JAX
Mouse Strain Datasheet - 008523
129S6.Cg-Tg(NPHS2-cre)295Lbh/BroJ
Also Known As: 129S6-podocin-cre
These 129S6 Podocin-Cre mice (harboring the p2.5P-Cre transgene) have expression of Cre recombinase directed to podocytes within kidney glomeruli by the human podocin (NPHS2) promoter/enhancer region and may be useful in generating Cre-lox conditional knockouts for studying the role of podocyte nephrobiology in renal disorders.
Donating Investigator
Frank Brosius, University of Michigan Medical School De
Genetic overview
| Genetic Background | Generation |
|---|---|
|
129S6/Tac |
|
Tg(NPHS2-cre)295Lbh
| Allele Type |
|---|
| Transgenic (Recombinase-expressing) |
Detailed Description
Mice harboring the p2.5P-Cre transgene are viable and fertile, with expression of Cre recombinase directed to podocytes within kidney glomeruli by the human podocin (NPHS2) promoter/enhancer region. Cre-recombinase activity is reported in podocytes during late capillary loop stage of glomerular development and persists in podocytes of mature glomeruli, with no evidence for cre expression detected in other tissues examined. Embryonic Cre-recombinase activity is also reported as early as 8.5 dpc. When bred with mice containing a loxP-flanked sequence, Cre-mediated recombination will result in deletion of the sequence. These 2.5P-Cre transgenic mice may be useful in generating conditional knockouts for studying the role of podocyte nephrobiology in renal disorders.
Development
The p2.5P-Cre transgene was designed with a 2.5 kb fragment of the human podocin (or NPHS2) promoter/enhancer region upstream of a Cre recombinase cassette followed by a murine protamine poly-adenylation signal. Reports indicate that the transgene was microinjected into (C57BL/6 X SJL)F2 mouse eggs. Mice from founder line 295 were found to have podocyte-specific cre activity, were backcrossed to C57BL/6J (Stock No. 008205) prior to backcross to 129S6/SvEvTac for 7 generations. The T1DR received the 129S6-2.5P-Cre transgenic at generation N5 and used speed congenic technology to complete the 129S6 congenic backcross. SNP data indicates that no C57BL/6 or SJL contaminating genome outside of the congenic region and the data indicate that the transgene inserted into chromosome 4.
Expression Data
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
|---|---|
| Site of Expression | cre recombinase expression in podocytes within kidney glomeruli. |
Control Suggestions
Selected References
- Moeller MJ; Sanden SK; Soofi A; Wiggins RC; Holzman LB. 2003. Podocyte-specific expression of cre recombinase in transgenic mice. Genesis 35(1):39-42. PubMed: 12481297MGI: J:81633
Tg(NPHS2-cre)295Lbh
Allele Symbol: Tg(NPHS2-cre)295Lbh
| Allele Name | transgene insertion 295, Lawrence B Holzman |
|---|---|
| Allele Type | Transgenic (Recombinase-expressing) |
| Allele Synonym(s) | 2.5P-Cre; NPHS2.Cre; PodoCre; Tg(NPHS2-cre)1Lbh; pod-Cre; podocin-Cre |
| Gene Symbol and Name | Tg(NPHS2-cre)295Lbh, transgene insertion 295, Lawrence B Holzman |
| Gene Synonym(s) | 2.5P-Cre; Tg(NPHS2-cre)1Lbh; Tg(NPHS2-cre)1Lbh; pod-Cre; podocin-Cre; transgene insertion 1, Lawrence B Holzman |
