Mice heterozygous for the semi-dominant Tottering 5 Jackson mutation exhibit a shaky gait with hind limbs splayed laterally from the body in contrast to the other tottering mutants . Also, unlike tottering mice, Tg-5J heterozygotes do not exhibit dyskinesia or absence seizures. Axonal swelling is observed in Purkinje cells from homozygotes as well as a decrease in branching. The Tg-5J mutation causes a shift in voltage activation and inactivation to lower voltages. This strain may be useful for studies of epilepsy and voltage-dependent calcium channels. 

The C57BL/10J background appears to be embryonic lethal as no homozygotes are produced in heterozygote x heterozygote matings. On a mixed BALB/cByJ and C57BL/10J background some homozygotes are produced, but die before 6 weeks of age.

Mice heterozygous for this semi-dominant spontaneous mutation of the calcium channel, voltage-dependent, P/Q type, alpha 1A subunit gene have a shaky gait, but do not exhibit dyskinesia or absence seizures. The Tottering-5J mutation causes a shift in voltage activation and inactivation to lower voltages. This strain may be useful for studies of epilepsy and voltage-dependent calcium channels.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

Typically mice are recovered in 12-16 weeks. <a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> to place an order or for more information.