JAX
Mouse Strain Datasheet - 008549
NOD.FVB-Tg(Itgax-DTR/EGFP)57Lan/JdkJ
Also Known As: CD11c-DTR/NOD, NOD.CD11c-DTR
Congenic NOD mice hemizygous for a simian diphtheria toxin receptor - green fluorescent protein fusion protein under the control of mouse integrin alpha X, Itgax, promoter (CD11c). These transgenic mice provide a diphtheria toxin inducible system that transiently depletes dendritic cell populations. This congenic NOD, transgenic strain is useful for studying the specific role of dendritic cells in the immune response, specifically type 1 diabetes.
Donating Investigator
Jonathan D Katz, Cincinnati Children's Research Foundatio
Genetic overview
| Genetic Background | Generation |
|---|---|
|
001976 NOD/ShiLtJ |
|
Tg(Itgax-DTR/EGFP)57Lan
| Allele Type |
|---|
| Transgenic (Inserted expressed sequence) |
Research Applications
- Diabetes and Obesity Research
- Immunology, Inflammation and Autoimmunity Research
- Research Tools
Detailed Description
Unmanipulated NOD congenic Itgax-DTR/EGFP (Cd11c-DTR) transgenic mice are viable, normal in size and develop spontaneous diabetes similar to NOD/ShiLtJ. All splenic CD8+ and CD8- DC express EGFP and are diphtheria toxin (DT) sensitive. Upon DT administration, mice harboring this transgene are transiently depleted of dendritic cell (DC) populations. Immunohistochemical and flow cytometric analysis reveals EGFP expression and DT-inducible depletion of CD11chigh DC in spleen, lymph node, lung, liver and lamina propria tissues, as well as the defined macrophage subpopulations of the alveolar, lamina propria, metallophillic and marginal zone. Rapid reduction of CD11c+ DC populations induced by intraperitoneal injection of DT persists for approximately 2 days, after which the cell population gradually recovers. While transient DC depletion was not associated with sign of illness or long-term defects, repeated DT induction induces an acute spike in the production of IFN-gamma and TNF-alpha and is lethal to the mouse. Long term depletion of this cell population without toxicity can be achieved by the generation of mixed irradiation chimeras. Irradiated NOD mice reconstituted with CD11c-DTR bone marrow treated long term with DT to ablate DC failed to develop insulitis. This mutant mouse strain may be useful in studies of the specific role of dendritic cells in the immune response, specifically type 1 diabetes.
Development
A transgene was designed to place a simian Diphtheria Toxin Receptor (DTR)-Enhanced Green Fluorescent Protein (EGFP, Stratagene) fusion protein under the control of the mouse integrin alpha X, Itgax, (CD11c) promoter. This transgene was introduced into fertilized FVB/N donor eggs. Progeny of founder 57 were backcrossed to NOD/ShiLtJ for more than 10 generations. In 2008, the Type 1 Diabetes Resource received this transgenic NOD congeic strain and mated to NOD/ShiLtJ (Stock No. 001976) for one generation prior to sibling mating. This transgene has been mapped to mouse Chromosome 1 (~52 cM; 87395187bp position) via single nucleotide polymorphism (SNP) analysis by The Jackson Laboratory.
