behavior/neurological phenotype

• enhanced learning
  • mice exhibit increased learning rate but similar initial coordination on the accelerating rotarod
  (MGI Ref ID J:214636)

• hyperactivity
  • mice show greater number of wall jumps
  (MGI Ref ID J:214636)
  • mice are hyperactive during open-field tests, showing increased total distance traveled and increased number of ambulatory episodes, however, no changes in movement velocity or in crossings through the center of the open field are seen
  (MGI Ref ID J:214636)

• increased stereotypic behavior
  • mice show increased vigor of stereotypic movements, indicated by greater force variance during periods of low mobility
  (MGI Ref ID J:214636)
  • the time spent performing stereotypic movements is enhanced during spontaneous open-field activity
  (MGI Ref ID J:214636)
  • mice exhibit an abnormal bias in the direction of rotation during locomotion
  (MGI Ref ID J:214636)
  • mice perform similarly to wild-type littermates on the first trial of an accelerating rotarod, however in the last several trials, mice exhibit enhanced performance, with increased time on the rotarod before falling off compared to wild-type mice
  (MGI Ref ID J:214636)

behavior/neurological phenotype

• abnormal spatial learning
  • after training, mice cross to the precise location of the hidden platform almost twice as often as wild-type mice
  (MGI Ref ID J:125344)
  • mice exhibit an increase in ability to find hidden platform in a Morris water maze and a decrease in training days
  (MGI Ref ID J:125344)
  • spatial learning behavior in a Morris water maze is enhanced
  (MGI Ref ID J:125344)

• abnormal social investigation
  • mice spend less time interacting with other mice compared to wild-type mice
  (MGI Ref ID J:125344)
  • response to a novel caged adult is decreased compared to in wild-type mice
  (MGI Ref ID J:125344)
  • Normal - however, locomotor activity, motor coordination, exploration of novel objects, and anxiety-related behaviors are normal and mice are capable of learning social interaction behaviors following repeated exposure to the same mouse
  (MGI Ref ID J:125344)

nervous system phenotype

• abnormal inhibitory postsynaptic currents
  • inhibitory postsynaptic currents (IPSCs) frequency is increased by 50% relative to in wild-type mice
  (MGI Ref ID J:125344)
  • IPSC in response to GABA puff is increased relative to in wild-type mice
  (MGI Ref ID J:125344)
  • IPSC strength is increased by about 50% relative to in wild-type mice
  (MGI Ref ID J:125344)