JAX
Mouse Strain Datasheet - 008549
NOD.FVB-Tg(Itgax-DTR/EGFP)57Lan/JdkJ
Also Known As: CD11c-DTR/NOD, NOD.CD11c-DTR
Congenic NOD mice hemizygous for a simian diphtheria toxin receptor - green fluorescent protein fusion protein under the control of mouse integrin alpha X, Itgax, promoter (CD11c). These transgenic mice provide a diphtheria toxin inducible system that transiently depletes dendritic cell populations. This congenic NOD, transgenic strain is useful for studying the specific role of dendritic cells in the immune response, specifically type 1 diabetes.
Donating Investigator
Jonathan D Katz, Cincinnati Children's Research Foundatio
Genetic overview
| Genetic Background | Generation |
|---|---|
|
001976 NOD/ShiLtJ |
|
Tg(Itgax-DTR/EGFP)57Lan
| Allele Type |
|---|
| Transgenic (Inserted expressed sequence) |
Research Applications
- Diabetes and Obesity Research
- Immunology, Inflammation and Autoimmunity Research
- Research Tools
Detailed Description
Unmanipulated NOD congenic Itgax-DTR/EGFP (Cd11c-DTR) transgenic mice are viable, normal in size and develop spontaneous diabetes similar to NOD/ShiLtJ. All splenic CD8+ and CD8- DC express EGFP and are diphtheria toxin (DT) sensitive. Upon DT administration, mice harboring this transgene are transiently depleted of dendritic cell (DC) populations. Immunohistochemical and flow cytometric analysis reveals EGFP expression and DT-inducible depletion of CD11chigh DC in spleen, lymph node, lung, liver and lamina propria tissues, as well as the defined macrophage subpopulations of the alveolar, lamina propria, metallophillic and marginal zone. Rapid reduction of CD11c+ DC populations induced by intraperitoneal injection of DT persists for approximately 2 days, after which the cell population gradually recovers. While transient DC depletion was not associated with sign of illness or long-term defects, repeated DT induction induces an acute spike in the production of IFN-gamma and TNF-alpha and is lethal to the mouse. Long term depletion of this cell population without toxicity can be achieved by the generation of mixed irradiation chimeras. Irradiated NOD mice reconstituted with CD11c-DTR bone marrow treated long term with DT to ablate DC failed to develop insulitis. This mutant mouse strain may be useful in studies of the specific role of dendritic cells in the immune response, specifically type 1 diabetes.
Development
A transgene was designed to place a simian Diphtheria Toxin Receptor (DTR)-Enhanced Green Fluorescent Protein (EGFP, Stratagene) fusion protein under the control of the mouse integrin alpha X, Itgax, (CD11c) promoter. This transgene was introduced into fertilized FVB/N donor eggs. Progeny of founder 57 were backcrossed to NOD/ShiLtJ for more than 10 generations. In 2008, the Type 1 Diabetes Resource received this transgenic NOD congeic strain and mated to NOD/ShiLtJ (Stock No. 001976) for one generation prior to sibling mating. This transgene has been mapped to mouse Chromosome 1 (~52 cM; 87395187bp position) via single nucleotide polymorphism (SNP) analysis by The Jackson Laboratory.
Expression Data
| Expressed Gene | DTR, Simian Diphtheria Toxin Receptor, |
|---|---|
| Expressed Gene | GFP, Green Fluorescent Protein, |
| Site of Expression | Expression of the transgene is specific to splenic dendritic cells. All CD8+ and CD8- dentritic cells in the spleen fluoresce and are DT sensititve. |
Control Suggestions
Selected References
- Saxena V; Ondr JK; Magnusen AF; Munn DH; Katz JD. 2007. The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse. J Immunol 179(8):5041-53. PubMed: 17911589MGI: J:137009
Tg(Itgax-DTR/EGFP)57Lan
Allele Symbol: Tg(Itgax-DTR/EGFP)57Lan
| Allele Name | transgene insertion 57, Richard A Lang |
|---|---|
| Allele Type | Transgenic (Inserted expressed sequence) |
| Allele Synonym(s) | CD11c-DTR; CD11c-DTR-GFP; CD11c-DTR/GFP; CD11c.DTR; CD11c/DTR Tg; CD11cDTR; CD11cDTR tg; DCKO; DTR-GFP; DTR-GRP; Itgax-DTR; Tg(Itgax-DTR/GFP)57Lan; Tg.Itgax-DTR/EGFP.57Lan |
| Gene Symbol and Name | Tg(Itgax-DTR/EGFP)57Lan, transgene insertion 57, Richard A Lang |
| Gene Synonym(s) | CD11c-DTR; CD11c-DTR/GFP; CD11c/DTR Tg; CD11cDTR tg; DCKO; DTR-GFP; DTR-GRP; Tg(Itgax-DTR/GFP)57Lan; Tg.Itgax-DTR/EGFP.57Lan; TgItgax-DTR/EGFP.57Lan |
| Promoter | Itgax, integrin alpha X, mouse, laboratory |
| Expressed Gene | DTR, Simian Diphtheria Toxin Receptor, |
| Expressed Gene | GFP, Green Fluorescent Protein, |
| Site of Expression | Expression of the transgene is specific to splenic dendritic cells. All CD8+ and CD8- dentritic cells in the spleen fluoresce and are DT sensititve. |
| Strain of Origin | FVB/N |
| Chromosome | UN |
| Molecular Note | The transgene contains a fusion product involving simian diphtheria toxin receptor and green fluorescent protein under the control of the mouse Itgax promoter (CD11c). Two lines were created (line 11 and line 57) with 1 to 2 copies and 20 copies of the transgene, respectively. All CD8+ and CD8- dendritic cells in the spleen fluoresce and are DT sensitive. Immunohistochemical and flow cytometric analyses show that expression of the transgene is specific to splenic dendritic cells. |
| Mutations Made By | Steffen Jung, Weizmann Institute of Science |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Diabetes and Obesity Research
- Type 1 Diabetes (IDDM) Analysis Strains
- NOD Transgenics
- Type 1 Diabetes (IDDM) Analysis Strains
- Immunology, Inflammation and Autoimmunity Research
- Autoimmunity
- Type 1 Diabetes
- Autoimmunity
- Research Tools
- Cancer Research
- tumor immunology
- xenograft/transplant host
- Fluorescent Proteins
- Immunology, Inflammation and Autoimmunity Research
- Cancer Research
Genotype: GFP related
- Research Tools
- Fluorescent Proteins
Mammalian Phenotype Terms by Genotype
Genotype: Tg(Itgax-DTR/EGFP)57Lan/0
NOD.FVB-Tg(Itgax-DTR/EGFP)57Lan/Jdk
mortality/aging
- premature death
- diphtheria toxin-treated mice produce a large spike of IFN-gamma and TNF-alpha before developing cachexia and dying unlike similarly treated wild-type mice (MGI Ref ID J:137009)
immune system phenotype
- abnormal professional antigen presenting cell physiology
- antigen presenting cells from irradiated wild-type mice reconstituted with bone marrow from Tg(Itgax-DTR/EGFP)57Lan that have received Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi cells have been treated with diphtheria toxin fail to present either peptide or whole islet cells to naive BDC2.5 T cells over a wide range of antigen concentrations unlike PBS-treated miceole islet cells to naive BDC2.5 T cells over a wide range of antigen concentrations unlike PBS-treated mice (MGI Ref ID J:137009)
- however, additional treatment with wild-type myeloid dendritic cells restores antigen presentation (MGI Ref ID J:137009)
- decreased NK T cell number
- diptheria toxin-treated mice receiving Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi cells exhibit a loss of intrapancreatic NK T cells (MGI Ref ID J:137009)
- however, spleen and nondraining secondary lymphoid compartments exhibit normal NK T cell numbers and the addition of plasmocytoid dendritic cells to mice restores pancreatic NK T cell numbers (MGI Ref ID J:137009)
- decreased dendritic cell number
- diphtheria toxin-treated mice exhibit ablation of all major dendritic cells from the spleen, pancreas, and lymph nodes unlike similarly treated wild-type mice (MGI Ref ID J:137009)
- diptheria toxin-treated mice receiving Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi cells exhibit a loss of intrapancreatic plasmacytoid dendritic cells (MGI Ref ID J:137009)
- decreased macrophage cell number
- diphtheria toxin-treated mice exhibit macrophage loss that is less than 5% to 8% (MGI Ref ID J:137009)
- decreased susceptibility to autoimmune diabetes
- irradiated wild-type mice reconstituted with bone marrow from Tg(Itgax-DTR/EGFP)57Lan that have received Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi cells have been treated with diphtheria toxin do not develop diabetes unlike PBS-treated mice (MGI Ref ID J:137009)
- increased interferon-gamma secretion
- in diphtheria toxin-treated mice (MGI Ref ID J:137009)
- increased tumor necrosis factor secretion
- in diphtheria toxin-treated mice (MGI Ref ID J:137009)
- insulitis
- however, use of plasmocytoid dendritic cells instead of myeloid dendritic cells fails to restore development of insulitis (MGI Ref ID J:137009)
- irradiated wild-type mice reconstituted with bone marrow from Tg(Itgax-DTR/EGFP)57Lan that have received Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi and wild-type myeloid dendritic cells and have been treated with diphtheria toxin develop insulitis (MGI Ref ID J:137009)
- mice receiving Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi and wild-type plasmocytoid dendritic cells and treated with diphtheria toxin exhibit delay in the development of insulitis (MGI Ref ID J:137009)
- mice receiving Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi cells and treated with diphtheria toxin exhibit an acceleration of insulitis (MGI Ref ID J:137009)
