JAX Mouse Strain Datasheet - 008191

B6;129S2-Trp53^tm1Tyj Nf1^tm1Tyj/J

Stock No:: 008191

Targeted Mutation

Cryo Recovery

Overview

These mice carry Trp53 and Nf1 targeted mutations on the same homolog of chromosome 11 (in cis). These mutations are approximately 10 Mbp apart and may segregate independently of one another. Double heterozygotes survive an average of five months and exhibit a significant increase in the percentage of soft tissue sarcomas. About 30% of tumors from the Nf1/Trp53 cis animals stain positively for S100 (consistent with glial cell origin) and exhibit classic histological features of malignant peripheral nerve sheath tumors (MPNSTs). This strain may be useful in studies of astrocytomas/glioblastomas and tumor suppressor genes.

Donating Investigator

Dr. Tyler Jacks, Massachusetts Institute of Technology

Genetic overview

Genetic Background	Generation

Nf1^tm1Tyj

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Nf1	neurofibromin 1

Trp53^tm1Tyj

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Trp53	transformation related protein 53

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Research Applications

Cancer Research
Developmental Biology Research
Apoptosis Research
Immunology, Inflammation and Autoimmunity Research
Research Tools

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Base Price

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$2,595.00 Domestic price Cryo Recovery

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Details

Detailed Description

These mice carry Trp53 and Nf1 targeted mutations (in cis) on chromosome 11. These mutations are approximately 10 Mbp apart and may segregate independently of one another. Double homozygotes are embryonic lethal. Double heterozygotes survive an average of five months and exhibit a significant increase in the percentage of soft tissue sarcomas compared with mice of other genotypes (Nf1 +/-, 5%; p53, 57%; Nf1/Trp53 trans, 36%; Nf1/Trp53 cis, 81%). Furthermore, although Nf1/Trp53 trans mice exclusively develop osteo-, fibro-, rhabdomyo-, and hemangiosarcomas, about 30% of tumors from the Nf1/Trp53 cis animals stain positively for S100 (consistent with glial cell origin) and exhibit classic histological features of malignant peripheral nerve sheath tumors (MPNSTs). This strain may be useful in studies of astrocytomas/glioblastomas and tumor suppressor genes.

Development

These mice carry two independently-created targeted mutations, Trp53^tm1Tjy and Nf1^tm1Tyj, that are approximately 10 Mbp apart on the same homolog of chromosome 11 (in cis). To create the Trp53 mutation, a targeting vector was designed to replace approximately 40% of the coding sequences (involving exons 2-6) with a neomycin resistance cassette. To create the Nf1 mutation, a targeting vector was designed to insert a neomycin resistance cassette and delete the first 42 codons of exon 31, the exon 31 splice acceptor site, and approximately 2 kb of intron 30. Each of the targeting vectors was independently electroporated into 129S2/SvPas-derived D3 embryonic stem (ES) cells. Independent strains carrying germline mutations in Trp53 and Nf1 were generated on a mixed 129S2/SvPas and C57BL/6 genetic background, and then then intercrossed. Mice that underwent meiotic recombination events placing both mutations on the same homolog of chromosome 11 (in cis) were selected. This double mutant strain was maintained on a mixed 129S2/SvPas and C57BL/6 genetic background by the donating laboratory prior to sending to The Jackson Laboratory Repository. Upon arrival, males that were heterozygous for both mutations were identified and used to cryopreserve sperm.

Selected References

Reilly KM; Loisel DA; Bronson RT; McLaughlin ME; Jacks T. 2000. Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. In: . . MGI: J:64364

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Genetics

Nf1^tm1Tyj

Allele Symbol: Nf1^tm1Tyj

Allele Name	targeted mutation 1, Tyler Jacks
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	Nf1-; Nf1ⁿ³¹
Gene Symbol and Name	Nf1, neurofibromin 1
Gene Synonym(s)	AW494271; Dsk9; Dsk9; Martin Hrabe de Angelis dark skin 9; Mhdadsk9; Mhdadsk9; NFNS; Nf-1; Nf-1; VRNF; WSS; dark skin 9; expressed sequence AW494271; neurofibromatosis 1; neurofibromin
Site of Expression	Nf1 is normally widely expressed.
Strain of Origin	129S2/SvPas
Chromosome	11
Molecular Note	A neomycin resistance cassette replaced the first 42 codons of exon 31, the exon 31 splice acceptor site, and approximately 2 kb of intron 30. This allele is a null allele; no stable full-length protein is made.
Mutations Made By	Dr. Tyler Jacks, Massachusetts Institute of Technology

Trp53^tm1Tyj

Allele Symbol: Trp53^tm1Tyj

Allele Name	targeted mutation 1, Tyler Jacks
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	Trp53-; Trp53^KO; p53-; p53^delta; p53^null; p53KO
Gene Symbol and Name	Trp53, transformation related protein 53
Gene Synonym(s)	BCC7; LFS1; P53; TRP53; p44; p53
Site of Expression	Normal Trp53 expression is widespread.
Strain of Origin	129S2/SvPas
Chromosome	11
General Note	This mutant allele was produced by a targeted neo insertion into the Trp53 locus. Homozygotes show no visible phenotype but develop tumors at 3-6 months of age. Heterozygotes develop tumors at 10 months of age. These mice model some of the features of human Li-Fraumeni syndrome (OMIM 151623), a form of familial breast cancer with mutations in TRP53 (J:16022)(J:16023) A specific human mutation found in hepatocellular carcinomas caused by hepatitis B infection or by aflatoxin exposure has been created in a mouse model, resulting in a similar gene product (J:27363).
Molecular Note	A neomycin cassette replaced 40% of the coding sequences beginning with exon 2 (upstream of the translation start site) and extending into exon 6.
Mutations Made By	Dr. Tyler Jacks, Massachusetts Institute of Technology

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Cancer Research
- Increased Tumor Incidence
  - Other Tissues/Organs
  - Other Tissues/Organs: brain
- Tumor Suppressor Genes
Developmental Biology Research
- Embryonic Lethality (Homozygous)

Genotype: Trp53^tm1Tyj related

Apoptosis Research
- Endogenous Regulators
Cancer Research
- Increased Tumor Incidence
  - Lymphomas
  - Other Tissues/Organs
  - Other Tissues/Organs: osteosarcoma
- Toxicology
- Tumor Suppressor Genes
Immunology, Inflammation and Autoimmunity Research
- Intracellular Signaling Molecules
Research Tools
- Toxicology Research
  - B and T cell deficiency, xenograft transplant host
  - drug/compound testing

Mammalian Phenotype Terms by Genotype

Genotype: Nf1^tm1Tyj/Nf1⁺ Trp53^tm1Tyj/Trp53⁺
involves: 129/Sv * C57BL/6

nervous system phenotype

increased neurofibrosarcoma incidence
- develop in cis-double heterozygotes, usually correlated with loss of one chromosome

mortality/aging

premature death
- cis-double heterozygotes die by 5 months of age and trans-double heterozygotes survive to the average age of 10 months

neoplasm

increased neurofibrosarcoma incidence
- develop in cis-double heterozygotes, usually correlated with loss of one chromosome

increased sarcoma incidence
- developed in both cis- and trans-double heterozygotes
- sarcomas in trans-double heterozygotes were similar to those found in mice with either single mutation and were usually correlated with loss of one chromosome

increased tumor incidence
- cis-double heterozygotes exhibit greater incidence of tumors than trans-double heterozygotes

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Nf1^tm1Tyj/Nf1⁺ Trp53^tm1Tyj/Trp53⁺
involves: 129S2/SvPas

nervous system phenotype

increased neurofibrosarcoma incidence
- form by 6 months of age

nervous system phenotype
- neural crest stem cells do not abnormally persist in the peripheral nervous system in adult mice

neoplasm

increased neurofibrosarcoma incidence
- form by 6 months of age

References

Reilly KM; Loisel DA; Bronson RT; McLaughlin ME; Jacks T. 2000. Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. In: . . MGI: J:64364

