fold decrease in the white adipose tissue of mice fed a high-fat diet
  (MGI Ref ID J:217569)

integument phenotype

• increased subcutaneous adipose tissue amount
  • 1.8-fold in mice fed a high-fat diet
  (MGI Ref ID J:217569)

adipose tissue phenotype

• increased gonadal fat pad weight
  • 1.6-fold in visceral (mesenteric, retroperitoneal, and gonadal) white adipose tissue mice fed a high-fat diet
  (MGI Ref ID J:217569)

• increased subcutaneous adipose tissue amount
  • 1.8-fold in mice fed a high-fat diet
  (MGI Ref ID J:217569)

• increased total body fat amount
  • 2-fold increase in mice fed a high-fat diet
  (MGI Ref ID J:217569)

• increased white adipose tissue mass
  • in mice fed a high-fat diet
  (MGI Ref ID J:217569)

• increased white fat cell size
  • in mice fed a high-fat diet
  (MGI Ref ID J:217569)

• increased retroperitoneal fat pad weight
  • 1.6-fold in visceral (mesenteric, retroperitoneal, and gonadal) white adipose tissue mice fed a high-fat diet
  (MGI Ref ID J:217569)

• increased brown adipose tissue mass
  • 2-fold in mice fed a high-fat diet
  (MGI Ref ID J:217569)

• increased brown fat cell size
  • in mice fed a high-fat diet
  (MGI Ref ID J:217569)

• increased mesenteric fat pad weight
  • 1.6-fold in visceral (mesenteric, retroperitoneal, and gonadal) white adipose tissue mice fed a high-fat diet
  (MGI Ref ID J:217569)

mammalian phenotype

• homeostasis/metabolism phenotype
  • Normal - mice fed a high-fat diet exhibit normal glucose sensitivity as similarly treated wild-type mice
  (MGI Ref ID J:217569)

• growth/size/body region phenotype
  • Normal - mice fed standard chow or a high-fat diet exhibit normal lean mass
  (MGI Ref ID J:217569)

hematopoietic system phenotype

• increased neutrophil cell number
  (MGI Ref ID J:217569)

• increased lymphocyte cell number
  (MGI Ref ID J:217569)

• increased monocyte cell number
  (MGI Ref ID J:217569)

immune system phenotype

• increased neutrophil cell number
  (MGI Ref ID J:217569)

• increased monocyte cell number
  (MGI Ref ID J:217569)

• increased lymphocyte cell number
  (MGI Ref ID J:217569)

mammalian phenotype

• adipose tissue phenotype
  • Normal - mice fed standard chow or a high-fat diet exhibit normal adiposity and lymphocyte numbers in white adipose tissue
  (MGI Ref ID J:217569)

• growth/size/body region phenotype
  • Normal - mice fed standard chow or a high-fat diet exhibit normal weight gain
  (MGI Ref ID J:217569)