endocrine/exocrine gland phenotype
- endocrine/exocrine gland phenotype
- irradiated wild-type mice reconstituted with bone marrow from Tg(Itgax-DTR/EGFP)57Lan that have received Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi cells have been treated with diphtheria toxin fail to develop insulitis unlike PBS-treated mice (MGI Ref ID J:137009)
- insulitis
- however, use of plasmocytoid dendritic cells instead of myeloid dendritic cells fails to restore development of insulitis (MGI Ref ID J:137009)
- irradiated wild-type mice reconstituted with bone marrow from Tg(Itgax-DTR/EGFP)57Lan that have received Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi and wild-type myeloid dendritic cells and have been treated with diphtheria toxin develop insulitis (MGI Ref ID J:137009)
- mice receiving Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi and wild-type plasmocytoid dendritic cells and treated with diphtheria toxin exhibit delay in the development of insulitis (MGI Ref ID J:137009)
- mice receiving Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi cells and treated with diphtheria toxin exhibit an acceleration of insulitis (MGI Ref ID J:137009)
growth/size/body region phenotype
- cachexia
- in diphtheria toxin-treated mice (MGI Ref ID J:137009)
hematopoietic system phenotype
- decreased NK T cell number
- diptheria toxin-treated mice receiving Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi cells exhibit a loss of intrapancreatic NK T cells (MGI Ref ID J:137009)
- however, spleen and nondraining secondary lymphoid compartments exhibit normal NK T cell numbers and the addition of plasmocytoid dendritic cells to mice restores pancreatic NK T cell numbers (MGI Ref ID J:137009)
- decreased dendritic cell number
- diphtheria toxin-treated mice exhibit ablation of all major dendritic cells from the spleen, pancreas, and lymph nodes unlike similarly treated wild-type mice (MGI Ref ID J:137009)
- diptheria toxin-treated mice receiving Tg(TcraBDC2.5)1Doi Tg(TcrbBDC2.5)2Doi cells exhibit a loss of intrapancreatic plasmacytoid dendritic cells (MGI Ref ID J:137009)
- decreased macrophage cell number
- diphtheria toxin-treated mice exhibit macrophage loss that is less than 5% to 8% (MGI Ref ID J:137009)
References
- Saxena V; Ondr JK; Magnusen AF; Munn DH; Katz JD. 2007. The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse. J Immunol 179(8):5041-53. PubMed: 17911589MGI: J:137009
Additional - Tg(Itgax-DTR/EGFP)57Lan related
- Ahmed KA; Wang L; Munegowda MA; Mulligan S; Gordon JR; Griebel P; Xiang J. 2012. Direct in vivo evidence of CD4+ T cell requirement for CTL response and memory via pMHC-I targeting and CD40L signaling. J Leukoc Biol 92(2):289-300. PubMed: 22544940MGI: J:186191
- Anzai A; Anzai T; Nagai S; Maekawa Y; Naito K; Kaneko H; Sugano Y; Takahashi T; Abe H; Mochizuki S; Sano M; Yoshikawa T; Okada Y; Koyasu S; Ogawa S; Fukuda K. 2012. Regulatory role of dendritic cells in postinfarction healing and left ventricular remodeling. Circulation 125(10):1234-45. PubMed: 22308302MGI: J:196620
- Aychek T; Mildner A; Yona S; Kim KW; Lampl N; Reich-Zeliger S; Boon L; Yogev N; Waisman A; Cua DJ; Jung S. 2015. IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology. Nat Commun 6:6525. PubMed: 25761673MGI: J:221887
- Bajwa A; Huang L; Ye H; Dondeti K; Song S; Rosin DL; Lynch KR; Lobo PI; Li L; Okusa MD. 2012. Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury. J Immunol 189(5):2584-96. PubMed: 22855711MGI: J:189850
- Ballesteros-Tato A; Leon B; Lund FE; Randall TD. 2013. CD4+ T helper cells use CD154-CD40 interactions to counteract T reg cell-mediated suppression of CD8+ T cell responses to influenza. J Exp Med 210(8):1591-601. PubMed: 23835849MGI: J:202249
- Bamboat ZM; Ocuin LM; Balachandran VP; Obaid H; Plitas G; Dematteo RP. 2010. Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion. J Clin Invest 120(2):559-69. PubMed: 20093775MGI: J:156672
- Bar-On L; Birnberg T; Kim KW; Jung S. 2011. Dendritic cell-restricted CD80/86 deficiency results in peripheral regulatory T-cell reduction but is not associated with lymphocyte hyperactivation. Eur J Immunol 41(2):291-8. PubMed: 21267999MGI: J:175433
- Bates JT; Graff AH; Phipps JP; Grayson JM; Mizel SB. 2011. Enhanced Antigen Processing of Flagellin Fusion Proteins Promotes the Antigen-Specific CD8+ T Cell Response Independently of TLR5 and MyD88. J Immunol 186(11):6255-62. PubMed: 21515787MGI: J:173205
- Bates JT; Uematsu S; Akira S; Mizel SB. 2009. Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin. J Immunol 182(12):7539-47. PubMed: 19494277MGI: J:149297
- Bedenikovic G; Crouse J; Oxenius A. 2014. T-cell help dependence of memory CD8+ T-cell expansion upon vaccinia virus challenge relies on CD40 signaling. Eur J Immunol 44(1):115-26. PubMed: 24108445MGI: J:208658
- Behrens EM; Canna SW; Slade K; Rao S; Kreiger PA; Paessler M; Kambayashi T; Koretzky GA. 2011. Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice. J Clin Invest 121(6):2264-77. PubMed: 21576823MGI: J:173903
- Ben Baruch-Morgenstern N; Shik D; Moshkovits I; Itan M; Karo-Atar D; Bouffi C; Fulkerson PC; Rashkovan D; Jung S; Rothenberg ME; Munitz A. 2014. Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5-induced eosinophil development. Nat Immunol 15(1):36-44. PubMed: 24212998MGI: J:208993
- Bessa J; Jegerlehner A; Hinton HJ; Pumpens P; Saudan P; Schneider P; Bachmann MF. 2009. Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses. J Immunol 183(6):3788-99. PubMed: 19710454MGI: J:152307
- Bianchi T; Pincus LB; Wurbel MA; Rich BE; Kupper TS; Fuhlbrigge RC; Boes M. 2009. Maintenance of peripheral tolerance through controlled tissue homing of antigen-specific T cells in K14-mOVA mice. J Immunol 182(8):4665-74. PubMed: 19342642MGI: J:147741
- Birnberg T; Bar-On L; Sapoznikov A; Caton ML; Cervantes-Barragan L; Makia D; Krauthgamer R; Brenner O; Ludewig B; Brockschnieder D; Riethmacher D; Reizis B; Jung S. 2008. Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome. Immunity 29(6):986-97. PubMed: 19062318MGI: J:142682
- Bogunovic M; Ginhoux F; Helft J; Shang L; Hashimoto D; Greter M; Liu K; Jakubzick C; Ingersoll MA; Leboeuf M; Stanley ER; Nussenzweig M; Lira SA; Randolph GJ; Merad M. 2009. Origin of the lamina propria dendritic cell network. Immunity 31(3):513-25. PubMed: 19733489MGI: J:152688
- Bouchaud G; Gehrke S; Krieg C; Kolios A; Hafner J; Navarini AA; French LE; Boyman O. 2013. Epidermal IL-15Ralpha acts as an endogenous antagonist of psoriasiform inflammation in mouse and man. J Exp Med 210(10):2105-17. PubMed: 24019554MGI: J:204085
- Brennan TV; Lin L; Brandstadter JD; Rendell VR; Dredge K; Huang X; Yang Y. 2016. Heparan sulfate mimetic PG545-mediated antilymphoma effects require TLR9-dependent NK cell activation. J Clin Invest 126(1):207-19. PubMed: 26649979MGI: J:230038
- Browne EP; Littman DR. 2009. Myd88 is required for an antibody response to retroviral infection. PLoS Pathog 5(2):e1000298. PubMed: 19214214MGI: J:162196
- Buela KA; Hendricks RL. 2015. Cornea-infiltrating and lymph node dendritic cells contribute to CD4+ T cell expansion after herpes simplex virus-1 ocular infection. J Immunol 194(1):379-87. PubMed: 25422507MGI: J:230695
- Bunn PT; Stanley AC; de Labastida Rivera F; Mulherin A; Sheel M; Alexander CE; Faleiro RJ; Amante FH; Montes De Oca M; Best SE; James KR; Kaye PM; Haque A; Engwerda CR. 2014. Tissue requirements for establishing long-term CD4+ T cell-mediated immunity following Leishmania donovani infection. J Immunol 192(8):3709-18. PubMed: 24634490MGI: J:210012
- Butovsky O; Kunis G; Koronyo-Hamaoui M; Schwartz M. 2007. Selective ablation of bone marrow-derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model. Eur J Neurosci 26(2):413-6. PubMed: 17623022MGI: J:127277
- Campbell IK; van Nieuwenhuijze A; Segura E; O'Donnell K; Coghill E; Hommel M; Gerondakis S; Villadangos JA; Wicks IP. 2011. Differentiation of inflammatory dendritic cells is mediated by NF-kappaB1-dependent GM-CSF production in CD4 T cells. J Immunol 186(9):5468-77. PubMed: 21421852MGI: J:172752
- Chappell CP; Draves KE; Giltiay NV; Clark EA. 2012. Extrafollicular B cell activation by marginal zone dendritic cells drives T cell-dependent antibody responses. J Exp Med 209(10):1825-40. PubMed: 22966002MGI: J:191423
- Chiba S; Baghdadi M; Akiba H; Yoshiyama H; Kinoshita I; Dosaka-Akita H; Fujioka Y; Ohba Y; Gorman JV; Colgan JD; Hirashima M; Uede T; Takaoka A; Yagita H; Jinushi M. 2012. Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. Nat Immunol 13(9):832-42. PubMed: 22842346MGI: J:187594
- Cho KW; Morris DL; DelProposto JL; Geletka L; Zamarron B; Martinez-Santibanez G; Meyer KA; Singer K; O'Rourke RW; Lumeng CN. 2014. An MHC II-dependent activation loop between adipose tissue macrophages and CD4+ T cells controls obesity-induced inflammation. Cell Rep 9(2):605-17. PubMed: 25310975MGI: J:218539
- Choi DH; Kim KS; Yang SH; Chung DH; Song B; Sprent J; Cho JH; Sung YC. 2011. Dendritic Cell Internalization of alpha-Galactosylceramide from CD8 T Cells Induces Potent Antitumor CD8 T-cell Responses. Cancer Res 71(24):7442-51. PubMed: 22028323MGI: J:178846
