Mice homozygous for the underwhite 6 Jackson mutation have a dirty white colored coat whereas their heterozygous siblings are normal agouti colored. Homozygotes can be identified as pups by their light colored skin compared with heterozygous littermates. The eyes are red, but darken with age.
The underwhite 6 Jackson mutation arose spontaneously in 2007 in the CAST/EiJ inbred strain at The Jackson Laboratory. This mutant subline has been maintained by sibling intercrossing ever since.
|Allele Name||underwhite 6 Jackson|
|Gene Symbol and Name||Slc45a2, solute carrier family 45, member 2|
|Strain of Origin||CAST/EiJ|
|Molecular Note||This spontaneous mutation was proven allelic with underwhite 7 Jackson by failed complementation test. The molecular lesion is an intragenic deletion that spans exons 4-7.|