Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous (Not Specified) | Atp8a2 | ATPase, aminophospholipid transporter-like, class I, type 8A, member 2 |
Homozygotes display an abnormal, wobbling gait by 2 weeks of age and are smaller than control littermates. At 3 weeks of age dystrophic axons and vacuoles are found in the spinal cord, white matter, cerebellar peduncles, and eighth cranial nerve root.
The agitans-like 2 Jackson mutation arose spontaneously in the AKR/J inbred strain at The Jackson Laboratory in 2006, when that inbred was at generation F250. This mutation has been maintained on this same inbred background by sibling breeding and reached generation F16 in 2010.
Allele Name | agitans-like 2 Jackson |
---|---|
Allele Type | Spontaneous (Not Specified) |
Allele Synonym(s) | |
Gene Symbol and Name | Atp8a2, ATPase, aminophospholipid transporter-like, class I, type 8A, member 2 |
Gene Synonym(s) | |
Strain of Origin | AKR/J |
Chromosome | 14 |
Molecular Note | This mutation failed to complement in an allele test with the original agil mutation, which failed to complement in an allele test with the agil-3J allele, which was found to be a mutation in this gene. |
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