- Chu DK; Jimenez-Saiz R; Verschoor CP; Walker TD; Goncharova S; Llop-Guevara A; Shen P; Gordon ME; Barra NG; Bassett JD; Kong J; Fattouh R; McCoy KD; Bowdish DM; Erjefalt JS; Pabst O; Humbles AA; Kolbeck R; Waserman S; Jordana M. 2014. Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo. J Exp Med 211(8):1657-72. PubMed: 25071163MGI: J:214840
- Chyou S; Benahmed F; Chen J; Kumar V; Tian S; Lipp M; Lu TT. 2011. Coordinated regulation of lymph node vascular-stromal growth first by CD11c+ cells and then by T and B cells. J Immunol 187(11):5558-67. PubMed: 22031764MGI: J:179758
- Ciavarra RP; Stephens A; Nagy S; Sekellick M; Steel C. 2006. Evaluation of immunological paradigms in a virus model: are dendritic cells critical for antiviral immunity and viral clearance? J Immunol 177(1):492-500. PubMed: 16785546MGI: J:134380
- Coghill JM; Fowler KA; West ML; Fulton LM; van Deventer H; McKinnon KP; Vincent BG; Lin K; Panoskaltsis-Mortari A; Cook DN; Blazar BR; Serody JS. 2013. CC chemokine receptor 8 potentiates donor Treg survival and is critical for the prevention of murine graft-versus-host disease. Blood 122(5):825-36. PubMed: 23798714MGI: J:202274
- Cohen JN; Tewalt EF; Rouhani SJ; Buonomo EL; Bruce AN; Xu X; Bekiranov S; Fu YX; Engelhard VH. 2014. Tolerogenic properties of lymphatic endothelial cells are controlled by the lymph node microenvironment. PLoS One 9(2):e87740. PubMed: 24503860MGI: J:212969
- Cohen-Fredarow A; Tadmor A; Raz T; Meterani N; Addadi Y; Nevo N; Solomonov I; Sagi I; Mor G; Neeman M; Dekel N. 2014. Ovarian dendritic cells act as a double-edged pro-ovulatory and anti-inflammatory sword. Mol Endocrinol 28(7):1039-54. PubMed: 24825398MGI: J:215254
- Dando SJ; Naranjo Golborne C; Chinnery HR; Ruitenberg MJ; McMenamin PG. 2016. A case of mistaken identity: CD11c-eYFP(+) cells in the normal mouse brain parenchyma and neural retina display the phenotype of microglia, not dendritic cells. Glia 64(8):1331-49. PubMed: 27189804MGI: J:232788
- Darrasse-Jeze G; Deroubaix S; Mouquet H; Victora GD; Eisenreich T; Yao KH; Masilamani RF; Dustin ML; Rudensky A; Liu K; Nussenzweig MC. 2009. Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J Exp Med 206(9):1853-62. PubMed: 19667061MGI: J:152171
- Denning TL; Wang YC; Patel SR; Williams IR; Pulendran B. 2007. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol 8(10):1086-94. PubMed: 17873879MGI: J:125258
- Desai DD; Harbers SO; Flores M; Colonna L; Downie MP; Bergtold A; Jung S; Clynes R. 2007. Fc gamma receptor IIB on dendritic cells enforces peripheral tolerance by inhibiting effector T cell responses. J Immunol 178(10):6217-26. PubMed: 17475849MGI: J:146123
- Diao J; Zhao J; Winter E; Cattral MS. 2011. Tumors suppress in situ proliferation of cytotoxic T cells by promoting differentiation of Gr-1(+) conventional dendritic cells through IL-6. J Immunol 186(9):5058-67. PubMed: 21430223MGI: J:172866
- Didierlaurent A; Goulding J; Patel S; Snelgrove R; Low L; Bebien M; Lawrence T; van Rijt LS; Lambrecht BN; Sirard JC; Hussell T. 2008. Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection. J Exp Med 205(2):323-9. PubMed: 18227219MGI: J:131869
- Diehl GE; Longman RS; Zhang JX; Breart B; Galan C; Cuesta A; Schwab SR; Littman DR. 2013. Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells. Nature 494(7435):116-20. PubMed: 23334413MGI: J:210086
- Divangahi M; Desjardins D; Nunes-Alves C; Remold HG; Behar SM. 2010. Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis. Nat Immunol 11(8):751-8. PubMed: 20622882MGI: J:162390
- Do JS; Min B. 2009. Differential requirements of MHC and of DCs for endogenous proliferation of different T-cell subsets in vivo. Proc Natl Acad Sci U S A 106(48):20394-8. PubMed: 19920180MGI: J:155564
- Dolfi DV; Duttagupta PA; Boesteanu AC; Mueller YM; Oliai CH; Borowski AB; Katsikis PD. 2011. Dendritic cells and CD28 costimulation are required to sustain virus-specific CD8+ T cell responses during the effector phase in vivo. J Immunol 186(8):4599-608. PubMed: 21389258MGI: J:172460
- Elhaik-Goldman S; Kafka D; Yossef R; Hadad U; Elkabets M; Vallon-Eberhard A; Hulihel L; Jung S; Ghadially H; Braiman A; Apte RN; Mandelboim O; Dagan R; Mizrachi-Nebenzahl Y; Porgador A. 2011. The Natural Cytotoxicity Receptor 1 Contribution to Early Clearance of Streptococcus pneumoniae and to Natural Killer-Macrophage Cross Talk. PLoS One 6(8):e23472. PubMed: 21887255MGI: J:176154
- Engel D; Dobrindt U; Tittel A; Peters P; Maurer J; Gutgemann I; Kaissling B; Kuziel W; Jung S; Kurts C. 2006. Tumor necrosis factor alpha- and inducible nitric oxide synthase-producing dendritic cells are rapidly recruited to the bladder in urinary tract infection but are dispensable for bacterial clearance. Infect Immun 74(11):6100-7. PubMed: 16966414MGI: J:113552
- Fei M; Bhatia S; Oriss TB; Yarlagadda M; Khare A; Akira S; Saijo S; Iwakura Y; Fallert Junecko BA; Reinhart TA; Foreman O; Ray P; Kolls J; Ray A. 2011. TNF-{alpha} from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection. Proc Natl Acad Sci U S A 108(13):5360-5. PubMed: 21402950MGI: J:171233
- Felmy B; Songhet P; Slack EM; Muller AJ; Kremer M; Van Maele L; Cayet D; Heikenwalder M; Sirard JC; Hardt WD. 2013. NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium. PLoS One 8(10):e77204. PubMed: 24143212MGI: J:209119
- Ferrington DA; Roehrich H; Chang AA; Huang CW; Maldonado M; Bratten W; Rageh AA; Heuss ND; Gregerson DS; Nelson EF; Yuan C. 2013. Corneal wound healing is compromised by immunoproteasome deficiency. PLoS One 8(1):e54347. PubMed: 23365662MGI: J:195798
- Fooksman DR; Nussenzweig MC; Dustin ML. 2014. Myeloid cells limit production of antibody-secreting cells after immunization in the lymph node. J Immunol 192(3):1004-12. PubMed: 24376270MGI: J:207304
- Frank GM; Buela KA; Maker DM; Harvey SA; Hendricks RL. 2012. Early responding dendritic cells direct the local NK response to control herpes simplex virus 1 infection within the cornea. J Immunol 188(3):1350-9. PubMed: 22210909MGI: J:180749
- Freitag N; Tirado-Gonzalez I; Barrientos G; Herse F; Thijssen VL; Weedon-Fekjaer SM; Schulz H; Wallukat G; Klapp BF; Nevers T; Sharma S; Staff AC; Dechend R; Blois SM. 2013. Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia. Proc Natl Acad Sci U S A 110(28):11451-6. PubMed: 23798433MGI: J:198814
- Fujii S; Goto A; Shimizu K. 2009. Antigen mRNA-transfected, allogeneic fibroblasts loaded with NKT-cell ligand confer antitumor immunity. Blood 113(18):4262-72. PubMed: 19164596MGI: J:148431
- Fukuyama T; Kasper LH; Boussouar F; Jeevan T; van Deursen J; Brindle PK. 2009. Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development. Mol Cell Biol 29(14):3894-904. PubMed: 19433445MGI: J:150146
- Fukuyama Y; Tokuhara D; Sekine S; Aso K; Kataoka K; Davydova J; Yamamoto M; Gilbert RS; Tokuhara Y; Fujihashi K; Kunisawa J; Yuki Y; Kiyono H; McGhee JR; Fujihashi K. 2013. Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses. PLoS One 8(4):e60453. PubMed: 23565250MGI: J:199945
- Gao N; Yin J; Yoon GS; Mi QS; Yu FS. 2011. Dendritic cell-epithelium interplay is a determinant factor for corneal epithelial wound repair. Am J Pathol 179(5):2243-53. PubMed: 21924232MGI: J:177373
- Garaude J; Kent A; van Rooijen N; Blander JM. 2012. Simultaneous targeting of toll- and nod-like receptors induces effective tumor-specific immune responses. Sci Transl Med 4(120):120ra16. PubMed: 22323829MGI: J:183811
- Garrod KR; Liu FC; Forrest LE; Parker I; Kang SM; Cahalan MD. 2010. NK cell patrolling and elimination of donor-derived dendritic cells favor indirect alloreactivity. J Immunol 184(5):2329-36. PubMed: 20139277MGI: J:159639
- Gerard A; Khan O; Beemiller P; Oswald E; Hu J; Matloubian M; Krummel MF. 2013. Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8(+) T cells. Nat Immunol 14(4):356-63. PubMed: 23475183MGI: J:194908
- Gereke M; Jung S; Buer J; Bruder D. 2009. Alveolar type II epithelial cells present antigen to CD4(+) T cells and induce Foxp3(+) regulatory T cells. Am J Respir Crit Care Med 179(5):344-55. PubMed: 19096007MGI: J:165000
- GeurtsvanKessel CH; Willart MA; Bergen IM; van Rijt LS; Muskens F; Elewaut D; Osterhaus AD; Hendriks R; Rimmelzwaan GF; Lambrecht BN. 2009. Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus-infected mice. J Exp Med 206(11):2339-49. PubMed: 19808255MGI: J:154071
- GeurtsvanKessel CH; Willart MA; van Rijt LS; Muskens F; Kool M; Baas C; Thielemans K; Bennett C; Clausen BE; Hoogsteden HC; Osterhaus AD; Rimmelzwaan GF; Lambrecht BN. 2008. Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells. J Exp Med 205(7):1621-34. PubMed: 18591406MGI: J:137452
- Goold HD; Escors D; Conlan TJ; Chakraverty R; Bennett CL. 2011. Conventional dendritic cells are required for the activation of helper-dependent CD8 T cell responses to a model antigen after cutaneous vaccination with lentiviral vectors. J Immunol 186(8):4565-72. PubMed: 21389256MGI: J:172461
