STOCK Reln^rl-8J/J

Stock number: 008764
Research areas: Neurobiology Research

Description

This strain is extinct. Please search the JAX^® Mice Database for strains carrying the Reln gene.

Detailed description

Like other reeler mutants, reeler 8 Jackson homozygotes display a wobbly gait and ataxia by two weeks of age. More severe than many reeler mutants, reeler 8 Jackson homozygotes on this background die by approximately three weeks of age. The Cerebellum is small with scrambled Purkinje and granule cells, there is scrambled layering in the cortex, and the neurons of the hippocampal gyrus are scattered in irregular wavy layers.

Development

The reeler 8 Jackson mutation was ENU induced in C57BL/6J and subsequently crossed to C3Fe.Cg-Rw then C3Fe.Cg-Hm +/+ Rw, before being maintained by closed colony breeding and sibling inbreeding. The resulting line is black (a/a) and reached generation F13 in 2008.

Allele

Symbol: Reln^rl-8J
Name: reeler 8 Jackson
MGI accession ID: MGI:3814321
Generation method: Chemically induced (ENU)
Marker symbol: Reln
Marker name: reelin
Marker synonyms: ETL7; LIS2; PRO1598; Reelen; reeler; Rl
Chromosome: 5
Strain of origin: C57BL/6J
Molecular note: Non-complementation with reeler 7 Jackson showed that this mutation is an allele of Reln.