AKR/J-Atp8a2^agil-2J/J

Stock number: 008657
Product name: agitans-like 2 Jackson

Description

Please see Stock No. 021203 for this allele.

Detailed description

Homozygotes display an abnormal, wobbling gait by 2 weeks of age and are smaller than control littermates. At 3 weeks of age dystrophic axons and vacuoles are found in the spinal cord, white matter, cerebellar peduncles, and eighth cranial nerve root.

Development

The agitans-like 2 Jackson mutation arose spontaneously in the AKR/J inbred strain at The Jackson Laboratory in 2006, when that inbred was at generation F250. This mutation has been maintained on this same inbred background by sibling breeding and reached generation F16 in 2010.