Expression Data
| Expressed Gene | DTR, Simian Diphtheria Toxin Receptor, |
|---|---|
| Expressed Gene | GFP, Green Fluorescent Protein, |
| Site of Expression | Expression of the transgene is specific to splenic dendritic cells. All CD8+ and CD8- dentritic cells in the spleen fluoresce and are DT sensititve. |
Control Suggestions
Selected References
- Saxena V; Ondr JK; Magnusen AF; Munn DH; Katz JD. 2007. The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse.. In: . . MGI: J:137009
Tg(Itgax-DTR/EGFP)57Lan
Allele Symbol: Tg(Itgax-DTR/EGFP)57Lan
| Allele Name | transgene insertion 57, Richard A Lang |
|---|---|
| Allele Type | Transgenic (Inserted expressed sequence) |
| Allele Synonym(s) | CD11c-DTR; CD11c-DTR-GFP; CD11c-DTR/GFP; CD11c.DTR; CD11c/DTR Tg; CD11cDTR; CD11cDTR tg; DCKO; DTR-GFP; DTR-GRP; Itgax-DTR; Tg(Itgax-DTR/GFP)57Lan; Tg.Itgax-DTR/EGFP.57Lan |
| Gene Symbol and Name | Tg(Itgax-DTR/EGFP)57Lan, transgene insertion 57, Richard A Lang |
| Gene Synonym(s) | CD11c-DTR; CD11c-DTR/GFP; CD11c/DTR Tg; CD11cDTR tg; DCKO; DTR-GFP; DTR-GRP; Tg(Itgax-DTR/GFP)57Lan; Tg.Itgax-DTR/EGFP.57Lan; TgItgax-DTR/EGFP.57Lan |
| Promoter | Itgax, integrin alpha X, mouse, laboratory |
| Expressed Gene | DTR, Simian Diphtheria Toxin Receptor, |
| Expressed Gene | GFP, Green Fluorescent Protein, |
| Site of Expression | Expression of the transgene is specific to splenic dendritic cells. All CD8+ and CD8- dentritic cells in the spleen fluoresce and are DT sensititve. |
| Strain of Origin | FVB/N |
| Chromosome | UN |
| Molecular Note | The transgene contains a fusion product involving simian diphtheria toxin receptor and green fluorescent protein under the control of the mouse Itgax promoter (CD11c). Two lines were created (line 11 and line 57) with 1 to 2 copies and 20 copies of the transgene, respectively. All CD8+ and CD8- dendritic cells in the spleen fluoresce and are DT sensitive. Immunohistochemical and flow cytometric analyses show that expression of the transgene is specific to splenic dendritic cells. |
| Mutations Made By | Steffen Jung, Weizmann Institute of Science |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Diabetes and Obesity Research
- Type 1 Diabetes (IDDM) Analysis Strains
- NOD Transgenics
- Type 1 Diabetes (IDDM) Analysis Strains
- Immunology, Inflammation and Autoimmunity Research
- Autoimmunity
- Type 1 Diabetes
- Autoimmunity
- Research Tools
- Cancer Research
- tumor immunology
- xenograft/transplant host
- Fluorescent Proteins
- Immunology, Inflammation and Autoimmunity Research
- Cancer Research
Genotype: GFP related
- Research Tools
- Fluorescent Proteins
Mammalian Phenotype Terms by Genotype
Genotype: Tg(Itgax-DTR/EGFP)57Lan/0
NOD.FVB-Tg(Itgax-DTR/EGFP)57Lan/Jdk
mortality/aging
- premature death
- diphtheria toxin-treated mice produce a large spike of IFN-gamma and TNF-alpha before developing cachexia and dying unlike similarly treated wild-type mice (MGI Ref ID J:137009)
immune system phenotype
- abnormal professional antigen presenting cell physiology
- antigen presenting cells from irradiated wild-type mice reconstituted with bone marrow from Tg(Itgax-DTR/EGFP)57Lan that have received Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi cells have been treated with diphtheria toxin fail to present either peptide or whole islet cells to naive BDC2.5 T cells over a wide range of antigen concentrations unlike PBS-treated miceole islet cells to naive BDC2.5 T cells over a wide range of antigen concentrations unlike PBS-treated mice (MGI Ref ID J:137009)