- Guimond M; Freud AG; Mao HC; Yu J; Blaser BW; Leong JW; Vandeusen JB; Dorrance A; Zhang J; Mackall CL; Caligiuri MA. 2010. In vivo role of Flt3 ligand and dendritic cells in NK cell homeostasis. J Immunol 184(6):2769-75. PubMed: 20142363MGI: J:160121
- Guimond M; Veenstra RG; Grindler DJ; Zhang H; Cui Y; Murphy RD; Kim SY; Na R; Hennighausen L; Kurtulus S; Erman B; Matzinger P; Merchant MS; Mackall CL. 2009. Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells. Nat Immunol 10(2):149-57. PubMed: 19136960MGI: J:144504
- Guo Z; Tilburgs T; Wong B; Strominger JL. 2014. Dysfunction of dendritic cells in aged C57BL/6 mice leads to failure of natural killer cell activation and of tumor eradication. Proc Natl Acad Sci U S A 111(39):14199-204. PubMed: 25225399MGI: J:216479
- Gupta A; Probst HC; Vuong V; Landshammer A; Muth S; Yagita H; Schwendener R; Pruschy M; Knuth A; van den Broek M. 2012. Radiotherapy promotes tumor-specific effector CD8+ T cells via dendritic cell activation. J Immunol 189(2):558-66. PubMed: 22685313MGI: J:189554
- Hammad H; Plantinga M; Deswarte K; Pouliot P; Willart MA; Kool M; Muskens F; Lambrecht BN. 2010. Inflammatory dendritic cells--not basophils--are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen. J Exp Med 207(10):2097-111. PubMed: 20819925MGI: J:165817
- Hapfelmeier S; Muller AJ; Stecher B; Kaiser P; Barthel M; Endt K; Eberhard M; Robbiani R; Jacobi CA; Heikenwalder M; Kirschning C; Jung S; Stallmach T; Kremer M; Hardt WD. 2008. Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitis. J Exp Med 205(2):437-50. PubMed: 18268033MGI: J:132107
- Harbers SO; Crocker A; Catalano G; D'Agati V; Jung S; Desai DD; Clynes R. 2007. Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance. J Clin Invest 117(5):1361-9. PubMed: 17446931MGI: J:122114
- Harper SJ; Ali JM; Wlodek E; Negus MC; Harper IG; Chhabra M; Qureshi MS; Mallik M; Bolton E; Bradley JA; Pettigrew GJ. 2015. CD8 T-cell recognition of acquired alloantigen promotes acute allograft rejection. Proc Natl Acad Sci U S A 112(41):12788-93. PubMed: 26420874MGI: J:225573
- Hashimoto D; Chow A; Noizat C; Teo P; Beasley MB; Leboeuf M; Becker CD; See P; Price J; Lucas D; Greter M; Mortha A; Boyer SW; Forsberg EC; Tanaka M; van Rooijen N; Garcia-Sastre A; Stanley ER; Ginhoux F; Frenette PS; Merad M. 2013. Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity 38(4):792-804. PubMed: 23601688MGI: J:196958
- He LZ; Crocker A; Lee J; Mendoza-Ramirez J; Wang XT; Vitale LA; O'Neill T; Petromilli C; Zhang HF; Lopez J; Rohrer D; Keler T; Clynes R. 2007. Antigenic targeting of the human mannose receptor induces tumor immunity. J Immunol 178(10):6259-67. PubMed: 17475854MGI: J:146119
- Hebel K; Griewank K; Inamine A; Chang HD; Muller-Hilke B; Fillatreau S; Manz RA; Radbruch A; Jung S. 2006. Plasma cell differentiation in T-independent type 2 immune responses is independent of CD11c(high) dendritic cells. Eur J Immunol 36(11):2912-9. PubMed: 17051619MGI: J:117008
- Heuss ND; Lehmann U; Norbury CC; McPherson SW; Gregerson DS. 2012. Local activation of dendritic cells alters the pathogenesis of autoimmune disease in the retina. J Immunol 188(3):1191-200. PubMed: 22219322MGI: J:180741
- Heymann F; Meyer-Schwesinger C; Hamilton-Williams EE; Hammerich L; Panzer U; Kaden S; Quaggin SE; Floege J; Grone HJ; Kurts C. 2009. Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. J Clin Invest 119(5):1286-97. PubMed: 19381017MGI: J:194725
- Hickman HD; Li L; Reynoso GV; Rubin EJ; Skon CN; Mays JW; Gibbs J; Schwartz O; Bennink JR; Yewdell JW. 2011. Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells. J Exp Med 208(12):2511-24. PubMed: 22042976MGI: J:178641
- Hsieh SH; Lin JS; Huang JH; Wu SY; Chu CL; Kung JT; Wu-Hsieh BA. 2011. Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis. Infect Immun 79(11):4493-502. PubMed: 21911464MGI: J:177771
- Huang L; Li L; Lemos H; Chandler PR; Pacholczyk G; Baban B; Barber GN; Hayakawa Y; McGaha TL; Ravishankar B; Munn DH; Mellor AL. 2013. Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responses. J Immunol 191(7):3509-13. PubMed: 23986532MGI: J:205962
- Iijima N; Mattei LM; Iwasaki A. 2011. Recruited inflammatory monocytes stimulate antiviral Th1 immunity in infected tissue. Proc Natl Acad Sci U S A 108(1):284-9. PubMed: 21173243MGI: J:169008
- Ise W; Inoue T; McLachlan JB; Kometani K; Kubo M; Okada T; Kurosaki T. 2014. Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells. Proc Natl Acad Sci U S A 111(32):11792-7. PubMed: 25071203MGI: J:213941
- Ivanov S; Scallan JP; Kim KW; Werth K; Johnson MW; Saunders BT; Wang PL; Kuan EL; Straub AC; Ouhachi M; Weinstein EG; Williams JW; Briseno C; Colonna M; Isakson BE; Gautier EL; Forster R; Davis MJ; Zinselmeyer BH; Randolph GJ. 2016. CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability. J Clin Invest 126(4):1581-91. PubMed: 26999610MGI: J:234708
- Janelsins BM; Sumpter TL; Tkacheva OA; Rojas-Canales DM; Erdos G; Mathers AR; Shufesky WJ; Storkus WJ; Falo LD Jr; Morelli AE; Larregina AT. 2013. Neurokinin-1 receptor agonists bias therapeutic dendritic cells to induce type 1 immunity by licensing host dendritic cells to produce IL-12. Blood 121(15):2923-33. PubMed: 23365459MGI: J:196402
- Jiao J; Dragomir AC; Kocabayoglu P; Rahman AH; Chow A; Hashimoto D; Leboeuf M; Kraus T; Moran T; Carrasco-Avino G; Friedman SL; Merad M; Aloman C. 2014. Central role of conventional dendritic cells in regulation of bone marrow release and survival of neutrophils. J Immunol 192(7):3374-82. PubMed: 24591364MGI: J:209877
- Johnson S; Zhan Y; Sutherland RM; Mount AM; Bedoui S; Brady JL; Carrington EM; Brown LE; Belz GT; Heath WR; Lew AM. 2009. Selected Toll-like receptor ligands and viruses promote helper-independent cytotoxic T cell priming by upregulating CD40L on dendritic cells. Immunity 30(2):218-27. PubMed: 19200758MGI: J:146462
- Jones DD; Racine R; Wittmer ST; Harston L; Papillion AM; Dishaw LM; Randall TD; Woodland DL; Winslow GM. 2015. The omentum is a site of protective IgM production during intracellular bacterial infection. Infect Immun 83(5):2139-47. PubMed: 25776744MGI: J:229710
- Joshi SK; Lang GA; Devera TS; Johnson AM; Kovats S; Lang ML. 2012. Differential contribution of dendritic cell CD1d to NKT cell-enhanced humoral immunity and CD8+ T cell activation. J Leukoc Biol 91(5):783-90. PubMed: 22331103MGI: J:183803
- Jung S; Unutmaz D; Wong P; Sano G; De los Santos K; Sparwasser T; Wu S; Vuthoori S; Ko K; Zavala F; Pamer EG; Littman DR; Lang RA. 2002. In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens. Immunity 17(2):211-20. PubMed: 12196292MGI: J:93488
- Kaiser P; Regoes RR; Dolowschiak T; Wotzka SY; Lengefeld J; Slack E; Grant AJ; Ackermann M; Hardt WD. 2014. Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatment. PLoS Biol 12(2):e1001793. PubMed: 24558351MGI: J:208411
- Kapur R; Kim M; Aslam R; McVey MJ; Tabuchi A; Luo A; Liu J; Li Y; Shanmugabhavananthan S; Speck ER; Zufferey A; Yousef G; Zhang H; Rondina MT; Weyrich AS; Porcelijn L; Kuebler WM; Slutsky AS; Semple JW. 2017. T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10. Blood 129(18):2557-2569. PubMed: 28202460MGI: J:241536
- Kassim SH; Rajasagi NK; Zhao X; Chervenak R; Jennings SR. 2006. In vivo ablation of CD11c-positive dendritic cells increases susceptibility to herpes simplex virus type 1 infection and diminishes NK and T-cell responses. J Virol 80(8):3985-93. PubMed: 16571815MGI: J:144132
- Katzman SD; O'Gorman WE; Villarino AV; Gallo E; Friedman RS; Krummel MF; Nolan GP; Abbas AK. 2010. Duration of antigen receptor signaling determines T-cell tolerance or activation. Proc Natl Acad Sci U S A 107(42):18085-90. PubMed: 20921406MGI: J:165535
- Khare A; Krishnamoorthy N; Oriss TB; Fei M; Ray P; Ray A. 2013. Cutting edge: inhaled antigen upregulates retinaldehyde dehydrogenase in lung CD103+ but not plasmacytoid dendritic cells to induce Foxp3 de novo in CD4+ T cells and promote airway tolerance. J Immunol 191(1):25-9. PubMed: 23733880MGI: J:205351
- Khoo LH; Thiam CH; Soh SY; Angeli V. 2015. Splenic extrafollicular reactions and BM plasma cells sustain IgM response associated with hypercholesterolemia. Eur J Immunol 45(5):1300-12. PubMed: 25639537MGI: J:229268
- Kim ML; Chae JJ; Park YH; De Nardo D; Stirzaker RA; Ko HJ; Tye H; Cengia L; DiRago L; Metcalf D; Roberts AW; Kastner DL; Lew AM; Lyras D; Kile BT; Croker BA; Masters SL. 2015. Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1beta. J Exp Med 212(6):927-38. PubMed: 26008898MGI: J:224778
- Kim TS; Hanak M; Trampont PC; Braciale TJ. 2015. Stress-associated erythropoiesis initiation is regulated by type 1 conventional dendritic cells. J Clin Invest 125(10):3965-80. PubMed: 26389678MGI: J:226390
- Kim TS; Hufford MM; Sun J; Fu YX; Braciale TJ. 2010. Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection. J Exp Med 207(6):1161-72. PubMed: 20513748MGI: J:163416
- King IL; Amiel E; Tighe M; Mohrs K; Veerapen N; Besra G; Mohrs M; Leadbetter EA. 2013. The mechanism of splenic invariant NKT cell activation dictates localization in vivo. J Immunol 191(2):572-82. PubMed: 23785119MGI: J:205445