Additional - Nf1^tm1Tyj related

Amlin-Van Schaick JC; Kim S; DiFabio C; Lee MH; Broman KW; Reilly KM. 2012. Arlm1 is a male-specific modifier of astrocytoma resistance on mouse Chr 12.. In: . . MGI: J:186764
Bessler WK; Kim G; Hudson FZ; Mund JA; Mali R; Menon K; Kapur R; Clapp DW; Ingram DA Jr; Stansfield BK. 2016. Nf1+/- monocytes/macrophages induce neointima formation via CCR2 activation.. In: . . MGI: J:229474
Birnbaum RA; O'Marcaigh A; Wardak Z; Zhang YY; Dranoff G; Jacks T; Clapp DW; Shannon KM. 2000. Nf1 and Gmcsf interact in myeloid leukemogenesis.. In: . . MGI: J:60155
Boyanapalli M; Lahoud OB; Messiaen L; Kim B; Anderle de Sylor MS; Duckett SJ; Somara S; Mikol DD. 2006. Neurofibromin binds to caveolin-1 and regulates ras, FAK, and Akt.. In: . . MGI: J:104986
Buchstaller J; McKeever PE; Morrison SJ. 2012. Tumorigenic Cells Are Common in Mouse MPNSTs but Their Frequency Depends upon Tumor Genotype and Assay Conditions.. In: . . MGI: J:181460
Carbe C; Zhang X. 2011. Lens induction requires attenuation of ERK signaling by Nf1.. In: . . MGI: J:169235
Chao RC; Pyzel U; Fridlyand J; Kuo YM; Teel L; Haaga J; Borowsky A; Horvai A; Kogan SC; Bonifas J; Huey B; Jacks TE; Albertson DG; Shannon KM. 2005. Therapy-induced malignant neoplasms in Nf1 mutant mice.. In: . . MGI: J:103509
Chen S; Burgin S; McDaniel A; Li X; Yuan J; Chen M; Khalaf W; Clapp DW; Yang FC. 2010. Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of phosphatidylinositol 3-kinase.. In: . . MGI: J:167633
Choi G; Huang B; Pinarbasi E; Braunstein SE; Horvai AE; Kogan S; Bhatia S; Faddegon B; Nakamura JL. 2012. Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms.. In: . . MGI: J:193638
Cichowski K; Shih TS; Schmitt E; Santiago S; Reilly K; McLaughlin ME; Bronson RT; Jacks T. 1999. Mouse models of tumor development in neurofibromatosis type 1.. In: . . MGI: J:58876
Costa RM; Federov NB; Kogan JH; Murphy GG; Stern J; Ohno M; Kucherlapati R; Jacks T; Silva AJ. 2002. Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1.. In: . . MGI: J:74257
Dai C; Santagata S; Tang Z; Shi J; Cao J; Kwon H; Bronson RT; Whitesell L; Lindquist S. 2012. Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis.. In: . . MGI: J:191670
De Raedt T; Beert E; Pasmant E; Luscan A; Brems H; Ortonne N; Helin K; Hornick JL; Mautner V; Kehrer-Sawatzki H; Clapp W; Bradner J; Vidaud M; Upadhyaya M; Legius E; Cichowski K. 2014. PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies.. In: . . MGI: J:217077
De Raedt T; Walton Z; Yecies JL; Li D; Chen Y; Malone CF; Maertens O; Jeong SM; Bronson RT; Lebleu V; Kalluri R; Normant E; Haigis MC; Manning BD; Wong KK; Macleod KF; Cichowski K. 2011. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors.. In: . . MGI: J:175966
Deo M; Huang JL; Fuchs H; de Angelis MH; Van Raamsdonk CD. 2013. Differential effects of neurofibromin gene dosage on melanocyte development.. In: . . MGI: J:196495
Dodd RD; Lee CL; Overton T; Huang W; Eward WC; Luo L; Ma Y; Ingram DR; Torres KE; Cardona DM; Lazar AJ; Kirsch DG. 2017. NF1+/- Hematopoietic Cells Accelerate Malignant Peripheral Nerve Sheath Tumor Development without Altering Chemotherapy Response.. In: . . MGI: J:243271
Duan JH; Hodgdon KE; Hingtgen CM; Nicol GD. 2014. N-type calcium current, Cav2.2, is enhanced in small-diameter sensory neurons isolated from Nf1+/- mice.. In: . . MGI: J:210619
Gutmann DH; Winkeler E; Kabbarah O; Hedrick N; Dudley S; Goodfellow PJ; Liskay RM. 2003. Mlh1 deficiency accelerates myeloid leukemogenesis in neurofibromatosis 1 (Nf1) heterozygous mice.. In: . . MGI: J:84658
Hawes JJ; Tuskan RG; Reilly KM. 2007. Nf1 expression is dependent on strain background: implications for tumor suppressor haploinsufficiency studies.. In: . . MGI: J:121636
He Y; Rhodes SD; Chen S; Wu X; Yuan J; Yang X; Jiang L; Li X; Takahashi N; Xu M; Mohammad KS; Guise TA; Yang FC. 2012. c-Fms signaling mediates neurofibromatosis Type-1 osteoclast gain-in-functions.. In: . . MGI: J:194861
Henkemeyer M; Rossi DJ; Holmyard DP; Puri MC; Mbamalu G; Harpal K; Shih TS; Jacks T; Pawson T. 1995. Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein.. In: . . MGI: J:29825
Hiatt K; Ingram DA; Huddleston H; Spandau DF; Kapur R; Clapp DW. 2004. Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells.. In: . . MGI: J:89131
Hingtgen CM; Roy SL; Clapp DW. 2006. Stimulus-evoked release of neuropeptides is enhanced in sensory neurons from mice with a heterozygous mutation of the Nf1 gene.. In: . . MGI: J:104588
Hodgdon KE; Hingtgen CM; Nicol GD. 2012. Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels.. In: . . MGI: J:184640
Huse JT; Holland EC. 2009. Genetically engineered mouse models of brain cancer and the promise of preclinical testing.. In: . . MGI: J:173443
Ingram DA; Hiatt K; King AJ; Fisher L; Shivakumar R; Derstine C; Wenning MJ; Diaz B; Travers JB; Hood A; Marshall M; Williams DA; Clapp DW. 2001. Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro.. In: . . MGI: J:71331
Ingram DA; Yang FC; Travers JB; Wenning MJ; Hiatt K; New S; Hood A; Shannon K; Williams DA; Clapp DW. 2000. Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo.. In: . . MGI: J:59248
Ingram DA; Zhang L; McCarthy J; Wenning MJ; Fisher L; Yang FC; Clapp DW; Kapur R. 2002. Lymphoproliferative defects in mice lacking the expression of neurofibromin: functional and biochemical consequences of Nf1 deficiency in T-cell development and function.. In: . . MGI: J:79702
Jacks T; Shih TS; Schmitt EM; Bronson RT; Bernards A; Weinberg RA. 1994. Tumour predisposition in mice heterozygous for a targeted mutation in Nf1.. In: . . MGI: J:18542
Johannessen CM; Johnson BW; Williams SM; Chan AW; Reczek EE; Lynch RC; Rioth MJ; McClatchey A; Ryeom S; Cichowski K. 2008. TORC1 is essential for NF1-associated malignancies.. In: . . MGI: J:144615
Joseph NM; Mosher JT; Buchstaller J; Snider P; McKeever PE; Lim M; Conway SJ; Parada LF; Zhu Y; Morrison SJ. 2008. The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells.. In: . . MGI: J:131914
Khalaf WF; Yang FC; Chen S; White H; Bessler W; Ingram DA; Clapp DW. 2007. K-ras is critical for modulating multiple c-kit-mediated cellular functions in wild-type and Nf1+/- mast cells.. In: . . MGI: J:143972
Koenigsmann J; Rudolph C; Sander S; Kershaw O; Gruber AD; Bullinger L; Schlegelberger B; Carstanjen D. 2009. Nf1 haploinsufficiency and Icsbp deficiency synergize in the development of leukemias.. In: . . MGI: J:148716
Lakkis MM; Epstein JA. 1998. Neurofibromin modulation of ras activity is required for normal endocardial-mesenchymal transformation in the developing heart.. In: . . MGI: J:50306
Lakkis MM; Golden JA; O'Shea KS; Epstein JA. 1999. Neurofibromin deficiency in mice causes exencephaly and is a modifier for Splotch neural tube defects.. In: . . MGI: J:56680
Lasater EA; Bessler WK; Mead LE; Horn WE; Clapp DW; Conway SJ; Ingram DA; Li F. 2008. Nf1+/- mice have increased neointima formation via hyperactivation of a Gleevec sensitive molecular pathway.. In: . . MGI: J:137662
Lasater EA; Li F; Bessler WK; Estes ML; Vemula S; Hingtgen CM; Dinauer MC; Kapur R; Conway SJ; Ingram DA Jr. 2010. Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans.. In: . . MGI: J:158570
Lepoutre-Lussey C; Thibault C; Buffet A; Morin A; Badoual C; Benit P; Rustin P; Ottolenghi C; Janin M; Castro-Vega LJ; Trapman J; Gimenez-Roqueplo AP; Favier J. 2016. From Nf1 to Sdhb knockout: Successes and failures in the quest for animal models of pheochromocytoma.. In: . . MGI: J:236514
Li F; Munchhof AM; White HA; Mead LE; Krier TR; Fenoglio A; Chen S; Wu X; Cai S; Yang FC; Ingram DA. 2006. Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells.. In: . . MGI: J:109530
Li W; Cui Y; Kushner SA; Brown RA; Jentsch JD; Frankland PW; Cannon TD; Silva AJ. 2005. The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1.. In: . . MGI: J:103691
Lock R; Ingraham R; Maertens O; Miller AL; Weledji N; Legius E; Konicek BM; Yan SC; Graff JR; Cichowski K. 2016. Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers.. In: . . MGI: J:237073
Mahgoub N; Taylor BR; Gratiot M; Kohl NE; Gibbs JB; Jacks T; Shannon KM. 1999. In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells.. In: . . MGI: J:57842