- however, additional treatment with wild-type myeloid dendritic cells restores antigen presentation (MGI Ref ID J:137009)
- decreased NK T cell number
- diptheria toxin-treated mice receiving Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi cells exhibit a loss of intrapancreatic NK T cells (MGI Ref ID J:137009)
- however, spleen and nondraining secondary lymphoid compartments exhibit normal NK T cell numbers and the addition of plasmocytoid dendritic cells to mice restores pancreatic NK T cell numbers (MGI Ref ID J:137009)
- decreased dendritic cell number
- diphtheria toxin-treated mice exhibit ablation of all major dendritic cells from the spleen, pancreas, and lymph nodes unlike similarly treated wild-type mice (MGI Ref ID J:137009)
- diptheria toxin-treated mice receiving Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi cells exhibit a loss of intrapancreatic plasmacytoid dendritic cells (MGI Ref ID J:137009)
- decreased macrophage cell number
- diphtheria toxin-treated mice exhibit macrophage loss that is less than 5% to 8% (MGI Ref ID J:137009)
- decreased susceptibility to autoimmune diabetes
- irradiated wild-type mice reconstituted with bone marrow from Tg(Itgax-DTR/EGFP)57Lan that have received Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi cells have been treated with diphtheria toxin do not develop diabetes unlike PBS-treated mice (MGI Ref ID J:137009)
- increased interferon-gamma secretion
- in diphtheria toxin-treated mice (MGI Ref ID J:137009)
- increased tumor necrosis factor secretion
- in diphtheria toxin-treated mice (MGI Ref ID J:137009)
- insulitis
- however, use of plasmocytoid dendritic cells instead of myeloid dendritic cells fails to restore development of insulitis (MGI Ref ID J:137009)
- irradiated wild-type mice reconstituted with bone marrow from Tg(Itgax-DTR/EGFP)57Lan that have received Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi and wild-type myeloid dendritic cells and have been treated with diphtheria toxin develop insulitis (MGI Ref ID J:137009)
- mice receiving Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi and wild-type plasmocytoid dendritic cells and treated with diphtheria toxin exhibit delay in the development of insulitis (MGI Ref ID J:137009)
- mice receiving Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi cells and treated with diphtheria toxin exhibit an acceleration of insulitis (MGI Ref ID J:137009)
endocrine/exocrine gland phenotype
- endocrine/exocrine gland phenotype
- irradiated wild-type mice reconstituted with bone marrow from Tg(Itgax-DTR/EGFP)57Lan that have received Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi cells have been treated with diphtheria toxin fail to develop insulitis unlike PBS-treated mice (MGI Ref ID J:137009)
- insulitis
- however, use of plasmocytoid dendritic cells instead of myeloid dendritic cells fails to restore development of insulitis (MGI Ref ID J:137009)
- irradiated wild-type mice reconstituted with bone marrow from Tg(Itgax-DTR/EGFP)57Lan that have received Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi and wild-type myeloid dendritic cells and have been treated with diphtheria toxin develop insulitis (MGI Ref ID J:137009)
- mice receiving Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi and wild-type plasmocytoid dendritic cells and treated with diphtheria toxin exhibit delay in the development of insulitis (MGI Ref ID J:137009)
- mice receiving Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi cells and treated with diphtheria toxin exhibit an acceleration of insulitis (MGI Ref ID J:137009)
