JAX
Mouse Strain Datasheet - 007845
B6;129S4-Myf5tm3(cre)Sor/J
This strain has been discontinued. The Myf5tm3(cre)Sor targeted mutation has been cryopreserved under Stock No. 007893 B6.129S4-Myf5tm3(cre)Sor/J
This strain expresses Cre recombinase from the endogenous Myf5 locus. When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in tissue-specific deletion of the target. This mutant mouse strain represents a model that may be useful in studies of skeletal development.
Donating Investigator
Dr. Philippe Soriano, Mount Sinai School of Medicine
Genetic overview
| Genetic Background | Generation |
|---|---|
|
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Myf5tm3(cre)Sor
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Recombinase-expressing) | Myf5 | myogenic factor 5 |
Detailed Description
This strain expresses Cre recombinase from the endogenous Myf5 locus. When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in tissue-specific deletion of the target. Recombination occurs skeletal muscle and the dermis, and in several ectopic locations. Homozygotes for this allele have a perinatal lethal phenotype and die at birth. Homozygotes display abnormal rib development and some fusions of the cervical or thoracic vertebrae. This mutant mouse strain represents a model that may be useful in studies of skeletal development.
Development
A targeting vector containing nuclear localized cre coding sequence, loxP site flanked neomycin resistance cassette and a diphtheria toxin gene was inserted 90 bp upstream of the initiation codon to disrupt the targeted gene. The endogenous Myf5 promoter drives expression of the Cre recombinase. The construct was electroporated into 129S4/SvJaeSor-derived AK7 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. The resulting chimeric animals were crossed to Cre recombinase expressing strain to remove the neomycin selection cassette and then backcrossed to C57BL/6J mice for one generation.
Expression Data
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
|---|---|
| Site of Expression | skeletal muscle, dermis, and several ectopic locations |
Control Suggestions
Selected References
- Tallquist MD; Weismann KE; Hellstrom M; Soriano P. 2000. Early myotome specification regulates PDGFA expression and axial skeleton development Development 127(23):5059-70. PubMed: 11060232MGI: J:65301
Myf5tm3(cre)Sor
Allele Symbol: Myf5tm3(cre)Sor
| Allele Name | targeted mutation 3, Philippe Soriano |
|---|---|
| Allele Type | Targeted (Recombinase-expressing) |
| Allele Synonym(s) | Mif5-Cre; Myf5Cre-So; Myf5Cre; Myf5CreSOR |
| Gene Symbol and Name | Myf5, myogenic factor 5 |
| Gene Synonym(s) | B130010J22Rik; B130010J22Rik; Myf-5; RIKEN cDNA B130010J22 gene; bHLHc2 |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | skeletal muscle, dermis, and several ectopic locations |
| Strain of Origin | 129S4/SvJaeSor |
| Chromosome | 10 |
| Molecular Note | A cre cDNA was inserted between a SacI site and a KpnI site in the 5'UTR of the Myf5 gene. An adjacent loxP-flanked neomycin cassette was removed by Cre- mediated recombination. |
| Mutations Made By | Dr. Philippe Soriano, Mount Sinai School of Medicine |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Developmental Biology Research
- Perinatal Lethality
- Homozygous
- Skeletal Defects
- Perinatal Lethality
- Research Tools
- Cre-lox System
- Cre Recombinase Expression
- Developmental Biology Research
- Cre-lox System
