Mice that are homozygous for the mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Screening of third generation mice (G3) on standard chow identified a 6 week old male (born 5/27/2002) with a 4 hour fasted plasma high density lipoprotein (HDL) of 112.2 mg/dl. Retesting one week later confirmed this observation with a reading of 120.6 mg/dl. This mutant mouse strain may be useful in lipoprotein studies.
This phenotypic deviant was identified following multidose ethylnitrosourea (ENU) treatments to induce mutations in male founder C57BL/6J mice (Stock No. 000664), in complex heart, lung, blood, and sleep disorders at the Mouse Heart, Lung, Blood, and Sleep Disorders (HLBS) Center at The Jackson Laboratory.