growth/size/body region phenotype
- cachexia
- in diphtheria toxin-treated mice (MGI Ref ID J:137009)
hematopoietic system phenotype
- decreased NK T cell number
- diptheria toxin-treated mice receiving Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi cells exhibit a loss of intrapancreatic NK T cells (MGI Ref ID J:137009)
- however, spleen and nondraining secondary lymphoid compartments exhibit normal NK T cell numbers and the addition of plasmocytoid dendritic cells to mice restores pancreatic NK T cell numbers (MGI Ref ID J:137009)
- decreased dendritic cell number
- diphtheria toxin-treated mice exhibit ablation of all major dendritic cells from the spleen, pancreas, and lymph nodes unlike similarly treated wild-type mice (MGI Ref ID J:137009)
- diptheria toxin-treated mice receiving Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi cells exhibit a loss of intrapancreatic plasmacytoid dendritic cells (MGI Ref ID J:137009)
- decreased macrophage cell number
- diphtheria toxin-treated mice exhibit macrophage loss that is less than 5% to 8% (MGI Ref ID J:137009)
References
- Saxena V; Ondr JK; Magnusen AF; Munn DH; Katz JD. 2007. The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse.. In: . . MGI: J:137009
Additional - Tg(Itgax-DTR/EGFP)57Lan related
- Ahmed KA; Wang L; Munegowda MA; Mulligan S; Gordon JR; Griebel P; Xiang J. 2012. Direct in vivo evidence of CD4+ T cell requirement for CTL response and memory via pMHC-I targeting and CD40L signaling.. In: . . MGI: J:186191
- Anzai A; Anzai T; Nagai S; Maekawa Y; Naito K; Kaneko H; Sugano Y; Takahashi T; Abe H; Mochizuki S; Sano M; Yoshikawa T; Okada Y; Koyasu S; Ogawa S; Fukuda K. 2012. Regulatory role of dendritic cells in postinfarction healing and left ventricular remodeling.. In: . . MGI: J:196620
- Aychek T; Mildner A; Yona S; Kim KW; Lampl N; Reich-Zeliger S; Boon L; Yogev N; Waisman A; Cua DJ; Jung S. 2015. IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology.. In: . . MGI: J:221887
- Bajwa A; Huang L; Ye H; Dondeti K; Song S; Rosin DL; Lynch KR; Lobo PI; Li L; Okusa MD. 2012. Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury.. In: . . MGI: J:189850
- Ballesteros-Tato A; Leon B; Lund FE; Randall TD. 2013. CD4+ T helper cells use CD154-CD40 interactions to counteract T reg cell-mediated suppression of CD8+ T cell responses to influenza.. In: . . MGI: J:202249
- Bamboat ZM; Ocuin LM; Balachandran VP; Obaid H; Plitas G; Dematteo RP. 2010. Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion.. In: . . MGI: J:156672
- Bar-On L; Birnberg T; Kim KW; Jung S. 2011. Dendritic cell-restricted CD80/86 deficiency results in peripheral regulatory T-cell reduction but is not associated with lymphocyte hyperactivation.. In: . . MGI: J:175433
- Bates JT; Graff AH; Phipps JP; Grayson JM; Mizel SB. 2011. Enhanced Antigen Processing of Flagellin Fusion Proteins Promotes the Antigen-Specific CD8+ T Cell Response Independently of TLR5 and MyD88.. In: . . MGI: J:173205
- Bates JT; Uematsu S; Akira S; Mizel SB. 2009. Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin.. In: . . MGI: J:149297
- Bedenikovic G; Crouse J; Oxenius A. 2014. T-cell help dependence of memory CD8+ T-cell expansion upon vaccinia virus challenge relies on CD40 signaling.. In: . . MGI: J:208658
- Behrens EM; Canna SW; Slade K; Rao S; Kreiger PA; Paessler M; Kambayashi T; Koretzky GA. 2011. Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice.. In: . . MGI: J:173903
