KK(Cg)-fsq/J

Stock number: 008296
Research areas: Neurobiology Research

Description

This strain has been discontinued, please refer to Stock No. 017007

Detailed description

At approximately two months of age, flying squirrel homozygotes stiffen throughout their trunk and limbs, particularly on the ventral side of the body, and when picked up take on a rigid spread out posture. As a result they walk with a slight stagger. Homozygotes are not fertile but do live to adulthood.

Development

The flying squirrel mutation arose spontaneously in the KK.Cg-A^y background and in 1998 in vitro fertilization was performed using a homozygous fsq male and nonagouti (a/a) females from the KK/Cg-A^y/J strain. The resultant offspring were intercrossed to generate this nonagouti strain, which has been maintained by breeding hosts of fsq homozygous ovarian transplants with +/? sibling males and then intercrossing the heterozygous offspring.

Allele

Symbol: fsq
Name: flying squirrel
MGI accession ID: MGI:3772851
Generation method: Spontaneous
Marker symbol: fsq
Marker name: flying squirrel
Chromosome: 10
Strain of origin: KK.Cg-A^y/J
Molecular note: fsq is a spontaneous mutation that was discovered at The Jackson Laboratory.