| Promoter | NPHS2, NPHS2, podocin, human |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | cre recombinase expression in podocytes within kidney glomeruli. |
| Strain of Origin | (C57BL/6 x SJL)F2 |
| Chromosome | UN |
| General Note | 24 transgenic founders were created. Phenotypic analysis was performed on founder line #295. |
| Molecular Note | The human NPHS2 promoter, including the entire 5' untranslated region, was used to drive cre recombinase expression in podocytes. |
| Mutations Made By | Lawrence Holzman, University of Pennsylvania |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Cardiovascular Research
- Cre-lox System
- Cre-lox System
- Cre Recombinase Expression
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
- Tissue/Cell Markers
- Tissue/Cell Markers: Cre-lox System
- Tissue/Cell Markers: kidney specific marker
- Cardiovascular Research
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
References
- Moeller MJ; Sanden SK; Soofi A; Wiggins RC; Holzman LB. 2003. Podocyte-specific expression of cre recombinase in transgenic mice. Genesis 35(1):39-42. PubMed: 12481297MGI: J:81633
Additional - Tg(NPHS2-cre)295Lbh related
- Arora S; Husain M; Kumar D; Patni H; Pathak S; Mehrotra D; Reddy VK; Reddy LR; Salhan D; Yadav A; Mathieson PW; Saleem MA; Chander PN; Singhal PC. 2009. Human immunodeficiency virus downregulates podocyte apoE expression. Am J Physiol Renal Physiol 297(3):F653-61. PubMed: 19553347MGI: J:152103
- Blattner SM; Hodgin JB; Nishio M; Wylie SA; Saha J; Soofi AA; Vining C; Randolph A; Herbach N; Wanke R; Atkins KB; Gyung Kang H; Henger A; Brakebusch C; Holzman LB; Kretzler M. 2013. Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury. Kidney Int 84(5):920-30. PubMed: 23677246MGI: J:208738
- Bollee G; Flamant M; Schordan S; Fligny C; Rumpel E; Milon M; Schordan E; Sabaa N; Vandermeersch S; Galaup A; Rodenas A; Casal I; Sunnarborg SW; Salant DJ; Kopp JB; Threadgill DW; Quaggin SE; Dussaule JC; Germain S; Mesnard L; Endlich K; Boucheix C; Belenfant X; Callard P; Endlich N; Tharaux PL. 2011. Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nat Med 17(10):1242-50. PubMed: 21946538MGI: J:177277
- Boucher I; Yu W; Beaudry S; Negoro H; Tran M; Pollak MR; Henderson JM; Denker BM. 2012. Galpha12 activation in podocytes leads to cumulative changes in glomerular collagen expression, proteinuria and glomerulosclerosis. Lab Invest 92(5):662-75. PubMed: 22249312MGI: J:183428
- Brahler S; Ising C; Hagmann H; Rasmus M; Hoehne M; Kurschat C; Kisner T; Goebel H; Shankland S; Addicks K; Thaiss F; Schermer B; Pasparakis M; Benzing T; Brinkkoetter PT. 2012. Intrinsic proinflammatory signaling in podocytes contributes to podocyte damage and prolonged proteinuria. Am J Physiol Renal Physiol 303(10):F1473-85. PubMed: 22975019MGI: J:190128
- Brukamp K; Jim B; Moeller MJ; Haase VH. 2007. Hypoxia and podocyte-specific Vhlh deletion confer risk of glomerular disease. Am J Physiol Renal Physiol 293(4):F1397-407. PubMed: 17609290MGI: J:143007