- Kirby AC; Beattie L; Maroof A; van Rooijen N; Kaye PM. 2009. SIGNR1-negative red pulp macrophages protect against acute streptococcal sepsis after Leishmania donovani-induced loss of marginal zone macrophages. Am J Pathol 175(3):1107-15. PubMed: 19644016MGI: J:152907
- Klebanoff CA; Spencer SP; Torabi-Parizi P; Grainger JR; Roychoudhuri R; Ji Y; Sukumar M; Muranski P; Scott CD; Hall JA; Ferreyra GA; Leonardi AJ; Borman ZA; Wang J; Palmer DC; Wilhelm C; Cai R; Sun J; Napoli JL; Danner RL; Gattinoni L; Belkaid Y; RestifoNP. 2013. Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells. J Exp Med 210(10):1961-76. PubMed: 23999499MGI: J:203429
- Ko HJ; Brady JL; Ryg-Cornejo V; Hansen DS; Vremec D; Shortman K; Zhan Y; Lew AM. 2014. GM-CSF-responsive monocyte-derived dendritic cells are pivotal in Th17 pathogenesis. J Immunol 192(5):2202-9. PubMed: 24489100MGI: J:209938
- Kono H; Karmarkar D; Iwakura Y; Rock KL. 2010. Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death. J Immunol 184(8):4470-8. PubMed: 20220089MGI: J:160055
- Kool M; Soullie T; van Nimwegen M; Willart MA; Muskens F; Jung S; Hoogsteden HC; Hammad H; Lambrecht BN. 2008. Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. J Exp Med 205(4):869-82. PubMed: 18362170MGI: J:133978
- Krebs DL; Chehal MK; Sio A; Huntington ND; Da ML; Ziltener P; Inglese M; Kountouri N; Priatel JJ; Jones J; Tarlinton DM; Anderson GP; Hibbs ML; Harder KW. 2012. Lyn-dependent signaling regulates the innate immune response by controlling dendritic cell activation of NK cells. J Immunol 188(10):5094-105. PubMed: 22491248MGI: J:188683
- Kumamoto Y; Hirai T; Wong PW; Kaplan DH; Iwasaki A. 2016. CD301b+ dendritic cells suppress T follicular helper cells and antibody responses to protein antigens. Elife 5:. PubMed: 27657168MGI: J:238018
- Kumar V; Dasoveanu DC; Chyou S; Tzeng TC; Rozo C; Liang Y; Stohl W; Fu YX; Ruddle NH; Lu TT. 2015. A dendritic-cell-stromal axis maintains immune responses in lymph nodes. Immunity 42(4):719-30. PubMed: 25902483MGI: J:229773
- Kupz A; Guarda G; Gebhardt T; Sander LE; Short KR; Diavatopoulos DA; Wijburg OL; Cao H; Waithman JC; Chen W; Fernandez-Ruiz D; Whitney PG; Heath WR; Curtiss R 3rd; Tschopp J; Strugnell RA; Bedoui S. 2012. NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8 T cells. Nat Immunol 13(2):162-9. PubMed: 22231517MGI: J:181212
- Kupz A; Zedler U; Staber M; Perdomo C; Dorhoi A; Brosch R; Kaufmann SH. 2016. ESAT-6-dependent cytosolic pattern recognition drives noncognate tuberculosis control in vivo. J Clin Invest 126(6):2109-22. PubMed: 27111234MGI: J:237079
- Kurashima Y; Amiya T; Fujisawa K; Shibata N; Suzuki Y; Kogure Y; Hashimoto E; Otsuka A; Kabashima K; Sato S; Sato T; Kubo M; Akira S; Miyake K; Kunisawa J; Kiyono H. 2014. The enzyme Cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis. Immunity 40(4):530-41. PubMed: 24726878MGI: J:209953
- Kurche JS; Burchill MA; Sanchez PJ; Haluszczak C; Kedl RM. 2010. Comparison of OX40 Ligand and CD70 in the Promotion of CD4+ T Cell Responses. J Immunol 185(4):2106-15. PubMed: 20639485MGI: J:162543
- Kuwajima S; Sato T; Ishida K; Tada H; Tezuka H; Ohteki T. 2006. Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation. Nat Immunol 7(7):740-6. PubMed: 16715101MGI: J:112665
- LaCasse CJ; Janikashvili N; Larmonier CB; Alizadeh D; Hanke N; Kartchner J; Situ E; Centuori S; Har-Noy M; Bonnotte B; Katsanis E; Larmonier N. 2011. Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-gamma-dependent mechanism. J Immunol 187(12):6310-7. PubMed: 22075702MGI: J:180408
- Lantier L; Lacroix-Lamande S; Potiron L; Metton C; Drouet F; Guesdon W; Gnahoui-David A; Le Vern Y; Deriaud E; Fenis A; Rabot S; Descamps A; Werts C; Laurent F. 2013. Intestinal CD103+ dendritic cells are key players in the innate immune control of Cryptosporidium parvum infection in neonatal mice. PLoS Pathog 9(12):e1003801. PubMed: 24367259MGI: J:238037
- Lauterbach H; Bathke B; Gilles S; Traidl-Hoffmann C; Luber CA; Fejer G; Freudenberg MA; Davey GM; Vremec D; Kallies A; Wu L; Shortman K; Chaplin P; Suter M; O'Keeffe M; Hochrein H. 2010. Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC. J Exp Med 207(12):2703-17. PubMed: 20975040MGI: J:176879
- Lee PY; Weinstein JS; Nacionales DC; Scumpia PO; Li Y; Butfiloski E; van Rooijen N; Moldawer L; Satoh M; Reeves WH. 2008. A Novel Type I IFN-Producing Cell Subset in Murine Lupus. J Immunol 180(7):5101-8. PubMed: 18354236MGI: J:133377
- Leon B; Ballesteros-Tato A; Randall TD; Lund FE. 2014. Prolonged antigen presentation by immune complex-binding dendritic cells programs the proliferative capacity of memory CD8 T cells. J Exp Med 211(8):1637-55. PubMed: 25002751MGI: J:214725
- Lin KL; Fulton LM; Berginski M; West ML; Taylor NA; Moran TP; Coghill JM; Blazar BR; Bear JE; Serody JS. 2014. Intravital imaging of donor allogeneic effector and regulatory T cells with host dendritic cells during GVHD. Blood 123(10):1604-14. PubMed: 24415540MGI: J:209503
- Linehan JL; Dileepan T; Kashem SW; Kaplan DH; Cleary P; Jenkins MK. 2015. Generation of Th17 cells in response to intranasal infection requires TGF-beta1 from dendritic cells and IL-6 from CD301b+ dendritic cells. Proc Natl Acad Sci U S A 112(41):12782-7. PubMed: 26417101MGI: J:225575
- Liu CH; Fan YT; Dias A; Esper L; Corn RA; Bafica A; Machado FS; Aliberti J. 2006. Cutting edge: dendritic cells are essential for in vivo IL-12 production and development of resistance against Toxoplasma gondii infection in mice. J Immunol 177(1):31-5. PubMed: 16785494MGI: J:134413
- Liu Z; Noh HS; Chen J; Kim JH; Falo LD Jr; You Z. 2008. Potent tumor-specific protection ignited by adoptively transferred CD4+ T cells. J Immunol 181(6):4363-70. PubMed: 18768895MGI: J:139077
- London A; Itskovich E; Benhar I; Kalchenko V; Mack M; Jung S; Schwartz M. 2011. Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages. J Exp Med 208(1):23-39. PubMed: 21220455MGI: J:176855
- Lu M; Munford RS. 2011. The transport and inactivation kinetics of bacterial lipopolysaccharide influence its immunological potency in vivo. J Immunol 187(6):3314-20. PubMed: 21849675MGI: J:179236
- Lucas M; Schachterle W; Oberle K; Aichele P; Diefenbach A. 2007. Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity 26(4):503-17. PubMed: 17398124MGI: J:123584
- Magalhaes JG; Rubino SJ; Travassos LH; Le Bourhis L; Duan W; Sellge G; Geddes K; Reardon C; Lechmann M; Carneiro LA; Selvanantham T; Fritz JH; Taylor BC; Artis D; Mak TW; Comeau MR; Croft M; Girardin SE; Philpott DJ. 2011. Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation. Proc Natl Acad Sci U S A 108(36):14896-901. PubMed: 21856952MGI: J:175223
- Mandaric S; Walton SM; Rulicke T; Richter K; Girard-Madoux MJ; Clausen BE; Zurunic A; Kamanaka M; Flavell RA; Jonjic S; Oxenius A. 2012. IL-10 suppression of NK/DC crosstalk leads to poor priming of MCMV-specific CD4 T cells and prolonged MCMV persistence. PLoS Pathog 8(8):e1002846. PubMed: 22876184MGI: J:195373
- Markey KA; Banovic T; Kuns RD; Olver SD; Don AL; Raffelt NC; Wilson YA; Raggatt LJ; Pettit AR; Bromberg JS; Hill GR; MacDonald KP. 2009. Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation. Blood 113(22):5644-9. PubMed: 19336758MGI: J:148895
- Mascanfroni ID; Yeste A; Vieira SM; Burns EJ; Patel B; Sloma I; Wu Y; Mayo L; Ben-Hamo R; Efroni S; Kuchroo VK; Robson SC; Quintana FJ. 2013. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nat Immunol 14(10):1054-63. PubMed: 23995234MGI: J:208218
- McAleer JP; Zammit DJ; Lefrancois L; Rossi RJ; Vella AT. 2007. The lipopolysaccharide adjuvant effect on T cells relies on nonoverlapping contributions from the MyD88 pathway and CD11c+ cells. J Immunol 179(10):6524-35. PubMed: 17982041MGI: J:153867
- McCartney SA; Vermi W; Lonardi S; Rossini C; Otero K; Calderon B; Gilfillan S; Diamond MS; Unanue ER; Colonna M. 2011. RNA sensor-induced type I IFN prevents diabetes caused by a beta cell-tropic virus in mice. J Clin Invest 121(4):1497-507. PubMed: 21403398MGI: J:172007
- McDonald KG; McDonough JS; Dieckgraefe BK; Newberry RD. 2010. Dendritic cells produce CXCL13 and participate in the development of murine small intestine lymphoid tissues. Am J Pathol 176(5):2367-77. PubMed: 20304952MGI: J:160774
- Meredith MM; Liu K; Darrasse-Jeze G; Kamphorst AO; Schreiber HA; Guermonprez P; Idoyaga J; Cheong C; Yao KH; Niec RE; Nussenzweig MC. 2012. Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage. J Exp Med 209(6):1153-65. PubMed: 22615130MGI: J:189122
- Milam JE; Erb-Downward JR; Chen GH; Osuchowski MF; McDonald R; Chensue SW; Toews GB; Huffnagle GB; Olszewski MA. 2010. CD11c+ cells are required to prevent progression from local acute lung injury to multiple organ failure and death. Am J Pathol 176(1):218-26. PubMed: 19948830MGI: J:156379
- Milo I; Sapoznikov A; Kalchenko V; Tal O; Krauthgamer R; van Rooijen N; Dudziak D; Jung S; Shakhar G. 2013. Dynamic imaging reveals promiscuous crosspresentation of blood-borne antigens to naive CD8+ T cells in the bone marrow. Blood 122(2):193-208. PubMed: 23637125MGI: J:200965
