Overview

This strain has been discontinued, please refer to Stock No. 019145

The underwhite 6 Jackson mutation is a model of type IV oculocutaneous albinism that causes a dirty white coat color on this otherwise agouti background along with hypopigmentation of the skin and eyes.

Genetic overview

Genetic Background	Generation

Slc45a2^uw-6J

Allele Type	Gene Symbol	Gene Name
Spontaneous	Slc45a2	solute carrier family 45, member 2

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Research Applications

Mouse/Human Gene Homologs
Dermatology Research

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Details

Detailed Description

Mice homozygous for the underwhite 6 Jackson mutation have a dirty white colored coat whereas their heterozygous siblings are normal agouti colored. Homozygotes can be identified as pups by their light colored skin compared with heterozygous littermates. The eyes are red, but darken with age.

Development

The underwhite 6 Jackson mutation arose spontaneously in 2007 in the CAST/EiJ inbred strain at The Jackson Laboratory. This mutant subline has been maintained by sibling intercrossing ever since.

Control Suggestions

Heterozygote

Additional Information

Considerations for Choosing Controls

Selected References

Karst SY; Berry ML; Bergstrom DE; Donahue LR. 2013. Underwhite 6 Jackson, a new spontaneous mouse mutation in Slc45a2 MGI Direct Data SubmissionMGI: J:190732

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Genetics

Slc45a2^uw-6J

Allele Symbol: Slc45a2^uw-6J

Allele Name	underwhite 6 Jackson
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	Slc45a2, solute carrier family 45, member 2
Gene Synonym(s)
Strain of Origin	CAST/EiJ
Chromosome	15
Molecular Note	This spontaneous mutation was proven allelic with underwhite 7 Jackson by failed complementation test. The molecular lesion is an intragenic deletion that spans exons 4-7.

Disease/Phenotype

Disease Terms

Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.

oculocutaneous albinism

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Slc45a2^uw-6J related

Mouse/Human Gene Homologs
- albinism, oculocutaneous, type IV, OCA4
Dermatology Research
- Color and White Spotting Defects

Mammalian Phenotype Terms by Genotype

The following phenotype relates to a compound genotype created using this strain

Genotype: Slc45a2^uw-6J/Slc45a2^uw-6J
CAST/EiJ-Slc45a2/GrsrJ

integument phenotype

decreased skin pigmentation
- newborn homozygotes can be distinguished from heterozygous littermtaes by their lighter skin color

diluted coat color
- on an agouti background the coat color is dirty white

pigmentation phenotype

decreased eye pigmentation
- homozygotes have red eyes when young, but the eye color darkens with age

decreased skin pigmentation
- newborn homozygotes can be distinguished from heterozygous littermtaes by their lighter skin color

diluted coat color
- on an agouti background the coat color is dirty white

vision/eye phenotype

decreased eye pigmentation
- homozygotes have red eyes when young, but the eye color darkens with age

References

Karst SY; Berry ML; Bergstrom DE; Donahue LR. 2013. Underwhite 6 Jackson, a new spontaneous mouse mutation in Slc45a2 MGI Direct Data SubmissionMGI: J:190732

Additional - Slc45a2^uw-6J related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Mating System
- Homozygote x Heterozygote
- Heterozygote x Homozygote
Appearance
- dirty white coat color
  Related Genotype: A/A Slc45a2^uw-6J/Slc45a2^uw-6J
  
  agouti
  Related Genotype: A/A Slc45a2^uw-6J/Slc45a2⁺

Terms Of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

Genetic overview

Research Applications

Detailed Description

Development

Control Suggestions

Additional Information

Selected References

Slc45a2uw-6J

Allele Symbol: Slc45a2uw-6J

Disease Terms

Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Slc45a2uw-6J related

Mammalian Phenotype Terms by Genotype

Genotype: Slc45a2uw-6J/Slc45a2uw-6JCAST/EiJ-Slc45a2/GrsrJ

integument phenotype

pigmentation phenotype

vision/eye phenotype

References

Additional - Slc45a2uw-6J related

Genotyping Protocols

Mating System

Appearance

Terms Of Use

Licensing Information

Slc45a2^uw-6J

Allele Symbol: Slc45a2^uw-6J

Genotype: Slc45a2^uw-6J related

Genotype: Slc45a2^uw-6J/Slc45a2^uw-6J
CAST/EiJ-Slc45a2/GrsrJ

Additional - Slc45a2^uw-6J related