- Cre-lox System
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
Mammalian Phenotype Terms by Genotype
Genotype: Myf5tm3(cre)Sor/Myf5tm3(cre)Sor
involves: 129S4/SvJae * C57BL/6J
skeleton phenotype
- abnormal rib development
- animals show more rib formation than Myf5tm1Jae homozygotes, but ribs frequently do not extend to the vertebrae (MGI Ref ID J:65301)
- cervical vertebral fusion
- fusions are seen in most animals, but are less severe than in Myf5tm1Jae homozygotes (MGI Ref ID J:65301)
- thoracic vertebral fusion
- fusions are seen in most animals, but are less severe than in Myf5tm1Jae homozygotes (MGI Ref ID J:65301)
References
- Tallquist MD; Weismann KE; Hellstrom M; Soriano P. 2000. Early myotome specification regulates PDGFA expression and axial skeleton development Development 127(23):5059-70. PubMed: 11060232MGI: J:65301
Additional - Myf5tm3(cre)Sor related
- Abou-Khalil R; Le Grand F; Pallafacchina G; Valable S; Authier FJ; Rudnicki MA; Gherardi RK; Germain S; Chretien F; Sotiropoulos A; Lafuste P; Montarras D; Chazaud B. 2009. Autocrine and paracrine angiopoietin 1/Tie-2 signaling promotes muscle satellite cell self-renewal. Cell Stem Cell 5(3):298-309. PubMed: 19733541MGI: J:154124
- Al-Massadi O; Porteiro B; Kuhlow D; Kohler M; Gonzalez-Rellan MJ; Garcia-Lavandeira M; Diaz-Rodriguez E; Quinones M; Senra A; Alvarez CV; Lopez M; Dieguez C; Schulz TJ; Nogueiras R. 2016. Pharmacological and Genetic Manipulation of p53 in Brown Fat at Adult But Not Embryonic Stages Regulates Thermogenesis and Body Weight in Male Mice. Endocrinology 157(7):2735-49. PubMed: 27183316MGI: J:239719
- An CI; Dong Y; Hagiwara N. 2011. Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6. BMC Dev Biol 11:59. PubMed: 21985497MGI: J:178848
- Angione AR; Jiang C; Pan D; Wang YX; Kuang S. 2011. PPARdelta regulates satellite cell proliferation and skeletal muscle regeneration. Skelet Muscle 1(1):33. PubMed: 22040534MGI: J:183730
- Beedle AM; Turner AJ; Saito Y; Lueck JD; Foltz SJ; Fortunato MJ; Nienaber PM; Campbell KP. 2012. Mouse fukutin deletion impairs dystroglycan processing and recapitulates muscular dystrophy. J Clin Invest 122(9):3330-42. PubMed: 22922256MGI: J:187144
- Clow C; Jasmin BJ. 2010. Brain-derived neurotrophic factor regulates satellite cell differentiation and skeltal muscle regeneration. Mol Biol Cell 21(13):2182-90. PubMed: 20427568MGI: J:165062
- Comai G; Sambasivan R; Gopalakrishnan S; Tajbakhsh S. 2014. Variations in the efficiency of lineage marking and ablation confound distinctions between myogenic cell populations. Dev Cell 31(5):654-67. PubMed: 25490270MGI: J:228101
- Dick SA; Chang NC; Dumont NA; Bell RA; Putinski C; Kawabe Y; Litchfield DW; Rudnicki MA; Megeney LA. 2015. Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells. Proc Natl Acad Sci U S A 112(38):E5246-52. PubMed: 26372956MGI: J:226994
- Dong F; Sun X; Liu W; Ai D; Klysik E; Lu MF; Hadley J; Antoni L; Chen L; Baldini A; Francis-West P; Martin JF. 2006. Pitx2 promotes development of splanchnic mesoderm-derived branchiomeric muscle. Development 133(24):4891-9. PubMed: 17107996MGI: J:119660
- Genetic Resource Science at The Jackson Laboratory. 2012. Expression/Specificity Patterns of Cre Alleles, 2012 Direct Data Submission from Genetic Resource Science :. MGI: J:184579
- Gensch N; Borchardt T; Schneider A; Riethmacher D; Braun T. 2008. Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis. Development 135(9):1597-604. PubMed: 18367555MGI: J:134484