- Ben Baruch-Morgenstern N; Shik D; Moshkovits I; Itan M; Karo-Atar D; Bouffi C; Fulkerson PC; Rashkovan D; Jung S; Rothenberg ME; Munitz A. 2014. Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5-induced eosinophil development.. In: . . MGI: J:208993
- Bessa J; Jegerlehner A; Hinton HJ; Pumpens P; Saudan P; Schneider P; Bachmann MF. 2009. Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses.. In: . . MGI: J:152307
- Bianchi T; Pincus LB; Wurbel MA; Rich BE; Kupper TS; Fuhlbrigge RC; Boes M. 2009. Maintenance of peripheral tolerance through controlled tissue homing of antigen-specific T cells in K14-mOVA mice.. In: . . MGI: J:147741
- Birnberg T; Bar-On L; Sapoznikov A; Caton ML; Cervantes-Barragan L; Makia D; Krauthgamer R; Brenner O; Ludewig B; Brockschnieder D; Riethmacher D; Reizis B; Jung S. 2008. Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome.. In: . . MGI: J:142682
- Bogunovic M; Ginhoux F; Helft J; Shang L; Hashimoto D; Greter M; Liu K; Jakubzick C; Ingersoll MA; Leboeuf M; Stanley ER; Nussenzweig M; Lira SA; Randolph GJ; Merad M. 2009. Origin of the lamina propria dendritic cell network.. In: . . MGI: J:152688
- Bouchaud G; Gehrke S; Krieg C; Kolios A; Hafner J; Navarini AA; French LE; Boyman O. 2013. Epidermal IL-15Ralpha acts as an endogenous antagonist of psoriasiform inflammation in mouse and man.. In: . . MGI: J:204085
- Brennan TV; Lin L; Brandstadter JD; Rendell VR; Dredge K; Huang X; Yang Y. 2016. Heparan sulfate mimetic PG545-mediated antilymphoma effects require TLR9-dependent NK cell activation.. In: . . MGI: J:230038
- Browne EP; Littman DR. 2009. Myd88 is required for an antibody response to retroviral infection.. In: . . MGI: J:162196
- Buela KA; Hendricks RL. 2015. Cornea-infiltrating and lymph node dendritic cells contribute to CD4+ T cell expansion after herpes simplex virus-1 ocular infection.. In: . . MGI: J:230695
- Bunn PT; Stanley AC; de Labastida Rivera F; Mulherin A; Sheel M; Alexander CE; Faleiro RJ; Amante FH; Montes De Oca M; Best SE; James KR; Kaye PM; Haque A; Engwerda CR. 2014. Tissue requirements for establishing long-term CD4+ T cell-mediated immunity following Leishmania donovani infection.. In: . . MGI: J:210012
- Butovsky O; Kunis G; Koronyo-Hamaoui M; Schwartz M. 2007. Selective ablation of bone marrow-derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model.. In: . . MGI: J:127277
- Campbell IK; van Nieuwenhuijze A; Segura E; O'Donnell K; Coghill E; Hommel M; Gerondakis S; Villadangos JA; Wicks IP. 2011. Differentiation of inflammatory dendritic cells is mediated by NF-kappaB1-dependent GM-CSF production in CD4 T cells.. In: . . MGI: J:172752
- Chappell CP; Draves KE; Giltiay NV; Clark EA. 2012. Extrafollicular B cell activation by marginal zone dendritic cells drives T cell-dependent antibody responses.. In: . . MGI: J:191423
- Chiba S; Baghdadi M; Akiba H; Yoshiyama H; Kinoshita I; Dosaka-Akita H; Fujioka Y; Ohba Y; Gorman JV; Colgan JD; Hirashima M; Uede T; Takaoka A; Yagita H; Jinushi M. 2012. Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1.. In: . . MGI: J:187594
- Cho KW; Morris DL; DelProposto JL; Geletka L; Zamarron B; Martinez-Santibanez G; Meyer KA; Singer K; O'Rourke RW; Lumeng CN. 2014. An MHC II-dependent activation loop between adipose tissue macrophages and CD4+ T cells controls obesity-induced inflammation.. In: . . MGI: J:218539
- Choi DH; Kim KS; Yang SH; Chung DH; Song B; Sprent J; Cho JH; Sung YC. 2011. Dendritic Cell Internalization of alpha-Galactosylceramide from CD8 T Cells Induces Potent Antitumor CD8 T-cell Responses.. In: . . MGI: J:178846