Mahgoub N; Taylor BR; Le Beau MM; Gratiot M; Carlson KM; Atwater SK ; Jacks T ; Shannon KM. 1999. Myeloid malignancies induced by alkylating agents in Nf1 mice.. In: . . MGI: J:55413
Malone CF; Fromm JA; Maertens O; DeRaedt T; Ingraham R; Cichowski K. 2014. Defining key signaling nodes and therapeutic biomarkers in NF1-mutant cancers.. In: . . MGI: J:217840
Mangues R; Corral T; Lu S; Symmans WF; Liu L; Pellicer A. 1998. NF1 inactivation cooperates with N-ras in in vivo lymphogenesis activating Erk by a mechanism independent of its Ras-GTPase accelerating activity.. In: . . MGI: J:52704
McDaniel AS; Allen JD; Park SJ; Jaffer ZM; Michels EG; Burgin SJ; Chen S; Bessler WK; Hofmann C; Ingram DA; Chernoff J; Clapp DW. 2008. Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells.. In: . . MGI: J:142439
Molosh AI; Johnson PL; Spence JP; Arendt D; Federici LM; Bernabe C; Janasik SP; Segu ZM; Khanna R; Goswami C; Zhu W; Park SJ; Li L; Mechref YS; Clapp DW; Shekhar A. 2014. Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase.. In: . . MGI: J:219424
Mroue R; Huang B; Braunstein S; Firestone AJ; Nakamura JL. 2015. Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice.. In: . . MGI: J:224780
Munchhof AM; Li F; White HA; Mead LE; Krier TR; Fenoglio A; Li X; Yuan J; Yang FC; Ingram DA. 2006. Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells.. In: . . MGI: J:109532
Nagasubramanian R; Hansen RJ; Delaney SM; Cherian MM; Samson LD; Kogan SC; Dolan ME. 2008. Survival and tumorigenesis in O6-methylguanine DNA methyltransferase-deficient mice following cyclophosphamide exposure.. In: . . MGI: J:152129
Nakamura JL; Phong C; Pinarbasi E; Kogan SC; Vandenberg S; Horvai AE; Faddegon BA; Fiedler D; Shokat K; Houseman BT; Chao R; Pieper RO; Shannon K. 2011. Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice.. In: . . MGI: J:167772
Nebesio TD; Ming W; Chen S; Clegg T; Yuan J; Yang Y; Estwick SA; Li Y; Li X; Hingtgen CM; Yang FC. 2007. Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy.. In: . . MGI: J:156102
Patmore DM; Welch S; Fulkerson PC; Wu J; Choi K; Eaves D; Kordich JJ; Collins MH; Cripe TP; Ratner N. 2012. In vivo regulation of TGF-beta by R-Ras2 revealed through loss of the RasGAP protein NF1.. In: . . MGI: J:191804
Pemov A; Park C; Reilly KM; Stewart DR. 2010. Evidence of perturbations of cell cycle and DNA repair pathways as a consequence of human and murine NF1-haploinsufficiency.. In: . . MGI: J:159679
Reilly KM; Broman KW; Bronson RT; Tsang S; Loisel DA; Christy ES; Sun Z; Diehl J; Munroe DJ; Tuskan RG. 2006. An imprinted locus epistatically influences Nstr1 and Nstr2 to control resistance to nerve sheath tumors in a neurofibromatosis type 1 mouse model.. In: . . MGI: J:105038
Reilly KM; Tuskan RG; Christy E; Loisel DA; Ledger J; Bronson RT; Smith CD; Tsang S; Munroe DJ; Jacks T. 2004. Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects.. In: . . MGI: J:92444
Rhodes SD; Wu X; He Y; Chen S; Yang H; Staser KW; Wang J; Zhang P; Jiang C; Yokota H; Dong R; Peng X; Yang X; Murthy S; Azhar M; Mohammad KS; Xu M; Guise TA; Yang FC. 2013. Hyperactive transforming growth factor-beta1 signaling potentiates skeletal defects in a neurofibromatosis type 1 mouse model.. In: . . MGI: J:231256
Rhodes SD; Zhang W; Yang D; Yang H; Chen S; Wu X; Li X; Yang X; Mohammad KS; Guise TA; Bergner AL; Stevenson DA; Yang FC. 2015. Dystrophic spinal deformities in a neurofibromatosis type 1 murine model.. In: . . MGI: J:229201
Ribeiro S; Napoli I; White IJ; Parrinello S; Flanagan AM; Suter U; Parada LF; Lloyd AC. 2013. Injury signals cooperate with Nf1 loss to relieve the tumor-suppressive environment of adult peripheral nerve.. In: . . MGI: J:203786
Sanchez-Macedo N; Feng J; Faubert B; Chang N; Elia A; Rushing EJ; Tsuchihara K; Bungard D; Berger SL; Jones RG; Mak TW; Zaugg K. 2013. Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model.. In: . . MGI: J:228258
Sharma R; Wu X; Rhodes SD; Chen S; He Y; Yuan J; Li J; Yang X; Li X; Jiang L; Kim ET; Stevenson DA; Viskochil D; Xu M; Yang FC. 2013. Hyperactive Ras/MAPK signaling is critical for tibial nonunion fracture in neurofibromin-deficient mice.. In: . . MGI: J:202235
Silva AJ; Frankland PW; Marowitz Z; Friedman E; Lazlo G; Cioffi D; Jacks T; Bourtchuladze R. 1997. A mouse model for the learning and memory deficits associated with neurofibromatosis type I.. In: . . MGI: J:38703
Silvestre DC; Gil GA; Tomasini N; Bussolino DF; Caputto BL. 2010. Growth of peripheral and central nervous system tumors is supported by cytoplasmic c-Fos in humans and mice.. In: . . MGI: J:158701
Stansfield BK; Bessler WK; Mali R; Mund JA; Downing B; Li F; Sarchet KN; Distasi MR; Conway SJ; Kapur R; Ingram DA Jr. 2013. Heterozygous inactivation of the Nf1 gene in myeloid cells enhances neointima formation via a rosuvastatin-sensitive cellular pathway.. In: . . MGI: J:192569
Stansfield BK; Bessler WK; Mali R; Mund JA; Downing BD; Kapur R; Ingram DA Jr. 2014. Ras-Mek-Erk signaling regulates Nf1 heterozygous neointima formation.. In: . . MGI: J:205128
Staser K; Yang FC; Clapp DW. 2010. Mast cells and the neurofibroma microenvironment.. In: . . MGI: J:162828
Su W; Xing R; Guha A; Gutmann DH; Sherman LS. 2007. Mice with GFAP-targeted loss of neurofibromin demonstrate increased axonal MET expression with aging.. In: . . MGI: J:156097
Switon K; Kotulska K; Janusz-Kaminska A; Zmorzynska J; Jaworski J. 2017. Molecular neurobiology of mTOR.. In: . . MGI: J:238268
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Walrath JC; Fox K; Truffer E; Gregory Alvord W; Quinones OA; Reilly KM. 2009. Chr 19(A/J) modifies tumor resistance in a sex- and parent-of-origin-specific manner.. In: . . MGI: J:147432
Wang HF; Shih YT; Chen CY; Chao HW; Lee MJ; Hsueh YP. 2011. Valosin-containing protein and neurofibromin interact to regulate dendritic spine density.. In: . . MGI: J:184421
Wang Y; Nicol GD; Clapp DW; Hingtgen CM. 2005. Sensory neurons from Nf1 haploinsufficient mice exhibit increased excitability.. In: . . MGI: J:128643
Weiss WA; Aldape K; Mohapatra G; Feuerstein BG; Bishop JM. 1997. Targeted expression of MYCN causes neuroblastoma in transgenic mice.. In: . . MGI: J:41126
Weiss WA; Israel M; Cobbs C; Holland E; James CD; Louis DN; Marks C; McClatchey AI; Roberts T; Van Dyke T; Wetmore C; Chiu IM; Giovannini M; Guha A; Higgins RJ; Marino S; Radovanovic I; Reilly K; Aldape K. 2002. Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum.. In: . . MGI: J:79667
Wu X; Estwick SA; Chen S; Yu M; Ming W; Nebesio TD; Li Y; Yuan J; Kapur R; Ingram D; Yoder MC; Yang FC. 2006. Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells.. In: . . MGI: J:114925
Xu J; Ismat FA; Wang T; Yang J; Epstein JA. 2007. NF1 regulates a Ras-dependent vascular smooth muscle proliferative injury response.. In: . . MGI: J:142994
Yan J; Chen S; Zhang Y; Li X; Li Y; Wu X; Yuan J; Robling AG; Karpur R; Chan RJ; Yang FC. 2008. Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1.. In: . . MGI: J:132466
Yang A; Reeves RH. 2011. Increased Survival following Tumorigenesis in Ts65Dn Mice That Model Down Syndrome.. In: . . MGI: J:171978
Yang FC; Chen S; Clegg T; Li X; Morgan T; Estwick SA; Yuan J; Khalaf W; Burgin S; Travers J; Parada LF; Ingram DA; Clapp DW. 2006. Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling.. In: . . MGI: J:112050
Yang FC; Chen S; Robling AG; Yu X; Nebesio TD; Yan J; Morgan T; Li X; Yuan J; Hock J; Ingram DA; Clapp DW. 2006. Hyperactivation of p21 and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions.. In: . . MGI: J:114609
Yu X; Chen S; Potter OL; Murthy SM; Li J; Pulcini JM; Ohashi N; Winata T; Everett ET; Ingram D; Clapp WD; Hock JM. 2005. Neurofibromin and its inactivation of Ras are prerequisites for osteoblast functioning.. In: . . MGI: J:104976
Zhang W; Rhodes SD; Zhao L; He Y; Zhang Y; Shen Y; Yang D; Wu X; Li X; Yang X; Park SJ; Chen S; Turner C; Yang FC. 2011. Primary osteopathy of vertebrae in a neurofibromatosis type 1 murine model.. In: . . MGI: J:172512
van der Vaart T; van Woerden GM; Elgersma Y; de Zeeuw CI; Schonewille M. 2011. Motor deficits in neurofibromatosis type 1 mice: the role of the cerebellum.. In: . . MGI: J:185707

