The 120 Kb deletion in the spontaneous mutation, grizzle belly, represents the smallest complete deletion among the Kit ligand (Steel) alleles.  Mice homozygous for the mutation die just before or after birth.  Mice that survive to postnatal day 1 display a substantial decrease in peripheral red blood cells (RBC) and a severe anemia.  Heterozygotes exhibit a mild anemia, and some decrease in peripheral RBC. In the homozygous embryo there is an absence of primordial germ cells (PGCs) by E11.5; an intermediate number of PGCs are found in the heterozygote.  Like the other mutations at the Steel locus, this allele causes abnormal pigmentation.  Heterozygotes can be identified by a head spot and light belly.  This strain may be useful for research in hematopoiesis, pigmentation and gametogenesis.

This spontaneous mutation in the Kit ligand, grizzle belly, is perinatally lethal in the homozygous state. Heterozygotes exhibit a mild anemia, a head spot and light belly. This strain may be useful for research in hematopoiesis, pigmentation and gametogenesis.





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