The mouse Thy1 gene promoter drives expression of a fusion protein made from ECFP and the bovine Vamp2 (Syb2) gene. Expression of the bovine gene is not eliminated. ECFP expression is neuron specific and signal may be found in various brain regions and neuromuscular junctions (NMJ).
Dr. Thomas C. Sudhof, Stanford University School of Medicine
Genetic Background | Generation |
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Allele Type |
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Transgenic (Reporter) |
Mice that are homozygous for the transgene are viable, normal in size and do not display any gross physical abnormalities. The mouse Thy1 gene promoter drives expression of a fusion protein made from ECFP and the bovine Vamp2 (Syb2) gene. Expression of the bovine gene is not eliminated. ECFP expression is neuron specific and signal may be found in various brain regions and neuromuscular junctions (NMJ).
A transgenic vector incorporating an ECFP/bovine Vamp2 (Syb2) fusion protein directed by a mouse Thy1 promoter was created. Approximately 10 copies of the transgene were introduced to a mixed B6SJL (C57BL/6 x SJL) background.
Expressed Gene | CFP, Cyan Fluorescent Protein, jellyfish |
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Site of Expression | ECFP expression is neuron specific and signal may be found in various brain regions and neuromuscular junctions. |
Allele Name | transgene insertion 1, Thomas C Sudhof |
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Allele Type | Transgenic (Reporter) |
Allele Synonym(s) | BRO Syb2-ECFP |
Gene Symbol and Name | Tg(Thy1-ECFP/VAMP2)1Sud, transgene insertion 1, Thomas C Sudhof |
Gene Synonym(s) | |
Promoter | Thy1, thymus cell antigen 1, theta, mouse, laboratory |
Expressed Gene | CFP, Cyan Fluorescent Protein, jellyfish |
Site of Expression | ECFP expression is neuron specific and signal may be found in various brain regions and neuromuscular junctions. |
Strain of Origin | C57BL/6 x SJL |
Chromosome | UN |
Molecular Note | A transgenic vector incorporating an ECFP/bovine Vamp2 (Syb2) fusion protein directed by a mouse Thy1 promoter was created. Approximately 10 copies of the transgene were introduced to a mixed C57BL/6 x SJL background. ECFP expression is neuron specific and signal may be found in various brain regions and neuromuscular junctions (NMJ). |
When maintained as a live colony, hemizygotes or homozygotes may be bred. Breeding to B6SJLF1 improves productivity.
When using the BRO; Syb 2-ECFP transgenic, UTSD#1896 mouse strain in a publication, please cite the originating article(s) and include JAX stock #008004 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Hemizygous or Non carrier for Tg(Thy1-ECFP/VAMP2)1Sud |
Frozen Mouse Embryo | B6;SJL-Tg(Thy1-ECFP/VAMP2)1Sud/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6;SJL-Tg(Thy1-ECFP/VAMP2)1Sud/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6;SJL-Tg(Thy1-ECFP/VAMP2)1Sud/J Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | B6;SJL-Tg(Thy1-ECFP/VAMP2)1Sud/J Frozen Embryo | $3373.50 |
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