Additional - Trp53^tm1Tyj related

Aarabi S; Bhatt KA; Shi Y; Paterno J; Chang EI; Loh SA; Holmes JW; Longaker MT; Yee H; Gurtner GC. 2007. Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis.. In: . . MGI: J:143834
Ablamunits V; Cohen Y; Brazee IB; Gaetz HP; Vinson C; Klebanov S. 2006. Susceptibility to Induced and Spontaneous Carcinogenesis Is Increased in Fatless A-ZIP/F-1 but not in Obese ob/ob Mice.. In: . . MGI: J:112412
Adams CM; Eischen CM. 2014. Inactivation of p53 is insufficient to allow B cells and B-cell lymphomas to survive without Dicer.. In: . . MGI: J:213117
Adriaens C; Standaert L; Barra J; Latil M; Verfaillie A; Kalev P; Boeckx B; Wijnhoven PW; Radaelli E; Vermi W; Leucci E; Lapouge G; Beck B; van den Oord J; Nakagawa S; Hirose T; Sablina AA; Lambrechts D; Aerts S; Blanpain C; Marine JC. 2016. p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity.. In: . . MGI: J:240137
Aggarwal P; Lessie MD; Lin DI; Pontano L; Gladden AB; Nuskey B; Goradia A; Wasik MA; Klein-Szanto AJ; Rustgi AK; Bassing CH; Diehl JA. 2007. Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication.. In: . . MGI: J:127316
Aghi M; Cohen KS; Klein RJ; Scadden DT; Chiocca EA. 2006. Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes.. In: . . MGI: J:112935
Ahkter S; Richie CT; Zhang N; Behringer RR; Zhu C; Legerski RJ. 2005. Snm1-deficient mice exhibit accelerated tumorigenesis and susceptibility to infection.. In: . . MGI: J:102381
Ahronian LG; Zhu LJ; Chen YW; Chu HC; Klimstra DS; Lewis BC. 2016. A novel KLF6-Rho GTPase axis regulates hepatocellular carcinoma cell migration and dissemination.. In: . . MGI: J:230812
Akala OO; Park IK; Qian D; Pihalja M; Becker MW; Clarke MF. 2008. Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors.. In: . . MGI: J:134785
Akhter S; Lam YC; Chang S; Legerski RJ. 2010. The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development.. In: . . MGI: J:217052
Al-Massadi O; Porteiro B; Kuhlow D; Kohler M; Gonzalez-Rellan MJ; Garcia-Lavandeira M; Diaz-Rodriguez E; Quinones M; Senra A; Alvarez CV; Lopez M; Dieguez C; Schulz TJ; Nogueiras R. 2016. Pharmacological and Genetic Manipulation of p53 in Brown Fat at Adult But Not Embryonic Stages Regulates Thermogenesis and Body Weight in Male Mice.. In: . . MGI: J:239719
Alexandrova EM; Petrenko O; Nemajerova A; Romano RA; Sinha S; Moll UM. 2013. DeltaNp63 regulates select routes of reprogramming via multiple mechanisms.. In: . . MGI: J:228996
Almeida MQ; Muchow M; Boikos S; Bauer AJ; Griffin KJ; Tsang KM; Cheadle C; Watkins T; Wen F; Starost MF; Bossis I; Nesterova M; Stratakis CA. 2010. Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling.. In: . . MGI: J:158372
Alt JR; Greiner TC; Cleveland JL; Eischen CM. 2003. Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis.. In: . . MGI: J:82477
Alvarez JV; Pan TC; Ruth J; Feng Y; Zhou A; Pant D; Grimley JS; Wandless TJ; Demichele A; Chodosh LA. 2013. Par-4 Downregulation Promotes Breast Cancer Recurrence by Preventing Multinucleation following Targeted Therapy.. In: . . MGI: J:199068
Amlin-Van Schaick JC; Kim S; DiFabio C; Lee MH; Broman KW; Reilly KM. 2012. Arlm1 is a male-specific modifier of astrocytoma resistance on mouse Chr 12.. In: . . MGI: J:186764
Amrani YM; Gill J; Matevossian A; Alonzo ES; Yang C; Shieh JH; Moore MA; Park CY; Sant'Angelo DB; Denzin LK. 2011. The Paf oncogene is essential for hematopoietic stem cell function and development.. In: . . MGI: J:177782
Apostolidis PA; Woulfe DS; Chavez M; Miller WM; Papoutsakis ET. 2012. Role of tumor suppressor p53 in megakaryopoiesis and platelet function.. In: . . MGI: J:191403
Arendt LM; Rugowski DE; Grafwallner-Huseth TA; Garcia-Barchino MJ; Rui H; Schuler LA. 2011. Prolactin-induced mouse mammary carcinomas model estrogen resistant luminal breast cancer.. In: . . MGI: J:173131
Artandi SE; Chang S; Lee SL; Alson S; Gottlieb GJ; Chin L; DePinho RA. 2000. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice [see comments]. In: . . MGI: J:63843
Asai T; Liu Y; Di Giandomenico S; Bae N; Ndiaye-Lobry D; Deblasio A; Menendez S; Antipin Y; Reva B; Wevrick R; Nimer SD. 2012. Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cells.. In: . . MGI: J:189173
Asakura A; Rudnicki MA. 2003. Rhabdomyosarcomagenesis-Novel pathway found.. In: . . MGI: J:88121
Aslanian A; Iaquinta PJ; Verona R; Lees JA. 2004. Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics.. In: . . MGI: J:90855
Atanassov BS; Evrard YA; Multani AS; Zhang Z; Tora L; Devys D; Chang S; Dent SY. 2009. Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance.. In: . . MGI: J:154202
Ayanga B; Price R; Gu X; Lozano G; Evans SC. 2006. Genetic mapping of a putative tumor suppressor locus that influences tumorigenesis and metastasis in mice.. In: . . MGI: J:108788
Bachy E; Urb M; Chandra S; Robinot R; Bricard G; de Bernard S; Traverse-Glehen A; Gazzo S; Blond O; Khurana A; Baseggio L; Heavican T; Ffrench M; Crispatzu G; Mondiere P; Schrader A; Taillardet M; Thaunat O; Martin N; Dalle S; Le Garff-Tavernier M; Salles G; Lachuer J; Hermine O; Asnafi V; Roussel M; Lamy T; Herling M; Iqbal J; Buffat L; Marche PN; Gaulard P; Kronenberg M; Defrance T; Genestier L. 2016. CD1d-restricted peripheral T cell lymphoma in mice and humans.. In: . . MGI: J:233315
Backlund MG; Trasti SL; Backlund DC; Cressman VL; Godfrey V; Koller BH. 2001. Impact of ionizing radiation and genetic background on mammary tumorigenesis in p53-deficient mice.. In: . . MGI: J:71052
Baek KH; Shin HJ; Yoo JK; Cho JH; Choi YH; Sung YC; McKeon F; Lee CW. 2003. p53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest.. In: . . MGI: J:121196
Bailey DP; Kashyap M; Bouton LA; Murray PJ; Ryan JJ. 2006. Interleukin-10 induces apoptosis in developing mast cells and macrophages.. In: . . MGI: J:112579
Baker DJ; Jin F; Jeganathan KB; van Deursen JM. 2009. Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity.. In: . . MGI: J:155824
Baker DJ; Weaver RL; van Deursen JM. 2013. p21 both attenuates and drives senescence and aging in BubR1 progeroid mice.. In: . . MGI: J:198507
Bakthavatchalu V; Dey S; Xu Y; Noel T; Jungsuwadee P; Holley AK; Dhar SK; Batinic-Haberle I; St Clair DK. 2012. Manganese superoxide dismutase is a mitochondrial fidelity protein that protects Polgamma against UV-induced inactivation.. In: . . MGI: J:190273
Baldauf C; Jeschke A; Kanbach V; Catala-Lehnen P; Baumhoer D; Gerull H; Buhs S; Amling M; Nollau P; Harroch S; Schinke T. 2015. The Protein Tyrosine Phosphatase Rptpzeta Suppresses Osteosarcoma Development in Trp53-Heterozygous Mice.. In: . . MGI: J:243104
Balsitis S; Dick F; Lee D; Farrell L; Hyde RK; Griep AE; Dyson N; Lambert PF. 2005. Examination of the pRb-dependent and pRb-independent functions of E7 in vivo.. In: . . MGI: J:101623
Banerjee A; Thyagarajan K; Chatterjee S; Chakraborty P; Kesarwani P; Soloshchenko M; Al-Hommrani M; Andrijauskaite K; Moxley K; Janakiraman H; Scheffel MJ; Helke K; Armenson K; Palanisamy V; Rubinstein MP; Mayer EG; Cole DJ; Paulos CM; Voelkel-Johnson C; Nishimura MI; Mehrotra S. 2016. Lack of p53 Augments Antitumor Functions in Cytolytic T Cells.. In: . . MGI: J:235134
Barabino A; Plamondon V; Abdouh M; Chatoo W; Flamier A; Hanna R; Zhou S; Motoyama N; Hebert M; Lavoie J; Bernier G. 2016. Loss of Bmi1 causes anomalies in retinal development and degeneration of cone photoreceptors.. In: . . MGI: J:235536
Barboza JA; Iwakuma T; Terzian T; El-Naggar AK; Lozano G. 2008. Mdm2 and Mdm4 loss regulates distinct p53 activities.. In: . . MGI: J:139880
Barboza JA; Liu G; Ju Z; El-Naggar AK; Lozano G. 2006. p21 delays tumor onset by preservation of chromosomal stability.. In: . . MGI: J:118255
Bardeesy N; Bastian BC; Hezel A; Pinkel D; DePinho RA; Chin L. 2001. Dual inactivation of RB and p53 pathways in RAS-induced melanomas.. In: . . MGI: J:67799
Bardeesy N; Morgan J; Sinha M; Signoretti S; Srivastava S; Loda M; Merlino G; DePinho RA. 2002. Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia.. In: . . MGI: J:73973
