Overview

Also Known As: B6-iDTR, ROSA26iDTR

The Cre-inducible expression of DTR in these iDTR mutant mice render cells susceptible to ablation following Diphtheria toxin administration.

Donating Investigator

Ari Waisman, Johannes Gutenberg University of Mainz

Genetic overview

Genetic Background	Generation
	N?+pN2F13 (2019-07-12 00:00:00)

Gt(ROSA)26Sor^{tm1(HBEGF)Awai}

Allele Type	Gene Symbol	Gene Name
Targeted (Conditional ready (e.g. floxed), Inserted expressed sequence)	Gt(ROSA)26Sor	gene trap ROSA 26, Philippe Soriano

View Genetics

Research Applications

Neurobiology Research
Research Tools

View All Research Applications

Base Price

Starting at:

$255.00 Domestic price for female 4-week

View Price List

Details

Detailed Description

Mice homozygous for this iDTR mutation are viable and fertile. These mice have the simian Diphtheria Toxin Receptor (DTR; from simian Hbegf) inserted into the Gt(ROSA)26Sor (ROSA26) locus. Widespread expression of DTR is blocked by an upstream loxP-flanked STOP sequence. When bred to Cre recombinase-expressing mice, the STOP sequence is deleted in tissues where Cre is present, permitting DTR expression. Cells expressing DTR are rendered susceptible to ablation following Diphtheria toxin administration.

For example, when bred to a strain with a Cd19 null allele and expressing Cre recombinase during the B lymphocyte development (Stock No. 006785), this mutant mouse strain may be useful in studies of lymphocyte cell ablation.

When crossed to a strain expressing Cre recombinase in oocytes (see Stock No. 011062), this mutant mouse strain may be useful in studies of ovarian development.

When crossed to a strain expressing Cre recombinase in the pituitary and, at lower levels, in the testes (see Stock No. 011069), this mutant mouse strain may be useful in studies of metabolic dysfunction.

Of note, iDTR mice are also available on a BALB/cBy congenic background (as Stock No. 008040) and a NOD congenic background (as Stock No. 016603).

Of note, The Jackson Laboratory Repository also distributes RC::L-DTA mice (Stock No. 026944), which have Cre recombinase-dependent inverted tox176 attenuated diphtheria toxin subunit alpha gene (DTA*G128D), as well as widespread eGFP fluorescence in the absence of Cre recombinase.

Development

A targeting vector was designed with a loxP-flanked STOP cassette upstream of the open reading frame of the simian Diphtheria Toxin Receptor (DTR; from simian hbEGF cDNA (base pair 56-682)). The loxP-flanked region contains two SV40 polyA signals, an frt-flanked neomycin resistance gene, and a transcriptional STOP cassette. This construct was inserted into the Gt(ROSA)26Sor locus via electroporation of C57BL/6-derived Bruce4 ES embryonic stem (ES) cells. Correctly targeted ES cells were microinjected in CB20 blastocysts. Chimeric mice were bred to C57BL/6 to generate heterozygous "iDTR" mice. The donating investigator reported that these iDTR mice were maintained as homozygotes on the C57BL/6 genetic background (see SNP note below) prior to arrival at The Jackson Laboratory.

A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 3 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.

Expression Data

Expressed Gene	DTR, Simian Diphtheria Toxin Receptor,
Expressed Gene	HBEGF, heparin binding EGF like growth factor, chimpanzee
Site of Expression

Control Suggestions

000664 C57BL/6J

Additional Information

Considerations for Choosing Controls

Selected References

Buch T; Heppner FL; Tertilt C; Heinen TJ; Kremer M; Wunderlich FT; Jung S; Waisman A. 2005. A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat Methods 2(6):419-26PubMed: 15908920 MGI: J:131076