- Canaud G; Bienaime F; Viau A; Treins C; Baron W; Nguyen C; Burtin M; Berissi S; Giannakakis K; Muda AO; Zschiedrich S; Huber TB; Friedlander G; Legendre C; Pontoglio M; Pende M; Terzi F. 2013. AKT2 is essential to maintain podocyte viability and function during chronic kidney disease. Nat Med 19(10):1288-96. PubMed: 24056770MGI: J:202319
- Chan TD; Wood K; Hermes JR; Butt D; Jolly CJ; Basten A; Brink R. 2012. Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen. Immunity 37(5):893-904. PubMed: 23142780MGI: J:190871
- Chase SE; Encina CV; Stolzenburg LR; Tatum AH; Holzman LB; Krendel M. 2012. Podocyte-specific knockout of myosin 1e disrupts glomerular filtration. Am J Physiol Renal Physiol 303(7):F1099-106. PubMed: 22811491MGI: J:188500
- Chen S; Wassenhove-McCarthy D; Yamaguchi Y; Holzman L; van Kuppevelt TH; Orr AW; Funk S; Woods A; McCarthy K. 2010. Podocytes require the engagement of cell surface heparan sulfate proteoglycans for adhesion to extracellular matrices. Kidney Int 78(11):1088-99. PubMed: 20463653MGI: J:184264
- Chen S; Wassenhove-McCarthy DJ; Yamaguchi Y; Holzman LB; van Kuppevelt TH; Jenniskens GJ; Wijnhoven TJ; Woods AC; McCarthy KJ. 2008. Loss of heparan sulfate glycosaminoglycan assembly in podocytes does not lead to proteinuria. Kidney Int 74(3):289-99. PubMed: 18480751MGI: J:152871
- Chuang PY; Xu J; Dai Y; Jia F; Mallipattu SK; Yacoub R; Gu L; Premsrirut PK; He JC. 2014. In vivo RNA interference models of inducible and reversible Sirt1 knockdown in kidney cells. Am J Pathol 184(7):1940-56. PubMed: 24952428MGI: J:213867
- Dai C; Saleem MA; Holzman LB; Mathieson P; Liu Y. 2010. Hepatocyte growth factor signaling ameliorates podocyte injury and proteinuria. Kidney Int 77(11):962-73. PubMed: 20375988MGI: J:184271
- Dai C; Stolz DB; Bastacky SI; St-Arnaud R; Wu C; Dedhar S; Liu Y. 2006. Essential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signaling. J Am Soc Nephrol 17(8):2164-75. PubMed: 16837631MGI: J:129286
- Dai C; Stolz DB; Kiss LP; Monga SP; Holzman LB; Liu Y. 2009. Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria. J Am Soc Nephrol 20(9):1997-2008. PubMed: 19628668MGI: J:166330
- El-Aouni C; Herbach N; Blattner SM; Henger A; Rastaldi MP; Jarad G; Miner JH; Moeller MJ; St-Arnaud R; Dedhar S; Holzman LB; Wanke R; Kretzler M. 2006. Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis. J Am Soc Nephrol 17(5):1334-44. PubMed: 16611717MGI: J:129244
- Faria D; Rock JR; Romao AM; Schweda F; Bandulik S; Witzgall R; Schlatter E; Heitzmann D; Pavenstadt H; Herrmann E; Kunzelmann K; Schreiber R. 2014. The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function. Kidney Int 85(6):1369-81. PubMed: 24476694MGI: J:210158
- Garg P; Verma R; Cook L; Soofi A; Venkatareddy M; George B; Mizuno K; Gurniak C; Witke W; Holzman LB. 2010. Actin-depolymerizing factor cofilin-1 is necessary in maintaining mature podocyte architecture. J Biol Chem 285(29):22676-88. PubMed: 20472933MGI: J:165315