Barkic M; Crnomarkovic S; Grabusic K; Bogetic I; Panic L; Tamarut S; Cokaric M; Jeric I; Vidak S; Volarevic S. 2009. The p53 tumor suppressor causes congenital malformations in Rpl24-deficient mice and promotes their survival.. In: . . MGI: J:148991
Barlow C; Brown KD; Deng CX; Tagle DA; Wynshaw-Boris A. 1997. Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways.. In: . . MGI: J:76690
Barlow C; Liyanage M; Moens PB; Deng CX; Ried T; Wynshaw-Boris A. 1997. Partial rescue of the prophase I defects of Atm-deficient mice by p53 and p21 null alleles.. In: . . MGI: J:44388
Barone E; Cenini G; Di Domenico F; Noel T; Wang C; Perluigi M; St Clair DK; Butterfield DA. 2015. Basal brain oxidative and nitrative stress levels are finely regulated by the interplay between superoxide dismutase 2 and p53.. In: . . MGI: J:238598
Bazzi H; Anderson KV. 2014. Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo.. In: . . MGI: J:208632
Becker KA; Lu S; Dickinson ES; Dunphy KA; Mathews L; Schneider SS; Jerry DJ. 2005. Estrogen and progesterone regulate radiation-induced p53 activity in mammary epithelium through TGF-beta-dependent pathways.. In: . . MGI: J:101763
Beekman C; Nichane M; De Clercq S; Maetens M; Floss T; Wurst W; Bellefroid E; Marine JC. 2006. Evolutionarily conserved role of nucleostemin: controlling proliferation of stem/progenitor cells during early vertebrate development.. In: . . MGI: J:118144
Bekaert S; Derradji H; Meyer TD; Michaux A; Buset J; Neefs M; Mergeay M; Jacquet P; Van Oostveldt P; Baatout S. 2005. Telomere shortening is associated with malformation in p53-deficient mice after irradiation during specific stages of development.. In: . . MGI: J:105007
Belle JI; Langlais D; Petrov JC; Pardo M; Jones RG; Gros P; Nijnik A. 2015. p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1 deficiency.. In: . . MGI: J:222019
Belle JI; Petrov JC; Langlais D; Robert F; Cencic R; Shen S; Pelletier J; Gros P; Nijnik A. 2016. Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance.. In: . . MGI: J:235706
Bender CF; Sikes ML; Sullivan R; Huye LE; Le Beau MM; Roth DB; Mirzoeva OK; Oltz EM; Petrini JH. 2002. Cancer predisposition and hematopoietic failure in Rad50(S/S) mice.. In: . . MGI: J:78820
Berges RR; Furuya Y; Remington L; English HF; Jacks T; Isaacs JT. 1993. Cell proliferation, DNA repair, and p53 function are not required for programmed death of prostatic glandular cells induced by androgen ablation.. In: . . MGI: J:111328
Berman DM; Karhadkar SS; Hallahan AR; Pritchard JI; Eberhart CG; Watkins DN; Chen JK; Cooper MK; Taipale J; Olson JM; Beachy PA. 2002. Medulloblastoma growth inhibition by hedgehog pathway blockade.. In: . . MGI: J:79798
Bertout JA; Patel SA; Fryer BH; Durham AC; Covello KL; Olive KP; Goldschmidt MH; Simon MC. 2009. Heterozygosity for hypoxia inducible factor 1alpha decreases the incidence of thymic lymphomas in a p53 mutant mouse model.. In: . . MGI: J:147359
Beumer TL; Roepers-Gajadien HL; Gademan IS; van Buul PP; Gil-Gomez G; Rutgers DH; de Rooij DG. 1998. The role of the tumor suppressor p53 in spermatogenesis.. In: . . MGI: J:114210
Bildsoe H; Loebel DA; Jones VJ; Hor AC; Braithwaite AW; Chen YT; Behringer RR; Tam PP. 2013. The mesenchymal architecture of the cranial mesoderm of mouse embryos is disrupted by the loss of Twist1 function.. In: . . MGI: J:193413
Blackburn AC; Brown JS; Naber SP; Otis CN; Wood JT; Jerry DJ. 2003. BALB/c alleles for Prkdc and Cdkn2a interact to modify tumor susceptibility in Trp53+/- mice.. In: . . MGI: J:83496
Blackburn AC; Hill LZ; Roberts AL; Wang J; Aud D; Jung J; Nikolcheva T; Allard J; Peltz G; Otis CN; Cao QJ; Ricketts RS; Naber SP; Mollenhauer J; Poustka A; Malamud D; Jerry DJ. 2007. Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer risk.. In: . . MGI: J:122161
Blackburn AC; McLary SC; Naeem R; Luszcz J; Stockton DW; Donehower LA; Mohammed M; Mailhes JB; Soferr T; Naber SP; Otis CN; Jerry DJ. 2004. Loss of heterozygosity occurs via mitotic recombination in Trp53+/- mice and associates with mammary tumor susceptibility of the BALB/c strain.. In: . . MGI: J:91874
Blanco-Aparicio C; Canamero M; Cecilia Y; Pequeno B; Renner O; Ferrer I; Carnero A. 2010. Exploring the gain of function contribution of AKT to mammary tumorigenesis in mouse models.. In: . . MGI: J:157988
Blin-Wakkach C; Breuil V; Quincey D; Bagnis C; Carle GF. 2006. Establishment and characterization of new osteoclast progenitor cell lines derived from osteopetrotic and wild type mice.. In: . . MGI: J:111156
Blough MD; Zlatescu MC; Cairncross JG. 2007. O6-methylguanine-DNA methyltransferase regulation by p53 in astrocytic cells.. In: . . MGI: J:117421
Boesten LS; Zadelaar SM; De Clercq S; Francoz S; van Nieuwkoop A; Biessen EA; Hofmann F; Feil S; Feil R; Jochemsen AG; Zurcher C; Havekes LM; van Vlijmen BJ; Marine JC. 2006. Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death.. In: . . MGI: J:132251
Bolcun-Filas E; Rinaldi VD; White ME; Schimenti JC. 2014. Reversal of female infertility by Chk2 ablation reveals the oocyte DNA damage checkpoint pathway.. In: . . MGI: J:207474
Bondar T; Medzhitov R. 2010. p53-mediated hematopoietic stem and progenitor cell competition.. In: . . MGI: J:158953
Borges HL; Bird J; Wasson K; Cardiff RD; Varki N; Eckmann L; Wang JY. 2005. Tumor promotion by caspase-resistant retinoblastoma protein.. In: . . MGI: J:102483
Bortner DM; Rosenberg MP. 1997. Induction of mammary gland hyperplasia and carcinomas in transgenic mice expressing human cyclin E.. In: . . MGI: J:56329
Botchkarev VA; Komarova EA; Siebenhaar F; Botchkareva NV; Komarov PG; Maurer M; Gilchrest BA; Gudkov AV. 2000. p53 is essential for chemotherapy-induced hair loss.. In: . . MGI: J:64779
Botchkarev VA; Komarova EA; Siebenhaar F; Botchkareva NV; Sharov AA; Komarov PG; Maurer M; Gudkov AV; Gilchrest BA. 2001. p53 Involvement in the control of murine hair follicle regression.. In: . . MGI: J:108257
Bouchard C; Lee S; Paulus-Hock V; Loddenkemper C; Eilers M; Schmitt CA. 2007. FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf.. In: . . MGI: J:126308
Bowman T; Symonds H; Gu L; Yin C; Oren M; Van Dyke T. 1996. Tissue-specific inactivation of p53 tumor suppression in the mouse.. In: . . MGI: J:54288
Brichkina A; Bertero T; Loh HM; Nguyen NT; Emelyanov A; Rigade S; Ilie M; Hofman P; Gaggioli C; Bulavin DV. 2016. p38MAPK builds a hyaluronan cancer niche to drive lung tumorigenesis.. In: . . MGI: J:237913
Brochier C; Dennis G; Rivieccio MA; McLaughlin K; Coppola G; Ratan RR; Langley B. 2013. Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons.. In: . . MGI: J:198424
Bruins W; Bruning O; Jonker MJ; Zwart E; van der Hoeven TV; Pennings JL; Rauwerda H; de Vries A; Breit TM. 2008. The absence of Ser389 phosphorylation in p53 affects the basal gene expression level of many p53-dependent genes and alters the biphasic response to UV exposure in mouse embryonic fibroblasts.. In: . . MGI: J:132668
Bu P; Evrard YA; Lozano G; Dent SY. 2007. Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos.. In: . . MGI: J:121357
Buchstaller J; McKeever PE; Morrison SJ. 2012. Tumorigenic Cells Are Common in Mouse MPNSTs but Their Frequency Depends upon Tumor Genotype and Assay Conditions.. In: . . MGI: J:181460
Bullitt E; Wolthusen PA; Brubaker L; Lin W; Zeng D; Van Dyke T. 2006. Malignancy-associated vessel tortuosity: a computer-assisted, MR angiographic study of choroid plexus carcinoma in genetically engineered mice.. In: . . MGI: J:110646
Busuttil V; Droin N; McCormick L; Bernassola F; Candi E; Melino G; Green DR. 2010. NF-kappaB inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2.. In: . . MGI: J:165536
Camboni M; Hammond S; Martin LT; Martin PT. 2012. Induction of a regenerative microenvironment in skeletal muscle is sufficient to induce embryonal rhabdomyosarcoma in p53-deficient mice.. In: . . MGI: J:180024
Campana AL; Rondi-Reig L; Tobin C; Lohof AM; Picquet F; Falempin M; Weitzman JB; Mariani J. 2003. p53 inactivation leads to impaired motor synchronization in mice.. In: . . MGI: J:89637
