Floxed homozygous mice express intact nicastrin gene.  They are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exon 3 deleted in the cre-expressing tissue(s). General deletion in all tissues results in E9.0 embryonic lethality.  g-secretase activity is abolished in cells derived from homozygous cre-recombined mice.  These mice are useful to study the role of g-secretase in various tissues in combination with tissue specific cre lines.




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Floxed homozygous mice express intact nicastrin gene. They are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exon 3 deleted in the cre-expressing tissue(s). These mice are useful to study the role of g-secretase in various tissues in combination with tissue specific cre lines.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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