Mice homozygous for spontaneous mutation of the calcium channel, voltage-dependent, alpha 2/delta subunit 2 gene exhibit ataxia, paroxysomal dyskinesia and absence seizures. Ducky 2J mice may be useful for studies of epilepsy and voltage-dependent calcium channels.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Cacna2d2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 |
Mice homozygous for ducky-2J mutation exhibit ataxia and paroxysomal dyskinesia, however, they lack the "ducky" gait found in mice homozygous for the ducky allele (du) . EEG recordings reveal infrequent bilateral spike wave discharges accompanied by behavioral arrest. Absence seizures are increased in comparison to ducky mice (personal communication). This strain may be useful for studies of epilepsy and voltage-dependent calcium channels.
This spontaneous mutation arose on C57BLKS/J and was maintained by brother x sister matings in the laboratory of Dr. Wayne Frankel and Dr. Verity Letts at The Jackson Laboratory. It was donated to the Repository in 2008.
Allele Name | ducky 2 Jackson |
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Allele Type | Spontaneous |
Allele Synonym(s) | du2J |
Gene Symbol and Name | Cacna2d2, calcium channel, voltage-dependent, alpha 2/delta subunit 2 |
Gene Synonym(s) | |
Strain of Origin | C57BLKS/J |
Chromosome | 9 |
Molecular Note | A 2 bp deletion within exon 9 is predicted to cause a frameshift and premature truncation of the encoded protein. Northern blot analysis on mRNA derived from brain tissue of homozygous mice showed no difference in transcription levels compared to wild type, suggesting stability of the mutated transcript. |
When maintaining a live colony, these mice are bred as heterozygotes.
When using the C57BLKS/J-Cacna2d2du-2J/LetJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #008625 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or Wild-type for Cacna2d2<du-2J> |
Frozen Mouse Embryo | C57BLKS/J-Cacna2d2<du-2J>/LetJ | $2595.00 |
Frozen Mouse Embryo | C57BLKS/J-Cacna2d2<du-2J>/LetJ | $2595.00 |
Frozen Mouse Embryo | C57BLKS/J-Cacna2d2<du-2J>/LetJ | $3373.50 |
Frozen Mouse Embryo | C57BLKS/J-Cacna2d2<du-2J>/LetJ | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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