Cancino GI; Yiu AP; Fatt MP; Dugani CB; Flores ER; Frankland PW; Josselyn SA; Miller FD; Kaplan DR. 2013. p63 Regulates Adult Neural Precursor and Newly Born Neuron Survival to Control Hippocampal-Dependent Behavior.. In: . . MGI: J:199784
Cang Y; Zhang J; Nicholas SA; Bastien J; Li B; Zhou P; Goff SP. 2006. Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells.. In: . . MGI: J:117820
Cang Y; Zhang J; Nicholas SA; Kim AL; Zhou P; Goff SP. 2007. DDB1 is essential for genomic stability in developing epidermis.. In: . . MGI: J:125911
Cano CE; Gommeaux J; Pietri S; Culcasi M; Garcia S; Seux M; Barelier S; Vasseur S; Spoto RP; Pebusque MJ; Dusetti NJ; Iovanna JL; Carrier A. 2009. Tumor protein 53-induced nuclear protein 1 is a major mediator of p53 antioxidant function.. In: . . MGI: J:143030
Caprio C; Baldini A. 2014. p53 suppression partially rescues the mutant phenotype in mouse models of DiGeorge syndrome.. In: . . MGI: J:216364
Celli GB; de Lange T. 2005. DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion.. In: . . MGI: J:105516
Cellurale C; Weston CR; Reilly J; Garlick DS; Jerry DJ; Sluss HK; Davis RJ. 2010. Role of JNK in a Trp53-dependent mouse model of breast cancer.. In: . . MGI: J:163993
Ch'ang HJ; Maj JG; Paris F; Xing HR; Zhang J; Truman JP; Cardon-Cardo C; Haimovitz-Friedman A; Kolesnick R; Fuks Z. 2005. ATM regulates target switching to escalating doses of radiation in the intestines.. In: . . MGI: J:98312
Chand HS; Montano G; Huang X; Randell SH; Mebratu Y; Petersen H; Tesfaigzi Y. 2014. A genetic variant of p53 restricts the mucous secretory phenotype by regulating SPDEF and Bcl-2 expression.. In: . . MGI: J:225704
Chao C; Herr D; Chun J; Xu Y. 2006. Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression.. In: . . MGI: J:109354
Charytonowicz E; Terry M; Coakley K; Telis L; Remotti F; Cordon-Cardo C; Taub RN; Matushansky I. 2012. PPARgamma agonists enhance ET-743-induced adipogenic differentiation in a transgenic mouse model of myxoid round cell liposarcoma.. In: . . MGI: J:184491
Chatoo W; Abdouh M; David J; Champagne MP; Ferreira J; Rodier F; Bernier G. 2009. The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity.. In: . . MGI: J:144496
Chaturvedi V; Sitailo LA; Qin JZ; Bodner B; Denning MF; Curry J; Zhang W; Brash D; Nickoloff BJ. 2005. Knockdown of p53 levels in human keratinocytes accelerates Mcl-1 and Bcl-x(L) reduction thereby enhancing UV-light induced apoptosis.. In: . . MGI: J:100759
Chau JF; Jia D; Wang Z; Liu Z; Hu Y; Zhang X; Jia H; Lai KP; Leong WF; Au BJ; Mishina Y; Chen YG; Biondi C; Robertson E; Xie D; Liu H; He L; Wang X; Yu Q; Li B. 2012. A crucial role for bone morphogenetic protein-Smad1 signalling in the DNA damage response.. In: . . MGI: J:205636
Chavez-Reyes A; Parant JM; Amelse LL; de Oca Luna RM; Korsmeyer SJ; Lozano G. 2003. Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets.. In: . . MGI: J:87065
Chen CM; Behringer RR. 2004. Ovca1 regulates cell proliferation, embryonic development, and tumorigenesis.. In: . . MGI: J:88090
Chen D; Kon N; Zhong J; Zhang P; Yu L; Gu W. 2013. Differential Effects on ARF Stability by Normal versus Oncogenic Levels of c-Myc Expression.. In: . . MGI: J:199251
Chen D; Zheng W; Lin A; Uyhazi K; Zhao H; Lin H. 2012. Pumilio 1 suppresses multiple activators of p53 to safeguard spermatogenesis.. In: . . MGI: J:182280
Chen J; Li Y; Yu TS; McKay RM; Burns DK; Kernie SG; Parada LF. 2012. A restricted cell population propagates glioblastoma growth after chemotherapy.. In: . . MGI: J:186769
Chen W; Cooper TK; Zahnow CA; Overholtzer M; Zhao Z; Ladanyi M; Karp JE; Gokgoz N; Wunder JS; Andrulis IL; Levine AJ; Mankowski JL; Baylin SB. 2004. Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis.. In: . . MGI: J:94629
Cheng Y; Chikwava K; Wu C; Zhang H; Bhagat A; Pei D; Choi JK; Tong W. 2016. LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.. In: . . MGI: J:234661
Cheo DL; Meira LB; Burns DK; Reis AM; Issac T; Friedberg EC. 2000. Ultraviolet B radiation-induced skin cancer in mice defective in the Xpc, Trp53, and Apex (HAP1) genes: genotype-specific effects on cancer predisposition and pathology of tumors. In: . . MGI: J:61421
Cheo DL; Meira LB; Hammer RE; Burns DK; Doughty AT; Friedberg EC. 1996. Synergistic interactions between XPC and p53 mutations in double-mutant mice: neural tube abnormalities and accelerated UV radiation-induced skin cancer.. In: . . MGI: J:103622
Cheung CC; Yang C; Berger T; Zaugg K; Reilly P; Elia AJ; Wakeham A; You-Ten A; Chang N; Li L; Wan Q; Mak TW. 2010. Identification of BERP (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABAA receptors.. In: . . MGI: J:161372
Chi YH; Ward JM; Cheng LI; Yasunaga J; Jeang KT. 2009. Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice.. In: . . MGI: J:147512
Chiang YJ; Difilippantonio MJ; Tessarollo L; Morse HC; Hodes RJ. 2012. Exon 1 disruption alters tissue-specific expression of mouse p53 and results in selective development of B cell lymphomas.. In: . . MGI: J:195018
Chin L; Artandi SE; Shen Q; Tam A; Lee SL; Gottlieb GJ; Greider CW; DePinho RA. 1999. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis.. In: . . MGI: J:54988
Cichowski K; Shih TS; Schmitt E; Santiago S; Reilly K; McLaughlin ME; Bronson RT; Jacks T. 1999. Mouse models of tumor development in neurofibromatosis type 1.. In: . . MGI: J:58876
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Wei L; Leibowitz BJ; Wang X; Epperly M; Greenberger J; Zhang L; Yu J. 2016. Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice.. In: . . MGI: J:239622
Wei Q; Dong G; Yang T; Megyesi J; Price PM; Dong Z. 2007. Activation and involvement of p53 in cisplatin-induced nephrotoxicity.. In: . . MGI: J:125768
Weiss WA; Israel M; Cobbs C; Holland E; James CD; Louis DN; Marks C; McClatchey AI; Roberts T; Van Dyke T; Wetmore C; Chiu IM; Giovannini M; Guha A; Higgins RJ; Marino S; Radovanovic I; Reilly K; Aldape K. 2002. Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum.. In: . . MGI: J:79667
Weitzman JB; Fiette L; Matsuo K; Yaniv M. 2000. JunD protects cells from p53-dependent senescence and apoptosis. In: . . MGI: J:65879
Wendel HG; Malina A; Zhao Z; Zender L; Kogan SC; Cordon-Cardo C; Pelletier J; Lowe SW. 2006. Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo.. In: . . MGI: J:112099
Wetmore C; Eberhart DE; Curran T. 2001. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.. In: . . MGI: J:67452
Whang YE; Tran C; Henderson C; Syljuasen RG; Rozengurt N; McBride WH; Sawyers CL. 2000. c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency.. In: . . MGI: J:62221
White JD; Rachel C; Vermeulen R; Davies M; Grounds MD. 2002. The role of p53 in vivo during skeletal muscle post-natal development and regeneration: studies in p53 knockout mice.. In: . . MGI: J:100049
Widau RC; Zheng Y; Sung CY; Zelivianskaia A; Roach LE; Bachmeyer KM; Abramova T; Desgardin A; Rosner A; Cunningham JM; Skapek SX. 2012. p19Arf Represses Platelet-Derived Growth Factor Receptor beta by Transcriptional and Posttranscriptional Mechanisms.. In: . . MGI: J:189250
Wikonkal NM; Remenyik E; Knezevic D; Zhang W; Liu M; Zhao H; Berton TR; Johnson DG; Brash DE. 2003. Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice.. In: . . MGI: J:84051
Wilhelmsson U; Eliasson C; Bjerkvig R; Pekny M. 2003. Loss of GFAP expression in high-grade astrocytomas does not contribute to tumor development or progression.. In: . . MGI: J:84194
Williams BO; Remington L; Albert DM; Mukai S; Bronson RT; Jacks T. 1994. Cooperative tumorigenic effects of germline mutations in Rb and p53.. In: . . MGI: J:19542
Williams BR; Mirzoeva OK; Morgan WF; Lin J; Dunnick W; Petrini JH. 2002. A murine model of nijmegen breakage syndrome.. In: . . MGI: J:75956
Williams TM; Lee H; Cheung MW; Cohen AW; Razani B; Iyengar P; Scherer PE; Pestell RG; Lisanti MP. 2004. Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia.. In: . . MGI: J:90334