- Misharin AV; Cuda CM; Saber R; Turner JD; Gierut AK; Haines GK 3rd; Berdnikovs S; Filer A; Clark AR; Buckley CD; Mutlu GM; Budinger GR; Perlman H. 2014. Nonclassical Ly6C(-) monocytes drive the development of inflammatory arthritis in mice. Cell Rep 9(2):591-604. PubMed: 25373902MGI: J:218528
- Miyake K; Shiozawa N; Nagao T; Yoshikawa S; Yamanishi Y; Karasuyama H. 2017. Trogocytosis of peptide-MHC class II complexes from dendritic cells confers antigen-presenting ability on basophils. Proc Natl Acad Sci U S A 114(5):1111-1116. PubMed: 28096423MGI: J:240740
- Miyake Y; Asano K; Kaise H; Uemura M; Nakayama M; Tanaka M. 2007. Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens. J Clin Invest 117(8):2268-78. PubMed: 17657313MGI: J:123958
- Mortier E; Woo T; Advincula R; Gozalo S; Ma A. 2008. IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation. J Exp Med 205(5):1213-25. PubMed: 18458113MGI: J:136221
- Motomura Y; Kanno S; Asano K; Tanaka M; Hasegawa Y; Katagiri H; Saito T; Hara H; Nishio H; Hara T; Yamasaki S. 2015. Identification of Pathogenic Cardiac CD11c+ Macrophages in Nod1-Mediated Acute Coronary Arteritis. Arterioscler Thromb Vasc Biol 35(6):1423-33. PubMed: 25838430MGI: J:241622
- Mott KR; Gate D; Zandian M; Allen SJ; Rajasagi NK; van Rooijen N; Chen S; Arditi M; Rouse BT; Flavell RA; Town T; Ghiasi H. 2011. Macrophage IL-12p70 Signaling Prevents HSV-1-Induced CNS Autoimmunity Triggered by Autoaggressive CD4+ Tregs. Invest Ophthalmol Vis Sci 52(5):2321-33. PubMed: 21220560MGI: J:171538
- Mott KR; Underhill D; Wechsler SL; Ghiasi H. 2008. Lymphoid-related CD11c+ CD8alpha+ dendritic cells are involved in enhancing herpes simplex virus type 1 latency. J Virol 82(20):9870-9. PubMed: 18667491MGI: J:153404
- Mourao-Sa D; Robinson MJ; Zelenay S; Sancho D; Chakravarty P; Larsen R; Plantinga M; Van Rooijen N; Soares MP; Lambrecht B; Reis E Sousa C. 2011. CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses. Eur J Immunol 41(10):3040-53. PubMed: 21728173MGI: J:176982
- Moussion C; Girard JP. 2011. Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules. Nature 479(7374):542-6. PubMed: 22080953MGI: J:178295
- Muniz LR; Pacer ME; Lira SA; Furtado GC. 2011. A critical role for dendritic cells in the formation of lymphatic vessels within tertiary lymphoid structures. J Immunol 187(2):828-34. PubMed: 21666055MGI: J:178041
- Murillo O; Dubrot J; Palazon A; Arina A; Azpilikueta A; Alfaro C; Solano S; Ochoa MC; Berasain C; Gabari I; Perez-Gracia JL; Berraondo P; Hervas-Stubbs S; Melero I. 2009. In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb. Eur J Immunol 39(9):2424-36. PubMed: 19662633MGI: J:152180
- Nakano H; Lin KL; Yanagita M; Charbonneau C; Cook DN; Kakiuchi T; Gunn MD. 2009. Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses. Nat Immunol 10(4):394-402. PubMed: 19252492MGI: J:148008
- O'Connor RA; Leech MD; Suffner J; Hammerling GJ; Anderton SM. 2010. Myelin-reactive, TGF-beta-induced regulatory T cells can be programmed to develop Th1-like effector function but remain less proinflammatory than myelin-reactive Th1 effectors and can suppress pathogenic T cell clonal expansion in vivo. J Immunol 185(12):7235-43. PubMed: 21084662MGI: J:167459
- Obata T; Shibata N; Goto Y; Ishikawa I; Sato S; Kunisawa J; Kiyono H. 2013. Critical role of dendritic cells in T cell retention in the interfollicular region of Peyer's patches. J Immunol 191(2):942-8. PubMed: 23772027MGI: J:204815
- Obeid M; Tesniere A; Ghiringhelli F; Fimia GM; Apetoh L; Perfettini JL; Castedo M; Mignot G; Panaretakis T; Casares N; Metivier D; Larochette N; van Endert P; Ciccosanti F; Piacentini M; Zitvogel L; Kroemer G. 2007. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med 13(1):54-61. PubMed: 17187072MGI: J:140379
- Oertli M; Sundquist M; Hitzler I; Engler DB; Arnold IC; Reuter S; Maxeiner J; Hansson M; Taube C; Quiding-Jarbrink M; Muller A. 2012. DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection. J Clin Invest 122(3):1082-96. PubMed: 22307326MGI: J:184486
- Ohteki T; Tada H; Ishida K; Sato T; Maki C; Yamada T; Hamuro J; Koyasu S. 2006. Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo. J Exp Med 203(10):2329-38. PubMed: 16966429MGI: J:124624
- Osterholzer JJ; Milam JE; Chen GH; Toews GB; Huffnagle GB; Olszewski MA. 2009. Role of dendritic cells and alveolar macrophages in regulating early host defense against pulmonary infection with Cryptococcus neoformans. Infect Immun 77(9):3749-58. PubMed: 19564388MGI: J:152249
- Ouchi T; Kubo A; Yokouchi M; Adachi T; Kobayashi T; Kitashima DY; Fujii H; Clausen BE; Koyasu S; Amagai M; Nagao K. 2011. Langerhans cell antigen capture through tight junctions confers preemptive immunity in experimental staphylococcal scalded skin syndrome. J Exp Med 208(13):2607-13. PubMed: 22143886MGI: J:179051
- Padilla J; Daley E; Chow A; Robinson K; Parthasarathi K; McKenzie AN; Tschernig T; Kurup VP; Donaldson DD; Grunig G. 2005. IL-13 regulates the immune response to inhaled antigens. J Immunol 174(12):8097-105. PubMed: 15944318MGI: J:100867
- Park SJ; Burdick MD; Mehrad B. 2012. Neutrophils Mediate Maturation and Efflux of Lung Dendritic Cells in Response to Aspergillus fumigatus Germ Tubes. Infect Immun 80(5):1759-65. PubMed: 22392929MGI: J:182680
- Patsouris D; Li PP; Thapar D; Chapman J; Olefsky JM; Neels JG. 2008. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab 8(4):301-9. PubMed: 18840360MGI: J:143426
- Paulson KE; Zhu SN; Chen M; Nurmohamed S; Jongstra-Bilen J; Cybulsky MI. 2010. Resident intimal dendritic cells accumulate lipid and contribute to the initiation of atherosclerosis. Circ Res 106(2):383-90. PubMed: 19893012MGI: J:170071
- Paveglio SA; Allard J; Foster Hodgkins SR; Ather JL; Bevelander M; Campbell JM; Whittaker LeClair LA; McCarthy SM; van der Vliet A; Suratt BT; Boyson JE; Uematsu S; Akira S; Poynter ME. 2011. Airway epithelial indoleamine 2,3-dioxygenase inhibits CD4+ T cells during Aspergillus fumigatus antigen exposure. Am J Respir Cell Mol Biol 44(1):11-23. PubMed: 20118221MGI: J:186825
- Plaks V; Birnberg T; Berkutzki T; Sela S; BenYashar A; Kalchenko V; Mor G; Keshet E; Dekel N; Neeman M; Jung S. 2008. Uterine DCs are crucial for decidua formation during embryo implantation in mice. J Clin Invest 118(12):3954-65. PubMed: 19033665MGI: J:144732
- Plaks V; Boldajipour B; Linnemann JR; Nguyen NH; Kersten K; Wolf Y; Casbon AJ; Kong N; van den Bijgaart RJ; Sheppard D; Melton AC; Krummel MF; Werb Z. 2015. Adaptive Immune Regulation of Mammary Postnatal Organogenesis. Dev Cell 34(5):493-504. PubMed: 26321127MGI: J:239781
- Poeck H; Besch R; Maihoefer C; Renn M; Tormo D; Morskaya SS; Kirschnek S; Gaffal E; Landsberg J; Hellmuth J; Schmidt A; Anz D; Bscheider M; Schwerd T; Berking C; Bourquin C; Kalinke U; Kremmer E; Kato H; Akira S; Meyers R; Hacker G; Neuenhahn M; Busch D;Ruland J; Rothenfusser S; Prinz M; Hornung V; Endres S; Tuting T; Hartmann G. 2008. 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nat Med 14(11):1256-63. PubMed: 18978796MGI: J:143226
- Probst HC; Tschannen K; Odermatt B; Schwendener R; Zinkernagel RM; Van Den Broek M. 2005. Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells. Clin Exp Immunol 141(3):398-404. PubMed: 16045728MGI: J:106223
- Probst HC; van den Broek M. 2005. Priming of CTLs by lymphocytic choriomeningitis virus depends on dendritic cells. J Immunol 174(7):3920-4. PubMed: 15778347MGI: J:97970
- Qing X; Koo GC; Salmon JE. 2012. Complement regulates conventional DC-mediated NK-cell activation by inducing TGF-beta1 in Gr-1+ myeloid cells. Eur J Immunol 42(7):1723-34. PubMed: 22535677MGI: J:187776
- Qiu X; Zhu L; Pollard JW. 2009. Colony-stimulating factor-1-dependent macrophage functions regulate the maternal decidua immune responses against Listeria monocytogenes infections during early gestation in mice. Infect Immun 77(1):85-97. PubMed: 18852237MGI: J:144590
- Rahman S; Manuel SL; Khan ZK; Wigdahl B; Acheampong E; Tangy F; Jain P. 2010. Depletion of dendritic cells enhances susceptibility to cell-free infection of human T cell leukemia virus type 1 in CD11c-diphtheria toxin receptor transgenic mice. J Immunol 184(10):5553-61. PubMed: 20382884MGI: J:161006
- Rangel-Moreno J; Carragher DM; de la Luz Garcia-Hernandez M; Hwang JY; Kusser K; Hartson L; Kolls JK; Khader SA; Randall TD. 2011. The development of inducible bronchus-associated lymphoid tissue depends on IL-17. Nat Immunol 12(7):639-46. PubMed: 21666689MGI: J:174312
- Raposo C; Graubardt N; Cohen M; Eitan C; London A; Berkutzki T; Schwartz M. 2014. CNS repair requires both effector and regulatory T cells with distinct temporal and spatial profiles. J Neurosci 34(31):10141-55. PubMed: 25080578MGI: J:215779
- Richert LE; Rynda-Apple A; Harmsen AL; Han S; Wiley JA; Douglas T; Larson K; Morton RV; Harmsen AG. 2014. CD11c(+) cells primed with unrelated antigens facilitate an accelerated immune response to influenza virus in mice. Eur J Immunol 44(2):397-408. PubMed: 24222381MGI: J:208992
- Riol-Blanco L; Ordovas-Montanes J; Perro M; Naval E; Thiriot A; Alvarez D; Paust S; Wood JN; von Andrian UH. 2014. Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation. Nature 510(7503):157-61. PubMed: 24759321MGI: J:212830
