These targeted mutation mice carry a tamoxifen-inducible Cre cassette knocked into the 3' UTR of the gene. When crossed with a strain containing a loxP site flanked sequence of interest, the offspring are useful for generating 4-hydroxytamoxifen-induced, Cre-mediated targeted deletions specifically in large neurons. Although the donating investigator reports that homozygous males may not be fertile and homozygous females may have reduced fertility, homozygous colonies at The Jackson Laboratory have no reported fertility problems.

These targeted mutation mice carry a tamoxifen-inducible Cre cassette knocked into the 3' UTR of the Nefl, neurofilament, light polypeptide gene. When crossed with a strain containing a loxP site flanked sequence of interest, the offspring are useful for generating 4-hydroxytamoxifen-induced, Cre-mediated targeted deletions specifically in large neurons.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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