- Gee HY; Sadowski CE; Aggarwal PK; Porath JD; Yakulov TA; Schueler M; Lovric S; Ashraf S; Braun DA; Halbritter J; Fang H; Airik R; Vega-Warner V; Cho KJ; Chan TA; Morris LG; ffrench-Constant C; Allen N; McNeill H; Buscher R; Kyrieleis H; Wallot M; Gaspert A; Kistler T; Milford DV; Saleem MA; Keng WT; Alexander SI; Valentini RP; Licht C; Teh JC; Bogdanovic R; Koziell A; Bierzynska A; Soliman NA; Otto EA; Lifton RP; Holzman LB; Sibinga NE; Walz G; Tufro A; Hildebrandt F. 2016. FAT1 mutations cause a glomerulotubular nephropathy. Nat Commun 7:10822. PubMed: 26905694MGI: J:234732
- Genetic Resource Science at The Jackson Laboratory. 2013. Expression/Specificity Patterns of Cre Alleles, 2013 Direct Data Submission from Genetic Resource Science :. MGI: J:193672
- George B; Verma R; Soofi AA; Garg P; Zhang J; Park TJ; Giardino L; Ryzhova L; Johnstone DB; Wong H; Nihalani D; Salant DJ; Hanks SK; Curran T; Rastaldi MP; Holzman LB. 2012. Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease. J Clin Invest 122(2):674-92. PubMed: 22251701MGI: J:184498
- Godel M; Hartleben B; Herbach N; Liu S; Zschiedrich S; Lu S; Debreczeni-Mor A; Lindenmeyer MT; Rastaldi MP; Hartleben G; Wiech T; Fornoni A; Nelson RG; Kretzler M; Wanke R; Pavenstadt H; Kerjaschki D; Cohen CD; Hall MN; Ruegg MA; Inoki K; Walz G; Huber TB. 2011. Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. J Clin Invest 121(6):2197-209. PubMed: 21606591MGI: J:174021
- Goldberg S; Adair-Kirk TL; Senior RM; Miner JH. 2010. Maintenance of glomerular filtration barrier integrity requires laminin alpha5. J Am Soc Nephrol 21(4):579-86. PubMed: 20150535MGI: J:185850
- Guo JK; Marlier A; Shi H; Shan A; Ardito TA; Du ZP; Kashgarian M; Krause DS; Biemesderfer D; Cantley LG. 2012. Increased tubular proliferation as an adaptive response to glomerular albuminuria. J Am Soc Nephrol 23(3):429-37. PubMed: 22193389MGI: J:231134
- Guo JK; Shi H; Koraishy F; Marlier A; Ding Z; Shan A; Cantley LG. 2013. The Terminator mouse is a diphtheria toxin-receptor knock-in mouse strain for rapid and efficient enrichment of desired cell lineages. Kidney Int 84(5):1041-6. PubMed: 23739236MGI: J:235558
- Guzman J; Jauregui AN; Merscher-Gomez S; Maiguel D; Muresan C; Mitrofanova A; Diez-Sampedro A; Szust J; Yoo TH; Villarreal R; Pedigo C; Molano RD; Johnson K; Kahn B; Hartleben B; Huber TB; Saha J; Burke GW 3rd; Abel ED; Brosius FC; Fornoni A. 2014. Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy. Diabetes 63(2):701-14. PubMed: 24101677MGI: J:209030
- Hackl MJ; Burford JL; Villanueva K; Lam L; Susztak K; Schermer B; Benzing T; Peti-Peterdi J. 2013. Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags. Nat Med 19(12):1661-6. PubMed: 24270544MGI: J:206843
- Hartleben B; Godel M; Meyer-Schwesinger C; Liu S; Ulrich T; Kobler S; Wiech T; Grahammer F; Arnold SJ; Lindenmeyer MT; Cohen CD; Pavenstadt H; Kerjaschki D; Mizushima N; Shaw AS; Walz G; Huber TB. 2010. Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest 120(4):1084-96. PubMed: 20200449MGI: J:159695
- Hartleben B; Widmeier E; Wanner N; Schmidts M; Kim ST; Schneider L; Mayer B; Kerjaschki D; Miner JH; Walz G; Huber TB. 2012. Role of the polarity protein Scribble for podocyte differentiation and maintenance. PLoS One 7(5):e36705. PubMed: 22586490MGI: J:190169