- Goudy S; Angel P; Jacobs B; Hill C; Mainini V; Smith AL; Kousa YA; Caprioli R; Prince LS; Baldwin S; Schutte BC. 2013. Cell-autonomous and non-cell-autonomous roles for IRF6 during development of the tongue. PLoS One 8(2):e56270. PubMed: 23451037MGI: J:199408
- Gruenbaum-Cohen Y; Harel I; Umansky KB; Tzahor E; Snapper SB; Shilo BZ; Schejter ED. 2012. The actin regulator N-WASp is required for muscle-cell fusion in mice. Proc Natl Acad Sci U S A 109(28):11211-6. PubMed: 22736793MGI: J:186396
- Gunther S; Kim J; Kostin S; Lepper C; Fan CM; Braun T. 2013. Myf5-positive satellite cells contribute to pax7-dependent long-term maintenance of adult muscle stem cells. Cell Stem Cell 13(5):590-601. PubMed: 23933088MGI: J:202693
- Haldar M; Karan G; Watanabe S; Guenther S; Braun T; Capecchi MR. 2014. Response: Contributions of the Myf5-independent lineage to myogenesis. Dev Cell 31(5):539-41. PubMed: 25490265MGI: J:217688
- Hallock PT; Xu CF; Park TJ; Neubert TA; Curran T; Burden SJ. 2010. Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L. Genes Dev 24(21):2451-61. PubMed: 21041412MGI: J:165470
- Han D; Zhao H; Parada C; Hacia JG; Bringas P Jr; Chai Y. 2012. A TGFbeta-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development. Development 139(9):1640-50. PubMed: 22438570MGI: J:184019
- Harel I; Maezawa Y; Avraham R; Rinon A; Ma HY; Cross JW; Leviatan N; Hegesh J; Roy A; Jacob-Hirsch J; Rechavi G; Carvajal J; Tole S; Kioussi C; Quaggin S; Tzahor E. 2012. Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis. Proc Natl Acad Sci U S A 109(46):18839-44. PubMed: 23112163MGI: J:191738
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- Hatley ME; Tang W; Garcia MR; Finkelstein D; Millay DP; Liu N; Graff J; Galindo RL; Olson EN. 2012. A mouse model of rhabdomyosarcoma originating from the adipocyte lineage. Cancer Cell 22(4):536-46. PubMed: 23079662MGI: J:192027
- Hosokawa R; Oka K; Yamaza T; Iwata J; Urata M; Xu X; Bringas P Jr; Nonaka K; Chai Y. 2010. TGF-beta mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue-tissue interactions during tongue morphogenesis. Dev Biol 341(1):186-95. PubMed: 20193675MGI: J:160001
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- Hu JK; McGlinn E; Harfe BD; Kardon G; Tabin CJ. 2012. Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation. Genes Dev 26(18):2088-102. PubMed: 22987639MGI: J:187741
- Huh MS; Parker MH; Scime A; Parks R; Rudnicki MA. 2004. Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation. J Cell Biol 166(6):865-76. PubMed: 15364961MGI: J:92502
- Huh MS; Price O'Dea T; Ouazia D; McKay BC; Parise G; Parks RJ; Rudnicki MA; Picketts DJ. 2012. Compromised genomic integrity impedes muscle growth after Atrx inactivation. J Clin Invest 122(12):4412-23. PubMed: 23114596MGI: J:193998
- Hung CM; Calejman CM; Sanchez-Gurmaches J; Li H; Clish CB; Hettmer S; Wagers AJ; Guertin DA. 2014. Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Disease. Cell Rep 8(1):256-71. PubMed: 25001283MGI: J:212069
- Iyer CC; McGovern VL; Murray JD; Gombash SE; Zaworski PG; Foust KD; Janssen PM; Burghes AH. 2015. Low levels of Survival Motor Neuron protein are sufficient for normal muscle function in the SMNDelta7 mouse model of SMA. Hum Mol Genet 24(21):6160-73. PubMed: 26276812MGI: J:226174
- Jin Q; Wang C; Kuang X; Feng X; Sartorelli V; Ying H; Ge K; Dent SY. 2014. Gcn5 and PCAF regulate PPARgamma and Prdm16 expression to facilitate brown adipogenesis. Mol Cell Biol 34(19):3746-53. PubMed: 25071153MGI: J:224343
