Mice homozygous for this spontaneous mutation of the calcium channel, voltage-dependent, gamma subunit 2 gene have an ataxic gait. Although EEG readings show no spike wave discharge, absence seizures are observed. (personal communication). Stargazer 3J mice may be useful in studies of epilepsy and voltage-dependent calcium channels.
Read More +Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Cacng2 | calcium channel, voltage-dependent, gamma subunit 2 |
Homozygotes for the stargazer 3 Jackson allele exhibit a much milder phenotype than mice homozygous for the stargazer allele. Mice are identified at 3-4 weeks by an ataxic gait. Although EEG readings show no spike wave discharge, absence seizures are observed. (personal communication) This strain may be useful in studies of epilepsy and voltage-dependent calcium channels.
This spontaneous mutation arose on BALB/cJ in the production colonies of The Jackson Laboratory. It was backcrossed a minimum of ten generations to C57BL/6J in the laboratory of Dr. Wayne Frankel and Dr. Verity Letts and donated to the Repository in 2008.
Allele Name | stargazer 3 Jackson |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Cacng2, calcium channel, voltage-dependent, gamma subunit 2 |
Gene Synonym(s) | |
Strain of Origin | BALB/cJ |
Chromosome | 15 |
Molecular Note | The phenotype of the stargazer 3J mouse has been attributed to an early transposon (ETn) insertion into intron 2, approximately 2 kb downstream from the site of the ETn insertion that gave rise to the original stargazer mutation. RT-PCR analysis demonstrated that in addition to two aberrant transcripts generated by the insertion, some normally spliced mRNA was detected, suggesting that this mutation does not represent a complete null allele. |
When maintaining a live colony, these mice are bred as homozygotes.
When using the B6.C-Cacng2stg-3J/LetJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #008624 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Cacng2<stg-3J> |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.