- Harvey SJ; Jarad G; Cunningham J; Rops AL; van der Vlag J; Berden JH; Moeller MJ; Holzman LB; Burgess RW; Miner JH. 2007. Disruption of glomerular basement membrane charge through podocyte-specific mutation of agrin does not alter glomerular permselectivity. Am J Pathol 171(1):139-52. PubMed: 17591961MGI: J:122821
- Hathaway CK; Gasim AM; Grant R; Chang AS; Kim HS; Madden VJ; Bagnell CR Jr; Jennette JC; Smithies O; Kakoki M. 2015. Low TGFbeta1 expression prevents and high expression exacerbates diabetic nephropathy in mice. Proc Natl Acad Sci U S A 112(18):5815-20. PubMed: 25902541MGI: J:221419
- Hayashi K; Sasamura H; Nakamura M; Azegami T; Oguchi H; Sakamaki Y; Itoh H. 2014. KLF4-dependent epigenetic remodeling modulates podocyte phenotypes and attenuates proteinuria. J Clin Invest 124(6):2523-37. PubMed: 24812666MGI: J:212916
- Hohne M; Ising C; Hagmann H; Volker LA; Brahler S; Schermer B; Brinkkoetter PT; Benzing T. 2013. Light microscopic visualization of podocyte ultrastructure demonstrates oscillating glomerular contractions. Am J Pathol 182(2):332-8. PubMed: 23246153MGI: J:193169
- Huber TB; Hartleben B; Winkelmann K; Schneider L; Becker JU; Leitges M; Walz G; Haller H; Schiffer M. 2009. Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome. J Am Soc Nephrol 20(4):798-806. PubMed: 19279126MGI: J:164628
- Ishizaka M; Gohda T; Takagi M; Omote K; Sonoda Y; Oliva Trejo JA; Asao R; Hidaka T; Asanuma K; Horikoshi S; Tomino Y. 2015. Podocyte-specific deletion of Rac1 leads to aggravation of renal injury in STZ-induced diabetic mice. Biochem Biophys Res Commun 467(3):549-55. PubMed: 26435502MGI: J:233082
- Ising C; Bharill P; Brinkkoetter S; Brahler S; Schroeter C; Koehler S; Hagmann H; Merkwirth C; Hohne M; Muller RU; Fabretti F; Schermer B; Bloch W; Kerjaschki D; Kurschat CE; Benzing T; Brinkkoetter PT. 2016. Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier. Am J Pathol 186(5):1128-39. PubMed: 27105734MGI: J:232205
- Ising C; Koehler S; Brahler S; Merkwirth C; Hohne M; Baris OR; Hagmann H; Kann M; Fabretti F; Dafinger C; Bloch W; Schermer B; Linkermann A; Bruning JC; Kurschat CE; Muller RU; Wiesner RJ; Langer T; Benzing T; Brinkkoetter PT. 2015. Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure. EMBO Mol Med 7(3):275-87. PubMed: 25643582MGI: J:232673
- Jia Q; McDill BW; Sankarapandian B; Wu S; Liapis H; Holzman LB; Capecchi MR; Miner JH; Chen F. 2008. Ablation of developing podocytes disrupts cellular interactions and nephrogenesis both inside and outside the glomerulus. Am J Physiol Renal Physiol 295(6):F1790-8. PubMed: 18842818MGI: J:166011
- Johnstone DB; Ikizler O; Zhang J; Holzman LB. 2013. Background strain and the differential susceptibility of podocyte-specific deletion of Myh9 on murine models of experimental glomerulosclerosis and HIV nephropathy. PLoS One 8(7):e67839. PubMed: 23874454MGI: J:204412
- Johnstone DB; Zhang J; George B; Leon C; Gachet C; Wong H; Parekh R; Holzman LB. 2011. Podocyte-specific deletion of Myh9 encoding nonmuscle myosin heavy chain 2A predisposes mice to glomerulopathy. Mol Cell Biol 31(10):2162-70. PubMed: 21402784MGI: J:173971