Wilson AM; Morquette B; Abdouh M; Unsain N; Barker PA; Feinstein E; Bernier G; Di Polo A. 2013. ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo.. In: . . MGI: J:194279
Wissing ER; Boyer JG; Kwong JQ; Sargent MA; Karch J; McNally EM; Otsu K; Molkentin JD. 2014. P38alpha MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism.. In: . . MGI: J:219250
Wloga EH; Criniti V; Yamasaki L; Bronson RT. 2004. Lymphomagenesis and female-specific lethality in p53-deficient mice occur independently of E2f1.. In: . . MGI: J:91560
Wolvetang EJ; Wilson TJ; Sanij E; Busciglio J; Hatzistavrou T; Seth A; Hertzog PJ; Kola I. 2003. ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway.. In: . . MGI: J:81680
Wong KS; Li YJ; Howard J; Ben-David Y. 1999. Loss of p53 in F-MuLV induced-erythroleukemias accelerates the acquisition of mutational events that confers immortality and growth factor independence.. In: . . MGI: J:58012
Woodward J; Taylor GC; Soares DC; Boyle S; Sie D; Read D; Chathoth K; Vukovic M; Tarrats N; Jamieson D; Campbell KJ; Blyth K; Acosta JC; Ylstra B; Arends MJ; Kranc KR; Jackson AP; Bickmore WA; Wood AJ. 2016. Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability.. In: . . MGI: J:236233
Wu B; Qiu W; Wang P; Yu H; Cheng T; Zambetti GP; Zhang L; Yu J. 2007. p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion.. In: . . MGI: J:135945
Wu J; Trogadis J; Bremner R. 2001. Rod and cone degeneration in the rd mouse is p53 independent.. In: . . MGI: J:126023
Wu L; Multani AS; He H; Cosme-Blanco W; Deng Y; Deng JM; Bachilo O; Pathak S; Tahara H; Bailey SM; Deng Y; Behringer RR; Chang S. 2006. Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres.. In: . . MGI: J:112184
Wu X; Northcott PA; Dubuc A; Dupuy AJ; Shih DJ; Witt H; Croul S; Bouffet E; Fults DW; Eberhart CG; Garzia L; Van Meter T; Zagzag D; Jabado N; Schwartzentruber J; Majewski J; Scheetz TE; Pfister SM; Korshunov A; Li XN; Scherer SW; Cho YJ; Akagi K; MacDonald TJ; Koster J; McCabe MG; Sarver AL; Collins VP; Weiss WA; Largaespada DA; Collier LS; Taylor MD. 2012. Clonal selection drives genetic divergence of metastatic medulloblastoma.. In: . . MGI: J:181542
Wu X; Sandhu S; Patel N; Triggs-Raine B; Ding H. 2010. EMG1 is essential for mouse pre-implantation embryo development.. In: . . MGI: J:165972
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Xiao A; Wu H; Pandolfi PP; Louis DN; Van Dyke T. 2002. Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation.. In: . . MGI: J:77132
Xing D; Orsulic S. 2006. A mouse model for the molecular characterization of brca1-associated ovarian carcinoma.. In: . . MGI: J:112932
Xiong S; Pant V; Suh YA; Van Pelt CS; Wang Y; Valentin-Vega YA; Post SM; Lozano G. 2010. Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4.. In: . . MGI: J:164225
Xiong S; Tu H; Kollareddy M; Pant V; Li Q; Zhang Y; Jackson JG; Suh YA; Elizondo-Fraire AC; Yang P; Chau G; Tashakori M; Wasylishen AR; Ju Z; Solomon H; Rotter V; Liu B; El-Naggar AK; Donehower LA; Martinez LA; Lozano G. 2014. Pla2g16 phospholipase mediates gain-of-function activities of mutant p53.. In: . . MGI: J:212246
Xiong S; Van Pelt CS; Elizondo-Fraire AC; Fernandez-Garcia B; Lozano G. 2007. Loss of Mdm4 results in p53-dependent dilated cardiomyopathy.. In: . . MGI: J:137114
Xiong X; Zhao Y; Tang F; Wei D; Thomas D; Wang X; Liu Y; Zheng P; Sun Y. 2014. Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis.. In: . . MGI: J:223276
Xu E; Zhang J; Chen X. 2013. MDM2 expression is repressed by the RNA-binding protein RNPC1 via mRNA stability.. In: . . MGI: J:198026
Xu H; Menendez S; Schlegelberger B; Bae N; Aplan PD; Gohring G; Deblasio TR; Nimer SD. 2012. Loss of p53 accelerates the complications of myelodysplastic syndrome in a NUP98-HOXD13-driven mouse model.. In: . . MGI: J:192937
Xu M; Yu Q; Subrahmanyam R; Difilippantonio MJ; Ried T; Sen JM. 2008. Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo.. In: . . MGI: J:132650
Xu Y; Yang EM; Brugarolas J; Jacks T; Baltimore D. 1998. Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice.. In: . . MGI: J:49262
Xu Z; Sharp PP; Yao Y; Segal D; Ang CH; Khaw SL; Aubrey BJ; Gong J; Kelly GL; Herold MJ; Strasser A; Roberts AW; Alexander WS; Burns CJ; Huang DC; Glaser SP. 2016. BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.. In: . . MGI: J:232796
Yahagi N; Shimano H; Matsuzaka T; Najima Y; Sekiya M; Nakagawa Y; Ide T; Tomita S; Okazaki H; Tamura Y; Iizuka Y; Ohashi K; Gotoda T; Nagai R; Kimura S; Ishibashi S; Osuga J; Yamada N. 2003. p53 Activation in adipocytes of obese mice.. In: . . MGI: J:120652
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Yallowitz AR; Li D; Lobko A; Mott D; Nemajerova A; Marchenko N. 2015. Mutant p53 Amplifies Epidermal Growth Factor Receptor Family Signaling to Promote Mammary Tumorigenesis.. In: . . MGI: J:220187
Yamanishi Y; Boyle DL; Pinkoski MJ; Mahboubi A; Lin T; Han Z; Zvaifler NJ; Green DR; Firestein GS. 2002. Regulation of Joint Destruction and Inflammation by p53 in Collagen-Induced Arthritis.. In: . . MGI: J:73730
Yan CT; Boboila C; Souza EK; Franco S; Hickernell TR; Murphy M; Gumaste S; Geyer M; Zarrin AA; Manis JP; Rajewsky K; Alt FW. 2007. IgH class switching and translocations use a robust non-classical end-joining pathway.. In: . . MGI: J:126758
Yan H; Blackburn AC; McLary SC; Tao L; Roberts AL; Xavier EA; Dickinson ES; Seo JH; Arenas RB; Otis CN; Cao QJ; Lawlor RG; Osborne BA; Kittrell FS; Medina D; Jerry DJ. 2010. Pathways contributing to development of spontaneous mammary tumors in BALB/c-Trp53+/- mice.. In: . . MGI: J:158515
Yan J; Di Y; Shi H; Rao H; Huo K. 2010. Overexpression of SCYL1-BP1 stabilizes functional p53 by suppressing MDM2-mediated ubiquitination.. In: . . MGI: J:165421
Yan W; Scoumanne A; Jung YS; Xu E; Zhang J; Zhang Y; Ren C; Sun P; Chen X. 2016. Mice deficient in poly(C)-binding protein 4 are susceptible to spontaneous tumors through increased expression of ZFP871 that targets p53 for degradation.. In: . . MGI: J:231514
Yang A; Reeves RH. 2011. Increased Survival following Tumorigenesis in Ts65Dn Mice That Model Down Syndrome.. In: . . MGI: J:171978
Yang DH; Fazili Z; Smith ER; Cai KQ; Klein-Szanto A; Cohen C; Horowitz IR; Xu XX. 2006. Disabled-2 Heterozygous Mice Are Predisposed to Endometrial and Ovarian Tumorigenesis and Exhibit Sex-Biased Embryonic Lethality in a p53-Null Background.. In: . . MGI: J:110173
Yang X; Klein R; Tian X; Cheng HT; Kopan R; Shen J. 2004. Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway.. In: . . MGI: J:90392
Yao R; Natsume Y; Saiki Y; Shioya H; Takeuchi K; Yamori T; Toki H; Aoki I; Saga T; Noda T. 2012. Disruption of Tacc3 function leads to in vivo tumor regression.. In: . . MGI: J:179414
Yazinski SA; Westcott PM; Ong K; Pinkas J; Peters RM; Weiss RS. 2009. Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration.. In: . . MGI: J:155573
Yeh JR; Ju R; Brdlik CM; Zhang W; Zhang Y; Matyskiela ME; Shotwell JD; Crews CM. 2006. Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest.. In: . . MGI: J:111701
Yi W; Hu X; Chen Z; Liu L; Tian Y; Chen H; Cong YS; Yang F; Zhang L; Rudolph KL; Zhang Z; Zhao Y; Ju Z. 2015. Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner.. In: . . MGI: J:225921
Yin C; Knudson CM; Korsmeyer SJ; Van Dyke T. 1997. Bax suppresses tumorigenesis and stimulates apoptosis in vivo.. In: . . MGI: J:38331
Yin Y; Stahl BC; DeWolf WC; Morgentaler A. 2002. P53 and Fas are sequential mechanisms of testicular germ cell apoptosis.. In: . . MGI: J:105850
Yin Y; Stahl BC; DeWolf WC; Morgentaler A. 1998. p53-mediated germ cell quality control in spermatogenesis.. In: . . MGI: J:110639
Yin Z; Menendez D; Resnick MA; French JE; Janardhan KS; Jetten AM. 2012. RAP80 is critical in maintaining genomic stability and suppressing tumor development.. In: . . MGI: J:191827
Young LC; Keuling AM; Lai R; Nation PN; Tron VA; Andrew SE. 2007. The associated contributions of p53 and the DNA mismatch repair protein Msh6 to spontaneous tumorigenesis.. In: . . MGI: J:125800
