Congenic NOD mice homozygous for the Faslgld mutation develop lymphadenopathy and systemic autoimmunity. It has been reported that this model displays an accelerated Lupus phenotype compared to the C57BL/6 congenic background. This model is useful for studying apoptosis of lymphocytes, particularly T cells, and Lupus.
Li Wen, Yale School of Medicine
Genetic Background | Generation |
---|---|
001976 NOD/ShiLtJ |
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Fasl | Fas ligand (TNF superfamily, member 6) |
NOD congenic mice homozygous for the Faslgld spontaneous mutation are viable and fertile. The donating investigator reports that homozygous males and females develop lymphadenopathy and systemic autoimmunity beginning at 8 weeks of age, but do not develop diabetes. The Lupus phenotype is accelerated in this strain when compared to the B6-Faslgldstrain. This mutant strain may be useful in the studies of apoptosis of lymphocytes, particularly T cells, and in studies of Lupus.
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized.. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
The spontaneous mutation Faslgld, Fas ligand (TNF superfamily, member 6); generalized lymphoproliferative disease found on Chr 1, was transferred from a C57BL/6 congenic background (Stock No. 001021) to the NOD/Caj (substrain maintained at Yale) background through 12 generations of backcrossing prior to making homozygous for the mutation. In 2008, the T1DR received this strain at N12F20.
Allele Name | generalized lymphoproliferative disease |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | CD95-; FasL-; gld; Tnfsf6gld |
Gene Symbol and Name | Fasl, Fas ligand (TNF superfamily, member 6) |
Gene Synonym(s) | |
Strain of Origin | C3H/HeJ |
Chromosome | 1 |
Molecular Note | A T-to-C transition point mutation near the 3' end of the coding sequence causes a replacement of a highly conserved phenylalanine with a leucine at position 273 (p.F273L) in the extracellular region of the encoded protein. |
When using the NOD.gld mouse strain in a publication, please cite the originating article(s) and include JAX stock #008223 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Fasl<gld> |
Frozen Mouse Embryo | NOD.C3(B6)-Fasl<gld>/LwnJ Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | NOD.C3(B6)-Fasl<gld>/LwnJ Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | NOD.C3(B6)-Fasl<gld>/LwnJ Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | NOD.C3(B6)-Fasl<gld>/LwnJ Frozen Embryo | $3373.50 |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.