View All References

Genetics

Gt(ROSA)26Sor^{tm1(HBEGF)Awai}

Allele Symbol: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}

Allele Name	targeted mutation 1, Ari Waisman
Allele Type	Targeted (Conditional ready (e.g. floxed), Inserted expressed sequence)
Allele Synonym(s)	targeted mutation 1, Ari Waisman; Gt(ROSA)26Sor^{tm1(HBEGF)Awai}
Gene Symbol and Name	Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano
Gene Synonym(s)	beta geo; ROSA26; R26; Gtrgeo26; Gtrosa26; Gtrgeo26; Gtrosa26; AV258896; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26; SETD5-AS1; Thumpd3as1
Expressed Gene	DTR, Simian Diphtheria Toxin Receptor,
Expressed Gene	HBEGF, heparin binding EGF like growth factor, chimpanzee
Strain of Origin	B6.Cg-Thy1^a
Chromosome	6
Molecular Note	A targeting vector was designed with a loxP-flanked STOP cassette upstream of the open reading frame of the simian Diphtheria Toxin Receptor (DTR; from simian hbEGF cDNA (base pair 56-682)). The loxP-flanked region contains two SV40 polyA signals, an frt-flanked neomycin resistance gene, and a transcriptional STOP cassette. This construct was inserted into the Gt(ROSA)26Sor locus via electroporation of C57BL/6-derived Bruce4 ES embryonic stem (ES) cells. Widespread expression of DTR is blocked by an upstream loxP-flanked STOP sequence. When bred to Cre recombinase-expressing mice, the STOP sequence is deleted in tissues where Cre is present, permitting DTR expression. Cells expressing DTR are rendered susceptible to ablation following Diphtheria toxin administration.
Mutations Made By	Ari Waisman, Johannes Gutenberg University of Mainz

Disease/Phenotype

Disease Terms

Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.

isolated growth hormone deficiency

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Neurobiology Research
- Cre-lox System
  - loxP-flanked Sequences
Research Tools
- Cre-lox System
  - loxP-flanked Sequences
- Genetics Research
  - Mutagenesis and Transgenesis: Cre-lox System
  - Mutagenesis and Transgenesis
- Diabetes and Obesity Research
  - loxP
- Reproductive Biology Research
  - Cre-lox System
- Cell Biology Research
- Cardiovascular Research
  - Cre-lox System
- Developmental Biology Research
  - Cre-lox System

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Cd19^tm1(cre)Cgn/? Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor^{tm1(HBEGF)Awai}
involves: 129P2/OlaHsd * C57BL/6

hematopoietic system phenotype

abnormal B cell morphology
- CD19-expressing B cells are absent after intraperitoneal injection of diptheria toxin for 7 days

abnormal bone marrow cell number
- in bone marrow, drastic reductions in numbers of immature and mature B cells is observed

abnormal lymphocyte cell number
- in bone marrow, drastic reductions in numbers of immature and mature B cells is observed

abnormal lymphocyte morphology
- after 3 or 7 days of diptheria toxin treatment, splenic B to T lymphocyte ratio decreases from 2.1 in controls to 0.6 and 0.3 respectively in double transgenic mice

abnormal splenic cell ratio
- with diptheria toxin treatment 3 times daily for 7 days, B cells are virtually absent from the spleen

absent immature B cells
- in bone marrow, drastic reductions in numbers of immature and mature B cells is observed

absent mature B cells
- in bone marrow, drastic reductions in numbers of immature and mature B cells is observed

immune system phenotype

abnormal B cell morphology
- CD19-expressing B cells are absent after intraperitoneal injection of diptheria toxin for 7 days

abnormal lymph node cell ratio
- with diptheria toxin treatment 3 times daily for 7 days, B cells are virtually absent from the lymph nodes

abnormal lymphocyte cell number
- in bone marrow, drastic reductions in numbers of immature and mature B cells is observed

abnormal lymphocyte morphology
- after 3 or 7 days of diptheria toxin treatment, splenic B to T lymphocyte ratio decreases from 2.1 in controls to 0.6 and 0.3 respectively in double transgenic mice

abnormal splenic cell ratio
- with diptheria toxin treatment 3 times daily for 7 days, B cells are virtually absent from the spleen

absent immature B cells
- in bone marrow, drastic reductions in numbers of immature and mature B cells is observed

absent mature B cells
- in bone marrow, drastic reductions in numbers of immature and mature B cells is observed

Genotype: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor^{tm1(HBEGF)Awai} Tg(Gdf9-icre)5092Coo/0
involves: C57BL/6

cellular phenotype

oocyte degeneration
- oocytes have undergone apoptosis in preantral follicles

endocrine/exocrine gland phenotype

abnormal granulosa cell morphology
- cells have undergone apoptosis in preantral follicles

abnormal ovarian follicle morphology
- with diptheria toxin administration to 8-week-old pregnant females, oocytes and granulosa cells in preantral oocytes show apoptosis 9 days later, in contrast to treated controls where atretic follicles but not preantral follicles show apoptosis

abnormal ovary morphology

reproductive system phenotype

abnormal granulosa cell morphology
- cells have undergone apoptosis in preantral follicles