- Rivera A; Hohl TM; Collins N; Leiner I; Gallegos A; Saijo S; Coward JW; Iwakura Y; Pamer EG. 2011. Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation. J Exp Med 208(2):369-81. PubMed: 21242294MGI: J:176853
- Rivollier A; He J; Kole A; Valatas V; Kelsall BL. 2012. Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon. J Exp Med 209(1):139-55. PubMed: 22231304MGI: J:181701
- Robb RJ; Lineburg KE; Kuns RD; Wilson YA; Raffelt NC; Olver SD; Varelias A; Alexander KA; Teal BE; Sparwasser T; Hammerling GJ; Markey KA; Koyama M; Clouston AD; Engwerda CR; Hill GR; MacDonald KP. 2012. Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation. Blood 119(24):5898-908. PubMed: 22538855MGI: J:188644
- Robinson RT; Khader SA; Martino CA; Fountain JJ; Teixeira-Coelho M; Pearl JE; Smiley ST; Winslow GM; Woodland DL; Walter MJ; Conejo-Garcia JR; Gubler U; Cooper AM. 2010. Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rbeta1 isoform that enhances DC migration. J Exp Med 207(3):591-605. PubMed: 20212068MGI: J:158809
- Ruane D; Brane L; Reis BS; Cheong C; Poles J; Do Y; Zhu H; Velinzon K; Choi JH; Studt N; Mayer L; Lavelle EC; Steinman RM; Mucida D; Mehandru S. 2013. Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract. J Exp Med 210(9):1871-88. PubMed: 23960190MGI: J:202859
- Salazar-Gonzalez RM; Niess JH; Zammit DJ; Ravindran R; Srinivasan A; Maxwell JR; Stoklasek T; Yadav R; Williams IR; Gu X; McCormick BA; Pazos MA; Vella AT; Lefrancois L; Reinecker HC; McSorley SJ. 2006. CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches. Immunity 24(5):623-32. PubMed: 16713979MGI: J:113363
- Sapoznikov A; Fischer JA; Zaft T; Krauthgamer R; Dzionek A; Jung S. 2007. Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells. J Exp Med 204(8):1923-33. PubMed: 17646404MGI: J:125954
- Sapoznikov A; Pewzner-Jung Y; Kalchenko V; Krauthgamer R; Shachar I; Jung S. 2008. Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches. Nat Immunol 9(4):388-95. PubMed: 18311142MGI: J:133263
- Schindler D; Gutierrez MG; Beineke A; Rauter Y; Rohde M; Foster S; Goldmann O; Medina E. 2012. Dendritic Cells Are Central Coordinators of the Host Immune Response to Staphylococcus aureus Bloodstream Infection. Am J Pathol 181(4):1327-37. PubMed: 22885107MGI: J:188587
- Schleicher U; Liese J; Knippertz I; Kurzmann C; Hesse A; Heit A; Fischer JA; Weiss S; Kalinke U; Kunz S; Bogdan C. 2007. NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. J Exp Med 204(4):893-906. PubMed: 17389237MGI: J:125611
- Schmidt-Christensen A; Hansen L; Ilegems E; Fransen-Pettersson N; Dahl U; Gupta S; Larefalk A; Hannibal TD; Schulz A; Berggren PO; Holmberg D. 2013. Imaging dynamics of CD11c(+) cells and Foxp3(+) cells in progressive autoimmune insulitis in the NOD mouse model of type 1 diabetes. Diabetologia 56(12):2669-78. PubMed: 23963325MGI: J:203961
- Schmieg J; Yang G; Franck RW; Van Rooijen N; Tsuji M. 2005. Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion. Proc Natl Acad Sci U S A 102(4):1127-32. PubMed: 15644449MGI: J:96123
- Scholz J; Lukacs-Kornek V; Engel DR; Specht S; Kiss E; Eitner F; Floege J; Groene HJ; Kurts C. 2008. Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis. J Am Soc Nephrol 19(3):527-37. PubMed: 18235094MGI: J:150170
- Schreiber HA; Loschko J; Karssemeijer RA; Escolano A; Meredith MM; Mucida D; Guermonprez P; Nussenzweig MC. 2013. Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium. J Exp Med 210(10):2025-39. PubMed: 24043764MGI: J:202370
- Schuld NJ; Hussong SA; Kapphahn RJ; Lehmann U; Roehrich H; Rageh AA; Heuss ND; Bratten W; Gregerson DS; Ferrington DA. 2015. Immunoproteasome deficiency protects in the retina after optic nerve crush. PLoS One 10(5):e0126768. PubMed: 25978061MGI: J:235317
- Scumpia PO; McAuliffe PF; O'Malley KA; Ungaro R; Uchida T; Matsumoto T; Remick DG; Clare-Salzler MJ; Moldawer LL; Efron PA. 2005. CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis. J Immunol 175(5):3282-6. PubMed: 16116220MGI: J:113232
- Shaw CA; Starnbach MN. 2006. Stimulation of CD8+ T cells following diphtheria toxin-mediated antigen delivery into dendritic cells. Infect Immun 74(2):1001-8. PubMed: 16428746MGI: J:105010
- Shi Y; Wu W; Chai Q; Li Q; Hou Y; Xia H; Ren B; Xu H; Guo X; Jin C; Lv M; Wang Z; Fu YX; Zhu M. 2016. LTbetaR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration. Nat Commun 7:12369. PubMed: 27493002MGI: J:241268
- Shimizu K; Asakura M; Shinga J; Sato Y; Kitahara S; Hoshino K; Kaisho T; Schoenberger SP; Ezaki T; Fujii S. 2013. Invariant NKT cells induce plasmacytoid dendritic cell (DC) cross-talk with conventional DCs for efficient memory CD8+ T cell induction. J Immunol 190(11):5609-19. PubMed: 23630347MGI: J:204779
- Sivaganesh S; Harper SJ; Conlon TM; Callaghan CJ; Saeb-Parsy K; Negus MC; Motallebzadeh R; Bolton EM; Bradley JA; Pettigrew GJ. 2013. Copresentation of intact and processed MHC alloantigen by recipient dendritic cells enables delivery of linked help to alloreactive CD8 T cells by indirect-pathway CD4 T cells. J Immunol 190(11):5829-38. PubMed: 23630361MGI: J:204770
- Sivakumaran S; Henderson S; Ward S; Sousa PS; Manzo T; Zhang L; Conlan T; Means TK; D'Aveni M; Hermine O; Rubio MT; Chakraverty R; Bennett CL. 2016. Depletion of CD11c(+) cells in the CD11c.DTR model drives expansion of unique CD64(+) Ly6C(+) monocytes that are poised to release TNF-alpha. Eur J Immunol 46(1):192-203. PubMed: 26464217MGI: J:233857
- Snelgrove SL; Kausman JY; Lo C; Lo C; Ooi JD; Coates PT; Hickey MJ; Holdsworth SR; Kurts C; Engel DR; Kitching AR. 2012. Renal dendritic cells adopt a pro-inflammatory phenotype in obstructive uropathy to activate T cells but do not directly contribute to fibrosis. Am J Pathol 180(1):91-103. PubMed: 22079432MGI: J:180211
- Soderquest K; Powell N; Luci C; van Rooijen N; Hidalgo A; Geissmann F; Walzer T; Lord GM; Martin-Fontecha A. 2011. Monocytes control natural killer cell differentiation to effector phenotypes. Blood 117(17):4511-8. PubMed: 21389319MGI: J:172809
- Soudja SM; Ruiz AL; Marie JC; Lauvau G. 2012. Inflammatory Monocytes Activate Memory CD8(+) T and Innate NK Lymphocytes Independent of Cognate Antigen during Microbial Pathogen Invasion. Immunity 37(3):549-62. PubMed: 22940097MGI: J:187687
- Steel CD; Hahto SM; Ciavarra RP. 2009. Peripheral dendritic cells are essential for both the innate and adaptive antiviral immune responses in the central nervous system. Virology 387(1):117-26. PubMed: 19264338MGI: J:157148
- Tadagavadi RK; Reeves WB. 2010. Endogenous IL-10 attenuates cisplatin nephrotoxicity: role of dendritic cells. J Immunol 185(8):4904-11. PubMed: 20844196MGI: J:219402
- Tadagavadi RK; Reeves WB. 2010. Renal dendritic cells ameliorate nephrotoxic acute kidney injury. J Am Soc Nephrol 21(1):53-63. PubMed: 19875815MGI: J:185867
- Tait ED; Jordan KA; Dupont CD; Harris TH; Gregg B; Wilson EH; Pepper M; Dzierszinski F; Roos DS; Hunter CA. 2010. Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cells. J Immunol 185(3):1502-12. PubMed: 20592284MGI: J:162456
- Tang H; Cao W; Kasturi SP; Ravindran R; Nakaya HI; Kundu K; Murthy N; Kepler TB; Malissen B; Pulendran B. 2010. The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling. Nat Immunol 11(7):608-17. PubMed: 20495560MGI: J:161857
- Tatum AM; Watson AM; Schell TD. 2010. Direct presentation regulates the magnitude of the CD8(+) T cell response to cell-associated antigen through prolonged T cell proliferation. J Immunol 185(5):2763-72. PubMed: 20660711MGI: J:163267
- Terme M; Mignot G; Ullrich E; Bonmort M; Minard-Colin V; Jacquet A; Schultze JL; Kroemer G; Leclerc C; Chaput N; Zitvogel L. 2009. The dendritic cell-like functions of IFN-producing killer dendritic cells reside in the CD11b+ subset and are licensed by tumor cells. Cancer Res 69(16):6590-7. PubMed: 19679551MGI: J:151930
- Thanabalasuriar A; Neupane AS; Wang J; Krummel MF; Kubes P. 2016. iNKT Cell Emigration out of the Lung Vasculature Requires Neutrophils and Monocyte-Derived Dendritic Cells in Inflammation. Cell Rep 16(12):3260-72. PubMed: 27653688MGI: J:239120
- Tian T; Woodworth J; Skold M; Behar SM. 2005. In vivo depletion of CD11c+ cells delays the CD4+ T cell response to Mycobacterium tuberculosis and exacerbates the outcome of infection. J Immunol 175(5):3268-72. PubMed: 16116218MGI: J:113231
- Tittel AP; Heuser C; Ohliger C; Llanto C; Yona S; Hammerling GJ; Engel DR; Garbi N; Kurts C. 2012. Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice. Nat Methods 9(4):385-90. PubMed: 22367054MGI: J:194800
- Tonti E; Jimenez de Oya N; Galliverti G; Moseman EA; Di Lucia P; Amabile A; Sammicheli S; De Giovanni M; Sironi L; Chevrier N; Sitia G; Gennari L; Guidotti LG; von Andrian UH; Iannacone M. 2013. Bisphosphonates target B cells to enhance humoral immune responses. Cell Rep 5(2):323-30. PubMed: 24120862MGI: J:203773
- Tortola L; Rosenwald E; Abel B; Blumberg H; Schafer M; Coyle AJ; Renauld JC; Werner S; Kisielow J; Kopf M. 2012. Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk. J Clin Invest 122(11):3965-76. PubMed: 23064362MGI: J:193548