- Kato H; Gruenwald A; Suh JH; Miner JH; Barisoni-Thomas L; Taketo MM; Faul C; Millar SE; Holzman LB; Susztak K. 2011. Wnt/beta-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival. J Biol Chem 286(29):26003-15. PubMed: 21613219MGI: J:175392
- Kaufman L; Potla U; Coleman S; Dikiy S; Hata Y; Kurihara H; He JC; D'Agati VD; Klotman PE. 2010. Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis. J Biol Chem 285(33):25677-85. PubMed: 20562105MGI: J:165990
- Lefevre GM; Patel SR; Kim D; Tessarollo L; Dressler GR. 2010. Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype. PLoS Genet 6(10):e1001142. PubMed: 21060806MGI: J:167530
- Liu R; Zhong Y; Li X; Chen H; Jim B; Zhou MM; Chuang PY; He JC. 2014. Role of transcription factor acetylation in diabetic kidney disease. Diabetes 63(7):2440-53. PubMed: 24608443MGI: J:229493
- Ma H; Togawa A; Soda K; Zhang J; Lee S; Ma M; Yu Z; Ardito T; Czyzyk J; Diggs L; Joly D; Hatakeyama S; Kawahara E; Holzman L; Guan JL; Ishibe S. 2010. Inhibition of podocyte FAK protects against proteinuria and foot process effacement. J Am Soc Nephrol 21(7):1145-56. PubMed: 20522532MGI: J:185929
- Madhusudhan T; Wang H; Dong W; Ghosh S; Bock F; Thangapandi VR; Ranjan S; Wolter J; Kohli S; Shahzad K; Heidel F; Krueger M; Schwenger V; Moeller MJ; Kalinski T; Reiser J; Chavakis T; Isermann B. 2015. Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy. Nat Commun 6:6496. PubMed: 25754093MGI: J:221890
- Mallipattu SK; Horne SJ; D'Agati V; Narla G; Liu R; Frohman MA; Dickman K; Chen EY; Ma'ayan A; Bialkowska AB; Ghaleb AM; Nandan MO; Jain MK; Daehn I; Chuang PY; Yang VW; He JC. 2015. Kruppel-like factor 6 regulates mitochondrial function in the kidney. J Clin Invest 125(3):1347-61. PubMed: 25689250MGI: J:220539
- Mao J; Zeng Z; Xu Z; Li J; Jiang L; Fang Y; Xu X; Hu Z; He W; Yang J; Dai C. 2014. Mammalian target of rapamycin complex 1 activation in podocytes promotes cellular crescent formation. Am J Physiol Renal Physiol 307(9):F1023-32. PubMed: 24990893MGI: J:215925
- Moeller MJ; Soofi A; Sanden S; Floege J; Kriz W; Holzman LB. 2005. An efficient system for tissue-specific overexpression of transgenes in podocytes in vivo. Am J Physiol Renal Physiol 289(2):F481-8. PubMed: 15784842MGI: J:134739
- Nagayama Y; Braun GS; Jakobs CM; Maruta Y; van Roeyen CR; Klinkhammer BM; Boor P; Villa L; Raffetseder U; Trautwein C; Gortz D; Muller-Newen G; Ostendorf T; Floege J. 2014. Gp130-dependent signaling in the podocyte. Am J Physiol Renal Physiol 307(3):F346-55. PubMed: 24899055MGI: J:212106
- Oliva Trejo JA; Asanuma K; Kim EH; Takagi-Akiba M; Nonaka K; Hidaka T; Komatsu M; Tada N; Ueno T; Tomino Y. 2014. Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy. Biochem Biophys Res Commun 446(4):1190-6. PubMed: 24680677MGI: J:219471
- Payne H; Ponomaryov T; Watson SP; Brill A. 2017. Mice with a deficiency in CLEC-2 are protected against deep vein thrombosis. Blood 129(14):2013-2020. PubMed: 28104688MGI: J:240959