- Kan L; Liu Y; McGuire TL; Berger DM; Awatramani RB; Dymecki SM; Kessler JA. 2009. Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification. Stem Cells 27(1):150-6. PubMed: 18832590MGI: J:207284
- Kanagawa M; Yu CC; Ito C; Fukada S; Hozoji-Inada M; Chiyo T; Kuga A; Matsuo M; Sato K; Yamaguchi M; Ito T; Ohtsuka Y; Katanosaka Y; Miyagoe-Suzuki Y; Naruse K; Kobayashi K; Okada T; Takeda S; Toda T. 2013. Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration of its severe phenotype by limited gene expression. Hum Mol Genet 22(15):3003-15. PubMed: 23562821MGI: J:198535
- Klover P; Hennighausen L. 2007. Postnatal Body Growth Is Dependent on the Transcription Factors Signal Transducers and Activators of Transcription 5a/b in Muscle: A Role for Autocrine/Paracrine Insulin-Like Growth Factor I. Endocrinology 148(4):1489-97. PubMed: 17158201MGI: J:119237
- Le Grand F; Grifone R; Mourikis P; Houbron C; Gigaud C; Pujol J; Maillet M; Pages G; Rudnicki M; Tajbakhsh S; Maire P. 2012. Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration. J Cell Biol 198(5):815-32. PubMed: 22945933MGI: J:190460
- Le Grand F; Jones AE; Seale V; Scime A; Rudnicki MA. 2009. Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells. Cell Stem Cell 4(6):535-47. PubMed: 19497282MGI: J:149821
- Lee JE; Wang C; Xu S; Cho YW; Wang L; Feng X; Baldridge A; Sartorelli V; Zhuang L; Peng W; Ge K. 2013. H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation. Elife 2:e01503. PubMed: 24368734MGI: J:207891
- Lee YH; Petkova AP; Konkar AA; Granneman JG. 2015. Cellular origins of cold-induced brown adipocytes in adult mice. FASEB J 29(1):286-99. PubMed: 25392270MGI: J:218206
- Li P; Pashmforoush M; Sucov HM. 2010. Retinoic acid regulates differentiation of the secondary heart field and TGFbeta-mediated outflow tract septation. Dev Cell 18(3):480-5. PubMed: 20230754MGI: J:159110
- Lynes MD; Schulz TJ; Pan AJ; Tseng YH. 2015. Disruption of insulin signaling in Myf5-expressing progenitors leads to marked paucity of brown fat but normal muscle development. Endocrinology 156(5):1637-47. PubMed: 25625589MGI: J:222055
- Martinez TL; Kong L; Wang X; Osborne MA; Crowder ME; Van Meerbeke JP; Xu X; Davis C; Wooley J; Goldhamer DJ; Lutz CM; Rich MM; Sumner CJ. 2012. Survival Motor Neuron Protein in Motor Neurons Determines Synaptic Integrity in Spinal Muscular Atrophy. J Neurosci 32(25):8703-8715. PubMed: 22723710MGI: J:185657
- Martinez-Lopez N; Athonvarangkul D; Sahu S; Coletto L; Zong H; Bastie CC; Pessin JE; Schwartz GJ; Singh R. 2013. Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development. EMBO Rep 14(9):795-803. PubMed: 23907538MGI: J:203690
- Matheny RW Jr; Riddle-Kottke MA; Leandry LA; Lynch CM; Abdalla MN; Geddis AV; Piper DR; Zhao JJ. 2015. Role of phosphoinositide 3-OH kinase p110beta in skeletal myogenesis. Mol Cell Biol 35(7):1182-96. PubMed: 25605332MGI: J:224289
- Nitzki F; Zibat A; Frommhold A; Schneider A; Schulz-Schaeffer W; Braun T; Hahn H. 2011. Uncommitted precursor cells might contribute to increased incidence of embryonal rhabdomyosarcoma in heterozygous Patched1-mutant mice. Oncogene 30(43):4428-36. PubMed: 21602886MGI: J:178574
- Nixon M; Stewart-Fitzgibbon R; Fu J; Akhmedov D; Rajendran K; Mendoza-Rodriguez MG; Rivera-Molina YA; Gibson M; Berglund ED; Justice NJ; Berdeaux R. 2016. Skeletal muscle salt inducible kinase 1 promotes insulin resistance in obesity. Mol Metab 5(1):34-46. PubMed: 26844205MGI: J:236223
