Overview

This strain has been discontinued, please refer to Stock No. 017007

Genetic overview

Genetic Background	Generation

fsq

Allele Type	Gene Symbol	Gene Name
Spontaneous	fsq	flying squirrel

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Research Applications

Neurobiology Research

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Details

Detailed Description

At approximately two months of age, flying squirrel homozygotes stiffen throughout their trunk and limbs, particularly on the ventral side of the body, and when picked up take on a rigid spread out posture. As a result they walk with a slight stagger. Homozygotes are not fertile but do live to adulthood.

Development

The flying squirrel mutation arose spontaneously in the KK.Cg-A^y background and in 1998 in vitro fertilization was performed using a homozygous fsq male and nonagouti (a/a) females from the KK/Cg-A^y/J strain. The resultant offspring were intercrossed to generate this nonagouti strain, which has been maintained by breeding hosts of fsq homozygous ovarian transplants with +/? sibling males and then intercrossing the heterozygous offspring.

Control Suggestions

+/? from the colony

Additional Information

Considerations for Choosing Controls

Genetics

fsq

Allele Symbol: fsq

Allele Name	flying squirrel
Allele Type	Spontaneous
Allele Synonym(s)
Gene Symbol and Name	fsq, flying squirrel
Gene Synonym(s)
Strain of Origin	KK.Cg-A^y/J
Chromosome	10
Molecular Note	fsq is a spontaneous mutation that was discovered at The Jackson Laboratory.

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: fsq related

Neurobiology Research

Mammalian Phenotype Terms by Genotype

The following phenotype relates to a compound genotype created using this strain

Genotype: fsq/fsq
KK(Cg)-fsq/J

behavior/neurological phenotype

abnormal gait
- walk with a slight stagger

abnormal postural reflex
- take on a rigid spread out posture when picked up and sometimes clasp their legs inward

impaired righting response
- older homozygotes are unable to right themselves and their entire body seems rigid

mammalian phenotype

muscle phenotype
- Normal - muscle lesions are not found

muscle phenotype

muscle hypertonia
- by about 2 months of age the body is stiff overall, in both limbs and trunk, especially on the ventral side of the body

nervous system phenotype

hydrocephaly
- increased incidence of hydroencephaly

reproductive system phenotype

infertility

vision/eye phenotype

sutural cataract
- suture cataracts at 2 months of age

References

Additional - fsq related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Mating System
- Ovarian Transplant-Cross-Intercross
- homozygous ovarian transplant hosts are bred with +/? sibling males and then the heterozygous offspring are intercrosse

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