- Pedigo CE; Ducasa GM; Leclercq F; Sloan A; Mitrofanova A; Hashmi T; Molina-David J; Ge M; Lassenius MI; Forsblom C; Lehto M; Groop PH; Kretzler M; Eddy S; Martini S; Reich H; Wahl P; Ghiggeri G; Faul C; Burke GW 3rd; Kretz O; Huber TB; Mendez AJ; Merscher S; Fornoni A. 2016. Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury. J Clin Invest 126(9):3336-50. PubMed: 27482889MGI: J:237253
- Peng M; Falk MJ; Haase VH; King R; Polyak E; Selak M; Yudkoff M; Hancock WW; Meade R; Saiki R; Lunceford AL; Clarke CF; L Gasser D. 2008. Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease. PLoS Genet 4(4):e1000061. PubMed: 18437205MGI: J:136670
- Pitera JE; Turmaine M; Woolf AS; Scambler PJ. 2012. Generation of mice with a conditional null fraser syndrome 1 (Fras1) allele. Genesis 50(12):892-8. PubMed: 22730198MGI: J:190659
- Potla U; Ni J; Vadaparampil J; Yang G; Leventhal JS; Campbell KN; Chuang PY; Morozov A; He JC; D'Agati VD; Klotman PE; Kaufman L. 2014. Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury. J Clin Invest 124(4):1757-69. PubMed: 24642466MGI: J:209591
- Pozzi A; Jarad G; Moeckel GW; Coffa S; Zhang X; Gewin L; Eremina V; Hudson BG; Borza DB; Harris RC; Holzman LB; Phillips CL; Fassler R; Quaggin SE; Miner JH; Zent R. 2008. Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity. Dev Biol 316(2):288-301. PubMed: 18328474MGI: J:135414
- Riediger F; Quack I; Qadri F; Hartleben B; Park JK; Potthoff SA; Sohn D; Sihn G; Rousselle A; Fokuhl V; Maschke U; Purfurst B; Schneider W; Rump LC; Luft FC; Dechend R; Bader M; Huber TB; Nguyen G; Muller DN. 2011. Prorenin receptor is essential for podocyte autophagy and survival. J Am Soc Nephrol 22(12):2193-202. PubMed: 22034640MGI: J:232697
- Sachs N; Claessen N; Aten J; Kreft M; Teske GJ; Koeman A; Zuurbier CJ; Janssen H; Sonnenberg A. 2012. Blood pressure influences end-stage renal disease of Cd151 knockout mice. J Clin Invest 122(1):348-58. PubMed: 22201679MGI: J:184392
- Sachs N; Kreft M; van den Bergh Weerman MA; Beynon AJ; Peters TA; Weening JJ; Sonnenberg A. 2006. Kidney failure in mice lacking the tetraspanin CD151. J Cell Biol 175(1):33-9. PubMed: 17015618MGI: J:114988
- Schell C; Kretz O; Bregenzer A; Rogg M; Helmstadter M; Lisewski U; Gotthardt M; Tharaux PL; Huber TB; Grahammer F. 2015. Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response. PLoS One 10(6):e0129424. PubMed: 26076477MGI: J:233807
- Sheikh BN; Bechtel-Walz W; Lucci J; Karpiuk O; Hild I; Hartleben B; Vornweg J; Helmstadter M; Sahyoun AH; Bhardwaj V; Stehle T; Diehl S; Kretz O; Voss AK; Thomas T; Manke T; Huber TB; Akhtar A. 2016. MOF maintains transcriptional programs regulating cellular stress response. Oncogene 35(21):2698-710. PubMed: 26387537MGI: J:234312
- Soda K; Balkin DM; Ferguson SM; Paradise S; Milosevic I; Giovedi S; Volpicelli-Daley L; Tian X; Wu Y; Ma H; Son SH; Zheng R; Moeckel G; Cremona O; Holzman LB; De Camilli P; Ishibe S. 2012. Role of dynamin, synaptojanin, and endophilin in podocyte foot processes. J Clin Invest 122(12):4401-11. PubMed: 23187129MGI: J:194200
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