- Tzeng TC; Chyou S; Tian S; Webster B; Carpenter AC; Guaiquil VH; Lu TT. 2010. CD11chi dendritic cells regulate the re-establishment of vascular quiescence and stabilization after immune stimulation of lymph nodes. J Immunol 184(8):4247-57. PubMed: 20231692MGI: J:159876
- Unkel B; Hoegner K; Clausen BE; Lewe-Schlosser P; Bodner J; Gattenloehner S; Janssen H; Seeger W; Lohmeyer J; Herold S. 2012. Alveolar epithelial cells orchestrate DC function in murine viral pneumonia. J Clin Invest 122(10):3652-64. PubMed: 22996662MGI: J:191753
- Vallon-Eberhard A; Landsman L; Yogev N; Verrier B; Jung S. 2006. Transepithelial pathogen uptake into the small intestinal lamina propria. J Immunol 176(4):2465-9. PubMed: 16456006MGI: J:106225
- Van Maele L; Carnoy C; Cayet D; Songhet P; Dumoutier L; Ferrero I; Janot L; Erard F; Bertout J; Leger H; Sebbane F; Benecke A; Renauld JC; Hardt WD; Ryffel B; Sirard JC. 2010. TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa. J Immunol 185(2):1177-85. PubMed: 20566828MGI: J:162022
- Varol C; Landsman L; Fogg DK; Greenshtein L; Gildor B; Margalit R; Kalchenko V; Geissmann F; Jung S. 2007. Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J Exp Med 204(1):171-80. PubMed: 17190836MGI: J:125312
- Varol C; Vallon-Eberhard A; Elinav E; Aychek T; Shapira Y; Luche H; Fehling HJ; Hardt WD; Shakhar G; Jung S. 2009. Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity 31(3):502-12. PubMed: 19733097MGI: J:152689
- Veiga-Fernandes H; Coles MC; Foster KE; Patel A; Williams A; Natarajan D; Barlow A; Pachnis V; Kioussis D. 2007. Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis. Nature 446(7135):547-51. PubMed: 17322904MGI: J:120816
- Venet F; Chung CS; Huang X; Lomas-Neira J; Chen Y; Ayala A. 2009. Lymphocytes in the development of lung inflammation: a role for regulatory CD4+ T cells in indirect pulmonary lung injury. J Immunol 183(5):3472-80. PubMed: 19641139MGI: J:151875
- Venet F; Huang X; Chung CS; Chen Y; Ayala A. 2010. Plasmacytoid dendritic cells control lung inflammation and monocyte recruitment in indirect acute lung injury in mice. Am J Pathol 176(2):764-73. PubMed: 20042672MGI: J:156596
- Verschoor A; Neuenhahn M; Navarini AA; Graef P; Plaumann A; Seidlmeier A; Nieswandt B; Massberg S; Zinkernagel RM; Hengartner H; Busch DH. 2011. A platelet-mediated system for shuttling blood-borne bacteria to CD8alpha+ dendritic cells depends on glycoprotein GPIb and complement C3. Nat Immunol 12(12):1194-201. PubMed: 22037602MGI: J:179014
- Villablanca EJ; Raccosta L; Zhou D; Fontana R; Maggioni D; Negro A; Sanvito F; Ponzoni M; Valentinis B; Bregni M; Prinetti A; Steffensen KR; Sonnino S; Gustafsson JA; Doglioni C; Bordignon C; Traversari C; Russo V. 2010. Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses. Nat Med 16(1):98-105. PubMed: 20037595MGI: J:155862
- Wakkach A; Mansour A; Dacquin R; Coste E; Jurdic P; Carle GF; Blin-Wakkach C. 2008. Bone marrow microenvironment controls the in vivo differentiation of murine dendritic cells into osteoclasts. Blood 112(13):5074-83. PubMed: 18768394MGI: J:143799
- Wallet MA; Sen P; Flores RR; Wang Y; Yi Z; Huang Y; Mathews CE; Earp HS; Matsushima G; Wang B; Tisch R. 2008. MerTK is required for apoptotic cell-induced T cell tolerance. J Exp Med 205(1):219-32. PubMed: 18195070MGI: J:131291
- Walsh MP; Duncan B; Larabee S; Krauss A; Davis JP; Cui Y; Kim SY; Guimond M; Bachovchin W; Fry TJ. 2013. Val-boroPro accelerates T cell priming via modulation of dendritic cell trafficking resulting in complete regression of established murine tumors. PLoS One 8(3):e58860. PubMed: 23554941MGI: J:200168
- Wang H; Wu X; Wang Y; Oldenborg PA; Yang YG. 2010. CD47 is required for suppression of allograft rejection by donor-specific transfusion. J Immunol 184(7):3401-7. PubMed: 20208011MGI: J:160062
- Wathne GJ; Kissenpfennig A; Malissen B; Zurzolo C; Mabbott NA. 2012. Determining the role of mononuclear phagocytes in prion neuroinvasion from the skin. J Leukoc Biol 91(5):817-28. PubMed: 22389312MGI: J:183759
- Willart MA; Jan de Heer H; Hammad H; Soullie T; Deswarte K; Clausen BE; Boon L; Hoogsteden HC; Lambrecht BN. 2009. The lung vascular filter as a site of immune induction for T cell responses to large embolic antigen. J Exp Med 206(12):2823-35. PubMed: 19858325MGI: J:154860
- Winter S; Rehm A; Wichner K; Scheel T; Batra A; Siegmund B; Berek C; Lipp M; Hopken UE. 2011. Manifestation of Spontaneous and Early Autoimmune Gastritis in CCR7-Deficient Mice. Am J Pathol 179(2):754-65. PubMed: 21801869MGI: J:174601
- Wu HJ; Sawaya H; Binstadt B; Brickelmaier M; Blasius A; Gorelik L; Mahmood U; Weissleder R; Carulli J; Benoist C; Mathis D. 2007. Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk. J Exp Med 204(8):1911-22. PubMed: 17646407MGI: J:125952
- Yamada DH; Elsaesser H; Lux A; Timmerman JM; Morrison SL; de la Torre JC; Nimmerjahn F; Brooks DG. 2015. Suppression of Fcgamma-receptor-mediated antibody effector function during persistent viral infection. Immunity 42(2):379-90. PubMed: 25680277MGI: J:223826
- Yang CY; Vogt TK; Favre S; Scarpellino L; Huang HY; Tacchini-Cottier F; Luther SA. 2014. Trapping of naive lymphocytes triggers rapid growth and remodeling of the fibroblast network in reactive murine lymph nodes. Proc Natl Acad Sci U S A 111(1):E109-18. PubMed: 24367096MGI: J:206381
- Yang X; Zhang X; Fu ML; Weichselbaum RR; Gajewski TF; Guo Y; Fu YX. 2014. Targeting the tumor microenvironment with interferon-beta bridges innate and adaptive immune responses. Cancer Cell 25(1):37-48. PubMed: 24434209MGI: J:208155
- Yao S; Wang S; Zhu Y; Luo L; Zhu G; Flies S; Xu H; Ruff W; Broadwater M; Choi IH; Tamada K; Chen L. 2009. PD-1 on dendritic cells impedes innate immunity against bacterial infection. Blood 113(23):5811-8. PubMed: 19339692MGI: J:149357
- Yates JL; Racine R; McBride KM; Winslow GM. 2013. T cell-dependent IgM memory B cells generated during bacterial infection are required for IgG responses to antigen challenge. J Immunol 191(3):1240-9. PubMed: 23804710MGI: J:205726
- Yu X; Guo C; Yi H; Qian J; Fisher PB; Subjeck JR; Wang XY. 2013. A multifunctional chimeric chaperone serves as a novel immune modulator inducing therapeutic antitumor immunity. Cancer Res 73(7):2093-103. PubMed: 23333935MGI: J:196898
- Zaft T; Sapoznikov A; Krauthgamer R; Littman DR; Jung S. 2005. CD11chigh dendritic cell ablation impairs lymphopenia-driven proliferation of naive and memory CD8+ T cells. J Immunol 175(10):6428-35. PubMed: 16272295MGI: J:106224
- Zammit DJ; Cauley LS; Pham QM; Lefrancois L. 2005. Dendritic cells maximize the memory CD8 T cell response to infection. Immunity 22(5):561-70. PubMed: 15894274MGI: J:106222
- Zanoni I; Ostuni R; Barresi S; Di Gioia M; Broggi A; Costa B; Marzi R; Granucci F. 2012. CD14 and NFAT mediate lipopolysaccharide-induced skin edema formation in mice. J Clin Invest 122(5):1747-57. PubMed: 22466648MGI: J:184542
- Zhang L; Bridle BW; Chen L; Pol J; Spaner D; Boudreau JE; Rosen A; Bassett JD; Lichty BD; Bramson JL; Wan Y. 2013. Delivery of viral-vectored vaccines by B cells represents a novel strategy to accelerate CD8(+) T-cell recall responses. Blood 121(13):2432-9. PubMed: 23325836MGI: J:195882
- Zigmond E; Varol C; Farache J; Elmaliah E; Satpathy AT; Friedlander G; Mack M; Shpigel N; Boneca IG; Murphy KM; Shakhar G; Halpern Z; Jung S. 2012. Ly6C(hi) Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells. Immunity 37(6):1076-90. PubMed: 23219392MGI: J:191054
- de Goer de Herve MG; Dembele B; Vallee M; Herr F; Cariou A; Taoufik Y. 2010. Direct CD4 help provision following interaction of memory CD4 and CD8 T cells with distinct antigen-presenting dendritic cells. J Immunol 185(2):1028-36. PubMed: 20562265MGI: J:162023
- de Jong JM; Schuurhuis DH; Ioan-Facsinay A; Welling MM; Camps MG; van der Voort EI; Huizinga TW; Ossendorp F; Verbeek JS; Toes RE. 2006. Dendritic cells, but not macrophages or B cells, activate major histocompatibility complex class II-restricted CD4+ T cells upon immune-complex uptake in vivo. Immunology 119(4):499-506. PubMed: 16995881MGI: J:118521
- de Vries VC; Pino-Lagos K; Nowak EC; Bennett KA; Oliva C; Noelle RJ. 2011. Mast cells condition dendritic cells to mediate allograft tolerance. Immunity 35(4):550-61. PubMed: 22035846MGI: J:177851
- del Fresno C; Soulat D; Roth S; Blazek K; Udalova I; Sancho D; Ruland J; Ardavin C. 2013. Interferon-beta production via Dectin-1-Syk-IRF5 signaling in dendritic cells is crucial for immunity to C. albicans. Immunity 38(6):1176-86. PubMed: 23770228MGI: J:207582
- van Blijswijk J; Schraml BU; Rogers NC; Whitney PG; Zelenay S; Acton SE; Reis e Sousa C. 2015. Altered lymph node composition in diphtheria toxin receptor-based mouse models to ablate dendritic cells. J Immunol 194(1):307-15. PubMed: 25411201MGI: J:230701
- van Rijt LS; Jung S; Kleinjan A; Vos N; Willart M; Duez C; Hoogsteden HC; Lambrecht BN. 2005. In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J Exp Med 201(6):981-91. PubMed: 15781587MGI: J:106221