abnormal ovarian follicle morphology
- with diptheria toxin administration to 8-week-old pregnant females, oocytes and granulosa cells in preantral oocytes show apoptosis 9 days later, in contrast to treated controls where atretic follicles but not preantral follicles show apoptosis

abnormal ovary morphology

oocyte degeneration
- oocytes have undergone apoptosis in preantral follicles

Genotype: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺ Tg(Gh1-cre)bKnmn/0
involves: C57BL/6 * FVB/N

adipose tissue phenotype

increased retroperitoneal fat pad weight
- in diphtheria toxin-treated mice

increased subcutaneous adipose tissue amount
- in diphtheria toxin-treated mice

increased total body fat amount
- in diphtheria toxin-treated mice fed standard chow or a high fat diet

integument phenotype

increased subcutaneous adipose tissue amount
- in diphtheria toxin-treated mice

liver/biliary system phenotype

decreased liver triglyceride level
- in diphtheria toxin-treated mice fed a high-fat

decreased liver weight
- in diphtheria toxin-treated mice fed standard chow or a high fat diet

nervous system phenotype

decreased somatotroph cell number
- in diphtheria toxin-treated mice

small adenohypophysis
- in diphtheria toxin-treated mice

behavior/neurological phenotype

decreased fluid intake
- in diphtheria toxin-treated mice fed a low-fat

endocrine/exocrine gland phenotype

decreased somatotroph cell number
- in diphtheria toxin-treated mice

small adenohypophysis
- in diphtheria toxin-treated mice

growth/size/body region phenotype

decreased body weight
- in diphtheria toxin-treated mice fed a high fat diet

decreased lean body mass
- in diphtheria toxin-treated mice

homeostasis/metabolism phenotype

abnormal circulating hormone level

abnormal energy expenditure

abnormal gas homeostasis

abnormal glucose homeostasis

decreased circulating glucose level
- in diphtheria toxin-treated mice when fed a high-fat diet or a low-fat diet during an insulin tolerance test
- in diphtheria toxin-treated mice when fed standard chow

decreased circulating growth hormone level
- in diphtheria toxin-treated mice fed a high-fat or low-fat diet

decreased circulating insulin level
- in diphtheria toxin-treated mice when a high-fat diet or a low-fat diet

decreased circulating insulin-like growth factor I level
- in diphtheria toxin-treated mice fed a high-fat or low-fat diet

decreased energy expenditure
- in diphtheria toxin-treated mice fed a low-fat during the nocturnal phase or when mice are fed a high-fat diet

decreased liver triglyceride level
- in diphtheria toxin-treated mice fed a high-fat

decreased oxygen consumption
- in diphtheria toxin-treated mice fed a low-fat during the nocturnal phase

impaired glucose tolerance
- in diphtheria toxin-treated mice fed a high-fat

increased circulating leptin level
- in diphtheria toxin-treated mice

increased insulin sensitivity
- in diphtheria toxin-treated mice when fed standard chow, a high-fat diet, or a low-fat diet

increased respiratory quotient
- in diphtheria toxin-treated mice fed a low-fat

Genotype: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺ Tg(Krt1-15-cre/PGR)22Cot/0
involves: C57BL/6J * SJL/J

cellular phenotype

increased cell proliferation
- mice treated with RU486 prior to diphtheria toxin injection exhibit reduced proliferation and atrophy in the esophageal epithelia compared with wild-type mice

digestive/alimentary phenotype

abnormal esophageal epithelium morphology
- mice treated with RU486 prior to diphtheria toxin injection exhibit reduced proliferation and atrophy in the esophageal epithelia compared with wild-type mice

References

Buch T; Heppner FL; Tertilt C; Heinen TJ; Kremer M; Wunderlich FT; Jung S; Waisman A. 2005. A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat Methods 2(6):419-26PubMed: 15908920 MGI: J:131076

Additional References

Chen Y; Ikeda K; Yoneshiro T; Scaramozza A; Tajima K; Wang Q; Kim K; Shinoda K; Sponton CH; Brown Z; Brack A; Kajimura S. 2019. Thermal stress induces glycolytic beige fat formation via a myogenic state. Nature 565(7738):180-185PubMed: 30568302 MGI: J:269371
Kreisel T; Wolf B; Keshet E; Licht T. 2019. Unique role for dentate gyrus microglia in neuroblast survival and in VEGF-induced activation. Glia 67(4):594-618PubMed: 30453385 MGI: J:271655

