Homozygous mutants develop muscle degeneration and display retinoschisis.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Large1 | LARGE xylosyl- and glucuronyltransferase 1 |
Mice homozygous for the myodystrophy 3 Jackson mutation generally begin to display evidence of muscle degeneration at two to three months of age, although some exhibit symptoms as early as wean age. Inability to splay the hind legs outward when held up by the tail is an initial phenotype and this progresses with age to include swaying gait then dragging of the hind legs. Homozygotes also display retinoschisis and males are sterile.
The myodystrophy 3 Jackson mutation arose spontaneously at The Jackson Laboratory in 2006 in the strain NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (stock #005557). To maintain the mutation ovaries from a homozygous female were transplanted into a host which was bred to a C57BL/6J male and the line was then maintained by sibling intercrossing with the Prkdcscid and Il2rgtm1Wjl mutations bred out. In 2010 this strain reached generation N1F9.
Allele Name | myodystrophy 3 Jackson |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Large1, LARGE xylosyl- and glucuronyltransferase 1 |
Gene Synonym(s) | |
Strain of Origin | NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ |
Chromosome | 8 |
Molecular Note | A noncomplementation test with the veils mutation demonstrated that this mutation is an allele of the Large gene. |
When using the myodystrophy 3 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #008581 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Large<myd-3J> |
Frozen Mouse Embryo | STOCK Large1<myd-3J>/GrsrJ Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | STOCK Large1<myd-3J>/GrsrJ Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | STOCK Large1<myd-3J>/GrsrJ Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | STOCK Large1<myd-3J>/GrsrJ Frozen Embryo | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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