- Chu DK; Jimenez-Saiz R; Verschoor CP; Walker TD; Goncharova S; Llop-Guevara A; Shen P; Gordon ME; Barra NG; Bassett JD; Kong J; Fattouh R; McCoy KD; Bowdish DM; Erjefalt JS; Pabst O; Humbles AA; Kolbeck R; Waserman S; Jordana M. 2014. Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo.. In: . . MGI: J:214840
- Chyou S; Benahmed F; Chen J; Kumar V; Tian S; Lipp M; Lu TT. 2011. Coordinated regulation of lymph node vascular-stromal growth first by CD11c+ cells and then by T and B cells.. In: . . MGI: J:179758
- Ciavarra RP; Stephens A; Nagy S; Sekellick M; Steel C. 2006. Evaluation of immunological paradigms in a virus model: are dendritic cells critical for antiviral immunity and viral clearance?. In: . . MGI: J:134380
- Coghill JM; Fowler KA; West ML; Fulton LM; van Deventer H; McKinnon KP; Vincent BG; Lin K; Panoskaltsis-Mortari A; Cook DN; Blazar BR; Serody JS. 2013. CC chemokine receptor 8 potentiates donor Treg survival and is critical for the prevention of murine graft-versus-host disease.. In: . . MGI: J:202274
- Cohen JN; Tewalt EF; Rouhani SJ; Buonomo EL; Bruce AN; Xu X; Bekiranov S; Fu YX; Engelhard VH. 2014. Tolerogenic properties of lymphatic endothelial cells are controlled by the lymph node microenvironment.. In: . . MGI: J:212969
- Cohen-Fredarow A; Tadmor A; Raz T; Meterani N; Addadi Y; Nevo N; Solomonov I; Sagi I; Mor G; Neeman M; Dekel N. 2014. Ovarian dendritic cells act as a double-edged pro-ovulatory and anti-inflammatory sword.. In: . . MGI: J:215254
- Dando SJ; Naranjo Golborne C; Chinnery HR; Ruitenberg MJ; McMenamin PG. 2016. A case of mistaken identity: CD11c-eYFP(+) cells in the normal mouse brain parenchyma and neural retina display the phenotype of microglia, not dendritic cells.. In: . . MGI: J:232788
- Darrasse-Jeze G; Deroubaix S; Mouquet H; Victora GD; Eisenreich T; Yao KH; Masilamani RF; Dustin ML; Rudensky A; Liu K; Nussenzweig MC. 2009. Feedback control of regulatory T cell homeostasis by dendritic cells in vivo.. In: . . MGI: J:152171
- Denning TL; Wang YC; Patel SR; Williams IR; Pulendran B. 2007. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses.. In: . . MGI: J:125258
- Desai DD; Harbers SO; Flores M; Colonna L; Downie MP; Bergtold A; Jung S; Clynes R. 2007. Fc gamma receptor IIB on dendritic cells enforces peripheral tolerance by inhibiting effector T cell responses.. In: . . MGI: J:146123
- Diao J; Zhao J; Winter E; Cattral MS. 2011. Tumors suppress in situ proliferation of cytotoxic T cells by promoting differentiation of Gr-1(+) conventional dendritic cells through IL-6.. In: . . MGI: J:172866
- Didierlaurent A; Goulding J; Patel S; Snelgrove R; Low L; Bebien M; Lawrence T; van Rijt LS; Lambrecht BN; Sirard JC; Hussell T. 2008. Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection.. In: . . MGI: J:131869
- Diehl GE; Longman RS; Zhang JX; Breart B; Galan C; Cuesta A; Schwab SR; Littman DR. 2013. Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells.. In: . . MGI: J:210086
- Divangahi M; Desjardins D; Nunes-Alves C; Remold HG; Behar SM. 2010. Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis.. In: . . MGI: J:162390
- Do JS; Min B. 2009. Differential requirements of MHC and of DCs for endogenous proliferation of different T-cell subsets in vivo.. In: . . MGI: J:155564
- Dolfi DV; Duttagupta PA; Boesteanu AC; Mueller YM; Oliai CH; Borowski AB; Katsikis PD. 2011. Dendritic cells and CD28 costimulation are required to sustain virus-specific CD8+ T cell responses during the effector phase in vivo.. In: . . MGI: J:172460
