CAST/EiJ-Slc45a2^uw-6J/GrsrJ

Stock number: 008544
Research areas: Dermatology Research, Mouse/Human Gene Homologs

Description

This strain has been discontinued, please refer to Stock No. 019145

The underwhite 6 Jackson mutation is a model of type IV oculocutaneous albinism that causes a dirty white coat color on this otherwise agouti background along with hypopigmentation of the skin and eyes.

Detailed description

Mice homozygous for the underwhite 6 Jackson mutation have a dirty white colored coat whereas their heterozygous siblings are normal agouti colored. Homozygotes can be identified as pups by their light colored skin compared with heterozygous littermates. The eyes are red, but darken with age.

Development

The underwhite 6 Jackson mutation arose spontaneously in 2007 in the CAST/EiJ inbred strain at The Jackson Laboratory. This mutant subline has been maintained by sibling intercrossing ever since.

Allele

Symbol: Slc45a2^uw-6J
Name: underwhite 6 Jackson
MGI accession ID: MGI:5448550
Generation method: Spontaneous
Marker symbol: Slc45a2
Marker name: solute carrier family 45, member 2
Chromosome: 15
Strain of origin: CAST/EiJ
Molecular note: This spontaneous mutation was proven allelic with underwhite 7 Jackson by failed complementation test. The molecular lesion is an intragenic deletion that spans exons 4-7.