- Ogawa R; Ma Y; Yamaguchi M; Ito T; Watanabe Y; Ohtani T; Murakami S; Uchida S; De Gaspari P; Uezumi A; Nakamura M; Miyagoe-Suzuki Y; Tsujikawa K; Hashimoto N; Braun T; Tanaka T; Takeda S; Yamamoto H; Fukada S. 2015. Doublecortin marks a new population of transiently amplifying muscle progenitor cells and is required for myofiber maturation during skeletal muscle regeneration. Development 142(1):51-61. PubMed: 25480916MGI: J:237438
- Petchey LK; Risebro CA; Vieira JM; Roberts T; Bryson JB; Greensmith L; Lythgoe MF; Riley PR. 2014. Loss of Prox1 in striated muscle causes slow to fast skeletal muscle fiber conversion and dilated cardiomyopathy. Proc Natl Acad Sci U S A 111(26):9515-20. PubMed: 24938781MGI: J:212185
- Sanchez-Gurmaches J; Guertin DA. 2014. Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed. Nat Commun 5:4099. PubMed: 24942009MGI: J:238822
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- Seale P; Bjork B; Yang W; Kajimura S; Chin S; Kuang S; Scime A; Devarakonda S; Conroe HM; Erdjument-Bromage H; Tempst P; Rudnicki MA; Beier DR; Spiegelman BM. 2008. PRDM16 controls a brown fat/skeletal muscle switch. Nature 454(7207):961-7. PubMed: 18719582MGI: J:138823
- Shneider NA; Brown MN; Smith CA; Pickel J; Alvarez FJ. 2009. Gamma motor neurons express distinct genetic markers at birth and require muscle spindle-derived GDNF for postnatal survival. Neural Dev 4:42. PubMed: 19954518MGI: J:160727
- Shneider NA; Mentis GZ; Schustak J; O'Donovan MJ. 2009. Functionally reduced sensorimotor connections form with normal specificity despite abnormal muscle spindle development: the role of spindle-derived neurotrophin 3. J Neurosci 29(15):4719-35. PubMed: 19369542MGI: J:147957
- Stuelsatz P; Shearer A; Yablonka-Reuveni Z. 2014. Ancestral Myf5 gene activity in periocular connective tissue identifies a subset of fibro/adipogenic progenitors but does not connote a myogenic origin. Dev Biol 385(2):366-79. PubMed: 23969310MGI: J:205346
- Sun C; Berry WL; Olson LE. 2017. PDGFRalpha controls the balance of stromal and adipogenic cells during adipose tissue organogenesis. Development 144(1):83-94. PubMed: 28049691MGI: J:238410
- Tavares AL; Clouthier DE. 2015. Cre recombinase-regulated Endothelin1 transgenic mouse lines: novel tools for analysis of embryonic and adult disorders. Dev Biol 400(2):191-201. PubMed: 25725491MGI: J:221133
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- Tran TH; Shi X; Zaia J; Ai X. 2012. Heparan sulfate 6-O-endosulfatases (Sulfs) coordinate the Wnt signaling pathways to regulate myoblast fusion during skeletal muscle regeneration. J Biol Chem 287(39):32651-64. PubMed: 22865881MGI: J:191590
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- Watanabe S; Matsushita S; Hayasaka M; Hanaoka K. 2011. Generation of a conditional null allele of Lbx1. Genesis 49(10):803-10. PubMed: 21956886MGI: J:178868
- Xiao H; Zhang X; Goodrich DW. 2010. Construction of a dual affinity tagged allele of the Rb1 tumor suppressor gene in the mouse. Genesis 48(2):121-6. PubMed: 20027616MGI: J:158408
- Yin H; Pasut A; Soleimani VD; Bentzinger CF; Antoun G; Thorn S; Seale P; Fernando P; van Ijcken W; Grosveld F; Dekemp RA; Boushel R; Harper ME; Rudnicki MA. 2013. MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16. Cell Metab 17(2):210-24. PubMed: 23395168MGI: J:196607
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