Additional - Gt(ROSA)26Sor^{tm1(HBEGF)Awai} related

Technical Support

Contact Technical Support

Genotyping Protocols
- Probe: Gt(rosa)26sor^Tm1Sor Probe
- Standard PCR: Gt(ROSA)26Sor^tm1sor STD
- Genotyping resources and troubleshooting
Dietary Information
- LabDiet® 5K52 formulation (6% fat)
Breeding Considerations

When maintaining a live colony, homozygous mice may be bred.
- Additional Breeding and Husbandry Support
Mating System
- Homozygote x Homozygote
Citation
When using the ROSA26iDTR mouse strain in a publication, please cite the originating article(s) and include JAX stock #007900 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

AX11 (Maximum)

Pricing & Availability

Available Now

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service	Genotype	Price
	Heterozygous for Gt(ROSA)26Sor<tm1(HBEGF)Awai>

We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.

Related Products and Services

Frozen Mouse Embryo

$2,595.00 per straw or vial

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Terms Of Use

Terms of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCT(S)" means biological materials supplied by JACKSON, and their derivatives. "SERVICES" means projects conducted by JACKSON for other parties that may include but are not limited to the use of MICE or PRODUCTS. "RECIPIENT" means each recipient of MICE, PRODUCTS, or SERVICES provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE, PRODUCTS or SERVICES from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON’s prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED "AS IS". JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

Credit for PRODUCTS or SERVICES

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of, PRODUCTS or SERVICES, JACKSON will, at its option, provide credit or replacement for the PRODUCT received or the SERVICES provided; JACKSON makes no other representations and this shall be the exclusive remedy of the purchaser. Please note specific policy for live mice.

Animal Care and Use for SERVICES

Consistent with the requirement for a written understanding regarding animal care and use, the JACKSON Animal Care and Use Committee will review the animal care and use protocol(s) associated with any SERVICES to be performed at JACKSON, and JACKSON shall have ultimate responsibility and authority for the care of animals while on site or in JACKSON custody.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS, or SERVICES, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE, PRODUCTS or SERVICES are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or SERVICES. In addition, special terms and conditions of sale of certain MICE, PRODUCTS, or SERVICES may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and SERVICES by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or SERVICES shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or SERVICES by JACKSON.

Also Known As: B6-iDTR, ROSA26iDTR

Donating Investigator

Genetic overview

Research Applications

Base Price

Detailed Description

Development

Expression Data

Control Suggestions

Additional Information

Selected References

Gt(ROSA)26Sortm1(HBEGF)Awai

Allele Symbol: Gt(ROSA)26Sortm1(HBEGF)Awai

Disease Terms

Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Mammalian Phenotype Terms by Genotype

Genotype: Cd19tm1(cre)Cgn/? Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awaiinvolves: 129P2/OlaHsd * C57BL/6

hematopoietic system phenotype

immune system phenotype

Genotype: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sortm1(HBEGF)Awai Tg(Gdf9-icre)5092Coo/0involves: C57BL/6

cellular phenotype

endocrine/exocrine gland phenotype

reproductive system phenotype

Genotype: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+ Tg(Gh1-cre)bKnmn/0involves: C57BL/6 * FVB/N

adipose tissue phenotype

integument phenotype

liver/biliary system phenotype

nervous system phenotype

behavior/neurological phenotype

endocrine/exocrine gland phenotype

growth/size/body region phenotype

homeostasis/metabolism phenotype

Genotype: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+ Tg(Krt1-15-cre/PGR)22Cot/0involves: C57BL/6J * SJL/J

cellular phenotype

digestive/alimentary phenotype

References

Additional References

Additional - Gt(ROSA)26Sortm1(HBEGF)Awai related

Genotyping Protocols

Dietary Information

Breeding Considerations

Mating System

Citation

Animal Health Reports

Live Mouse

Cryorecovery - Pricing

Related Products and Services

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Gt(ROSA)26Sor^{tm1(HBEGF)Awai}

Allele Symbol: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}

Genotype: Cd19^tm1(cre)Cgn/? Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor^{tm1(HBEGF)Awai}
involves: 129P2/OlaHsd * C57BL/6

Genotype: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor^{tm1(HBEGF)Awai} Tg(Gdf9-icre)5092Coo/0
involves: C57BL/6

Genotype: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺ Tg(Gh1-cre)bKnmn/0
involves: C57BL/6 * FVB/N

Genotype: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺ Tg(Krt1-15-cre/PGR)22Cot/0
involves: C57BL/6J * SJL/J

Additional - Gt(ROSA)26Sor^{tm1(HBEGF)Awai} related