- E S; Seth A; Vogel P; Sommers M; Ong T; Pillai AB. 2017. Bidirectional immune tolerance in nonmyeloablative MHC-mismatched BMT for murine beta-thalassemia.. In: . . MGI: J:242848
- Elhaik-Goldman S; Kafka D; Yossef R; Hadad U; Elkabets M; Vallon-Eberhard A; Hulihel L; Jung S; Ghadially H; Braiman A; Apte RN; Mandelboim O; Dagan R; Mizrachi-Nebenzahl Y; Porgador A. 2011. The Natural Cytotoxicity Receptor 1 Contribution to Early Clearance of Streptococcus pneumoniae and to Natural Killer-Macrophage Cross Talk.. In: . . MGI: J:176154
- Engel D; Dobrindt U; Tittel A; Peters P; Maurer J; Gutgemann I; Kaissling B; Kuziel W; Jung S; Kurts C. 2006. Tumor necrosis factor alpha- and inducible nitric oxide synthase-producing dendritic cells are rapidly recruited to the bladder in urinary tract infection but are dispensable for bacterial clearance.. In: . . MGI: J:113552
- Fei M; Bhatia S; Oriss TB; Yarlagadda M; Khare A; Akira S; Saijo S; Iwakura Y; Fallert Junecko BA; Reinhart TA; Foreman O; Ray P; Kolls J; Ray A. 2011. TNF-{alpha} from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection.. In: . . MGI: J:171233
- Felmy B; Songhet P; Slack EM; Muller AJ; Kremer M; Van Maele L; Cayet D; Heikenwalder M; Sirard JC; Hardt WD. 2013. NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium.. In: . . MGI: J:209119
- Ferrington DA; Roehrich H; Chang AA; Huang CW; Maldonado M; Bratten W; Rageh AA; Heuss ND; Gregerson DS; Nelson EF; Yuan C. 2013. Corneal wound healing is compromised by immunoproteasome deficiency.. In: . . MGI: J:195798
- Fooksman DR; Nussenzweig MC; Dustin ML. 2014. Myeloid cells limit production of antibody-secreting cells after immunization in the lymph node.. In: . . MGI: J:207304
- Frank GM; Buela KA; Maker DM; Harvey SA; Hendricks RL. 2012. Early responding dendritic cells direct the local NK response to control herpes simplex virus 1 infection within the cornea.. In: . . MGI: J:180749
- Freitag N; Tirado-Gonzalez I; Barrientos G; Herse F; Thijssen VL; Weedon-Fekjaer SM; Schulz H; Wallukat G; Klapp BF; Nevers T; Sharma S; Staff AC; Dechend R; Blois SM. 2013. Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia.. In: . . MGI: J:198814
- Fujii S; Goto A; Shimizu K. 2009. Antigen mRNA-transfected, allogeneic fibroblasts loaded with NKT-cell ligand confer antitumor immunity.. In: . . MGI: J:148431
- Fukuyama T; Kasper LH; Boussouar F; Jeevan T; van Deursen J; Brindle PK. 2009. Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development.. In: . . MGI: J:150146
- Fukuyama Y; Tokuhara D; Sekine S; Aso K; Kataoka K; Davydova J; Yamamoto M; Gilbert RS; Tokuhara Y; Fujihashi K; Kunisawa J; Yuki Y; Kiyono H; McGhee JR; Fujihashi K. 2013. Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses.. In: . . MGI: J:199945
- Gao N; Yin J; Yoon GS; Mi QS; Yu FS. 2011. Dendritic cell-epithelium interplay is a determinant factor for corneal epithelial wound repair.. In: . . MGI: J:177373
- Garaude J; Kent A; van Rooijen N; Blander JM. 2012. Simultaneous targeting of toll- and nod-like receptors induces effective tumor-specific immune responses.. In: . . MGI: J:183811
- Garrod KR; Liu FC; Forrest LE; Parker I; Kang SM; Cahalan MD. 2010. NK cell patrolling and elimination of donor-derived dendritic cells favor indirect alloreactivity.. In: . . MGI: J:159639
- Gerard A; Khan O; Beemiller P; Oswald E; Hu J; Matloubian M; Krummel MF. 2013. Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8(+) T cells.. In: . . MGI: J:194908
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