Yu WN; Nogueira V; Sobhakumari A; Patra KC; Bhaskar PT; Hay N. 2015. Systemic Akt1 Deletion after Tumor Onset in p53(-/-) Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration.. In: . . MGI: J:232525
Yuan L; Liu JG; Hoja MR; Lightfoot DA; Hoog C. 2001. The checkpoint monitoring chromosomal pairing in male meiotic cells is p53-independent.. In: . . MGI: J:105790
Zeini M; Traves PG; Lopez-Fontal R; Pantoja C; Matheu A; Serrano M; Bosca L; Hortelano S. 2006. Specific contribution of p19(ARF) to nitric oxide-dependent apoptosis.. In: . . MGI: J:139500
Zelazny E; Li B; Anagnostopoulos AM; Coleman A; Perkins AS. 2001. Cooperating Oncogenic Events in Murine Mammary Tumorigenesis: Assessment of ErbB2, Mutant p53, and Mouse Mammary Tumor Virus.. In: . . MGI: J:70644
Zeng Q; Oakley B. 1999. p53 and Bax: putative death factors in taste cell turnover.. In: . . MGI: J:57477
Zhang C; Liu J; Liang Y; Wu R; Zhao Y; Hong X; Lin M; Yu H; Liu L; Levine AJ; Hu W; Feng Z. 2013. Tumour-associated mutant p53 drives the Warburg effect.. In: . . MGI: J:226220
Zhang G; Xie Y; Zhou Y; Xiang C; Chen L; Zhang C; Hou X; Chen J; Zong H; Liu G. 2017. p53 pathway is involved in cell competition during mouse embryogenesis.. In: . . MGI: J:239540
Zhang J; Cho SJ; Shu L; Yan W; Guerrero T; Kent M; Skorupski K; Chen H; Chen X. 2011. Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas.. In: . . MGI: J:174192
Zhang J; Schweers B; Dyer MA. 2004. The first knockout mouse model of retinoblastoma.. In: . . MGI: J:103618
Zhang J; Xu E; Ren C; Yan W; Zhang M; Chen M; Cardiff RD; Imai DM; Wisner E; Chen X. 2014. Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors.. In: . . MGI: J:216929
Zhang L; Anglesio MS; O'sullivan M; Zhang F; Yang G; Sarao R; Nghiem MP; Cronin S; Hara H; Melnyk N; Li L; Wada T; Liu PP; Farrar J; Arceci RJ; Sorensen PH; Penninger JM. 2007. The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers.. In: . . MGI: J:125183
Zhang L; Reynolds TL; Shan X; Desiderio S. 2011. Coupling of v(d)j recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis.. In: . . MGI: J:168974
Zhang M; Behbod F; Atkinson RL; Landis MD; Kittrell F; Edwards D; Medina D; Tsimelzon A; Hilsenbeck S; Green JE; Michalowska AM; Rosen JM. 2008. Identification of tumor-initiating cells in a p53-null mouse model of breast cancer.. In: . . MGI: J:138898
Zhang Q; He X; Chen L; Zhang C; Gao X; Yang Z; Liu G. 2012. Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development.. In: . . MGI: J:188490
Zhang S; Zheng M; Kibe R; Huang Y; Marrero L; Warren S; Zieske AW; Iwakuma T; Kolls JK; Cui Y. 2011. Trp53 negatively regulates autoimmunity via the STAT3-Th17 axis.. In: . . MGI: J:174321
Zhang X; Podsypanina K; Huang S; Mohsin SK; Chamness GC; Hatsell S; Cowin P; Schiff R; Li Y. 2005. Estrogen receptor positivity in mammary tumors of Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations.. In: . . MGI: J:99546
Zhao F; Obermann S; von Wasielewski R; Haile L; Manns MP; Korangy F; Greten TF. 2009. Increase in frequency of myeloid-derived suppressor cells in mice with spontaneous pancreatic carcinoma.. In: . . MGI: J:162293
Zheng S; El-Naggar AK; Kim ES; Kurie JM; Lozano G. 2007. A genetic mouse model for metastatic lung cancer with gender differences in survival.. In: . . MGI: J:129627
Zhou S; Gu L; He J; Zhang H; Zhou M. 2011. MDM2 Regulates Vascular Endothelial Growth Factor mRNA Stabilization in Hypoxia.. In: . . MGI: J:178311
Zhu F; Dolle ME; Berton TR; Kuiper RV; Capps C; Espejo A; McArthur MJ; Bedford MT; van Steeg H; de Vries A; Johnson DG. 2010. Mouse models for the p53 R72P polymorphism mimic human phenotypes.. In: . . MGI: J:162466
Zhu M; Weiss RS. 2007. Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells.. In: . . MGI: J:123894
Zhu Y; Guignard F; Zhao D; Liu L; Burns DK; Mason RP; Messing A; Parada LF. 2005. Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma.. In: . . MGI: J:101868
Zhuang J; Kamp WM; Li J; Liu C; Kang JG; Wang PY; Hwang PM. 2016. Forkhead Box O3A (FOXO3) and the Mitochondrial Disulfide Relay Carrier (CHCHD4) Regulate p53 Protein Nuclear Activity in Response to Exercise.. In: . . MGI: J:237639
Zhuang J; Wang PY; Huang X; Chen X; Kang JG; Hwang PM. 2013. Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.. In: . . MGI: J:201969
Zindy F; Lee Y; Kawauchi D; Ayrault O; Merzoug LB; Li Y; McKinnon PJ; Roussel MF. 2015. Dicer Is Required for Normal Cerebellar Development and to Restrain Medulloblastoma Formation.. In: . . MGI: J:237792
Zindy F; Nilsson LM; Nguyen L; Meunier C; Smeyne RJ; Rehg JE; Eberhart C; Sherr CJ; Roussel MF. 2003. Hemangiosarcomas, medulloblastomas, and other tumors in Ink4c/p53-null mice.. In: . . MGI: J:85515
Zou X; Cong F; Coutts M; Cattoretti G; Goff SP; Calame K. 2000. p53 deficiency increases transformation by v-Abl and rescues the ability of a C-terminally truncated v-Abl mutant To induce pre-B lymphoma In vivo. In: . . MGI: J:59574
Zou Y; Niu W; Qin S; Downes M; Burns DK; Zhang CL. 2012. The nuclear receptor TLX is required for gliomagenesis within the adult neurogenic niche.. In: . . MGI: J:192734
Zwaferink H; Stockinger S; Reipert S; Decker T. 2008. Stimulation of inducible nitric oxide synthase expression by beta interferon increases necrotic death of macrophages upon Listeria monocytogenes infection.. In: . . MGI: J:133523
Zwolinska AK; Heagle Whiting A; Beekman C; Sedivy JM; Marine JC. 2012. Suppression of Myc oncogenic activity by nucleostemin haploinsufficiency.. In: . . MGI: J:186119
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ter Brugge PJ; Ta VB; de Bruijn MJ; Keijzers G; Maas A; van Gent DC; Hendriks RW. 2009. A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigen.. In: . . MGI: J:150315
van Kesteren PC; Beems RB; Luijten M; Robinson J; de Vries A; van Steeg H. 2009. DNA repair-deficient Xpa/p53 knockout mice are sensitive to the non-genotoxic carcinogen cyclosporine A: escape of initiated cells from immunosurveillance?. In: . . MGI: J:146183
van Kesteren PC; Zwart PE; Pennings JL; Gottschalk WH; Kleinjans JC; van Delft JH; van Steeg H; Luijten M. 2011. Deregulation of Cancer-Related Pathways in Primary Hepatocytes Derived from DNA Repair-Deficient Xpa-/-p53+/- Mice upon Exposure to Benzo[a]pyrene.. In: . . MGI: J:175079
van Kranen HJ; Westerman A; Berg RJ; Kram N; van Kreijl CF; Wester PW; de Gruijl FR. 2005. Dose-dependent effects of UVB-induced skin carcinogenesis in hairless p53 knockout mice.. In: . . MGI: J:96767
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van de Wetering CI; Knudson CM. 2007. Chromosomal instability and supernumerary centrosomes represent precursor defects in a mouse model of T-cell lymphoma.. In: . . MGI: J:124884
van der Pluijm I; Garinis GA; Brandt RM; Gorgels TG; Wijnhoven SW; Diderich KE; de Wit J; Mitchell JR; van Oostrom C; Beems R; Niedernhofer LJ; Velasco S; Friedberg EC; Tanaka K; van Steeg H; Hoeijmakers JH; van der Horst GT. 2006. Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome.. In: . . MGI: J:122013
. 2016. Recurrent MET fusion genes represent a drug target in pediatric glioblastoma.. In: . . MGI: J:240751

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Nf1tm1Tyj

Allele Symbol: Nf1tm1Tyj

Trp53tm1Tyj

Allele Symbol: Trp53tm1Tyj

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Genotype: Trp53tm1Tyj related

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Genotype: Nf1tm1Tyj/Nf1+ Trp53tm1Tyj/Trp53+involves: 129/Sv * C57BL/6

nervous system phenotype

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neoplasm

Genotype: Nf1tm1Tyj/Nf1+ Trp53tm1Tyj/Trp53+involves: 129S2/SvPas

nervous system phenotype

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Nf1^tm1Tyj

Allele Symbol: Nf1^tm1Tyj

Trp53^tm1Tyj

Allele Symbol: Trp53^tm1Tyj

Genotype: Trp53^tm1Tyj related

Genotype: Nf1^tm1Tyj/Nf1⁺ Trp53^tm1Tyj/Trp53⁺
involves: 129/Sv * C57BL/6

Genotype: Nf1^tm1Tyj/Nf1⁺ Trp53^tm1Tyj/Trp53⁺
involves: 129S2/SvPas

Additional - Nf1^tm1Tyj related

Additional - Trp53^tm1Tyj related